Monte Willis

MD, PhD, MBA, Deputy Director, Indiana Center for Musculoskeletal Health, Vice-Chair of Research, Department of Pathology & Lab Medicine

  • 635 Barnhill Drive, MS 5067

    46202 Indianapolis

    United States

  • 6703 Citations
  • 44 h-Index
19982020

Research output per year

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Publications

Article

Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis

Jensen, B. C., Parry, T. L., Huang, W., Beak, J. Y., Ilaiwy, A., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Patterson, C., Johnson, G. L. & Willis, M. S., Dec 2017, In : British Journal of Pharmacology. 174, 24, p. 4797-4811 15 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

Schisler, J. C., Ronnebaum, S. M., Madden, M., Channell, M., Campen, M. & Willis, M. S., Apr 1 2015, In : Inhalation Toxicology. 27, 5, p. 272-280 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition

Ramana, K. V., Willis, M. S., White, M. D., Horton, J. W., Dimaio, J. M., Srivastava, D., Bhatnagar, A. & Srivastava, S. K., Oct 2006, In : Circulation. 114, 17, p. 1838-1846 9 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction

O'Neal, W. T., Griffin, W. F., Dries-Devlin, J. L., Kent, S. D., Chen, J., Willis, M. S. & Virag, J. A. I., Jun 2013, In : Medical Hypotheses. 80, 6, p. 738-744 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Episodic fever and neutropenia in a 22-year-old male

Ren, R., Willis, M. S. & Fedoriw, Y., Dec 1 2010, In : Laboratory Medicine. 41, 12, p. 708-712 5 p.

Research output: Contribution to journalArticle

Open Access

Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease

Oakley, R. H., Ren, R., Cruz-Topete, D., Bird, G. S., Myers, P. H., Boyle, M. C., Schneider, M. D., Willis, M. S. & Cidlowski, J. A., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17035-17040 6 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixation

Bender, L. M., Cotten, S. W., Fedoriw, Y., Willis, M. S. & McCudden, C. R., Feb 1 2013, In : Clinical Biochemistry. 46, 3, p. 255-258 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes

Nakamura, J., Shimomoto, T., Collins, L. B., Holley, D. W., Zhang, Z., Barbee, J. M., Sharma, V., Tian, X., Kondo, T., Uchida, K., Yi, X., Perkins, DI. O., Willis, M. S., Gold, A. & Bultman, S. J., Dec 1 2017, In : Scientific reports. 7, 1, 10787.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Exercise-induced alterations in skeletal muscle, heart, liver, and serum metabolome identified by non-targeted metabolomics analysis

Starnes, J. W., Parry, T. L., O’Neal, S. K., Bain, J. R., Muehlbauer, M. J., Honcoop, A., Ilaiwy, A., Christopher, P. M., Patterson, C. & Willis, M. S., 2017, In : Metabolites. 7, 3, 40.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Failure to thrive in a 14-month-old child

Willis, M. S. & Bennett, M. J., Jul 1 2003, In : Laboratory Medicine. 34, 7, p. 520-525 6 p.

Research output: Contribution to journalArticle

Open Access

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria

Ling, T. Y., Yi, F., Lu, T., Wang, X. L., Sun, X., Willis, M. S., Wu, L. Q., Shen, W. K., Adelman, J. P. & Lee, H. C., Mar 15 2019, In : Journal of Biological Chemistry. 294, 11, p. 4160-4168 9 p.

Research output: Contribution to journalArticle

Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1

Parry, T. L., Desai, G., Schisler, J. C., Li, L., Quintana, M. T., Stanley, N., Lockyer, P., Patterson, C. & Willis, M., Mar 1 2016, In : Cardiovascular Pathology. 25, 2, p. 127-140 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fever and neutropenia in an adolescent with leukemia

Willis, M. S. & Cavuoti, D., Sep 1 2003, In : Laboratory Medicine. 34, 9, p. 660-666 7 p.

Research output: Contribution to journalArticle

Open Access

Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure

Parry, T. L., Melehani, J. H., Ranek, M. J. & Willis, M. S., May 19 2015, In : Frontiers in Cardiovascular Medicine. 2, 25.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart

Willis, M. S., Homeister, J. W., Rosson, G. B., Annayev, Y., Holley, D., Holly, S. P., Madden, V. J., Godfrey, V., Parise, L. V. & Bultman, S. J., Aug 17 2012, In : Circulation research. 111, 5, p. e111-e122

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease

Cotton, S. W., Kornegay, J. N., Bogan, D. J., Wadosky, K. M., Patterson, C. & Willis, M. S., 2014, In : American Journal of Translational Research. 6, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genetics and heart failure: A concise guide for the clinician

Skrzynia, C., Berg, J. S., Willis, M. S. & Jensen, B. C., Dec 1 2015, In : Current Cardiology Reviews. 11, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

Li, J., Lange, L. A., Sabourin, J., Duan, Q., Valdar, W., Willis, M. S., Li, Y., Wilson, J. G. & Lange, E. M., Dec 1 2015, In : Journal of Human Genetics. 60, 12, p. 755-761 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans

Li, J., Lange, L. A., Duan, Q., Lu, Y., Singleton, A. B., Zonderman, A. B., Evans, M. K., Li, Y., Taylor, H. A., Willis, M. S., Nalls, M., Wilson, J. G. & Lange, E. M., Jan 15 2015, In : Human molecular genetics. 24, 2, p. 572-581 10 p., ddu454.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study

Raffield, L. M., Ellis, J., Olson, N. C., Duan, Q., Li, J., Durda, P., Pankratz, N., Keating, B. J., Wassel, C. L., Cushman, M., Wilson, J. G., Gross, M. D., Tracy, R. P., Rich, S. S., Reiner, A. P., Li, Y., Willis, M. S., Lange, E. M. & Lange, L. A., Mar 1 2018, In : Journal of Human Genetics. 63, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gliosarcoma cell death after radiosurgery in a rat model

Psarros, T. G., Mickey, B., Gilio, J., Drees, J., Gall, K., Carlson, D., Giller, C. & Willis, M. S., Jun 1 2005, In : Minimally Invasive Neurosurgery. 48, 3, p. 142-148 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Heart Rate Variability (HRV) as a Tool for Diagnostic and Monitoring Performance in Sport and Physical Activities

Makivić, B., Nikić, M. D. & Willis, M. S., 2013, In : Journal of Exercise Physiology Online. 16, 3, p. 103-131 29 p.

Research output: Contribution to journalArticle

38 Scopus citations

Hepatosplenomegaly in an 8-month-old child

Willis, M. S., Basinger, A. A., Fan, Z., Pendyal, S., Muenzer, J. & Hammett-Stabler, C., Nov 2006, In : Laboratory Medicine. 37, 11, p. 665-669+695

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo

Ilaiwy, A., Liu, M., Parry, T. L., Bain, J. R., Newgard, C. B., Schisler, J. C., Muehlbauer, M. J., Despa, F. & Willis, M. S., May 1 2016, In : Metabolomics. 12, 5, 95.

Research output: Contribution to journalArticle

8 Scopus citations

Hypercalcemia in a 56-year-old female

Pierce, K. A., Willis, M. S. & McCudden, C. R., Dec 1 2008, In : Laboratory Medicine. 39, 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis

Ilaiwy, A., ten Have, G. A. M., Bain, J. R., Muehlbauer, M. J., O'Neal, S. K., Berthiaume, J. M., Parry, T. L., Deutz, N. E. & Willis, M. S., Sep 2019, In : American Journal of Pathology. 189, 9, p. 1797-1813 17 p.

Research output: Contribution to journalArticle

IKKβ inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury

Moss, N. C., Stansfield, W. E., Willis, M. S., Tang, R. H. & Selzman, C. H., Oct 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 4, p. H2248-H2253

Research output: Contribution to journalArticle

82 Scopus citations

Image-Based Methods for Phase Estimation, Gating, and Temporal Superresolution of Cardiac Ultrasound

Chittajallu, D. R., McCormick, M., Gerber, S., Czernuszewicz, T. J., Gessner, R., Willis, M. S., Niethammer, M., Kwitt, R. & Aylward, S. R., Jan 2019, In : IEEE Transactions on Biomedical Engineering. 66, 1, p. 72-79 8 p., 8345790.

Research output: Contribution to journalArticle

Open Access

Image-guided robotic radiosurgery in a rat glioma model

Psarros, T. G., Mickey, B., Gall, K., Gilio, J., Delp, J., White, C., Drees, J., Willis, M., Pistemmna, D. & Giller, C. A., Oct 1 2004, In : Minimally Invasive Neurosurgery. 47, 5, p. 266-272 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Immunofixation reveals an apparent α heavy chain caused by precipitation of fibrinogen with IgA antiserum

Snyder, J. A., Willis, M. S. & Grenache, D. G., Jun 1 2006, In : Clinica Chimica Acta. 368, 1-2, p. 192-194 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde

Duryee, M. J., Klassen, L. W., Jones, B. L., Willis, M. S., Tuma, D. J. & Thiele, G. M., Aug 1 2008, In : International Immunopharmacology. 8, 8, p. 1112-1118 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo

Mota, R., Parry, T. L., Yates, C. C., Qiang, Z., Eaton, S. C., Mwiza, J. M., Tulasi, D., Schisler, J. C., Patterson, C., Zaglia, T., Sandri, M. & Willis, M. S., Jul 2018, In : American Journal of Pathology. 188, 7, p. 1676-1692 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection

Moss, N. C., Tang, R. H., Willis, M., Stansfield, W. E., Baldwin, A. S. & Selzman, C. H., Nov 1 2008, In : Journal of Thoracic and Cardiovascular Surgery. 136, 5, p. 1274-1279 6 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability

Willis, M. S., Klassen, L. W., Tuma, D. J., Sorrell, M. F. & Thiele, G. M., Jan 1 2002, In : Alcoholism: Clinical and Experimental Research. 26, 2, p. 158-164 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Kinome and transcriptome profiling reveal broad and distinct activities of erlotinib, sunitinib, and sorafenib in the mouse heart and suggest cardiotoxicity from combined signal transducer and activator of transcription and epidermal growth factor receptor inhibition

Stuhlmiller, T. J., Zawistowski, J. S., Chen, X., Sciaky, N., Angus, S. P., Hicks, S. T., Parry, T. L., Huang, W., Beak, J. Y., Willis, M. S., Johnson, G. L. & Jensen, B. C., Oct 1 2017, In : Journal of the American Heart Association. 6, 10, e006635.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Large multiethnic Candidate Gene Study for C-reactive protein levels: Identification of a novel association at CD36 in African Americans

Ellis, J., Lange, E. M., Li, J., Dupuis, J., Baumert, J., Walston, J. D., Keating, B. J., Durda, P., Fox, E. R., Palmer, C. D., Meng, Y. A., Young, T., Farlow, D. N., Schnabel, R. B., Marzi, C. S., Larkin, E., Martin, L. W., Bis, J. C., Auer, P., Ramachandran, V. S. & 16 others, Gabriel, S. B., Willis, M. S., Pankow, J. S., Papanicolaou, G. J., Rotter, J. I., Ballantyne, C. M., Gross, M. D., Lettre, G., Wilson, J. G., Peters, U., Koenig, W., Tracy, R. P., Redline, S., Reiner, A. P., Benjamin, E. J. & Lange, L. A., Aug 2014, In : Human genetics. 133, 8, p. 985-995 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells

Duryee, M. J., Klassen, L. W., Freeman, T. L., Willis, M. S., Tuma, D. J. & Thiele, G. M., Dec 2004, In : Alcoholism: Clinical and Experimental Research. 28, 12, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers

Jearawiriyapaisarn, N., Moulton, H. M., Sazani, P., Kole, R. & Willis, M. S., Feb 1 2010, In : Cardiovascular research. 85, 3, p. 444-453 10 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Low blast count myeloid disorders with Auer rods: A clinicopathologic analysis of 9 cases

Willis, M. S., McKenna, R. W., Peterson, L. A. C., Coad, J. E. & Kroft, S. H., Aug 2005, In : American journal of clinical pathology. 124, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

Files, D. C., Ilaiwy, A., Parry, T. L., Gibbs, K. W., Liu, C., Bain, J. R., Delbono, O., Muehlbauer, M. J. & Willis, M. S., Aug 1 2016, In : Metabolomics. 12, 8, 134.

Research output: Contribution to journalArticle

4 Scopus citations

Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor

Garner, L. B., Willis, M. S., Carlson, D. L., DiMaio, J. M., White, M. D., White, D. J., Adams IV, G. A., Horton, J. W. & Giroir, B. P., Dec 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 6 54-6, p. H2500-H2509

Research output: Contribution to journalArticle

74 Scopus citations

Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury

Willis, M. S., Carlson, D. L., DiMaio, J. M., White, M. D., White, D. J., Adams IV, G. A., Horton, J. W. & Giroir, B. P., Feb 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 2 57-2, p. H795-H804

Research output: Contribution to journalArticle

44 Scopus citations

Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage

Willis, M. S., Klassen, L. W., Carlson, D. L., Brouse, C. F. & Thiele, G. M., Jul 1 2004, In : International Immunopharmacology. 4, 7, p. 885-899 15 p.

Research output: Contribution to journalArticle

24 Scopus citations

Malondialdehyde-acetaldehyde-haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells

Willis, M. S., Klassen, L. W., Tuma, D. J. & Thiele, G. M., Mar 5 2002, In : International Immunopharmacology. 2, 4, p. 519-535 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Marked proteinuria in a young male

Willis, M. S. & Wians, F. H., Jan 1 2002, In : Laboratory Medicine. 33, 6, p. 463-466 4 p.

Research output: Contribution to journalArticle

Merits of non-invasive rat models of left ventricular heart failure

Carll, A. P., Willis, M. S., Lust, R. M., Costa, D. L. & Farraj, A. K., Jun 1 2011, In : Cardiovascular Toxicology. 11, 2, p. 91-112 22 p.

Research output: Contribution to journalArticle

28 Scopus citations

Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia

Der-Torossian, H., Wysong, A., Shadfar, S., Willis, M. S., McDunn, J. & Couch, M. E., Jun 2013, In : Journal of Cachexia, Sarcopenia and Muscle. 4, 2, p. 145-155 11 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Metabolomic analysis of cancer cachexia reveals distinct lipid and glucose alterations

O'Connell, T. M., Ardeshirpour, F., Asher, S. A., Winnike, J. H., Yin, X., George, J., Guttridge, D. C., He, W., Wysong, A., Willis, M. S. & Couch, M. E., Jul 2 2008, In : Metabolomics. 4, 3, p. 216-225 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

Callis, T. E., Pandya, K., Hee, Y. S., Tang, R. H., Tatsuguchi, M., Huang, Z. P., Chen, J. F., Deng, Z., Gunn, B., Shumate, J., Willis, M. S., Selzman, C. H. & Wang, D. Z., Sep 1 2009, In : Journal of Clinical Investigation. 119, 9, p. 2772-2786 15 p.

Research output: Contribution to journalArticle

Open Access
591 Scopus citations

Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart

Anderson, E. J., Katunga, L. A. & Willis, M. S., Feb 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 2, p. 179-193 15 p.

Research output: Contribution to journalArticle

78 Scopus citations