Monte Willis

MD, PhD, MBA, Deputy Director, Indiana Center for Musculoskeletal Health, Vice-Chair of Research, Department of Pathology & Lab Medicine

  • 635 Barnhill Drive, MS 5067

    46202 Indianapolis

    United States

  • 6095 Citations
  • 44 h-Index
19982019
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Publications 1998 2019

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Review article
2018
4 Citations (Scopus)

The role of heat shock proteins and co-chaperones in heart failure

Ranek, M. J., Stachowski, M. J., Kirk, J. A. & Willis, M., Jan 19 2018, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 373, 1738, 20160530.

Research output: Contribution to journalReview article

Open Access
heart failure
Heat-Shock Proteins
heat shock proteins
Heart Failure
Proteins
5 Citations (Scopus)

Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all

Abdullah, M., Berthiaume, J. M. & Willis, M., May 1 2018, In : Translational Research. 195, p. 48-61 14 p.

Research output: Contribution to journalReview article

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
NF-kappa B
Cardiovascular Diseases
Heart Diseases
Heart Failure
2017
91 Citations (Scopus)

Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association

American Heart Association Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; and Stroke Council, Nov 21 2017, In : Circulation. 136, 21, p. e393-e423

Research output: Contribution to journalReview article

Open Access
African Americans
Health
Cardiovascular Diseases
Disease Management
Heart Failure
2015
21 Citations (Scopus)

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Couch, M. E., Dittus, K., Toth, M. J., Willis, M., Guttridge, D. C., George, J. R., Barnes, C. A., Gourin, C. G. & Der-Torossian, H., Apr 1 2015, In : Head and Neck. 37, 4, p. 594-604 11 p.

Research output: Contribution to journalReview article

Cachexia
Head and Neck Neoplasms
Neoplasms
Wasting Syndrome
Search Engine
8 Citations (Scopus)

Cancer cachexia update in head and neck cancer: Pathophysiology and treatment

Couch, M. E., Dittus, K., Toth, M. J., Willis, M., Guttridge, D. C., George, J. R., Chang, E. Y., Gourin, C. G. & Der-Torossian, H., Jul 1 2015, In : Head and Neck. 37, 7, p. 1057-1072 16 p.

Research output: Contribution to journalReview article

Cachexia
Head and Neck Neoplasms
Search Engine
Combined Modality Therapy
Neoplasms
2014
26 Citations (Scopus)

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease

Bevilacqua, A., Willis, M. & Bultman, S. J., Mar 1 2014, In : Cardiovascular Pathology. 23, 2, p. 85-91 7 p.

Research output: Contribution to journalReview article

Chromatin Assembly and Disassembly
Sucrose
Cardiovascular Diseases
Heart Diseases
Endothelial Cells
35 Citations (Scopus)

The role of ubiquitin ligases in cardiac disease

Willis, M., Bevilacqua, A., Pulinilkunnil, T., Kienesberger, P., Tannu, M. & Patterson, C., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 43-53 11 p.

Research output: Contribution to journalReview article

Ligases
Ubiquitin
Heart Diseases
Proteasome Endopeptidase Complex
Quality Control
2013
147 Citations (Scopus)

Proteotoxicity and cardiac dysfunction - Alzheimer's disease of the heart?

Willis, M. & Patterson, C., Jan 31 2013, In : New England Journal of Medicine. 368, 5, p. 455-464 10 p.

Research output: Contribution to journalReview article

Alzheimer Disease
28 Citations (Scopus)

Targeting Angiogenesis and the Tumor Microenvironment

Samples, J., Willis, M. & Klauber-DeMore, N., Oct 1 2013, In : Surgical Oncology Clinics of North America. 22, 4, p. 629-639 11 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Extracellular Matrix
Neoplasms
Molecular Pathology
Lymph
2012
62 Citations (Scopus)

Back to your heart: Ubiquitin proteasome system-regulated signal transduction

Portbury, A. L., Ronnebaum, S. M., Zungu, M., Patterson, C. & Willis, M., Mar 1 2012, In : Journal of Molecular and Cellular Cardiology. 52, 3, p. 526-537 12 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Signal Transduction
Post Translational Protein Processing
Calcineurin
50 Citations (Scopus)
Sumoylation
Peroxisome Proliferator-Activated Receptors
Ubiquitination
Ubiquitin
Transcription Factors
2011
47 Citations (Scopus)

All the little pieces: Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifier and their potential relevance in the heart

Makhosazane, Z., Jonathan, S. & Willis, M., Oct 31 2011, In : Circulation Journal. 75, 11, p. 2513-2521 9 p.

Research output: Contribution to journalReview article

Open Access
Mitochondrial Dynamics
Ubiquitin
Mitochondria
Post Translational Protein Processing
Heart Diseases
Inborn Genetic Diseases
Heart Diseases
Technology
Long QT Syndrome
Molecular Pathology
5 Citations (Scopus)

Kids in america: Newborn screening for cystic fibrosis

Bender, L. M., Cotten, S. W. & Willis, M., Oct 1 2011, In : Laboratory Medicine. 42, 10, p. 595-601 7 p.

Research output: Contribution to journalReview article

Open Access
Cystic Fibrosis
Screening
Testing
Costs
Costs and Cost Analysis
39 Citations (Scopus)

Regulation of AMPK by the ubiquitin proteasome system

Zungu, M., Schisler, J. C., Essop, M. F., McCudden, C., Patterson, C. & Willis, M., Jan 1 2011, In : American Journal of Pathology. 178, 1, p. 4-11 8 p.

Research output: Contribution to journalReview article

AMP-Activated Protein Kinases
Proteasome Endopeptidase Complex
Ubiquitin
Ubiquitination
Ligases
37 Citations (Scopus)

Tear me down: Role of calpain in the development of cardiac ventricular hypertrophy

Patterson, C., Portbury, A. L., Schisler, J. C. & Willis, M., Aug 5 2011, In : Circulation research. 109, 4, p. 453-462 10 p.

Research output: Contribution to journalReview article

Open Access
Calpain
Cardiomegaly
Tears
Hypertrophy
Peptide Hydrolases
2010
10 Citations (Scopus)

Cardiac muscle ring finger-1-friend or foe?

Willis, M., Zungu, M. & Patterson, C., Jan 1 2010, In : Trends in Cardiovascular Medicine. 20, 1, p. 12-16 5 p.

Research output: Contribution to journalReview article

Creatine Kinase
Fingers
Myocardium
Ubiquitin
Phosphocreatine
19 Citations (Scopus)

Evolving molecular diagnostics for familial cardiomyopathies: At the heart of it all

Callis, T. E., Jensen, B. C., Weck, K. E. & Willis, M., Apr 1 2010, In : Expert Review of Molecular Diagnostics. 10, 3, p. 329-351 23 p.

Research output: Contribution to journalReview article

Molecular Pathology
Cardiomyopathies
Restrictive Cardiomyopathy
Arrhythmogenic Right Ventricular Dysplasia
Inheritance Patterns
63 Citations (Scopus)

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease

Willis, M. & Patterson, C., Oct 26 2010, In : Circulation. 122, 17, p. 1740-1751 12 p.

Research output: Contribution to journalReview article

Open Access
Myocardial Reperfusion Injury
Molecular Chaperones
Protein Folding
Cardiomegaly
Heat-Shock Proteins
129 Citations (Scopus)

Sent to destroy: The ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease

Willis, M., Townley-Tilson, W. H. D., Kang, E. Y., Homeister, J. W. & Patterson, C., Feb 1 2010, In : Circulation research. 106, 3, p. 463-478 16 p.

Research output: Contribution to journalReview article

Open Access
Proteasome Endopeptidase Complex
Ubiquitin
Quality Control
Cardiovascular Diseases
Autophagy
2 Citations (Scopus)

Sir Hans Adolf Krebs: Architect of metabolic cycles

Wilson, B. A., Schisler, J. C. & Willis, M., Jun 1 2010, In : Laboratory Medicine. 41, 6, p. 377-380 4 p.

Research output: Contribution to journalReview article

Open Access
8 Citations (Scopus)

The challenges and complexities of thyroid hormone replacement

Kansagra, S. M., McCudden, C. R. & Willis, M., Jun 1 2010, In : Laboratory Medicine. 41, 6, p. 338-348 11 p.

Research output: Contribution to journalReview article

Open Access
Thyroid Hormones
Hypothyroidism
Triiodothyronine
Thyroxine
Metabolism
54 Citations (Scopus)

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy

Carrier, L., Schlossarek, S., Willis, M. & Eschenhagen, T., Jan 1 2010, In : Cardiovascular Research. 85, 2, p. 330-338 9 p.

Research output: Contribution to journalReview article

Open Access
Nonsense Mediated mRNA Decay
Hypertrophic Cardiomyopathy
Proteasome Endopeptidase Complex
Ubiquitin
Proteins
2009
99 Citations (Scopus)

Build it up-Tear it down: Protein quality control in the cardiac sarcomere

Willis, M., Schisler, J. C., Portbury, A. L. & Patterson, C., Feb 1 2009, In : Cardiovascular Research. 81, 3, p. 439-448 10 p.

Research output: Contribution to journalReview article

Open Access
Sarcomeres
Tears
Quality Control
Ubiquitin
Proteins
17 Citations (Scopus)

Familial hypertrophic cardiomyopathy: Basic concepts and future molecular diagnostics

Rodríguez, J. E., McCudden, C. R. & Willis, M., Jun 1 2009, In : Clinical Biochemistry. 42, 9, p. 755-765 11 p.

Research output: Contribution to journalReview article

Familial Hypertrophic Cardiomyopathy
Molecular Pathology
Microarrays
Throughput
Defects
7 Citations (Scopus)

Recent advances in the detection of prostate cancer using epigenetic markers in commonly collected laboratory samples

Maxwell, A., McCudden, C. R., Wians, F. & Willis, M., Dec 1 2009, In : Laboratory Medicine. 40, 3, p. 171-178 8 p.

Research output: Contribution to journalReview article

Open Access
Biomarkers
Prostate-Specific Antigen
Epigenomics
Prostatic Neoplasms
CpG Islands
15 Citations (Scopus)

Seek and destroy: The ubiquitin-proteasome system in cardiac disease

Willis, M., Rodríoguez, J. E., Schisler, J. C. & Patterson, C., Dec 1 2009, In : Current Hypertension Reports. 11, 6, p. 396-405 10 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Heart Diseases
Ligases
Diabetic Cardiomyopathies
2008
20 Citations (Scopus)

Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease

Willis, M., Schisler, J. C. & Patterson, C., Jan 1 2008, In : Future Cardiology. 4, 1, p. 65-75 11 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
Appetite
Proteasome Endopeptidase Complex
Heart Diseases
Ubiquitin
12 Citations (Scopus)

Cystic fibrosis: newborn screening in America.

Kleven, D. T., McCudden, C. R. & Willis, M., Jul 1 2008, In : MLO: medical laboratory observer. 40, 7

Research output: Contribution to journalReview article

Cystic Fibrosis
Newborn Infant
Hope
Trypsinogen
Exocrine Pancreatic Insufficiency
100 Citations (Scopus)

The ubiquitin-proteasome system in cardiac dysfunction

Mearini, G., Schlossarek, S., Willis, M. & Carrier, L., Dec 1 2008, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1782, 12, p. 749-763 15 p.

Research output: Contribution to journalReview article

Open Access
Proteasome Endopeptidase Complex
Ubiquitin
Autophagy
Lysosomes
Biological Phenomena
16 Citations (Scopus)

You spin me round: MAFbx/Atrogin-1 feeds forward on FOXO transcription factors (like a record)

Schisler, J. C., Willis, M. & Patterson, C., Feb 15 2008, In : Cell Cycle. 7, 4, p. 440-443 4 p.

Research output: Contribution to journalReview article

Ubiquitin
Polyubiquitin
Hypertrophy
Transcription Factors
Ligases
2007
67 Citations (Scopus)

The bitter end: The ubiquitin-proteasome system and cardiac dysfunction

Patterson, C., Ike, C., Willis IV, P. W., Stouffer, G. A. & Willis, M., Mar 1 2007, In : Circulation. 115, 11, p. 1456-1463 8 p.

Research output: Contribution to journalReview article

Open Access
Proteasome Endopeptidase Complex
Ubiquitin
Heart Failure
Proteins
Tears
2006
96 Citations (Scopus)

Into the heart: The emerging role of the ubiquitin-proteasome system

Willis, M. & Patterson, C., Oct 1 2006, In : Journal of Molecular and Cellular Cardiology. 41, 4, p. 567-579 13 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Ubiquitin-Protein Ligases
Cardiomegaly
Heart Diseases

Toxoplasma infection: Making the best use of laboratory tests

Southern, P. & Willis, M., Aug 1 2006, In : Infections in Medicine. 23, 8, p. 362-376 15 p.

Research output: Contribution to journalReview article

Toxoplasma
Infection
Parasites
Immunocompromised Host
Prenatal Diagnosis
2005
35 Citations (Scopus)

Relapse of thrombotic thrombocytopenic purpura: Is it a continuum of disease?

Willis, M. & Bandarenko, N., Dec 1 2005, In : Seminars in Thrombosis and Hemostasis. 31, 6, p. 700-708 9 p.

Research output: Contribution to journalReview article

Thrombotic Thrombocytopenic Purpura
Recurrence
Plasma Exchange
L-Lactate Dehydrogenase
Vincristine
2004
22 Citations (Scopus)

Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.

Duryee, M. J., Willis, M., Freeman, T. L., Kuszynski, C. A., Tuma, D. J., Klassen, L. W. & Thiele, G. M., Jan 1 2004, In : Frontiers in bioscience : a journal and virtual library. 9, p. 3145-3155 11 p.

Research output: Contribution to journalReview article

Scavenger Receptors
Autoimmunity
Aldehydes
Liver
Alcoholic Liver Diseases
2003
107 Citations (Scopus)

The role of nutrition in preventing prostate cancer: A review of the proposed mechanism of action of various dietary substances

Willis, M. & Wians, F. H., Jan 1 2003, In : Clinica Chimica Acta. 330, 1-2, p. 57-83 27 p.

Research output: Contribution to journalReview article

Nutrition
Nutrients
Prostatic Neoplasms
Micronutrients
Antioxidants