Mircea Ivan

  • 10414 Citations
  • 36 h-Index
1993 …2020

Research output per year

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Publications

2020

Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression (Nature Communications, (2014), 5, 1, (5202), 10.1038/ncomms6202)

Rupaimoole, R., Wu, S. Y., Pradeep, S., Ivan, C., Pecot, C. V., Gharpure, K. M., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Zand, B., Dalton, H. J., Filant, J., Miller, J. B., Lu, C., Sadaoui, N. C., Mangala, L. S., Taylor, M., van den Beucken, T., Koch, E., Rodriguez-Aguayo, C. & 9 others, Huang, L., Bar-Eli, M., Wouters, B. G., Radovich, M., Ivan, M., Calin, G. A., Zhang, W., Lopez-Berestein, G. & Sood, A. K., Dec 1 2020, In : Nature communications. 11, 1, 2867.

Research output: Contribution to journalComment/debate

Open Access

Glycolysis, via NADH-dependent dimerisation of CtBPs, regulates hypoxia-induced expression of CAIX and stem-like breast cancer cell survival

Kreuzer, M., Banerjee, A., Birts, C. N., Darley, M., Tavassoli, A., Ivan, M. & Blaydes, J. P., 2020, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

Open Access

Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover

Davis, H. M., Deosthale, P. J., Pacheco-Costa, R., Essex, A. L., Atkinson, E. G., Aref, M. W., Dilley, J. E., Bellido, T., Ivan, M., Allen, M. R. & Plotkin, L. I., Mar 1 2020, In : FEBS Journal. 287, 5, p. 941-963 23 p.

Research output: Contribution to journalArticle

2019

Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers

Hancock, B. A., Chen, Y. H., Solzak, J. P., Ahmad, M. N., Wedge, D. C., Brinza, D., Scafe, C., Veitch, J., Gottimukkala, R., Short, W., Atale, R. V., Ivan, M., Badve, S. S., Schneider, B. P., Lu, X., Miller, K. D. & Radovich, M., Aug 5 2019, In : Breast Cancer Research. 21, 1, 87.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress

Moreno Leon, L., Gautier, M., Allan, R., Ilié, M., Nottet, N., Pons, N., Paquet, A., Lebrigand, K., Truchi, M., Fassy, J., Magnone, V., Kinnebrew, G., Radovich, M., Cheok, M. H. C., Barbry, P., Vassaux, G., Marquette, C. H., Ponzio, G., Ivan, M., Pottier, N. & 3 others, Hofman, P., Mari, B. & Rezzonico, R., Nov 14 2019, In : Oncogene. 38, 46, p. 7146-7165 20 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Enteral arg-gln dipeptide administration increases retinal docosahexaenoic acid and neuroprotectin D1 in a murine model of retinopathy of prematurity

Shaw, L. C., Calzi, S. L., Li, N., Moldovan, L., Sengupta-Caballero, N., Quigley, J. L., Ivan, M., Jun, B., Bazan, N. G., Boulton, M. E., Busik, J., Neu, J. & Grant, M. B., Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 858-869 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation

Sodi, V. L., Bacigalupa, Z. A., Ferrer, C. M., Lee, J. V., Gocal, W. A., Mukhopadhyay, D., Wellen, K. E., Ivan, M. & Reginato, M. J., Feb 15 2018, In : Oncogene. 37, 7, p. 924-934 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M. C., Filippi, M. D., Broxmeyer, H. E. & Kapur, R., Dec 1 2018, In : Nature communications. 9, 1, 3518.

Research output: Contribution to journalArticle

6 Scopus citations

The Many Faces of Long Noncoding RNAs in Cancer

Wu, X., Tudoran, O. M., Calin, G. A. & Ivan, M., Sep 20 2018, In : Antioxidants and Redox Signaling. 29, 9, p. 922-935 14 p.

Research output: Contribution to journalReview article

14 Scopus citations
2017

Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

Davis, H. M., Pacheco-Costa, R., Atkinson, E. G., Brun, L. R., Gortazar, A. R., Harris, J., Hiasa, M., Bolarinwa, S. A., Yoneda, T., Ivan, M., Bruzzaniti, A., Bellido, T. & Plotkin, L., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

43 Scopus citations

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Clinkenbeard, E. L., Hanudel, M. R., Stayrook, K. R., Appaiah, H. N., Farrow, E. G., Cass, T. A., Summers, L. J., Ip, C. S., Hum, J. M., Thomas, J. C., Ivan, M., Richine, B. M., Chan, R. J., Clemens, T. L., Schipani, E., Sabbagh, Y., Xu, L., Srour, E. F., Alvarez, M. B., Kacena, M. A. & 4 others, Salusky, I. B., Ganz, T., Nemeth, E. & White, K. E., Oct 27 2017, In : Haematologica. 102, 11, p. e427-e430

Research output: Contribution to journalLetter

36 Scopus citations

The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks

Ivan, M. & Kaelin, W. G., Jun 15 2017, In : Molecular Cell. 66, 6, p. 772-779 8 p.

Research output: Contribution to journalReview article

53 Scopus citations
12 Scopus citations

Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation

Brady, L. K., Wang, H., Radens, C. M., Bi, Y., Radovich, M., Maity, A., Ivan, C., Ivan, M., Barash, Y. & Koumenis, C., Oct 29 2017, In : PLoS Biology. 15, 10, e2002623.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2

Redis, R. S., Vela, L. E., Lu, W., Ferreira de Oliveira, J., Ivan, C., Rodriguez-Aguayo, C., Adamoski, D., Pasculli, B., Taguchi, A., Chen, Y., Fernandez, A. F., Valledor, L., Van Roosbroeck, K., Chang, S., Shah, M., Kinnebrew, G., Han, L., Atlasi, Y., Cheung, L. H., Huang, G. Y. & 25 others, Monroig, P., Ramirez, M. S., Catela Ivkovic, T., Van, L., Ling, H., Gafà, R., Kapitanovic, S., Lanza, G., Bankson, J. A., Huang, P., Lai, S. Y., Bast, R. C., Rosenblum, M. G., Radovich, M., Ivan, M., Bartholomeusz, G., Liang, H., Fraga, M. F., Widger, W. R., Hanash, S., Berindan-Neagoe, I., Lopez-Berestein, G., Ambrosio, A. L. B., Gomes Dias, S. M. & Calin, G. A., Feb 18 2016, In : Molecular Cell. 61, 4, p. 520-534 15 p.

Research output: Contribution to journalArticle

82 Scopus citations

Correction to Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 [Molecular Cell 61, 520-534, (2016)]

Redis, R. S., Vela, L. E., Lu, W., Ferreira de Oliveira, J., Ivan, C., Rodriguez-Aguayo, C., Adamoski, D., Pasculli, B., Taguchi, A., Chen, Y., Fernandez, A. F., Valledor, L., Van Roosbroeck, K., Chang, S., Shah, M., Kinnebrew, G., Han, L., Atlasi, Y., Cheung, L. H., Huang, G. Y. & 25 others, Monroig, P., Ramirez, M. S., Catela Ivkovic, T., Van, L., Ling, H., Gafà, R., Kapitanovic, S., Lanza, G., Bankson, J. A., Huang, P., Lai, S. Y., Bast, R. C., Rosenblum, M. G., Radovich, M., Ivan, M., Bartholomeusz, G., Liang, H., Fraga, M. F., Widger, W. R., Hanash, S., Berindan-Neagoe, I., Lopez-Berestein, G., Ambrosio, A. L. B., Gomes Dias, S. M. & Calin, G. A., Feb 18 2016, In : Molecular Cell. 61, 4, p. 640 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of HIF1a under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual targeting in patient-derived 3D pancreatic cancer models

Logsdon, D. P., Grimard, M., Luo, M., Shahda, S., Jiang, Y., Tong, Y., Yu, Z., Zyromski, N., Schipani, E., Carta, F., Supuran, C. T., Korc, M., Ivan, M., Kelley, M. R. & Fishel, M. L., Nov 2016, In : Molecular cancer therapeutics. 15, 11, p. 2722-2732 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2015

Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2

Fishel, M. L., Wu, X., Devlin, C. M., Logsdon, D. P., Jiang, Y., Luo, M., He, Y., Yu, Z., Tong, Y., Lipking, K. P., Maitra, A., Rajeshkumar, N. V., Scandura, G., Kelley, M. R. & Ivan, M., Jan 30 2015, In : Journal of Biological Chemistry. 290, 5, p. 3057-3068 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H. E., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

130 Scopus citations

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Rupaimoole, R., Wu, S. Y., Pradeep, S., Ivan, C., Pecot, C. V., Gharpure, K. M., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., Zand, B., Dalton, H. J., Filant, J., Miller, J. B., Lu, C., Sadaoui, N. C., Mangala, L. S., Taylor, M., Van Den Beucken, T., Koch, E., Rodriguez-Aguayo, C. & 9 others, Huang, L., Bar-Eli, M., Wouters, B. G., Radovich, M., Ivan, M., Calin, G. A., Zhang, W., Lopez-Berestein, G. & Sood, A. K., Feb 2015, In : Nature communications. 5, 5202.

Research output: Contribution to journalArticle

92 Scopus citations
2014

Characterizing the heterogeneity of triple-negative breast cancers using microdissected normal ductal epithelium and RNA-sequencing

Radovich, M., Clare, S. E., Atale, R., Pardo, I., Hancock, B. A., Solzak, J. P., Kassem, N., Mathieson, T., Storniolo, A. M. V., Rufenbarger, C., Lillemoe, H. A., Blosser, R. J., Choi, M. R., Sauder, C. A., Doxey, D., Henry, J. E., Hilligoss, E. E., Sakarya, O., Hyland, F. C., Hickenbotham, M. & 7 others, Zhu, J., Glasscock, J., Badve, S., Ivan, M., Liu, Y., Sledge, G. W. & Schneider, B. P., Jan 1 2014, In : Breast Cancer Research and Treatment. 143, 1, p. 57-68 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Lakhter, A. J., Hamilton, J., Dagher, P. C., Mukkamala, S., Hato, T., Dong, X. C., Mayo, L. D., Harris, R. A., Shekhar, A., Ivan, M., Brustovetsky, N. & Naidu, S. R., Jan 1 2014, In : Oncotarget. 5, 24, p. 12694-12703 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Gene expression analysis reveals distinct pathways of resistance to bevacizumab in xenograft models of human ER-positive breast cancer

Gökmen-Polar, Y., Goswami, C. P., Toroni, R. A., Sanders, K. L., Mehta, R., Sirimalle, U., Tanasa, B., Shen, C., Li, L., Ivan, M., Badve, S. & Sledge, G. W., 2014, In : Journal of Cancer. 5, 8, p. 633-645 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

HypoxamiRs and cancer: From biology to targeted therapy

Gee, H. E., Ivan, C., Calin, G. A. & Ivan, M., Sep 10 2014, In : Antioxidants and Redox Signaling. 21, 8, p. 1220-1238 19 p.

Research output: Contribution to journalReview article

55 Scopus citations

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

Van Den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S., Starmans, M. H. W., Yao, C. Q., Ivan, M., Ivan, C., Pecot, C. V., Boutros, P. C., Sood, A. K., Koritzinsky, M. & Wouters, B. G., 2014, In : Nature communications. 5, 5203.

Research output: Contribution to journalArticle

119 Scopus citations

MiR-210: Fine-tuning the hypoxic response

Ivan, M. & Huang, X., 2014, Advances in Experimental Medicine and Biology. Vol. 772. p. 205-227 23 p. (Advances in Experimental Medicine and Biology; vol. 772).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

MiR-210: Fine-tuning the hypoxic response

Ivan, M. & Huang, X., 2014, Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging, and Therapeutic Targets. Springer New York LLC, p. 205-227 23 p. (Advances in Experimental Medicine and Biology; vol. 772).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

57 Scopus citations
2013

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts

Kumar, K., Wigfield, S., Gee, H. E., Devlin, C. M., Singleton, D., Li, J. L., Buffa, F., Huffman, M., Sinn, A. L., Silver, J., Turley, H., Leek, R., Harris, A. L. & Ivan, M., Jun 1 2013, In : Journal of Molecular Medicine. 91, 6, p. 749-758 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

HINCUTs in cancer: Hypoxia-induced noncoding ultraconserved transcripts

Ferdin, J., Nishida, N., Wu, X., Nicoloso, M. S., Shah, M. Y., Devlin, C., Ling, H., Shimizu, M., Kumar, K., Cortez, M. A., Ferracin, M., Bi, Y., Yang, D., Czerniak, B., Zhang, W., Schmittgen, T. D., Voorhoeve, M. P., Reginato, M. J., Negrini, M., Davuluri, R. V. & 3 others, Kunej, T., Ivan, M. & Calin, G. A., Dec 1 2013, In : Cell Death and Differentiation. 20, 12, p. 1675-1687 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

MiR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress

Lezina, L., Purmessur, N., Antonov, A. V., Ivanova, T., Karpova, E., Krishan, K., Ivan, M., Aksenova, V., Tentler, D., Garabadgiu, A. V., Melino, G. & Barlev, N. A., Dec 2013, In : Cell Death and Disease. 4, 12, e953.

Research output: Contribution to journalArticle

58 Scopus citations
2012

Dihydroceramide-based response to hypoxia (Journal of Biological Chemistry (2011) 286, (38069-38078))

Devlin, C. M., Lahm, T., Hubbard, W. C., Van Demark, M., Wang, K. C., Wu, X., Bielawska, A., Obeid, L. M., Ivan, M. & Petrache, I., May 18 2012, In : Journal of Biological Chemistry. 287, 21, p. 17425 1 p.

Research output: Contribution to journalComment/debate

Targeting the insulin growth factor and the vascular endothelial growth factor pathways in ovarian cancer

Shao, M., Hollar, S., Chambliss, D., Schmitt, J., Emerson, R., Chelladurai, B., Perkins, S., Ivan, M. & Matei, D., Jul 1 2012, In : Molecular cancer therapeutics. 11, 7, p. 1576-1586 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

Dihydroceramide-based response to hypoxia

Devlin, C. M., Lahm, T., Hubbard, W. C., Van Demark, M., Wang, K. C., Wu, X., Bielawska, A., Obeid, L. M., Ivan, M. & Petrache, I., Nov 4 2011, In : Journal of Biological Chemistry. 286, 44, p. 38069-38078 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Impact of APE1/ref-1 redox inhibition on pancreatic tumor growth

Fishel, M. L., Jiang, Y., Rajeshkumar, N. V., Scandura, G., Sinn, A. L., He, Y., Shen, C., Jones, D. R., Pollok, K. E., Ivan, M., Maitra, A. & Kelley, M. R., Sep 2011, In : Molecular cancer therapeutics. 10, 9, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

Rao, X., Di Leva, G., Li, M., Fang, F., Devlin, C., Hartman-Frey, C., Burow, M. E., Ivan, M., Croce, C. M. & Nephew, K. P., Mar 3 2011, In : Oncogene. 30, 9, p. 1082-1097 16 p.

Research output: Contribution to journalArticle

255 Scopus citations

MiR-210: More than a silent player in hypoxia

Devlin, C., Greco, S., Martelli, F. & Ivan, M., Feb 1 2011, In : IUBMB Life. 63, 2, p. 94-100 7 p.

Research output: Contribution to journalReview article

187 Scopus citations

PDGF induced microRNA alterations in cancer cells

Shao, M., Rossi, S., Chelladurai, B., Shimizu, M., Ntukogu, O., Ivan, M., Calin, G. A. & Matei, D., May 2011, In : Nucleic acids research. 39, 10, p. 4035-4047 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2010

Blockade of FGF signaling: Therapeutic promise for ovarian cancer

Ivan, M. & Matei, D., Sep 1 2010, In : Cancer Biology and Therapy. 10, 5, p. 505-508 4 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

microRNA: Emerging therapeutic targets in acute ischemic diseases

Fasanaro, P., Greco, S., Ivan, M., Capogrossi, M. C. & Martelli, F., Jan 1 2010, In : Pharmacology and Therapeutics. 125, 1, p. 92-104 13 p.

Research output: Contribution to journalReview article

129 Scopus citations

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU

Favaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J. L., Vojnovic, B., das Neves, R. P., Glazer, P., Iborra, F., Ivan, M., Ragoussis, J. & Harris, A. L., 2010, In : PloS one. 5, 4, e10345.

Research output: Contribution to journalArticle

228 Scopus citations

MicroRNAs in cancer. From bench to bedside

Angelica Cortez, M., Ivan, C., Zhou, P., Wu, X., Ivan, M. & Adrian Calin, G., 2010, In : Advances in Cancer Research. 108, C, p. 113-157 45 p.

Research output: Contribution to journalArticle

40 Scopus citations
2009

An integrated approach for experimental target identification of hypoxia-induced miR-210

Fasanaro, P., Greco, S., Lorenzi, M., Pescatori, M., Brioschi, M., Kulshreshtha, R., Banfi, C., Stubbs, A., Calin, G. A., Ivan, M., Capogrossi, M. C. & Martelli, F., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 35134-35143 10 p.

Research output: Contribution to journalArticle

200 Scopus citations

Emerging roles of microRNAs in the molecular responses to hypoxia

Crosby, M. E., Devlin, C. M., Glazer, P. M., Calin, G. A. & Ivan, M., Nov 1 2009, In : Current Pharmaceutical Design. 15, 33, p. 3861-3866 6 p.

Research output: Contribution to journalReview article

64 Scopus citations

Erratum: Article on MicroRNAs and DNA repair (Cancer Res (2009) 69 (1221:1229))

Crosby, M. E., Kulshreshtha, R., Ivan, M. & Glazer, P. M., Apr 1 2009, In : Cancer Research. 69, 7, 1 p.

Research output: Contribution to journalComment/debate

"Micro"-management of DNA repair genes by hypoxia

Crosby, M. E., Glazer, P. M. & Ivan, M., Dec 15 2009, In : Cell Cycle. 8, 24, p. 4009-4010 2 p.

Research output: Contribution to journalShort survey

Open Access
3 Scopus citations

MicroRNA regulation of DNA repair gene expression in hypoxic stress

Crosby, M. E., Kulshreshtha, R., Ivan, M. & Glazer, P. M., Feb 1 2009, In : Cancer Research. 69, 3, p. 1221-1229 9 p.

Research output: Contribution to journalArticle

331 Scopus citations

Molecular responses to hypoxia: Ancient pathways, clinical promises

Kim, W. Y. & Ivan, M., Sep 1 2009, In : Journal of Cellular and Molecular Medicine. 13, 9 A, p. 2757-2758 2 p.

Research output: Contribution to journalEditorial

2008

A microRNA component of the hypoxic response

Kulshreshtha, R., Davuluri, R. V., Calin, G. A. & Ivan, M., Apr 1 2008, In : Cell Death and Differentiation. 15, 4, p. 667-671 5 p.

Research output: Contribution to journalReview article

196 Scopus citations

AMP-activated protein kinase is essential for survival in chronic hypoxia

Borger, D. R., Gavrilescu, L. C., Bucur, M. C., Ivan, M. & DeCaprio, J. A., May 30 2008, In : Biochemical and Biophysical Research Communications. 370, 2, p. 230-234 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hypoxia response and microRNAs: No longer two separate worlds

Ivan, M., Harris, A. L., Martelli, F. & Kulshreshtha, R., Sep 2008, In : Journal of Cellular and Molecular Medicine. 12, 5A, p. 1426-1431 6 p.

Research output: Contribution to journalReview article

161 Scopus citations