Michael Klemsz

  • 5337 Citations
  • 31 h-Index
1987 …2015

Research output per year

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Publications

  • 5337 Citations
  • 31 h-Index
  • 46 Article
  • 2 Letter
  • 1 Comment/debate
  • 1 Review article
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Article
2015

Oral immunotherapy with type v collagen in idiopathic pulmonary fibrosis

Wilkes, D. S., Chew, T., Flaherty, K. R., Frye, S., Gibson, K. F., Kaminski, N., Klemsz, M. J., Lange, W., Noth, I. & Rothhaar, K., May 1 2015, In : European Respiratory Journal. 45, 5, p. 1393-1402 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2008

Pillars article: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell, 1990. 61: 113-124.

Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C. & Maki, R. A., Aug 1 2008, In : Journal of immunology (Baltimore, Md. : 1950). 181, 3, p. 1597-1608 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons

Mann, B. A., Huang, J. H., Li, P., Chang, H. C., Slee, R. B., O'Sullivan, A., Mathur, A., Yeh, N., Klemsz, M. J., Brutkiewicz, R. R., Blum, J. S. & Kaplan, M. H., Jun 1 2008, In : Journal of Interferon and Cytokine Research. 28, 6, p. 367-379 13 p.

Research output: Contribution to journalArticle

44 Scopus citations
2005

Histone H4 HDAC activity is necessary for expression of the PU.1 gene

Laribee, R. N. & Klemsz, M. J., Sep 25 2005, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1730, 3, p. 226-234 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

PU.1 expression delineates heterogeneity in primary Th2 cells

Chang, H. C., Zhang, S., Thieu, V. T., Slee, R. B., Bruns, H. A., Laribee, R. N., Klemsz, M. J. & Kaplan, M. H., Jun 2005, In : Immunity. 22, 6, p. 693-703 11 p.

Research output: Contribution to journalArticle

112 Scopus citations
2004

Cathepsin E: A Novel Target for Regulation by Class II Transactivator

Yee, C. S. K., Yao, Y., Li, P., Klemsz, M. J., Blum, J. S. & Chang, C. H., May 1 2004, In : Journal of Immunology. 172, 9, p. 5528-5534 7 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations
52 Scopus citations

Human papillomavirus type 16 E7 protein increases acetylation of histone H3 in human foreskin keratinocytes

Zhang, B., Laribee, R. N., Klemsz, M. J. & Roman, A., Nov 10 2004, In : Virology. 329, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

p38 activation through Toll-like receptors modulates IFN-γ-induced expression of the Tap-1 gene only in macrophages

Cecil, A. A. & Klemsz, M. J., Mar 1 2004, In : Journal of Leukocyte Biology. 75, 3, p. 560-568 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2003

PU.1 regulates glutathione peroxidase expression in neutrophils

Throm, S. L. & Klemsz, M. J., Jul 1 2003, In : Journal of Leukocyte Biology. 74, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2001

Loss of PU.1 Expression following inhibition of histone deacetylases

Laribee, R. N. & Klemsz, M. J., Nov 1 2001, In : Journal of Immunology. 167, 9, p. 5160-5166 7 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations

PU.1 is a Lineage-specific Regulator of Tyrosine Phosphatase CD45

Anderson, K. L., Nelson, S. L., Perkin, H. B., Smith, K. A., Klemsz, M. J. & Torbett, B. E., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 7637-7642 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Regulation of the PU.1 gene by distal elements

Li, Y., Okuno, Y., Zhang, P., Radomska, H. S., Chen, H. M., Iwasaki, H., Akashi, K., Klemsz, M. J., McKercher, S. R., Maki, R. A. & Tenen, D. G., Nov 15 2001, In : Blood. 98, 10, p. 2958-2965 8 p.

Research output: Contribution to journalArticle

70 Scopus citations
2000

Negative regulation of pu.1 expression by inhibition of histone deacetylases

Nicholas Laribee, R. & Klemsz, M. J., Dec 1 2000, In : Blood. 96, 11 PART II, p. 133b

Research output: Contribution to journalArticle

Synergistic induction of the Tap-1 gene by IFN-γ and lipopolysaccharide in macrophages is regulated by STAT1

Cramer, L. A., Nelson, S. L. & Klemsz, M. J., Sep 15 2000, In : Journal of Immunology. 165, 6, p. 3190-3197 8 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
1999

DNA methylation and chromatin structure regulate PU. 1 Expression

Amaravadi, L. & Klemsz, M. J., Dec 1 1999, In : DNA and Cell Biology. 18, 12, p. 875-884 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
1997

Altered kinetics of Tap-1 gene expression in macrophages following stimulation with both IFN-γ and LPS

Cramer, L. A. & Klemsz, M. J., May 25 1997, In : Cellular Immunology. 178, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cloning and characterization of Exodus, a novel β-chemokine

Hromas, R., Gray, P. W., Chantry, D., Godiska, R., Krathwohl, M., Fife, K., Bell, G. I., Takeda, J., Aronica, S., Gordon, M., Cooper, S., Broxmeyer, H. E. & Klemsz, M. J., May 1 1997, In : Blood. 89, 9, p. 3315-3322 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Isolation and characterization of exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension

Hromas, R., Kim, C. H., Klemsz, M., Krathwohl, M., Fife, K., Cooper, S., Schnizlein-Bick, C. & Broxmeyer, H. E., Dec 1 1997, In : Journal of Immunology. 159, 6, p. 2554-2558 5 p.

Research output: Contribution to journalArticle

122 Scopus citations

Methylation of an ETS site in the intron enhancer of the keratin 18 gene participates in tissue-specific repression

Umezawa, A., Yamamoto, H., Rhodes, K., Klemsz, M. J., Maki, R. A. & Oshima, R. G., Sep 1997, In : Molecular and cellular biology. 17, 9, p. 4885-4894 10 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
1996

Activation of transcription by PU.1 requires both acidic and glutamine domains

Klemsz, M. J. & Maki, R. A., Jan 1996, In : Molecular and cellular biology. 16, 1, p. 390-397 8 p.

Research output: Contribution to journalArticle

Open Access
77 Scopus citations

A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex

Kodandapani, R., Pio, F., Ni, C. Z., Picciallit, G., Klemsz, M., McKercher, S., Maki, R. A. & Ely, K. R., Apr 4 1996, In : Nature. 380, 6573, p. 456-460 5 p.

Research output: Contribution to journalArticle

253 Scopus citations

Crystal structure of pu.1 ets domain-dna complex: a new pattern for helix-turn-helix recognition

Pio, F., Kodandapani, R., Ni, C. Z., Piccialli, G., McKercher, S., Klemsz, M., Maki, R. A. & Ely, K. R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1136

Research output: Contribution to journalArticle

Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells

Sutton, J., Costa, R., Klug, M., Field, L., Xu, D., Largaespada, D. A., Fletcher, C. F., Jenkins, N. A., Copeland, N. G., Klemsz, M. & Hromas, R., Sep 30 1996, In : Journal of Biological Chemistry. 271, 38, p. 23126-23133 8 p.

Research output: Contribution to journalArticle

156 Scopus citations

Hematopoietic transcriptional regulation by the myeloid zinc finger gene, MZF-1

Hromas, R., Davis, B., Rauscher, F. J., Klemsz, M., Tenen, D., Hoffman, S., Xu, D. & Morris, J. F., Dec 1 1996, In : Current Topics in Microbiology and Immunology. 211, p. 158-164 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

New insights on DNA recognition by ets proteins from the crystal structure of the PU.1 ETS domain-DNA complex

Pio, F., Kodapani, R., Ni, C. Z., Shepard, W., Klemsz, M., McKercher, S. R., Maki, R. A. & Ely, K. R., Sep 30 1996, In : Journal of Biological Chemistry. 271, 38, p. 23329-23337 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J. & Maki, R. A., Oct 15 1996, In : EMBO Journal. 15, 20, p. 5647-5658 12 p.

Research output: Contribution to journalArticle

863 Scopus citations

The transcription factor PU.1 is involved in macrophage proliferation

Celada, A., Borràs, F. E., Soler, C., Lloberas, J., Klemsz, M., Van Beveren, C., McKercher, S. & Maki, R. A., Jul 1 1996, In : Journal of Experimental Medicine. 184, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

106 Scopus citations
1995

Co-crystallization of an ETS domain (PU.1) in complex with DNA: Engineering the length of both protein and oligonucleotide

Pio, F., Ni, C. Z., Mitchell, R. S., Knight, J., McKercher, S., Klemszt, M., Lombardo, A., Maki, R. A. & Ely, K. R., Oct 13 1995, In : Journal of Biological Chemistry. 270, 41, p. 24258-24263 6 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro

Morris, J. F., Rauscher, F. J., Davis, B., Klemsz, M., Xu, D., Tenen, D. & Hromas, R., 1995, In : Blood. 86, 10, p. 3640-3647 8 p.

Research output: Contribution to journalArticle

89 Scopus citations
1994

Drosophila forkhead homologues are expressed in CD34+HLA-DR- primitive human hematopoietic progenitors

Hromas, R., Klemsz, M., Amaravadi, L., Hufford, T., Huang, I., Desai, A., Srour, E., Bruno, E. & Hoffman, R., Jan 1 1994, In : Leukemia and Lymphoma. 15, 5-6, p. 439-444 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pe-1, a novel ets oncogene family member, localizes to chromosome 1q21-q23

Klemsz, M., Hromas, R., Raskind, W., Bruno, E. & Hoffman, R., Mar 15 1994, In : Genomics. 20, 2, p. 291-294 4 p.

Research output: Contribution to journalArticle

18 Scopus citations
1993

Characterization of the ets oncogene family member, fli-1

Klemsz, M. J., Maki, R. A., Papayannopoulou, T., Moore, J. & Hromas, R., Jan 1 1993, In : Journal of Biological Chemistry. 268, 8, p. 5769-5773 5 p.

Research output: Contribution to journalArticle

73 Scopus citations

Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells

Hromas, R., Moore, J., Johnston, T., Socha, C. & Klemsz, M., 1993, In : Blood. 81, 11, p. 2854-2859 6 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

Pongubala, J. M. R., Van Beveren, C., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A. & Atchison, M. L., Jan 1 1993, In : Science. 259, 5101, p. 1622-1625 4 p.

Research output: Contribution to journalArticle

235 Scopus citations

Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11

Huppi, K., Siwarski, D., Shaughnessy, J., Klemsz, M. J., Shirakata, M., Maki, R. & Sakano, H., Jan 1 1993, In : Immunogenetics. 37, 4, p. 288-291 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1

Hromas, R., Orazi, A., Neiman, R. S., Maki, R., Van Beveran, C., Moore, J. & Klemsz, M., 1993, In : Blood. 82, 10, p. 2998-3004 7 p.

Research output: Contribution to journalArticle

Open Access
188 Scopus citations

Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neuroepithelioma

Hromas, R., May, W., Denny, C., Raskind, W., Moore, J., Maki, R. A., Beck, E. & Klemsz, M. J., Feb 20 1993, In : BBA - Gene Structure and Expression. 1172, 1-2, p. 155-158 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI- 1

May, W. A., Lessnick, S. L., Braun, B. S., Klemsz, M., Lewis, B. C., Lunsford, L. B., Hromas, R. & Denny, C. T., 1993, In : Molecular and cellular biology. 13, 12, p. 7393-7398 6 p.

Research output: Contribution to journalArticle

Open Access
417 Scopus citations
1992

PU.1 recruits a second nuclear factor to a site important for immunoglobulin κ 3' enhancer activity

Pongubala, J. M. R., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A. & Atchison, M. L., 1992, In : Molecular and cellular biology. 12, 1, p. 368-378 11 p.

Research output: Contribution to journalArticle

Open Access
304 Scopus citations
1990

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C. & Maki, R. A., Apr 6 1990, In : Cell. 61, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

731 Scopus citations
1989

Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands

Klemsz, M. J., Justement, L. B., Palmer, E. & Cambier, J. C., Jan 1 1989, In : Journal of Immunology. 143, 3, p. 1032-1039 8 p.

Research output: Contribution to journalArticle

81 Scopus citations
60 Scopus citations
1987

Differential Transmembrane Signaling in B Lymphocyte Activation

CAMBIER, JOHN. C., CHEN, ZHENG. Z., RANSOM, JOHN. T., COGGESHALL, K. MARK., KLEMSZ, MICHAEL. J., HARRIS, LESLEY. K., SANDOVAL, MCTOFUA. M. & NEWELL, M. KAREN., May 1987, In : Annals of the New York Academy of Sciences. 494, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nucleotide sequence of the mouse hck gene

Klemsz, M. J., Mckercher, S. R. & Maki, R. A., Nov 25 1987, In : Nucleic acids research. 15, 22, 1 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transmembrane Signals and Intracellular “Second Messengers” in the Regulation of Quiescent B‐Lymphocyte Activation

Cambier, J. C., Justement, L. B., KarenNewell, M., Chen, Z. Z., Harris, L. K., Sandoval, V. M., Klemsz, M. J. & Ransom, J. T., Feb 1987, In : Immunological Reviews. 95, 1, p. 37-57 21 p.

Research output: Contribution to journalArticle

108 Scopus citations