Monte Willis

MD, PhD, MBA, Deputy Director, Indiana Center for Musculoskeletal Health, Vice-Chair of Research, Department of Pathology & Lab Medicine

  • 635 Barnhill Drive, MS 5067

    46202 Indianapolis

    United States

  • 6612 Citations
  • 44 h-Index
19982020

Research output per year

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Publications

2016

Pathophysiology of Heart Failure and an Overview of Therapies

Berthiaume, J. M., Kirk, J. A., Ranek, M. J., Lyon, R. C., Sheikh, F., Jensen, B. C., Hoit, B. D., Butany, J., Tolend, M., Rao, V. & Willis, M. S., Jan 1 2016, Cardiovascular Pathology: Fourth Edition. Elsevier Inc., p. 271-339 69 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Post-analytical issues in the clinical laboratory

McCudden, C. R. & Willis, M., Jan 1 2016, Clinical Core Laboratory Testing. Springer US, p. 77-96 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteolysis in the interstitial space

Pizzo, S. V., Lundblad, R. L. & Willis, M., Aug 19 2016, CRC Press. 297 p.

Research output: Book/ReportBook

1 Scopus citations

The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo

Willis, M. S., Ilaiwy, A., Montgomery, M. D., Simpson, P. C. & Jensen, B. C., Oct 1 2016, In : Metabolomics. 12, 10, 155.

Research output: Contribution to journalArticle

3 Scopus citations

The Head and the Heart: The Alzheimer's Connection

Jensen, B. C. & Willis, M. S., Dec 6 2016, In : Journal of the American College of Cardiology. 68, 22, p. 2408-2411 4 p.

Research output: Contribution to journalEditorial

Open Access
4 Scopus citations
2015

Cancer cachexia update in head and neck cancer: Pathophysiology and treatment

Couch, M. E., Dittus, K., Toth, M. J., Willis, M. S., Guttridge, D. C., George, J. R., Chang, E. Y., Gourin, C. G. & Der-Torossian, H., Jul 1 2015, In : Head and Neck. 37, 7, p. 1057-1072 16 p.

Research output: Contribution to journalReview article

11 Scopus citations

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Couch, M. E., Dittus, K., Toth, M. J., Willis, M. S., Guttridge, D. C., George, J. R., Barnes, C. A., Gourin, C. G. & Der-Torossian, H., Apr 1 2015, In : Head and Neck. 37, 4, p. 594-604 11 p.

Research output: Contribution to journalReview article

28 Scopus citations

Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin

Schisler, J. C., Grevengoed, T. J., Pascual, F., Cooper, D. E., Ellis, J. M., Paul, D. S., Willis, M. S., Patterson, C., Jia, W. & Coleman, R. A., 2015, In : Journal of the American Heart Association. 4, 2, e001136.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Delayed contrast enhancement imaging of a murine model for ischemia reperfusion with carbon nanotube micro-CT

Burk, L. M., Wang, K. H., Wait, J. M., Kang, E., Willis, M., Lu, J., Zhou, O. & Lee, Y. Z., Jan 30 2015, In : PloS one. 10, 1, e0115607.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

Xie, L., Pi, X., Wang, Z., He, J., Willis, M. S. & Patterson, C., Mar 1 2015, In : Journal of Molecular and Cellular Cardiology. 80, p. 156-165 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

Schisler, J. C., Ronnebaum, S. M., Madden, M., Channell, M., Campen, M. & Willis, M. S., Apr 1 2015, In : Inhalation Toxicology. 27, 5, p. 272-280 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Erratum: MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo [J Bioenerg Biomembr, 46, (2014), (173-187), DOI 10.1007/s10863-014-9549-9]

Mattox, T. A., Young, M. E., Rubel, C. E., Spaniel, C., Rodríguez, J. E., Grevengoed, T. J., Gautel, M., Xu, Z., Anderson, E. J. & Willis, M. S., Jun 1 2015, In : Journal of Bioenergetics and Biomembranes. 47, 3, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure

Parry, T. L., Melehani, J. H., Ranek, M. J. & Willis, M. S., May 19 2015, In : Frontiers in Cardiovascular Medicine. 2, 25.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Genetics and heart failure: A concise guide for the clinician

Skrzynia, C., Berg, J. S., Willis, M. S. & Jensen, B. C., Dec 1 2015, In : Current Cardiology Reviews. 11, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

Li, J., Lange, L. A., Sabourin, J., Duan, Q., Valdar, W., Willis, M. S., Li, Y., Wilson, J. G. & Lange, E. M., Dec 1 2015, In : Journal of Human Genetics. 60, 12, p. 755-761 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans

Li, J., Lange, L. A., Duan, Q., Lu, Y., Singleton, A. B., Zonderman, A. B., Evans, M. K., Li, Y., Taylor, H. A., Willis, M. S., Nalls, M., Wilson, J. G. & Lange, E. M., Jan 15 2015, In : Human molecular genetics. 24, 2, p. 572-581 10 p., ddu454.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

He, J., Quintana, M. T., Sullivan, J., Parry, T., Grevengoed, T., Schisler, J. C., Hill, J. A., Yates, C. C., Mapanga, R. F., Essop, M. F., Stansfield, W. E., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Han, Y., Clarke, B. A. & Willis, M. S., Aug 5 2015, In : Cardiovascular Diabetology. 14, 1, 97.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet

Quintana, M. T., He, J., Sullivan, J., Grevengoed, T., Schisler, J., Han, Y., Hill, J. A., Yates, C. C., Stansfield, W. E., Mapanga, R. F., Essop, M. F., Muehlbauer, M. J., Newgard, C. B., Bain, J. R. & Willis, M. S., Dec 12 2015, In : BMC Endocrine Disorders. 15, 1, 36.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes

Banerjee, R., He, J., Spaniel, C., Quintana, M. T., Wang, Z., Bain, J. R., Newgard, C. B., Muehlbauer, M. J. & Willis, M. S., Apr 1 2015, In : Metabolomics. 11, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis

Banerjee, R., Bultman, S. J., Holley, D., Hillhouse, C., Bain, J. R., Newgard, C. B., Muehlbauer, M. J. & Willis, M. S., Oct 7 2015, In : Metabolomics. 11, 5, p. 1287-1301 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function

McCormick, M. E., Collins, C., Makarewich, C. A., Chen, Z., Rojas, M., Willis, M. S., Houser, S. R. & Tzima, E., Jan 19 2015, In : Journal of the American Heart Association. 4, 1, p. e001210

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

Rodríguez, J. E., Liao, J. Y., He, J., Schisler, J. C., Newgard, C. B., Drujan, D., Glass, D. J., Frederick, C. B., Yoder, B. C., Lalush, D. S., Patterson, C. & Willis, M. S., Sep 5 2015, In : Molecular and Cellular Endocrinology. 413, p. 36-48 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2014

Cellular and Molecular Pathobiology of Cardiovascular Disease

Willis, M., Homeister, J. & Stone, J., Jan 2014, Elsevier Inc. 320 p.

Research output: Book/ReportBook

2 Scopus citations

Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin

Paul, D. S., Grevengoed, T. J., Pascual, F., Ellis, J. M., Willis, M. S. & Coleman, R. A., Jun 2014, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1841, 6, p. 880-887 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic myostatin decrease in the golden retriever muscular dystrophy model does not significantly affect the ubiquitin proteasome system despite enhancing the severity of disease

Cotton, S. W., Kornegay, J. N., Bogan, D. J., Wadosky, K. M., Patterson, C. & Willis, M. S., 2014, In : American Journal of Translational Research. 6, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Large multiethnic Candidate Gene Study for C-reactive protein levels: Identification of a novel association at CD36 in African Americans

Ellis, J., Lange, E. M., Li, J., Dupuis, J., Baumert, J., Walston, J. D., Keating, B. J., Durda, P., Fox, E. R., Palmer, C. D., Meng, Y. A., Young, T., Farlow, D. N., Schnabel, R. B., Marzi, C. S., Larkin, E., Martin, L. W., Bis, J. C., Auer, P., Ramachandran, V. S. & 16 others, Gabriel, S. B., Willis, M. S., Pankow, J. S., Papanicolaou, G. J., Rotter, J. I., Ballantyne, C. M., Gross, M. D., Lettre, G., Wilson, J. G., Peters, U., Koenig, W., Tracy, R. P., Redline, S., Reiner, A. P., Benjamin, E. J. & Lange, L. A., Aug 2014, In : Human genetics. 133, 8, p. 985-995 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

Xu, L., Yates, C. C., Lockyer, P., Xie, L., Bevilacqua, A., He, J., Lander, C., Patterson, C. & Willis, M., Dec 1 2014, In : Journal of Molecular and Cellular Cardiology. 77, p. 86-101 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo

Mattox, T. A., Young, M. E., Rubel, C. E., Spaniel, C., Rodríguez, J. E., Grevengoed, T. J., Gautel, M., Xu, Z., Anderson, E. J. & Willis, M. S., Jun 2014, In : Journal of Bioenergetics and Biomembranes. 46, 3, p. 173-187 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo

Willis, M. S., Wadosky, K. M., Rodríguez, J. E., Schisler, J. C., Lockyer, P., Hilliard, E. G., Glass, D. J. & Patterson, C., Jan 1 2014, In : Cell Biochemistry and Function. 32, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling

Wadosky, K. M., Rodríguez, J. E., Hite, R. L., Min, J. N., Walton, B. L. & Willis, M. S., Apr 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 7, p. E723-E739

Research output: Contribution to journalArticle

20 Scopus citations

Muscle RING finger-1 promotes a maladaptive phenotype in chronic hypoxia-induced right ventricular remodeling

Campen, M. J., Paffett, M. L., Colombo, E. S., Lucas, S. N., Anderson, T., Nysus, M., Norenberg, J. P., Gershman, B., Hesterman, J., Hoppin, J. & Willis, M., May 8 2014, In : PLoS ONE. 9, 5, e97084.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis

Duryee, M. J., Willis, M. S., Schaffert, C. S., Reidelberger, R. D., Dusad, A., Anderson, D. R., Klassen, L. W. & Thiele, G. M., Feb 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 3, p. G208-G217

Research output: Contribution to journalArticle

11 Scopus citations

Protein Quality Control, The Ubiquitin Proteosome System, and Authophagy: When Worlds Collide

Willis, M. S. & Patterson, C., Jun 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 1-2 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Regulation of large conductance Ca2+-activated K+ (BK) Channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels

Yi, F., Wang, H., Chai, Q., Wang, X., Shen, W. K., Willis, M. S., Lee, H. C. & Lu, T., Apr 11 2014, In : Journal of Biological Chemistry. 289, 15, p. 10853-10864 12 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease

Bevilacqua, A., Willis, M. S. & Bultman, S. J., Mar 1 2014, In : Cardiovascular Pathology. 23, 2, p. 85-91 7 p.

Research output: Contribution to journalReview article

28 Scopus citations

The hypermetabolic giant: 18F-FDG avid giant cell tumor identified on PET-CT

O'Connor, W., Quintana, M., Smith, S., Willis, M. & Renner, J., 2014, In : Journal of Radiology Case Reports. 8, 6, p. 27-38 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The Pathophysiology of Cardiac Hypertrophy and Heart Failure

Stansfield, W. E., Ranek, M., Pendse, A., Schisler, J. C., Wang, S., Pulinilkunnil, T. & Willis, M. S., Jan 2014, Cellular and Molecular Pathobiology of Cardiovascular Disease. Elsevier Inc., p. 51-78 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

The role of ubiquitin ligases in cardiac disease

Willis, M. S., Bevilacqua, A., Pulinilkunnil, T., Kienesberger, P., Tannu, M. & Patterson, C., Jun 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 43-53 11 p.

Research output: Contribution to journalReview article

41 Scopus citations
2013

BMPER regulates cardiomyocyte size and vessel density in vivo

Willis, M. S., Dyer, L. A., Ren, R., Lockyer, P., Moreno-Miralles, I., Schisler, J. C. & Patterson, C., May 1 2013, In : Cardiovascular Pathology. 22, 3, p. 228-240 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cancer cachexia's metabolic signature in a murine model confirms a distinct entity

Der-Torossian, H., Asher, S. A., Winnike, J. H., Wysong, A., Yin, X., Willis, M. S., O'Connell, T. M. & Couch, M. E., Jun 1 2013, In : Metabolomics. 9, 3, p. 730-739 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise

Willis, M. S., Min, J. N., Wang, S., Mcdonough, H., Lockyer, P., Wadosky, K. M. & Patterson, C., Dec 2013, In : Cell Biochemistry and Function. 31, 8, p. 724-735 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Circulating tumor markers: Basic concepts and clinical applications

McCudden, C. R. & Willis, M., Jun 25 2013, Clinical Chemistry: Principles, Techniques, and Correlations: Seventh Edition. Wolters Kluwer Health Adis (ESP), p. 664-679 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction

O'Neal, W. T., Griffin, W. F., Dries-Devlin, J. L., Kent, S. D., Chen, J., Willis, M. S. & Virag, J. A. I., Jun 2013, In : Medical Hypotheses. 80, 6, p. 738-744 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease

Oakley, R. H., Ren, R., Cruz-Topete, D., Bird, G. S., Myers, P. H., Boyle, M. C., Schneider, M. D., Willis, M. S. & Cidlowski, J. A., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17035-17040 6 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixation

Bender, L. M., Cotten, S. W., Fedoriw, Y., Willis, M. S. & McCudden, C. R., Feb 1 2013, In : Clinical Biochemistry. 46, 3, p. 255-258 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Heart Rate Variability (HRV) as a Tool for Diagnostic and Monitoring Performance in Sport and Physical Activities

Makivić, B., Nikić, M. D. & Willis, M. S., 2013, In : Journal of Exercise Physiology Online. 16, 3, p. 103-131 29 p.

Research output: Contribution to journalArticle

35 Scopus citations

Laboratory markers of cardiac damage and function

Durando, M., Jensen, B. C. & Willis, M., Jun 25 2013, Clinical Chemistry: Principles, Techniques, and Correlations: Seventh Edition. Wolters Kluwer Health Adis (ESP), p. 545-567 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lean six sigma methodology for quality improvement in the clinical chemistry laboratory

Cotten, S. W., McCudden, C. R., Rogers, M. W. & Willis, M., Jun 25 2013, Clinical Chemistry: Principles, Techniques, and Correlations: Seventh Edition. Wolters Kluwer Health Adis (ESP), p. 90-99 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia

Der-Torossian, H., Wysong, A., Shadfar, S., Willis, M. S., McDunn, J. & Couch, M. E., Jun 2013, In : Journal of Cachexia, Sarcopenia and Muscle. 4, 2, p. 145-155 11 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations