Natalia Bogatcheva

  • Assistant Research Professor of Medicine, Cardiology
  • 2305 Citations
  • 27 h-Index
1991 …2019
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Publications 1991 2019

  • 2305 Citations
  • 27 h-Index
  • 61 Article
  • 2 Chapter
  • 1 Review article
2019

Conditioned Medium of Mesenchymal Stromal Cells: A New Class of Therapeutics

Bogatcheva, N. V. & Coleman, M. E., Nov 1 2019, In : Biochemistry (Moscow). 84, 11, p. 1375-1389 15 p.

Research output: Contribution to journalReview article

Liquid nitrogen
Conditioned Culture Medium
Biological Products
Mesenchymal Stromal Cells
RNA
2 Citations (Scopus)

HIV-Nef protein persists in the lungs of aviremic patients with HIV and induces endothelial cell death

Chelvanambi, S., Bogatcheva, N. V., Bednorz, M., Agarwal, S., Maier, B., Alves, N. J., Li, W., Syed, F., Saber, M. M., Dahl, N., Lu, H., Day, R. B., Smith, P., Jolicoeur, P., Yu, Q., Dhillon, N. K., Weissmann, N., Twigg, H. L. & Clauss, M., Mar 1 2019, In : American Journal of Respiratory Cell and Molecular Biology. 60, 3, p. 357-366 10 p.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus nef Gene Products
Endothelial cells
Cell death
Cell Death
Endothelial Cells
2018
2 Citations (Scopus)

AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice

Barwinska, D., Oueini, H., Poirier, C., Albrecht, M. E., Bogatcheva, N., Justice, M. J., Saliba, J., Schweitzer, K. S., Broxmeyer, H., March, K. L. & Petrache, I., Sep 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 3, p. L382-L386

Research output: Contribution to journalArticle

Emphysema
Smoke
Tobacco Products
Hematopoietic Stem Cells
Chemokine CXCL12
2 Citations (Scopus)

EMAPII Monoclonal Antibody Ameliorates Influenza A Virus-Induced Lung Injury

Lu, H., Chelvanambi, S., Poirier, C., Saliba, J., March, K. L., Clauss, M. & Bogatcheva, N., Jan 1 2018, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Influenza A virus
Lung Injury
Monoclonal Antibodies
Lung
Bronchoalveolar Lavage Fluid
2016
6 Citations (Scopus)

Pulmonary retention of adipose stromal cells following intravenous delivery is markedly altered in the presence of ARDS

Lu, H., Cook, T., Poirier, C., Merfeld-Clauss, S., Petrache, I., March, K. L. & Bogatcheva, N., 2016, In : Cell Transplantation. 25, 9, p. 1635-1643 9 p.

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Stromal Cells
Stem cells
Stem Cells
Lung
2015
15 Citations (Scopus)

Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis

Lu, H., Poirier, C., Cook, T., Traktuev, D., Merfeld-Clauss, S., Lease, B., Petrache, I., March, K. L. & Bogatcheva, N., Feb 21 2015, In : Journal of Translational Medicine. 13, 1, 67.

Research output: Contribution to journalArticle

Lung Injury
Stromal Cells
Conditioned Culture Medium
Lipopolysaccharides
Apoptosis
2014
18 Citations (Scopus)

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury

Aggarwal, S., Gross, C. M., Kumar, S., Dimitropoulou, C., Sharma, S., Gorshkov, B. A., Sridhar, S., Lu, Q., Bogatcheva, N., Jezierska-Drutel, A. J., Lucas, R., Verin, A. D., Catravas, J. D. & Black, S. M., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 3, p. 614-625 12 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Lung
Oxidative stress
Nitration
Vascular System Injuries
6 Citations (Scopus)

Sox18 Preserves the Pulmonary Endothelial Barrier Under Conditions of Increased Shear Stress

Gross, C. M., Aggarwal, S., Kumar, S., Tian, J., Kasa, A., Bogatcheva, N., Datar, S. A., Verin, A. D., Fineman, J. R. & Black, S. M., 2014, In : Journal of Cellular Physiology. 229, 11, p. 1802-1816 15 p.

Research output: Contribution to journalArticle

Claudin-5
Shear stress
Lung
Blood
Endothelial cells
2012
11 Citations (Scopus)

Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema

Poirier, C., Berdyshev, E. V., Dimitropoulou, C., Bogatcheva, N., Biddinger, P. W. & Verin, A. D., Dec 2012, In : Mammalian Genome. 23, 11-12, p. 758-763 6 p.

Research output: Contribution to journalArticle

Type A Niemann-Pick Disease
Emphysema
Sphingomyelin Phosphodiesterase
Osteogenesis Imperfecta
Lung
10 Citations (Scopus)

Taxol alleviates 2-methoxyestradiol-induced endothelial permeability

Gorshkov, B. A., Verin, A. D., Zemskova, M. A. & Bogatcheva, N., Jan 2012, In : Vascular Pharmacology. 56, 1-2, p. 56-63 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Permeability
Tubulin
Acetylation
Microtubules
2011
14 Citations (Scopus)

Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability

Bogatcheva, N., Zemskova, M. A., Gorshkov, B. A., Kim, K. M., Daglis, G. A., Poirier, C. & Verin, A. D., Dec 1 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 6, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Phosphorylation
Chemical activation
Monolayers
Protein C Inhibitor
27 Citations (Scopus)

The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): Beneficial or detrimental to endothelial barrier?

Bogatcheva, N., Zemskova, M. A., Poirier, C., Mirzapoiazova, T., Kolosova, I., Bresnick, A. R. & Verin, A. D., Dec 2011, In : Journal of Cellular Physiology. 226, 12, p. 3132-3146 15 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Phosphorylation
Lipopolysaccharides
Colforsin
Cyclic AMP-Dependent Protein Kinases
7 Citations (Scopus)

TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS

Poirier, C., Gorshkov, B. A., Zemskova, M. A., Bogatcheva, N. & Verin, A. D., Dec 15 2011, In : Respiratory Physiology and Neurobiology. 179, 2-3, p. 334-337 4 p.

Research output: Contribution to journalArticle

Blood Vessels
Lipopolysaccharides
Cyclic AMP-Dependent Protein Kinases
Lung
Messenger RNA
2009
56 Citations (Scopus)

Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability

Bogatcheva, N., Zemskova, M. A., Kovalenkov, Y., Poirier, C. & Verin, A. D., Dec 2009, In : Journal of Cellular Physiology. 221, 3, p. 750-759 10 p.

Research output: Contribution to journalArticle

Endothelial cells
Lipopolysaccharides
Endothelial Cells
Cyclic AMP-Dependent Protein Kinases
Lung
8 Citations (Scopus)
Disintegration
Endothelial cells
Blood vessels
Cytoskeleton
Linings
2008
116 Citations (Scopus)

The role of cytoskeleton in the regulation of vascular endothelial barrier function

Bogatcheva, N. & Verin, A. D., Nov 2008, In : Microvascular Research. 76, 3, p. 202-207 6 p.

Research output: Contribution to journalArticle

Disintegration
Endothelial cells
Blood vessels
Cytoskeleton
Linings
23 Citations (Scopus)

TIMAP is a positive regulator of pulmonary endothelial barrier function

Csortos, C., Czikora, I., Bogatcheva, N., Adyshev, D. M., Poirier, C., Olah, G. & Verin, A. D., Sep 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 3

Research output: Contribution to journalArticle

Endothelial Cells
Lung
Myosin-Light-Chain Phosphatase
Thrombin
Protein Phosphatase 1
2007
37 Citations (Scopus)

Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs

Feng, S., Bogatcheva, N., Truong, A., Korchin, B., Bishop, C. E., Klonisch, T., Agoulnik, I. U. & Agoulnik, A. I., Oct 2007, In : Biology of Reproduction. 77, 4, p. 671-680 10 p.

Research output: Contribution to journalArticle

Developmental Gene Expression Regulation
Insulin
Leydig Cells
Gene Expression
Transgenic Mice
53 Citations (Scopus)

Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction

Bogatcheva, N., Adyshev, D., Mambetsariev, B., Moldobaeva, N. & Verin, A. D., Feb 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 2

Research output: Contribution to journalArticle

rho-Associated Kinases
MAP Kinase Signaling System
Microtubules
Blood Vessels
Lung

Mitogen-activated protein kinases

Bogatcheva, N. & Verin, A. D., Jan 1 2007, Endothelial Biomedicine. Cambridge University Press, p. 737-745 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mitogen-Activated Protein Kinases
Mammals
Protein Kinases
Genes
Enzymes
31 Citations (Scopus)

Novel Mutations Involving the INSL3 Gene Associated With Cryptorchidism

El Houate, B., Rouba, H., Sibai, H., Barakat, A., Chafik, A., Chadli, E. B., Imken, L., Bogatcheva, N., Feng, S., Agoulnik, A. I. & McElreavey, K., May 2007, In : Journal of Urology. 177, 5, p. 1947-1951 5 p.

Research output: Contribution to journalArticle

Cryptorchidism
Hypospadias
Insulin
Mutation
Genes
77 Citations (Scopus)

Relaxin promotes prostate cancer progression

Feng, S., Agoulnik, I. U., Bogatcheva, N., Kamat, A. A., Kwabi-Addo, B., Li, R., Ayala, G., Ittmann, M. M. & Agoulnik, A. I., Mar 15 2007, In : Clinical Cancer Research. 13, 6, p. 1695-1702 8 p.

Research output: Contribution to journalArticle

Relaxin
Prostatic Neoplasms
Neoplasms
Transgenic Mice
Prostate
64 Citations (Scopus)
Leucine
G-Protein-Coupled Receptors
Cell Membrane
Hormones
Insulin
2006
17 Citations (Scopus)

Caldesmon is a cytoskeletal target for PKC in endothelium

Bogatcheva, N., Birukova, A., Borbiev, T., Kolosova, I., Liu, F., Garcia, J. G. N. & Verin, A. D., Dec 15 2006, In : Journal of Cellular Biochemistry. 99, 6, p. 1593-1605 13 p.

Research output: Contribution to journalArticle

Calmodulin-Binding Proteins
Cytoskeletal Proteins
Tetradecanoylphorbol Acetate
Protein Kinase C
Endothelium

Cytoskeletal Proteins

Verin, A. D. & Bogatcheva, N. V., Jan 1 2006, Encyclopedia of Respiratory Medicine, Four-Volume Set. Elsevier Inc., p. 615-622 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytoskeletal Proteins
Cytoskeleton
Contractile Proteins
Signal transduction
Physiology
29 Citations (Scopus)

Endocrine effects of relaxin overexpression in mice

Feng, S., Bogatcheva, N., Kamat, A. A., Truong, A. & Agoulnik, A. I., Jan 2006, In : Endocrinology. 147, 1, p. 407-414 8 p.

Research output: Contribution to journalArticle

Relaxin
Genetically Modified Animals
Nipples
G-Protein-Coupled Receptors
Transgenic Mice
51 Citations (Scopus)

Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: Clinical and functional characterization

Ferlin, A., Bogatcheva, N., Gianesello, L., Pepe, A., Vinanzi, C., Agoulnik, A. I. & Foresta, C., Jun 2006, In : Molecular Human Reproduction. 12, 6, p. 401-406 6 p.

Research output: Contribution to journalArticle

Insulin
Mutation
Genes
Cryptorchidism
Testicular Neoplasms
21 Citations (Scopus)

Mechanism of fluoride-induced MAP kinase activation in pulmonary artery endothelial cells

Bogatcheva, N., Wang, P., Birukova, A. A., Verin, A. D. & Garcia, J. G. N., Jun 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 6

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Fluorides
Pulmonary Artery
Calmodulin-Binding Proteins
Phosphotransferases
25 Citations (Scopus)

Over Expression of Insulin-Like 3 Does Not Prevent Cryptorchidism in GNRHR or HOXA10 Deficient Mice

Feng, S., Bogatcheva, N., Truong, A., Engel, W., Adham, I. M. & Agoulnik, A. I., Jul 2006, In : Journal of Urology. 176, 1, p. 399-404 6 p.

Research output: Contribution to journalArticle

Cryptorchidism
Insulin
Gene Expression
Inguinal Hernia
Androgen Receptors
45 Citations (Scopus)

The role of relaxin in endometrial cancer

Kamat, A. A., Feng, S., Agoulnik, I. U., Kheradmand, F., Bogatcheva, N., Coffey, D., Sood, A. K. & Agoulnik, A. I., Jan 2006, In : Cancer Biology and Therapy. 5, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Relaxin
Endometrial Neoplasms
Matrix Metalloproteinases
Cell Line
Matrix Metalloproteinase Inhibitors
2005
84 Citations (Scopus)

Arachidonic acid cascade in endothelial pathobiology

Bogatcheva, N., Sergeeva, M. G., Dudek, S. M. & Verin, A. D., May 2005, In : Microvascular Research. 69, 3, p. 107-127 21 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Blood Vessels
Eicosanoids
Endothelial cells
Metabolites
14 Citations (Scopus)

Genetic targeting of relaxin and Insl3 signaling in mice

Feng, S., Bogatcheva, N., Kamat, A. A. & Agoulnik, A. I., 2005, In : Annals of the New York Academy of Sciences. 1041, p. 82-90 9 p.

Research output: Contribution to journalArticle

Relaxin
Nipples
Insulin
Ligands
Muscle
43 Citations (Scopus)

INSL3/LGR8 role in testicular descent and cryptorchidism

Bogatcheva, N. & Agoulnik, A. I., Jan 2005, In : Reproductive BioMedicine Online. 10, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Cryptorchidism
Mutation
Genes
Scrotum
Testicular Neoplasms
2004
108 Citations (Scopus)

Genetic targeting of relaxin and insulin-like factor 3 receptors in mice

Kamat, A. A., Feng, S., Bogatcheva, N., Truong, A., Bishop, C. E. & Agoulnik, A. I., Oct 2004, In : Endocrinology. 145, 10, p. 4712-4720 9 p.

Research output: Contribution to journalArticle

Insulin
Relaxin
Testis
Prostate
Nipples
39 Citations (Scopus)

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism

Feng, S., Cortessis, V. K., Hwang, A., Hardy, B., Koh, C. J., Bogatcheva, N. & Agoulnik, A. I., Nov 2004, In : Urology. 64, 5, p. 1032-1036 5 p.

Research output: Contribution to journalArticle

Cryptorchidism
Mutation
Genes
Exons
Alleles
2003
31 Citations (Scopus)

Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide

Pearse, D. B., Shimoda, L. A., Verin, A. D., Bogatcheva, N., Moon, C., Ronnett, G. V., Welsh, L. E. & Becker, P. M., 2003, In : Endothelium: Journal of Endothelial Cell Research. 10, 6, p. 309-317 9 p.

Research output: Contribution to journalArticle

Guanosine Monophosphate
Hydrogen Peroxide
Lung
Electric Impedance
Endothelial Cells
144 Citations (Scopus)

GREAT/LGR8 Is the Only Receptor for Insulin-Like 3 Peptide

Bogatcheva, N., Truong, A., Feng, S., Engel, W., Adham, I. M. & Agoulnik, A. I., Dec 2003, In : Molecular Endocrinology. 17, 12, p. 2639-2646 8 p.

Research output: Contribution to journalArticle

Insulin Receptor
Peptides
Insulin
Cryptorchidism
Phenotype
24 Citations (Scopus)

Isolation and Expression Analysis of the Canine Insulin-Like Factor 3 Gene

Truong, A., Bogatcheva, N., Schelling, C., Dolf, G. & Agoulnik, A. I., Nov 2003, In : Biology of Reproduction. 69, 5, p. 1658-1664 7 p.

Research output: Contribution to journalArticle

Canidae
Steroidogenic Factor 1
Insulin
Cryptorchidism
Genes
52 Citations (Scopus)

Mitogen-Activated Protein Kinases in Endothelial Pathophysiology

Bogatcheva, N., Dudek, S. M., Garcia, J. G. N. & Verin, A. D., Nov 2003, In : Journal of Investigative Medicine. 51, 6, p. 341-352 12 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Endothelial cells
Cell Movement
Shear stress
Endothelial Cells
39 Citations (Scopus)

Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction

Bogatcheva, N., Verin, A. D., Wang, P., Birukova, A. A., Birukov, K. G., Mirzopoyazova, T., Adyshev, D. M., Chiang, E. T., Crow, M. T. & Garcia, J. G. N., Aug 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 2 29-2

Research output: Contribution to journalArticle

Myosin Light Chains
Phorbol Esters
Tetradecanoylphorbol Acetate
Endothelium
Actins
2002
61 Citations (Scopus)

Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability

Garcia, J. G. N., Wang, P., Schaphorst, K. L., Becker, P. M., Borbiev, T., Liu, F., Birukova, A., Jacobs, K., Bogatcheva, N. & Verin, A. D., 2002, In : FASEB Journal. 16, 9, p. 1064-1076 13 p.

Research output: Contribution to journalArticle

pertussis toxin
Pertussis Toxin
p38 Mitogen-Activated Protein Kinases
mitogen-activated protein kinase
Permeability
140 Citations (Scopus)

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: Potential role of glycogen synthase kinase-3β

Liu, F., Schaphorst, K. L., Verin, A. D., Jacobs, K., Birukova, A., Day, R. M., Bogatcheva, N., Bottaro, D. P. & Garcia, J. G. N., 2002, In : FASEB Journal. 16, 9, p. 950-962 13 p.

Research output: Contribution to journalArticle

hepatocyte growth factor
Glycogen Synthase Kinase 3
Hepatocyte Growth Factor
Endothelial cells
endothelial cells
141 Citations (Scopus)

Molecular mechanisms of thrombin-induced endothelial cell permeability.

Bogatcheva, N., Garcia, J. G. & Verin, A. D., Jan 2002, In : Biochemistry (Moscow). 67, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

Endothelial cells
Thrombin
Permeability
Endothelial Cells
Actomyosin
189 Citations (Scopus)

Mutations of the GREAT gene cause cryptorchidism

Gorlov, I. P., Kamat, A., Bogatcheva, N., Jones, E., Lamb, D. J., Truong, A., Bishop, C. E., McElreavey, K. & Agoulnik, A. I., Sep 15 2002, In : Human Molecular Genetics. 11, 19, p. 2309-2318 10 p.

Research output: Contribution to journalArticle

Cryptorchidism
G-Protein-Coupled Receptors
Testis
Mutation
Genes
11 Citations (Scopus)

Review: Structure and properties of small heat shock proteins (sHsp) and their interaction with cytoskeleton proteins

Gusev, N. B., Bogatcheva, N. & Marston, S. B., 2002, In : Biokhimiya. 67, 5, p. 613-623 11 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Proteins
Phosphorylation
Actins
Polymerization
31 Citations (Scopus)

Role of tyrosine kinase signaling in endothelial cell barrier regulation

Bogatcheva, N., Garcia, J. G. N. & Verin, A. D., Nov 1 2002, In : Vascular Pharmacology. 39, 4-5, p. 201-212 12 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Endothelial Cells
Phosphorylation
Tyrosine
Cell-Matrix Junctions
121 Citations (Scopus)

Structure and properties of small heat shock proteins (sHsp) and their interaction with cytoskeleton proteins

Gusev, N. B., Bogatcheva, N. & Marston, S. B., May 2002, In : Biochemistry (Moscow). 67, 5, p. 511-519 9 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Cytoskeleton
Proteins
Phosphorylation
Polymerization
2000
3 Citations (Scopus)

A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis

Maschan, A. A., Skorobogatova, E. V., Samotchatova, E. V., Balashov, D. N., Yourlova, M. I., Bogatcheva, N., Pashanov, E. D., Trakhtman, P. E., Timakov, A. M. & Rumiantzev, A. G., 2000, In : Bone Marrow Transplantation. 25, 2, p. 213-215 3 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Accelerated Phase
Blast Crisis
Fetal Blood
Transplants
Drug Therapy
12 Citations (Scopus)

Chronic overexpression of membrane-bound flt3 ligand by T lymphocytes in severe aplastic anaemia

Pfister, O., Chklovskaia, E., Jansen, W., Meszáros, K., Nissen, C., Rahner, C., Hurwitz, N., Bogatcheva, N., Lyman, S. D. & Wodnar-Filipowicz, A., 2000, In : British Journal of Haematology. 109, 1, p. 211-220 10 p.

Research output: Contribution to journalArticle

Aplastic Anemia
T-Lymphocytes
Membranes
Bone Marrow
Immunosuppressive Agents
7 Citations (Scopus)
Heat-Shock Proteins
Smooth Muscle
Muscle
Actins
Actin Cytoskeleton