Michael Vasko

  • 5254 Citations
  • 42 h-Index
1973 …2017
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Publications 1973 2017

  • 5254 Citations
  • 42 h-Index
  • 116 Article
  • 2 Chapter
2017
8 Citations (Scopus)

A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch

Ramsden, C. E., Domenichiello, A. F., Yuan, Z. X., Sapio, M. R., Keyes, G. S., Mishra, S. K., Gross, J. R., Majchrzak-Hong, S., Zamora, D., Horowitz, M. S., Davis, J. M., Sorokin, A. V., Dey, A., LaPaglia, D. M., Wheeler, J. J., Vasko, M., Mehta, N. N., Mannes, A. J. & Iadarola, M. J., Aug 22 2017, In : Science Signaling. 10, 493, 5241.

Research output: Contribution to journalArticle

Linoleic Acid
Systems Analysis
Skin
Derivatives
Rats
2 Citations (Scopus)
DNA Repair
DNA Damage
Sensory Receptor Cells
Calcitonin Gene-Related Peptide
Inflammation
2016
4 Citations (Scopus)

Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons

Robarge, J. D., Duarte, D. B., Shariati, B., Wang, R., Flockhart, D. A. & Vasko, M., Jul 1 2016, In : Experimental Neurology. 281, p. 53-65 13 p.

Research output: Contribution to journalArticle

letrozole
Aromatase Inhibitors
Sensory Receptor Cells
Hypersensitivity
exemestane
6 Citations (Scopus)

Epac activation sensitizes rat sensory neurons through activation of Ras

Shariati, B., Thompson, E. L., Nicol, G. & Vasko, M., Jan 1 2016, In : Molecular and Cellular Neuroscience. 70, p. 54-67 14 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Action Potentials
Calcitonin Gene-Related Peptide
Perfusion
Capsaicin
17 Citations (Scopus)
DNA-(Apurinic or Apyrimidinic Site) Lyase
Peripheral Nervous System Diseases
oxaliplatin
Drug Therapy
Sensory Receptor Cells
2 Citations (Scopus)
Cyclic AMP-Dependent Protein Kinases
Dinoprostone
Eicosanoids
Calcitonin Gene-Related Peptide
Capsaicin
7 Citations (Scopus)

Models of Inflammation: Carrageenan Air Pouch

Duarte, D. B., Vasko, M. & Fehrenbacher, J., Mar 18 2016, In : Current Protocols in Pharmacology. 72

Research output: Contribution to journalArticle

Carrageenan
Air
Inflammation
Irritants
Exudates and Transudates
4 Citations (Scopus)

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons

Georgiadis, M., Chen, Q., Meng, J., Guo, C., Wireman, R., Reed, A., Vasko, M. & Kelley, M., May 1 2016, In : DNA Repair. 41, p. 32-41 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Sensory Receptor Cells
Nicorandil
Cisplatin
2 Citations (Scopus)

The role of DNA damage and repair in toxicity to postmitotic cells caused by cancer therapies

Vasko, M., Shariati, B. & Zanville, N., Jun 21 2016, DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications: Second Edition. Elsevier Inc., p. 383-428 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
DNA Damage
Neoplasms
Skeletal Muscle
Poisons
2015
14 Citations (Scopus)

APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER

Kim, H. S., Guo, C., Thompson, E. L., Jiang, Y., Kelley, M., Vasko, M. & Lee, S-H., Sep 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 779, p. 96-104 9 p.

Research output: Contribution to journalArticle

Platinum
DNA Repair
Cisplatin
DNA
Proteins
15 Citations (Scopus)

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Barbosa, C., Tan, Z. Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M., Zhang, J. M. & Cummins, T., Sep 25 2015, In : Molecular Pain. 11, 1, 60.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Spinal Ganglia
Sodium
Neurons
Voltage-Gated Sodium Channels
2014
10 Citations (Scopus)

Nerve growth factor mediates a switch in intracellular signaling for PGE<inf>2</inf>-induced sensitization of sensory neurons from protein kinase A to Epac

Vasko, M., Habashy Malty, R., Guo, C., Duarte, D. B., Zhang, Y. & Nicol, G., Aug 15 2014, In : PLoS One. 9, 8, e104529.

Research output: Contribution to journalArticle

nerve growth factor
cAMP-dependent protein kinase
sensory neurons
Nerve Growth Factor
Sensory Receptor Cells
12 Citations (Scopus)

Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture

Pittman, S. K., Gracias, N. G., Vasko, M. & Fehrenbacher, J., Mar 2014, In : Experimental Neurology. 253, p. 146-153 8 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Paclitaxel
Capsaicin
Peripheral Nervous System Diseases
42 Citations (Scopus)

Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy

Kelley, M., Jiang, Y., Guo, C., Reed, A., Meng, H. & Vasko, M., Sep 4 2014, In : PLoS One. 9, 9, e106485.

Research output: Contribution to journalArticle

oxaliplatin
DNA-(Apurinic or Apyrimidinic Site) Lyase
cisplatin
peripheral nervous system diseases
Carboplatin
2012
24 Citations (Scopus)

CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy

Piekarz, A. D., Due, M. R., Khanna, M., Wang, B., Ripsch, M. S., Wang, R., Meroueh, S., Vasko, M., White, F. & Khanna, R., Jul 24 2012, In : Molecular Pain. 8, 54.

Research output: Contribution to journalArticle

Nociceptors
Nociception
Peripheral Nervous System Diseases
Calcium Channels
Acquired Immunodeficiency Syndrome
16 Citations (Scopus)

Models of inflammation: Carrageenan air pouch

Duarte, D. B., Vasko, M. & Fehrenbacher, J., Mar 2012, In : Current Protocols in Pharmacology. SUPPL.56, 5.6.

Research output: Contribution to journalArticle

Carrageenan
Air
Inflammation
Irritants
Exudates and Transudates
23 Citations (Scopus)
Freund's Adjuvant
Carrageenan
Edema
Hypersensitivity
Inflammation
6 Citations (Scopus)

The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies

Duarte, D. B. & Vasko, M., 2012, DNA Repair in Cancer Therapy. Elsevier Inc., p. 283-299 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Platinum Compounds
DNA Repair
DNA Damage
Alkylating Agents
temozolomide
2011
8 Citations (Scopus)

Ras signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/- mice

Duan, J. H., Wang, Y., Duarte, D., Vasko, M., Nicol, G. & Hingtgen, C. M., Jun 1 2011, In : Neuroscience Letters. 496, 2, p. 70-74 5 p.

Research output: Contribution to journalArticle

Capsaicin
Nerve Growth Factor
Sensory Receptor Cells
Neurofibromatosis 1 Genes
Neurofibromin 1
4 Citations (Scopus)

Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization

Duarte, D. B., Jian-Hong, D., Nicol, G., Vasko, M. & Hingtgen, C. M., Jul 2011, In : Journal of Neurophysiology. 106, 1, p. 309-318 10 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Capsaicin
Calcitonin Gene-Related Peptide
Sensory Receptor Cells
Neuropeptides
116 Citations (Scopus)

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

Brittain, J. M., Duarte, D. B., Wilson, S. M., Zhu, W., Ballard, C., Johnson, P., Liu, N., Xiong, W., Ripsch, M. S., Wang, Y., Fehrenbacher, J., Fitz, S. D., Khanna, M., Park, C. K., Schmutzler, B. S., Cheon, B. M., Due, M. R., Brustovetsky, T., Ashpole, N. M., Hudmon, A. & 12 others, Meroueh, S., Hingtgen, C. M., Broustovetski, N., Ji, R. R., Hurley, J., Jin, X., Shekhar, A., Xu, X-M., Oxford, G. S., Vasko, M., White, F. & Khanna, R., Jul 2011, In : Nature Medicine. 17, 7, p. 822-829 8 p.

Research output: Contribution to journalArticle

Trans-Activators
Neuralgia
Transcription
Hypersensitivity
Human Immunodeficiency Virus rev Gene Products
25 Citations (Scopus)

The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation

Vasko, M., Guo, C., Thompson, E. L. & Kelley, M., Sep 5 2011, In : DNA Repair. 10, 9, p. 942-952 11 p.

Research output: Contribution to journalArticle

Ionizing radiation
Ionizing Radiation
DNA Repair
Oxidation-Reduction
Repair
15 Citations (Scopus)

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel

Gracias, N. G., Cummins, T., Kelley, M., Basile, D., Iqbal, T. & Vasko, M., Jan 2011, In : NeuroToxicology. 32, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Paclitaxel
Vasodilation
Neurons
Rats
2010
16 Citations (Scopus)

Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons

Park, K. A., Fehrenbacher, J., Thompson, E. L., Duarte, D. B., Hingtgen, C. M. & Vasko, M., Dec 15 2010, In : Neuroscience. 171, 3, p. 910-923 14 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
Nerve Growth Factor
Sensory Receptor Cells
Capsaicin
Farnesyltranstransferase
11 Citations (Scopus)

The deorphanization of TRPV1 and the emergence of octadecadienoids as a new class of lipid transmitters

Flores, C. M. & Vasko, M., Jun 2010, In : Molecular Interventions. 10, 3, p. 137-140 4 p.

Research output: Contribution to journalArticle

Lipids
Pain
Nociceptors
Eicosanoids
Capsaicin
2009
15 Citations (Scopus)

Early and Late Contributions of Glutamate and CGRP to Mechanical Sensitization by Endothelin-1

Khodorova, A., Richter, J., Vasko, M. & Strichartz, G., Jul 2009, In : Journal of Pain. 10, 7, p. 740-749 10 p.

Research output: Contribution to journalArticle

Endothelin-1
Glutamic Acid
Hyperalgesia
Capsaicin
Injections
9 Citations (Scopus)

Local Antinociception Induced by Endothelin-1 in the Hairy Skin of the Rat's Back

Shrestha, S., Gracias, N. G., Mujenda, F., Khodorova, A., Vasko, M. & Strichartz, G. R., Jul 2009, In : Journal of Pain. 10, 7, p. 702-714 13 p.

Research output: Contribution to journalArticle

Endothelin-1
Skin
Nimodipine
Subcutaneous Injections
Epinephrine
162 Citations (Scopus)

Peripheral mechanisms of pain and analgesia

Stein, C., Clark, J. D., Oh, U., Vasko, M., Wilcox, G. L., Overland, A. C., Vanderah, T. W. & Spencer, R. H., Apr 2009, In : Brain Research Reviews. 60, 1, p. 90-113 24 p.

Research output: Contribution to journalArticle

Afferent Neurons
Analgesia
Opioid Analgesics
Pain
Nerve Growth Factor
45 Citations (Scopus)

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

Jiang, Y., Guo, C., Fishel, M., Wang, Z. Y., Vasko, M. & Kelley, M., Nov 2 2009, In : DNA Repair. 8, 11, p. 1273-1282 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Neuroblastoma
Oxidative Stress
Repair
Molecules
13 Citations (Scopus)

The c-kit signaling pathway is involved in the development of persistent pain

Sun, Y. G., Gracias, N. G., Drobish, J. K., Vasko, M., Gereau, R. W. & Chen, Z. F., Jul 2009, In : Pain. 144, 1-2, p. 178-186 9 p.

Research output: Contribution to journalArticle

Substantia Gelatinosa
Pain
Signal Transduction
Mutation
Nociception
2008
79 Citations (Scopus)

Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons

Jiang, Y., Guo, C., Vasko, M. & Kelley, M., Aug 1 2008, In : Cancer Research. 68, 15, p. 6425-6434 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Spinal Ganglia
Cisplatin
Oxygen
Neurons
59 Citations (Scopus)

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

Rimmerman, N., Bradshaw, H. B., Hughes, H. V., Chen, J. S. C., Hu, S. S. J., McHugh, D., Vefring, E., Jahnsen, J. A., Thompson, E. L., Masuda, K., Cravatt, B. F., Burstein, S., Vasko, M., Prieto, A. L., O'Dell, D. K. & Walker, J. M., Jul 2008, In : Molecular Pharmacology. 74, 1, p. 213-224 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Glycine
Nitric Oxide
Lipids
Calcium
4 Citations (Scopus)

Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung

Chiyo, M., Iwata, T., Webb, T. J., Vasko, M., Thompson, E. L., Heidler, K. M., Cummings, O., Yoshida, S., Fujisawa, T., Brand, D. D. & Wilkes, D. S., Mar 2008, In : American Journal of Transplantation. 8, 3, p. 537-546 10 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Collagen
Lymphocytes
Lung
Small Interfering RNA
33 Citations (Scopus)

Spinal N-methyl-d-aspartate receptors and nociception-evoked release of primary afferent substance P

Nazarian, A., Gu, G., Gracias, N. G., Wilkinson, K., Hua, X. Y., Vasko, M. & Yaksh, T. L., Mar 3 2008, In : Neuroscience. 152, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Nociception
Substance P
Aspartic Acid
Formaldehyde
2007
159 Citations (Scopus)
DNA Repair
Neurons
DNA Damage
Mitochondrial DNA
Reactive Oxygen Species
110 Citations (Scopus)
Nociceptors
Nerve Growth Factor
Sensory Receptor Cells
Neurons
Nerve Growth Factor Receptors
2006
57 Citations (Scopus)
Sphingosine
Nerve Growth Factor
Sensory Receptor Cells
Ceramides
Action Potentials
58 Citations (Scopus)
Sensory Receptor Cells
G-Protein-Coupled Receptors
Architectural Accessibility
GTP-Binding Proteins
Action Potentials
2005
37 Citations (Scopus)

Lipid mediators of sensitivity in sensory neurons

Park, K. A. & Vasko, M., Nov 2005, In : Trends in Pharmacological Sciences. 26, 11, p. 571-577 7 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Neurons
Lipids
Lysophospholipids
Inflammation
105 Citations (Scopus)

The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress

Vasko, M., Guo, C. & Kelley, M., Mar 2 2005, In : DNA Repair. 4, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Multifunctional Enzymes
DNA Repair Enzymes
Oxidative stress
Small Interfering RNA
Neurons
52 Citations (Scopus)
Receptors, Prostaglandin E, EP2 Subtype
Spinal Ganglia
Prostaglandin-Endoperoxide Synthases
Interleukin-1
Tumor Necrosis Factor-alpha
2004
28 Citations (Scopus)

Isolation and culture of sensory neurons from the dorsal-root ganglia of embryonic or adult rats.

Burkey, T. H., Hingtgen, C. M. & Vasko, M., 2004, In : Methods in molecular medicine. 99, p. 189-202 14 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Sensory Receptor Cells
Physiological Phenomena
Pathologic Processes
Neurons
92 Citations (Scopus)

The Biology and Pharmacology of Calcium Channel α2-δ Proteins Pfizer satellite symposium to the 2003 Society for Neuroscience Meeting Sheraton New Orleans Hotel New Orleans, LA November 10, 2003

Taylor, C. P., Catterall, W. A., Hofmann, F., Luo, Z. D., Wustrow, D. J., Vasko, M., Field, M. & Baron, S., Jun 2004, In : CNS Drug Reviews. 10, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Calcium Channels
Pharmacology
Pharmaceutical Preparations
Anti-Anxiety Agents
Proteins
2003
35 Citations (Scopus)

ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors

Huang, H., Wu, X., Nicol, G., Meller, S. & Vasko, M., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Adenosine Triphosphate
Peptides
Capsaicin
Protein Kinase C
259 Citations (Scopus)
Substance P
Neuropeptides
Protein Kinase C
Inflammation
Spinal Cord
2002
348 Citations (Scopus)

Cellular mechanisms of neurogenic inflammation

Richardson, J. D. & Vasko, M., Sep 2002, In : Journal of Pharmacology and Experimental Therapeutics. 302, 3, p. 839-845 7 p.

Research output: Contribution to journalArticle

Neurogenic Inflammation
Sensory Receptor Cells
Critical Pathways
Calcitonin Gene-Related Peptide
Wounds and Injuries
128 Citations (Scopus)
Ceramides
Second Messenger Systems
Nerve Growth Factor
Sensory Receptor Cells
Sphingomyelin Phosphodiesterase
53 Citations (Scopus)

Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals

Wang, X., Butowt, R., Vasko, M. & Von Bartheld, C. S., Feb 1 2002, In : Journal of Neuroscience. 22, 3, p. 931-945 15 p.

Research output: Contribution to journalArticle

Neurotrophin 3
Presynaptic Terminals
Nerve Growth Factors
R-SNARE Proteins
Calcium
13 Citations (Scopus)

Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE2-mediated sensitization of rat sensory neurons

Southall, M. D., Bolyard, L. A. & Vasko, M., 2002, In : Pain. 96, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Dinoprostone
Prostaglandins
Down-Regulation
Inflammation
2001
148 Citations (Scopus)

Prostaglandin Receptor Subtypes, EP3C and EP4, Mediate the Prostaglandin E2-induced cAMP Production and Sensitization of Sensory Neurons

Southall, M. D. & Vasko, M., May 11 2001, In : Journal of Biological Chemistry. 276, 19, p. 16083-16091 9 p.

Research output: Contribution to journalArticle

Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
Sensory Receptor Cells
Dinoprostone
Neurons