Monte Willis

MD, PhD, MBA, Deputy Director, Indiana Center for Musculoskeletal Health, Vice-Chair of Research, Department of Pathology & Lab Medicine

  • 635 Barnhill Drive, MS 5067

    46202 Indianapolis

    United States

  • 6703 Citations
  • 44 h-Index
19982020

Research output per year

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Publications

2013

Method evaluation

Henderson, M. P. A., Cotten, S. W., Rogers, M. W., Willis, M. & McCudden, C. R., Jun 25 2013, Clinical Chemistry: Principles, Techniques, and Correlations: Seventh Edition. Wolters Kluwer Health Adis (ESP), p. 52-89 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteotoxicity and cardiac dysfunction - Alzheimer's disease of the heart?

Willis, M. S. & Patterson, C., Jan 31 2013, In : New England Journal of Medicine. 368, 5, p. 455-464 10 p.

Research output: Contribution to journalReview article

163 Scopus citations

Reducing laboratory billing defects using six sigma principles

Levtzow, C. B. & Willis, M. S., Sep 1 2013, In : Laboratory Medicine. 44, 4, p. 358-371 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Rib Fractures and Death from Deletion of Osteoblast βcatenin in Adult Mice Is Rescued by Corticosteroids

Duan, J. Z., Lee, Y., Jania, C., Gong, J., Rojas, M., Burk, L., Willis, M., Homeister, J., Tilley, S., Rubin, J. & Deb, A., Feb 5 2013, In : PloS one. 8, 2, e55757.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Targeting Angiogenesis and the Tumor Microenvironment

Samples, J., Willis, M. & Klauber-DeMore, N., Oct 2013, In : Surgical Oncology Clinics of North America. 22, 4, p. 629-639 11 p.

Research output: Contribution to journalReview article

33 Scopus citations

The authors reply

Willis, M. S. & Patterson, C., 2013, In : New England Journal of Medicine. 368, 18, p. 1755 1 p.

Research output: Contribution to journalLetter

11 Scopus citations

The Maladaptive Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir) on the Rat Heart

Reyskens, K. M. S. E., Fisher, T. L., Schisler, J. C., O'Connor, W. G., Rogers, A. B., Willis, M. S., Planesse, C., Rondeau, P., Bourdon, E. & Essop, M. F., Sep 30 2013, In : PloS one. 8, 9, e73347.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
2014

Cellular and Molecular Pathobiology of Cardiovascular Disease

Willis, M., Homeister, J. & Stone, J., Jan 2014, Elsevier Inc. 320 p.

Research output: Book/ReportBook

2 Scopus citations

Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin

Paul, D. S., Grevengoed, T. J., Pascual, F., Ellis, J. M., Willis, M. S. & Coleman, R. A., Jun 2014, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1841, 6, p. 880-887 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease

Cotton, S. W., Kornegay, J. N., Bogan, D. J., Wadosky, K. M., Patterson, C. & Willis, M. S., 2014, In : American Journal of Translational Research. 6, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Large multiethnic Candidate Gene Study for C-reactive protein levels: Identification of a novel association at CD36 in African Americans

Ellis, J., Lange, E. M., Li, J., Dupuis, J., Baumert, J., Walston, J. D., Keating, B. J., Durda, P., Fox, E. R., Palmer, C. D., Meng, Y. A., Young, T., Farlow, D. N., Schnabel, R. B., Marzi, C. S., Larkin, E., Martin, L. W., Bis, J. C., Auer, P., Ramachandran, V. S. & 16 others, Gabriel, S. B., Willis, M. S., Pankow, J. S., Papanicolaou, G. J., Rotter, J. I., Ballantyne, C. M., Gross, M. D., Lettre, G., Wilson, J. G., Peters, U., Koenig, W., Tracy, R. P., Redline, S., Reiner, A. P., Benjamin, E. J. & Lange, L. A., Aug 2014, In : Human genetics. 133, 8, p. 985-995 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

Xu, L., Yates, C. C., Lockyer, P., Xie, L., Bevilacqua, A., He, J., Lander, C., Patterson, C. & Willis, M., Dec 1 2014, In : Journal of Molecular and Cellular Cardiology. 77, p. 86-101 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo

Mattox, T. A., Young, M. E., Rubel, C. E., Spaniel, C., Rodríguez, J. E., Grevengoed, T. J., Gautel, M., Xu, Z., Anderson, E. J. & Willis, M. S., Jun 2014, In : Journal of Bioenergetics and Biomembranes. 46, 3, p. 173-187 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo

Willis, M. S., Wadosky, K. M., Rodríguez, J. E., Schisler, J. C., Lockyer, P., Hilliard, E. G., Glass, D. J. & Patterson, C., Jan 1 2014, In : Cell Biochemistry and Function. 32, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling

Wadosky, K. M., Rodríguez, J. E., Hite, R. L., Min, J. N., Walton, B. L. & Willis, M. S., Apr 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 7, p. E723-E739

Research output: Contribution to journalArticle

21 Scopus citations

Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling

Campen, M. J., Paffett, M. L., Colombo, E. S., Lucas, S. N., Anderson, T., Nysus, M., Norenberg, J. P., Gershman, B., Hesterman, J., Hoppin, J. & Willis, M., May 8 2014, In : PLoS ONE. 9, 5, e97084.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis

Duryee, M. J., Willis, M. S., Schaffert, C. S., Reidelberger, R. D., Dusad, A., Anderson, D. R., Klassen, L. W. & Thiele, G. M., Feb 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 3, p. G208-G217

Research output: Contribution to journalArticle

11 Scopus citations

Protein Quality Control, The Ubiquitin Proteosome System, and Authophagy: When Worlds Collide

Willis, M. S. & Patterson, C., Jun 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 1-2 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Regulation of large conductance Ca2+-activated K+ (BK) Channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels

Yi, F., Wang, H., Chai, Q., Wang, X., Shen, W. K., Willis, M. S., Lee, H. C. & Lu, T., Apr 11 2014, In : Journal of Biological Chemistry. 289, 15, p. 10853-10864 12 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease

Bevilacqua, A., Willis, M. S. & Bultman, S. J., Mar 1 2014, In : Cardiovascular Pathology. 23, 2, p. 85-91 7 p.

Research output: Contribution to journalReview article

28 Scopus citations

The hypermetabolic giant: 18F-FDG avid giant cell tumor identified on PET-CT

O'Connor, W., Quintana, M., Smith, S., Willis, M. & Renner, J., 2014, In : Journal of Radiology Case Reports. 8, 6, p. 27-38 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

The Pathophysiology of Cardiac Hypertrophy and Heart Failure

Stansfield, W. E., Ranek, M., Pendse, A., Schisler, J. C., Wang, S., Pulinilkunnil, T. & Willis, M. S., Jan 2014, Cellular and Molecular Pathobiology of Cardiovascular Disease. Elsevier Inc., p. 51-78 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

The role of ubiquitin ligases in cardiac disease

Willis, M. S., Bevilacqua, A., Pulinilkunnil, T., Kienesberger, P., Tannu, M. & Patterson, C., Jun 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 43-53 11 p.

Research output: Contribution to journalReview article

41 Scopus citations
2015

Cancer cachexia update in head and neck cancer: Pathophysiology and treatment

Couch, M. E., Dittus, K., Toth, M. J., Willis, M. S., Guttridge, D. C., George, J. R., Chang, E. Y., Gourin, C. G. & Der-Torossian, H., Jul 1 2015, In : Head and Neck. 37, 7, p. 1057-1072 16 p.

Research output: Contribution to journalReview article

11 Scopus citations

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Couch, M. E., Dittus, K., Toth, M. J., Willis, M. S., Guttridge, D. C., George, J. R., Barnes, C. A., Gourin, C. G. & Der-Torossian, H., Apr 1 2015, In : Head and Neck. 37, 4, p. 594-604 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin

Schisler, J. C., Grevengoed, T. J., Pascual, F., Cooper, D. E., Ellis, J. M., Paul, D. S., Willis, M. S., Patterson, C., Jia, W. & Coleman, R. A., 2015, In : Journal of the American Heart Association. 4, 2, e001136.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Delayed contrast enhancement imaging of a murine model for ischemia reperfusion with carbon nanotube micro-CT

Burk, L. M., Wang, K. H., Wait, J. M., Kang, E., Willis, M., Lu, J., Zhou, O. & Lee, Y. Z., Jan 30 2015, In : PloS one. 10, 1, e0115607.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

Xie, L., Pi, X., Wang, Z., He, J., Willis, M. S. & Patterson, C., Mar 1 2015, In : Journal of Molecular and Cellular Cardiology. 80, p. 156-165 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

Schisler, J. C., Ronnebaum, S. M., Madden, M., Channell, M., Campen, M. & Willis, M. S., Apr 1 2015, In : Inhalation Toxicology. 27, 5, p. 272-280 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Erratum: MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo [J Bioenerg Biomembr, 46, (2014), (173-187), DOI 10.1007/s10863-014-9549-9]

Mattox, T. A., Young, M. E., Rubel, C. E., Spaniel, C., Rodríguez, J. E., Grevengoed, T. J., Gautel, M., Xu, Z., Anderson, E. J. & Willis, M. S., Jun 1 2015, In : Journal of Bioenergetics and Biomembranes. 47, 3, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure

Parry, T. L., Melehani, J. H., Ranek, M. J. & Willis, M. S., May 19 2015, In : Frontiers in Cardiovascular Medicine. 2, 25.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Genetics and heart failure: A concise guide for the clinician

Skrzynia, C., Berg, J. S., Willis, M. S. & Jensen, B. C., Dec 1 2015, In : Current Cardiology Reviews. 11, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

Li, J., Lange, L. A., Sabourin, J., Duan, Q., Valdar, W., Willis, M. S., Li, Y., Wilson, J. G. & Lange, E. M., Dec 1 2015, In : Journal of Human Genetics. 60, 12, p. 755-761 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans

Li, J., Lange, L. A., Duan, Q., Lu, Y., Singleton, A. B., Zonderman, A. B., Evans, M. K., Li, Y., Taylor, H. A., Willis, M. S., Nalls, M., Wilson, J. G. & Lange, E. M., Jan 15 2015, In : Human molecular genetics. 24, 2, p. 572-581 10 p., ddu454.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

He, J., Quintana, M. T., Sullivan, J., Parry, T., Grevengoed, T., Schisler, J. C., Hill, J. A., Yates, C. C., Mapanga, R. F., Essop, M. F., Stansfield, W. E., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Han, Y., Clarke, B. A. & Willis, M. S., Aug 5 2015, In : Cardiovascular Diabetology. 14, 1, 97.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet

Quintana, M. T., He, J., Sullivan, J., Grevengoed, T., Schisler, J., Han, Y., Hill, J. A., Yates, C. C., Stansfield, W. E., Mapanga, R. F., Essop, M. F., Muehlbauer, M. J., Newgard, C. B., Bain, J. R. & Willis, M. S., Dec 12 2015, In : BMC Endocrine Disorders. 15, 1, 36.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes

Banerjee, R., He, J., Spaniel, C., Quintana, M. T., Wang, Z., Bain, J. R., Newgard, C. B., Muehlbauer, M. J. & Willis, M. S., Apr 1 2015, In : Metabolomics. 11, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis

Banerjee, R., Bultman, S. J., Holley, D., Hillhouse, C., Bain, J. R., Newgard, C. B., Muehlbauer, M. J. & Willis, M. S., Oct 7 2015, In : Metabolomics. 11, 5, p. 1287-1301 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function

McCormick, M. E., Collins, C., Makarewich, C. A., Chen, Z., Rojas, M., Willis, M. S., Houser, S. R. & Tzima, E., Jan 19 2015, In : Journal of the American Heart Association. 4, 1, p. e001210

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

Rodríguez, J. E., Liao, J. Y., He, J., Schisler, J. C., Newgard, C. B., Drujan, D., Glass, D. J., Frederick, C. B., Yoder, B. C., Lalush, D. S., Patterson, C. & Willis, M. S., Sep 5 2015, In : Molecular and Cellular Endocrinology. 413, p. 36-48 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2016

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo

Bultman, S. J., Holley, D. W., G De Ridder, G., Pizzo, S. V., Sidorova, T. N., Murray, K. T., Jensen, B. C., Wang, Z., Bevilacqua, A., Chen, X., Quintana, M. T., Tannu, M., Rosson, G. B., Pandya, K. & Willis, M. S., May 1 2016, In : Cardiovascular Pathology. 25, 3, p. 258-269 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
Open Access
8 Scopus citations

Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling

Quintana, M. T., Parry, T. L., He, J., Yates, C. C., Sidorova, T. N., Murray, K. T., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Eaton, S. C., Hishiya, A., Takayama, S. & Willis, M. S., Aug 1 2016, In : American Journal of Pathology. 186, 8, p. 1989-2007 19 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis

Ilaiwy, A., Quintana, M. T., Bain, J. R., Muehlbauer, M. J., Brown, D. I., Stansfield, W. E. & Willis, M. S., Oct 1 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 80-92 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Corticosteroids are essential for maintaining cardiovascular function in male mice

Cruz-Topete, D., Myers, P. H., Foley, J. F., Willis, M. S. & Cidlowski, J. A., Jul 2016, In : Endocrinology. 157, 7, p. 2759-2771 13 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

Kornegay, J. N., Bogan, D. J., Bogan, J. R., Dow, J. L., Wang, J., Fan, Z., Liu, N., Warsing, L. C., Grange, R. W., Ahn, M., Balog-Alvarez, C. J., Cotten, S. W., Willis, M. S., Brinkmeyer-Langford, C., Zhu, H., Palandra, J., Morris, C. A., Styner, M. A. & Wagner, K. R., Apr 4 2016, In : Skeletal Muscle. 6, 1, 14.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1

Parry, T. L., Desai, G., Schisler, J. C., Li, L., Quintana, M. T., Stanley, N., Lockyer, P., Patterson, C. & Willis, M., Mar 1 2016, In : Cardiovascular Pathology. 25, 2, p. 127-140 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo

Ilaiwy, A., Liu, M., Parry, T. L., Bain, J. R., Newgard, C. B., Schisler, J. C., Muehlbauer, M. J., Despa, F. & Willis, M. S., May 1 2016, In : Metabolomics. 12, 5, 95.

Research output: Contribution to journalArticle

8 Scopus citations