Monte Willis

MD, PhD, MBA, Deputy Director, Indiana Center for Musculoskeletal Health, Vice-Chair of Research, Department of Pathology & Lab Medicine

  • 635 Barnhill Drive, MS 5067

    46202 Indianapolis

    United States

  • 6612 Citations
  • 44 h-Index
19982020

Research output per year

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Publications

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Article
2020

New insights into immunomodulation via overexpressing lipoic acid synthase as a therapeutic potential to reduce atherosclerosis

Tian, S., Nakamura, J., Hiller, S., Simington, S., Holley, D. W., Mota, R., Willis, M. S., Bultman, S. J., Luft, J. C., DeSimone, J. M., Jia, Z., Maeda, N. & Yi, X., 2020, (Accepted/In press) In : Vascular Pharmacology. 133-134, 106777.

Research output: Contribution to journalArticle

2019

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice

Oakley, R. H., Cruz-Topete, D., He, B., Foley, J. F., Myers, P. H., Xu, X., Gomez-Sanchez, C. E., Chambon, P., Willis, M. S. & Cidlowski, J. A., Apr 16 2019, In : Science Signaling. 12, 577, eaau9685.

Research output: Contribution to journalArticle

16 Scopus citations

Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle-Specific Ubiquitin Ligase MuRF1

Willis, M. S., Parry, T. L., Brown, D. I., Mota, R. I., Huang, W., Beak, J. Y., Sola, M., Zhou, C., Hicks, S. T., Caughey, M. C., D'agostino, R. B., Jordan, J., Hundley, W. G. & Jensen, B. C., Mar 1 2019, In : Circulation: Heart Failure. 12, 3, e005234.

Research output: Contribution to journalArticle

10 Scopus citations

F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria

Ling, T. Y., Yi, F., Lu, T., Wang, X. L., Sun, X., Willis, M. S., Wu, L. Q., Shen, W. K., Adelman, J. P. & Lee, H. C., Mar 15 2019, In : Journal of Biological Chemistry. 294, 11, p. 4160-4168 9 p.

Research output: Contribution to journalArticle

Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis

Ilaiwy, A., ten Have, G. A. M., Bain, J. R., Muehlbauer, M. J., O'Neal, S. K., Berthiaume, J. M., Parry, T. L., Deutz, N. E. & Willis, M. S., Sep 2019, In : American Journal of Pathology. 189, 9, p. 1797-1813 17 p.

Research output: Contribution to journalArticle

Image-Based Methods for Phase Estimation, Gating, and Temporal Superresolution of Cardiac Ultrasound

Chittajallu, D. R., McCormick, M., Gerber, S., Czernuszewicz, T. J., Gessner, R., Willis, M. S., Niethammer, M., Kwitt, R. & Aylward, S. R., Jan 2019, In : IEEE Transactions on Biomedical Engineering. 66, 1, p. 72-79 8 p., 8345790.

Research output: Contribution to journalArticle

Open Access

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

Rodrigues, A. C. Z., Messi, M. L., Wang, Z. M., Abba, M. C., Pereyra, A., Birbrair, A., Zhang, T., O’Meara, M., Kwan, P., Lopez, E. I. S., Willis, M. S., Mintz, A., Files, D. C., Furdui, C., Oppenheim, R. W. & Delbono, O., Mar 2019, In : Acta Physiologica. 225, 3, e13195.

Research output: Contribution to journalArticle

12 Scopus citations
2018

Applicability of precision medicine approaches to managing hypertension in rural populations

Halladay, J. R., Lenhart, K. C., Robasky, K., Jones, W., Homan, W. F., Cummings, D. M., Cené, C. W., Hinderliter, A. L., Miller, C. L., Donahue, K. E., Garcia, B. A., Keyserling, T. C., Ammerman, A. S., Patterson, C., Dewalt, D. A., Johnston, L. F., Willis, M. S. & Schisler, J. C., Jun 2018, In : Journal of Personalized Medicine. 8, 2, 16.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

Shi, C. H., Rubel, C., Soss, S. E., Sanchez-Hodge, R., Zhang, S., Madrigal, S. C., Ravi, S., McDonough, H., Page, R. C., Chazin, W. J., Patterson, C., Mao, C. Y., Willis, M. S., Luo, H. Y., Li, Y. S., Stevens, D. A., Tang, M. B., Du, P., Wang, Y. H., Hu, Z. W. & 2 others, Xu, Y. M. & Schisler, J. C., Sep 2018, In : PLoS Genetics. 14, 9, e1007664.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study

Raffield, L. M., Ellis, J., Olson, N. C., Duan, Q., Li, J., Durda, P., Pankratz, N., Keating, B. J., Wassel, C. L., Cushman, M., Wilson, J. G., Gross, M. D., Tracy, R. P., Rich, S. S., Reiner, A. P., Li, Y., Willis, M. S., Lange, E. M. & Lange, L. A., Mar 1 2018, In : Journal of Human Genetics. 63, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo

Mota, R., Parry, T. L., Yates, C. C., Qiang, Z., Eaton, S. C., Mwiza, J. M., Tulasi, D., Schisler, J. C., Patterson, C., Zaglia, T., Sandri, M. & Willis, M. S., Jul 2018, In : American Journal of Pathology. 188, 7, p. 1676-1692 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Modeling the transition from decompensated to pathological hypertrophy

Pascual, F., Schisler, J. C., Grevengoed, T. J., Willis, M. S. & Coleman, R. A., Apr 17 2018, In : Journal of the American Heart Association. 7, 8, e008293.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

Oakley, R. H., Campen, M. J., Paffett, M. L., Chen, X., Wang, Z., Parry, T. L., Hillhouse, C., Cidlowski, J. A. & Willis, M. S., Sep 21 2018, In : BMC Medical Genetics. 19, 1, 175.

Research output: Contribution to journalArticle

Open Access

Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats

Parry, T. L., Starnes, J. W., O’Neal, S. K., Bain, J. R., Muehlbauer, M. J., Honcoop, A., Ilaiwy, A., Christopher, P., Patterson, C. & Willis, M. S., Jan 1 2018, In : Metabolomics. 14, 1, 8.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity

Shimomoto, T., Collins, L. B., Yi, X., Holley, D. W., Zhang, Z., Tian, X., Uchida, K., Wang, C., Hörkkö, S., Willis, M. S., Gold, A., Bultman, S. J. & Nakamura, J., Feb 2017, In : PloS one. 12, 2, e0172172.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility

Willis, M. S., Holley, D. W., Wang, Z., Chen, X., Quintana, M., Jensen, B. C., Tannu, M., Parker, J., Jeyaraj, D., Jain, M. K., Wolfram, J. A., Lee, H. G. & Bultman, S. J., Apr 1 2017, In : Journal of Molecular and Cellular Cardiology. 105, p. 99-109 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease

Ravi, S., Schuck, R. N., Hilliard, E., Lee, C. R., Dai, X., Lenhart, K., Willis, M., Jensen, B. C., Stouffer, G. A., Patterson, C. & Schisler, J. C., Dec 1 2017, In : American Journal of Pathology. 187, 12, p. 2895-2911 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis

Jensen, B. C., Parry, T. L., Huang, W., Beak, J. Y., Ilaiwy, A., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Patterson, C., Johnson, G. L. & Willis, M. S., Dec 2017, In : British Journal of Pharmacology. 174, 24, p. 4797-4811 15 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes

Nakamura, J., Shimomoto, T., Collins, L. B., Holley, D. W., Zhang, Z., Barbee, J. M., Sharma, V., Tian, X., Kondo, T., Uchida, K., Yi, X., Perkins, DI. O., Willis, M. S., Gold, A. & Bultman, S. J., Dec 1 2017, In : Scientific reports. 7, 1, 10787.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Exercise-induced alterations in skeletal muscle, heart, liver, and serum metabolome identified by non-targeted metabolomics analysis

Starnes, J. W., Parry, T. L., O’Neal, S. K., Bain, J. R., Muehlbauer, M. J., Honcoop, A., Ilaiwy, A., Christopher, P. M., Patterson, C. & Willis, M. S., 2017, In : Metabolites. 7, 3, 40.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Kinome and transcriptome profiling reveal broad and distinct activities of erlotinib, sunitinib, and sorafenib in the mouse heart and suggest cardiotoxicity from combined signal transducer and activator of transcription and epidermal growth factor receptor inhibition

Stuhlmiller, T. J., Zawistowski, J. S., Chen, X., Sciaky, N., Angus, S. P., Hicks, S. T., Parry, T. L., Huang, W., Beak, J. Y., Willis, M. S., Johnson, G. L. & Jensen, B. C., Oct 1 2017, In : Journal of the American Heart Association. 6, 10, e006635.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

MMI-0100 inhibits cardiac fibrosis in a mouse model overexpressing cardiac myosin binding protein C

Meng, Q., Bhandary, B., Osinska, H., James, J., Xu, N., Shay-Winkler, K., Gulick, J., Willis, M. S., Lander, C. & Robbins, J., Sep 1 2017, In : Journal of the American Heart Association. 6, 9, e006590.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Non-targeted metabolomics analysis of Golden Retriever Muscular Dystrophy-affected muscles reveals alterations in arginine and proline metabolism, and elevations in glutamic and oleic acid in vivo

Abdullah, M., Kornegay, J. N., Honcoop, A., Parry, T. L., Balog-Alvarez, C. J., O’Neal, S. K., Bain, J. R., Muehlbauer, M. J., Newgard, C. B., Patterson, C. & Willis, M. S., Sep 2017, In : Metabolites. 7, 3, 38.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Non-targeted metabolomics analysis of the effects of tyrosine kinase inhibitors sunitinib and erlotinib on heart, muscle, liver and serum metabolism in vivo

Jensen, B. C., Parry, T. L., Huang, W., Ilaiwy, A., Bain, J. R., Muehlbauer, M. J., O’Neal, S. K., Patterson, C., Johnson, G. L. & Willis, M. S., Sep 1 2017, In : Metabolites. 7, 3, 31.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Post-translationally modified muscle-specific ubiquitin ligases as circulating biomarkers in experimental cancer cachexia

Mota, R., Rodríguez, J. E., Bonetto, A., O'Connell, T. M., Asher, S. A., Parry, T. L., Lockyer, P., McCudden, C. R., Couch, M. E. & Willis, M. S., Jan 1 2017, In : American Journal of Cancer Research. 7, 9, p. 1948-1958 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ubiquitin ligases and posttranslational regulation of energy in the heart: The hand that feeds

Brown, D. I., Parry, T. L. & Willis, M., Jul 1 2017, In : Comprehensive Physiology. 7, 3, p. 841-862 22 p.

Research output: Contribution to journalArticle

2 Scopus citations

Upregulation of autophagy genes and the unfolded protein response in human heart failure

Jensen, B. C., Bultman, S. J., Holley, D., Tang, W., de Ridder, G., Pizzo, S., Bowles, D. & Willis, M., Jan 30 2017, In : International Journal of Clinical and Experimental Medicine. 10, 1, p. 1051-1058 8 p., IJCEM0040108.

Research output: Contribution to journalArticle

5 Scopus citations
2016

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo

Bultman, S. J., Holley, D. W., G De Ridder, G., Pizzo, S. V., Sidorova, T. N., Murray, K. T., Jensen, B. C., Wang, Z., Bevilacqua, A., Chen, X., Quintana, M. T., Tannu, M., Rosson, G. B., Pandya, K. & Willis, M. S., May 1 2016, In : Cardiovascular Pathology. 25, 3, p. 258-269 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
Open Access
8 Scopus citations

Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling

Quintana, M. T., Parry, T. L., He, J., Yates, C. C., Sidorova, T. N., Murray, K. T., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Eaton, S. C., Hishiya, A., Takayama, S. & Willis, M. S., Aug 1 2016, In : American Journal of Pathology. 186, 8, p. 1989-2007 19 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis

Ilaiwy, A., Quintana, M. T., Bain, J. R., Muehlbauer, M. J., Brown, D. I., Stansfield, W. E. & Willis, M. S., Oct 1 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 80-92 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Corticosteroids are essential for maintaining cardiovascular function in male mice

Cruz-Topete, D., Myers, P. H., Foley, J. F., Willis, M. S. & Cidlowski, J. A., Jul 2016, In : Endocrinology. 157, 7, p. 2759-2771 13 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures

Kornegay, J. N., Bogan, D. J., Bogan, J. R., Dow, J. L., Wang, J., Fan, Z., Liu, N., Warsing, L. C., Grange, R. W., Ahn, M., Balog-Alvarez, C. J., Cotten, S. W., Willis, M. S., Brinkmeyer-Langford, C., Zhu, H., Palandra, J., Morris, C. A., Styner, M. A. & Wagner, K. R., Apr 4 2016, In : Skeletal Muscle. 6, 1, 14.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1

Parry, T. L., Desai, G., Schisler, J. C., Li, L., Quintana, M. T., Stanley, N., Lockyer, P., Patterson, C. & Willis, M., Mar 1 2016, In : Cardiovascular Pathology. 25, 2, p. 127-140 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo

Ilaiwy, A., Liu, M., Parry, T. L., Bain, J. R., Newgard, C. B., Schisler, J. C., Muehlbauer, M. J., Despa, F. & Willis, M. S., May 1 2016, In : Metabolomics. 12, 5, 95.

Research output: Contribution to journalArticle

8 Scopus citations

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

Files, D. C., Ilaiwy, A., Parry, T. L., Gibbs, K. W., Liu, C., Bain, J. R., Delbono, O., Muehlbauer, M. J. & Willis, M. S., Aug 1 2016, In : Metabolomics. 12, 8, 134.

Research output: Contribution to journalArticle

4 Scopus citations

MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo

Wadosky, K. M., Berthiaume, J. M., Tang, W., Zungu, M., Portman, M. A., Gerdes, A. M. & Willis, M. S., Apr 2016, In : Journal of Molecular Endocrinology. 56, 3, p. 273-290 18 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Nebulized Delivery of the MAPKAP Kinase 2 Peptide Inhibitor MMI-0100 Protects Against Ischemia-Induced Systolic Dysfunction

Brown, D. I., Cooley, B. C., Quintana, M. T., Lander, C. & Willis, M. S., Sep 1 2016, In : International Journal of Peptide Research and Therapeutics. 22, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo

Willis, M. S., Ilaiwy, A., Montgomery, M. D., Simpson, P. C. & Jensen, B. C., Oct 1 2016, In : Metabolomics. 12, 10, 155.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin

Schisler, J. C., Grevengoed, T. J., Pascual, F., Cooper, D. E., Ellis, J. M., Paul, D. S., Willis, M. S., Patterson, C., Jia, W. & Coleman, R. A., 2015, In : Journal of the American Heart Association. 4, 2, e001136.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Delayed contrast enhancement imaging of a murine model for ischemia reperfusion with carbon nanotube micro-CT

Burk, L. M., Wang, K. H., Wait, J. M., Kang, E., Willis, M., Lu, J., Zhou, O. & Lee, Y. Z., Jan 30 2015, In : PloS one. 10, 1, e0115607.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

Xie, L., Pi, X., Wang, Z., He, J., Willis, M. S. & Patterson, C., Mar 1 2015, In : Journal of Molecular and Cellular Cardiology. 80, p. 156-165 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

Schisler, J. C., Ronnebaum, S. M., Madden, M., Channell, M., Campen, M. & Willis, M. S., Apr 1 2015, In : Inhalation Toxicology. 27, 5, p. 272-280 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure

Parry, T. L., Melehani, J. H., Ranek, M. J. & Willis, M. S., May 19 2015, In : Frontiers in Cardiovascular Medicine. 2, 25.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Genetics and heart failure: A concise guide for the clinician

Skrzynia, C., Berg, J. S., Willis, M. S. & Jensen, B. C., Dec 1 2015, In : Current Cardiology Reviews. 11, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

Li, J., Lange, L. A., Sabourin, J., Duan, Q., Valdar, W., Willis, M. S., Li, Y., Wilson, J. G. & Lange, E. M., Dec 1 2015, In : Journal of Human Genetics. 60, 12, p. 755-761 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans

Li, J., Lange, L. A., Duan, Q., Lu, Y., Singleton, A. B., Zonderman, A. B., Evans, M. K., Li, Y., Taylor, H. A., Willis, M. S., Nalls, M., Wilson, J. G. & Lange, E. M., Jan 15 2015, In : Human molecular genetics. 24, 2, p. 572-581 10 p., ddu454.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

He, J., Quintana, M. T., Sullivan, J., Parry, T., Grevengoed, T., Schisler, J. C., Hill, J. A., Yates, C. C., Mapanga, R. F., Essop, M. F., Stansfield, W. E., Bain, J. R., Newgard, C. B., Muehlbauer, M. J., Han, Y., Clarke, B. A. & Willis, M. S., Aug 5 2015, In : Cardiovascular Diabetology. 14, 1, 97.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet

Quintana, M. T., He, J., Sullivan, J., Grevengoed, T., Schisler, J., Han, Y., Hill, J. A., Yates, C. C., Stansfield, W. E., Mapanga, R. F., Essop, M. F., Muehlbauer, M. J., Newgard, C. B., Bain, J. R. & Willis, M. S., Dec 12 2015, In : BMC Endocrine Disorders. 15, 1, 36.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes

Banerjee, R., He, J., Spaniel, C., Quintana, M. T., Wang, Z., Bain, J. R., Newgard, C. B., Muehlbauer, M. J. & Willis, M. S., Apr 1 2015, In : Metabolomics. 11, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

15 Scopus citations