Nadia Carlesso

  • 5003 Citations
  • 31 h-Index
1990 …2020

Research output per year

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Publications

  • 5003 Citations
  • 31 h-Index
  • 57 Article
  • 3 Comment/debate
  • 1 Conference contribution
  • 1 Review article
2020

Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia

Wang, H., Zhao, D., Nguyen, L. X., Wu, H., Li, L., Dong, D., Troadec, E., Zhu, Y., Hoang, D. H., Stein, A. S., Al Malki, M., Aldoss, I., Lin, A., Ghoda, L. Y., McDonald, T., Pichiorri, F., Carlesso, N., Kuo, Y. H., Zhang, B., Jin, J. & 1 others, Marcucci, G., Jan 1 2020, In : Leukemia. 34, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Rodriguez, S., Abundis, C., Boccalatte, F., Mehrotra, P., Chiang, M. Y., Yui, M. A., Wang, L., Zhang, H., Zollman, A., Bonfim-Silva, R., Kloetgen, A., Palmer, J., Sandusky, G., Wunderlich, M., Kaplan, M. H., Mulloy, J. C., Marcucci, G., Aifantis, I., Cardoso, A. A. & Carlesso, N., May 1 2020, In : Leukemia. 34, 5, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

Zhu, Y., He, X., Lin, Y. C., Dong, H., Zhang, L., Chen, X., Wang, Z., Shen, Y., Li, M., Wang, H., Sun, J., Nguyen, L. X., Zhang, H., Jiang, W., Yang, Y., Chen, J., Mu¨schen, M., Chen, C. W., Konopleva, M. Y., Sun, W. & 5 others, Jin, J., Carlesso, N., Marcucci, G., Luo, Y. & Li, L., Oct 10 2019, In : Blood. 134, 15, p. 1257-1268 12 p.

Research output: Contribution to journalArticle

2018

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

Kumar, B., Garcia, M., Weng, L., Jung, X., Murakami, J. L., Hu, X., McDonald, T., Lin, A., Kumar, A. R., Digiusto, D. L., Stein, A. S., Pullarkat, V. A., Hui, S. K., Carlesso, N., Kuo, Y. H., Bhatia, R., Marcucci, G. & Chen, C. C., Mar 1 2018, In : Leukemia. 32, 3, p. 575-587 13 p.

Research output: Contribution to journalArticle

66 Scopus citations

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

Zhang, B., Nguyen, L. X. T., Li, L., Zhao, D., Kumar, B., Wu, H., Lin, A., Pellicano, F., Hopcroft, L., Su, Y. L., Copland, M., Holyoake, T. L., Kuo, C. J., Bhatia, R., Snyder, D. S., Ali, H., Stein, A. S., Brewer, C., Wang, H., McDonald, T. & 12 others, Swiderski, P., Troadec, E., Chen, C. C., Dorrance, A., Pullarkat, V., Yuan, Y. C., Perrotti, D., Carlesso, N., Forman, S. J., Kortylewski, M., Kuo, Y. H. & Marcucci, G., May 1 2018, In : Nature Medicine. 24, 4, p. 450-462 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Copper 64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma

Caserta, E., Chea, J., Minnix, M., Viola, D., Vonderfecht, S., Yazaki, P., Crow, D., Khalife, J., Sanchez, J. F., Palmer, J. M., Hui, S., Carlesso, N., Keats, J., Kim, Y., Buettner, R., Marcucci, G., Rosen, S., Shively, J., Colcher, D., Krishnan, A. & 1 others, Pichiorri, F., Feb 15 2018, In : Blood. 131, 7, p. 741-745 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Erratum: Copper 64–labeled daratumumab as a PET/CT imaging tracer for multiple myeloma (Blood (2018) 131:7 (741-745) DOI: 10.1182/blood-2017-09-807263)

Caserta, E., Chea, J., Minnix, M., Poku, E. K., Viola, D., Vonderfecht, S., Yazaki, P., Crow, D., Khalife, J., Sanchez, J. F., Palmer, J. M., Hui, S., Carlesso, N., Keats, J., Kim, Y., Buettner, R., Marcucci, G., Rosen, S., Shively, J., Colcher, D. & 2 others, Krishnan, A. & Pichiorri, F., Jun 21 2018, In : Blood. 131, 25, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

Sun, J., He, X., Zhu, Y., Ding, Z., Dong, H., Feng, Y., Du, J., Wang, H., Wu, X., Zhang, L., Yu, X., Lin, A., McDonald, T., Zhao, D., Wu, H., Hua, W. K., Zhang, B., Feng, L., Tohyama, K., Bhatia, R. & 13 others, Oberdoerffer, P., Chung, Y. J., Aplan, P. D., Boultwood, J., Pellagatti, A., Khaled, S., Kortylewski, M., Pichiorri, F., Kuo, Y. H., Carlesso, N., Marcucci, G., Jin, H. & Li, L., Sep 6 2018, In : Cell Stem Cell. 23, 3, p. 355-369.e9

Research output: Contribution to journalArticle

14 Scopus citations
2017
1 Scopus citations

Neuropeptide Y regulates a vascular gateway for hematopoietic stem and progenitor cells

Singh, P., Hoggatt, J., Kamocka, M., Mohammad, K., Saunders, M. R., Li, H., Speth, J., Carlesso, N., Guise, T. & Pelus, L., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4527-4540 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma

Delgado-Calle, J., Anderson, J., Cregor, M. D., Hiasa, M., Chirgwin, J. M., Carlesso, N., Yoneda, T., Mohammad, K. S., Plotkin, L. I., Roodman, G. D. & Bellido, T., Mar 1 2016, In : Cancer Research. 76, 5, p. 1089-1100 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sepsis induces hematopoietic stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88

Zhang, H., Rodriguez, S., Wang, L., Wang, S., Serezani, H., Kapur, R., Cardoso, A. A. & Carlesso, N., Jun 14 2016, In : Stem Cell Reports. 6, 6, p. 940-956 17 p.

Research output: Contribution to journalArticle

28 Scopus citations

Structural and functional characterization of endothelial microparticles released by cigarette smoke

Serban, K. A., Rezania, S., Petrusca, D. N., Poirier, C., Cao, D., Justice, M. J., Patel, M., Tsvetkova, I., Kamocki, K., Mikosz, A., Schweitzer, K. S., Jacobson, S., Cardoso, A., Carlesso, N., Hubbard, W. C., Kechris, K., Dragnea, B., Berdyshev, E. V., McClintock, J. & Petrache, I., Aug 17 2016, In : Scientific reports. 6, 31596.

Research output: Contribution to journalArticle

39 Scopus citations
2015

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R. J., Wang, L., carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M. C., Jan 1 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Tu, X., Delgado-Calle, J., Condon, K. W., Maycas, M., Zhang, H., Carlesso, N., Taketo, M. M., Burr, D. B., Plotkin, L. I. & Bellido, T., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E478-E486

Research output: Contribution to journalArticle

110 Scopus citations

Segmentation of vascular structures and hematopoietic cells in 3D microscopy images and quantitative analysis

Mu, J., Yang, L., Kamocka, M., Zollman, A. L., Carlesso, N. & Chen, D. Z., 2015, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. SPIE, Vol. 9413. 941305

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
2014

CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche

Chitteti, B. R., Kobayashi, M., Cheng, Y., Zhang, H., Poteat, B. A., Broxmeyer, H. E., Pelus, L. M., Hanenberg, H., Zollman, A., Kamocka, M. M., Carlesso, N., Cardoso, A. A., Kacena, M. A. & Srour, E. F., Jul 24 2014, In : Blood. 124, 4, p. 519-529 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

Bi, P., Shan, T., Liu, W., Yue, F., Yang, X., Liang, X. R., Wang, J., Li, J., Carlesso, N., Liu, X. & Kuang, S., Aug 2014, In : Nature Medicine. 20, 8, p. 911-918 8 p.

Research output: Contribution to journalArticle

128 Scopus citations

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

106 Scopus citations
2013

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

Chen, H., Zhang, W., Sun, X., Yoshimoto, M., Chen, Z., Zhu, W., Liu, J., Shen, Y., Yong, W., Li, D., Zhang, J., Lin, Y., Li, B., VanDusen, N. J., Snider, P., Schwartz, R. J., Conway, S. J., Field, L. J., Yoder, M. C., Firulli, A. B. & 3 others, Carlesso, N., Towbin, J. A. & Shou, W., May 1 2013, In : Development (Cambridge). 140, 9, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
2012

Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence

Yoshimoto, M., Porayette, P., Glosson, N. L., Conway, S. J., Carlesso, N., Cardoso, A. A., Kaplan, M. H. & Yoder, M. C., Jun 14 2012, In : Blood. 119, 24, p. 5706-5714 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21 Cip1 expression and hampers tumour cell growth in vitro and in vivo

Raimondi, L., Ciarapica, R., De Salvo, M., Verginelli, F., Gueguen, M., Martini, C., De Sio, L., Cortese, G., Locatelli, M., Dang, T. P., Carlesso, N., Miele, L., Stifani, S., Limon, I., Locatelli, F. & Rota, R., May 2012, In : Cell Death and Differentiation. 19, 5, p. 871-881 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells

Hutter, C., Kauer, M., Simonitsch-Klupp, I., Jug, G., Schwentner, R., Leitner, J., Bock, P., Steinberger, P., Bauer, W., Carlesso, N., Minkov, M., Gadner, H., Stingl, G., Kovar, H. & Kriehuber, E., Dec 20 2012, In : Blood. 120, 26, p. 5199-5208 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

When IFN interferes with cell fate

Carlesso, N., Feb 9 2012, In : Blood. 119, 6, p. 1327-1329 3 p.

Research output: Contribution to journalComment/debate

2011

Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells

Cheng, Y. H., Chitteti, B. R., Streicher, D. A., Morgan, J. A., Rodriguez-Rodriguez, S., Carlesso, N., Srour, E. F. & Kacena, M. A., May 1 2011, In : Journal of Bone and Mineral Research. 26, 5, p. 1111-1121 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors

Batista, A., Barata, J. T., Raderschall, E., Sallan, S. E., Carlesso, N., Nadler, L. M. & Cardoso, A. A., Apr 2011, In : Experimental Hematology. 39, 4, p. 457-472.e3

Research output: Contribution to journalArticle

32 Scopus citations

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., Jun 16 2011, In : Blood. 117, 24, p. 6509-6519 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2010

Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function

Chitteti, B. R., Cheng, Y. H., Poteat, B., Rodriguez-Rodriguez, S., Goebel, W. S., Carlesso, N., Kacena, M. A. & Srour, E. F., Apr 22 2010, In : Blood. 115, 16, p. 3239-3248 10 p.

Research output: Contribution to journalArticle

94 Scopus citations

Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function

Chitteti, B. R., Cheng, Y. H., Streicher, D. A., Rodriguez-Rodriguez, S., Carlesso, N., Srour, E. F. & Kacena, M. A., Oct 1 2010, In : Journal of Cellular Biochemistry. 111, 2, p. 284-294 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Stem cell regulatory niches and their role in normal and malignant hematopoiesis

Carlesso, N. & Cardoso, A. A., Jul 1 2010, In : Current opinion in hematology. 17, 4, p. 281-286 6 p.

Research output: Contribution to journalReview article

54 Scopus citations
2009

Bone Marrow-Derived B Cells Preserve Ventricular Function After Acute Myocardial Infarction

Goodchild, T. T., Robinson, K. A., Pang, W., Tondato, F., Cui, J., Arrington, J., Godwin, L., Ungs, M., Carlesso, N., Weich, N., Poznansky, M. C. & Chronos, N. A. F., Oct 1 2009, In : JACC: Cardiovascular Interventions. 2, 10, p. 1005-1016 12 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis

Rodriguez, S., Chora, A., Goumnerov, B., Mumaw, C., Goebel, W. S., Fernandez, L., Baydoun, H., HogenEsch, H., Dombkowski, D. M., Karlewicz, C. A., Rice, S., Rahme, L. G. & Carlesso, N., Nov 5 2009, In : Blood. 114, 19, p. 4064-4076 13 p.

Research output: Contribution to journalArticle

79 Scopus citations
2008

Tumor necrosis factor-α and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

Fernandez, L., Rodriguez, S., Huang, H., Chora, A., Fernandes, J., Mumaw, C., Cruz, E., Pollok, K., Cristina, F., Price, J. E., Ferkowicz, M. J., Scadden, D. T., Clauss, M., Cardoso, A. A. & Carlesso, N., May 2008, In : Experimental Hematology. 36, 5, p. 545-558.e1

Research output: Contribution to journalArticle

40 Scopus citations
2007

Delta-like 4 induces Notch signaling in macrophages: Implications for inflammation

Fung, E., Tang, S. M. T., Canner, J. P., Morishige, K., Arboleda-Velasquez, J. F., Cardoso, A. A., Carlesso, N., Aster, J. C. & Aikawa, M., Jun 1 2007, In : Circulation. 115, 23, p. 2948-2956 9 p.

Research output: Contribution to journalArticle

150 Scopus citations
2006

Molecular and functional evidence for activity of murine IL-7 on human lymphocytes

Barata, J. T., Silva, A., Abecasis, M., Carlesso, N., Cumano, A. & Cardoso, A. A., Sep 2006, In : Experimental Hematology. 34, 9, p. 1132-1141 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2005

Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation

Sarmento, L. M., Huang, H., Limon, A., Gordon, W., Fernandes, J., Tavares, M. J., Miele, L., Cardoso, A. A., Classon, M. & Carlesso, N., Jul 4 2005, In : Journal of Experimental Medicine. 202, 1, p. 157-168 12 p.

Research output: Contribution to journalArticle

145 Scopus citations
2004

Notch-1 Regulates Cell Death Independently of Differentiation in Murine Erythroleukemia Cells Through Multiple Apoptosis and Cell Cycle Pathways

Jang, M. S., Miao, H., Carlesso, N., Shelly, L., Zlobin, A., Darack, N., Qin, J. Z., Nickoloff, B. J. & Miele, L., Jun 2004, In : Journal of cellular physiology. 199, 3, p. 418-433 16 p.

Research output: Contribution to journalArticle

64 Scopus citations
2003

Myeloid Expression of Cytochrome P450 4F3 Is Determined by a Lineage-specific Alternative Promoter

Christmas, P., Carlesso, N., Shang, H., Cheng, S. M., Weber, B. M., Preffer, F. I., Scadden, D. T. & Soberman, R. J., Jul 4 2003, In : Journal of Biological Chemistry. 278, 27, p. 25133-25142 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2002

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

Stier, S., Cheng, T., Dombkowski, D., Carlesso, N. & Scadden, D. T., Apr 1 2002, In : Blood. 99, 7, p. 2369-2378 10 p.

Research output: Contribution to journalArticle

306 Scopus citations

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells

Wang, Z., Miura, N., Bonelli, A., Mole, P., Carlesso, N., Olson, D. P. & Scadden, D. T., Apr 15 2002, In : Blood. 99, 8, p. 2740-2747 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2001

Alternative Splicing Determines the Function of CYP4F3 by Switching Substrate Specificity

Christmas, P., Jones, J. P., Patten, C. J., Rock, D. A., Zheng, Y., Cheng, S. M., Weber, B. M., Carlesso, N., Scadden, D. T., Rettie, A. E. & Soberman, R. J., Oct 12 2001, In : Journal of Biological Chemistry. 276, 41, p. 38166-38172 7 p.

Research output: Contribution to journalArticle

113 Scopus citations

The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells

Ellisen, L. W., Carlesso, N., Cheng, T., Scadden, D. T. & Haber, D. A., Apr 17 2001, In : EMBO Journal. 20, 8, p. 1897-1909 13 p.

Research output: Contribution to journalArticle

132 Scopus citations
2000

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

Lewin, M., Carlesso, N., Tung, C. H., Tang, X. W., Cory, D., Scadden, D. T. & Weissleder, R., May 3 2000, In : Nature Biotechnology. 18, 4, p. 410-414 5 p.

Research output: Contribution to journalArticle

1552 Scopus citations
1999

Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics

Carlesso, N., Aster, J. C., Sklar, J. & Scadden, D. T., Feb 1 1999, In : Blood. 93, 3, p. 838-848 11 p.

Research output: Contribution to journalArticle

212 Scopus citations
1997

Suppression of in vitro maintenance of non-promyelocytic myeloid leukemia clonogenic cells by all-trans retinoic acid: Modulating effects of dihydroxylated vitamin D3, α interferon and 'stem cell factor'

Ferrero, D., Carlesso, N., Bresso, P., Roux, V., Pregno, P., Gallo, E. & Pileri, A., Jan 1 1997, In : Leukemia Research. 21, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
1996

Bcr/Abl expression stimulates integrin function in hematopoietic cell lines

Bazzoni, G., Carlesso, N., Griffin, J. D. & Hemler, M. E., Jul 15 1996, In : Journal of Clinical Investigation. 98, 2, p. 521-528 8 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations