Nuria Morral

  • 3316 Citations
  • 29 h-Index
1989 …2020
If you made any changes in Pure, your changes will be visible here soon.

Publications 1989 2018

  • 3316 Citations
  • 29 h-Index
  • 52 Article
  • 2 Review article
  • 1 Chapter
2018
21 Citations (Scopus)

Gene therapy for inherited retinal and optic nerve degenerations

Moore, N. A., Morral, N., Ciulla, T. A. & Bracha, P., Jan 2 2018, In : Expert Opinion on Biological Therapy. 18, 1, p. 37-49 13 p.

Research output: Contribution to journalReview article

Gene therapy
Nerve Degeneration
Optic Nerve
Viruses
Genetic Therapy
2 Citations (Scopus)

Impact of silencing hepatic SREBP-1 on insulin signaling

Jideonwo, V., Hou, Y., Ahn, M., Surendran, S. & Morral, N., May 1 2018, In : PLoS One. 13, 5, e0196704.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
sterols
binding proteins
insulin
Insulin
2017
9 Citations (Scopus)

Gene therapy for age-related macular degeneration

Moore, N. A., Bracha, P., Hussain, R. M., Morral, N. & Ciulla, T. A., Oct 3 2017, In : Expert Opinion on Biological Therapy. 17, 10, p. 1235-1244 10 p.

Research output: Contribution to journalReview article

Gene therapy
Macular Degeneration
Genetic Therapy
Vascular Endothelial Growth Factor A
Geographic Atrophy
10 Citations (Scopus)

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Irimia, J. M., Meyer, C. M., Segvich, D. M., Surendran, S., De Paoli-Roach, A., Morral, N. & Roach, P., 2017, In : Journal of Biological Chemistry. 292, 25, p. 10455-10464 10 p.

Research output: Contribution to journalArticle

Liver Glycogen
Insulin Resistance
Insulin
Liver
Phosphorylation
2016
2 Citations (Scopus)

Gene targets of mouse miR-709: Regulation of distinct pools

Surendran, S., Jideonwo, V. N., Merchun, C., Ahn, M., Murray, J., Ryan, J., Dunn, K., Kota, J. & Morral, N., Jan 8 2016, In : Scientific Reports. 6, 18958.

Research output: Contribution to journalArticle

MicroRNAs
Cytoskeleton
Genes
Hepatocytes
Gene Pool
2015
2 Citations (Scopus)

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice

Mansouri, A., Pacheco-López, G., Ramachandran, D., Arnold, M., Leitner, C., Prip-Buus, C., Langhans, W. & Morral, N., Jan 15 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 2, p. R131-R137

Research output: Contribution to journalArticle

Fatty Acids
Eating
Food
Liver
Food Deprivation
2014
43 Citations (Scopus)

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., De Paoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Glycogen
Gene expression
Liver
Gene Expression
2013
6 Citations (Scopus)

Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors

Ahn, M., Gamble, A., Witting, S. R., Magrisso, J., Surendran, S., Obici, S. & Morral, N., Feb 1 2013, In : Human gene therapy methods. 24, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Product Packaging
Genome
Helper Viruses
Peptide Elongation Factor 1
Viral Genes
2012
3 Citations (Scopus)

ShRNA-induced interferon-stimulated gene analysis

Morral, N. & Witting, S. R., 2012, Methods in Molecular Biology. Vol. 820. p. 163-177 15 p. (Methods in Molecular Biology; vol. 820).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Interference
Interferons
Innate Immunity
Small Interfering RNA
Genes
2011
18 Citations (Scopus)

Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies

Park, J. S., Surendran, S., Kamendulis, L. M. & Morral, N., 2011, In : BMC Research Notes. 4, 8.

Research output: Contribution to journalArticle

Gene Silencing
MicroRNAs
Nucleic Acids
Small Interfering RNA
Transfection
10 Citations (Scopus)

Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules

Ahn, M., Witting, S. R., Ruiz, R., Saxena, R. & Morral, N., Dec 1 2011, In : Human Gene Therapy. 22, 12, p. 1483-1497 15 p.

Research output: Contribution to journalArticle

Small Interfering RNA
RNA Interference
Karyopherins
Gene Knockdown Techniques
Technology
2009
15 Citations (Scopus)

Accurate single-day titration of adenovirus vectors based on equivalence of protein VII nuclear dots and infectious particles

Walkiewicz, M. P., Morral, N. & Engel, D. A., Aug 2009, In : Journal of Virological Methods. 159, 2, p. 251-258 8 p.

Research output: Contribution to journalArticle

Nuclear Proteins
Adenoviridae
Viral Genome
Proteins
Staining and Labeling
18 Citations (Scopus)

Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors

Ruiz, R., Witting, S. R., Saxena, R. & Morral, N., Jan 1 2009, In : Human Gene Therapy. 20, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

Gene Silencing
Small Interfering RNA
Liver
Gene Knockdown Techniques
Technology
2008
29 Citations (Scopus)

Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response

Witting, S. R., Brown, M., Saxena, R., Nabinger, S. & Morral, N., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 2120-2128 9 p.

Research output: Contribution to journalArticle

Adenoviridae
Liver
Interferons
Small Interfering RNA
Fatty Acid-Binding Proteins
2007
35 Citations (Scopus)

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver

Morral, N., Edenberg, H., Witting, S. R., Altomonte, J., Chu, T. & Brown, M., Jul 2007, In : Journal of Lipid Research. 48, 7, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

Metabolism
Liver
Triglycerides
Fatty Acids
Genes
35 Citations (Scopus)

Transcription releases protein VII from adenovirus chromatin

Chen, J., Morral, N. & Engel, D. A., Dec 20 2007, In : Virology. 369, 2, p. 411-422 12 p.

Research output: Contribution to journalArticle

Adenoviridae
Chromatin
Viral Structures
Viral DNA
Proteins
2004
5 Citations (Scopus)

Gene therapy for type 1 diabetes: New approaches

Morral, N., Apr 2004, In : Minerva Medica. 95, 2, p. 93-104 12 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genetic Therapy
Insulin
Glucose
Liver
2003
51 Citations (Scopus)

Novel targets and therapeutic strategies for type 2 diabetes

Morral, N., May 2003, In : Trends in Endocrinology and Metabolism. 14, 4, p. 169-175 7 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Insulin
Glucose
Genetically Modified Animals
Lipolysis
2002
23 Citations (Scopus)

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes

Morral, N., McEvoy, R., Dong, H., Meseck, M., Altomonte, J., Thung, S. & Woo, S. L. C., 2002, In : Human Gene Therapy. 13, 13, p. 1561-1570 10 p.

Research output: Contribution to journalArticle

Glucokinase
Type 1 Diabetes Mellitus
Adenoviridae
Liver
Insulin
35 Citations (Scopus)

Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats

Dong, H., Altomonte, J., Morral, N., Meseck, M., Thung, S. N. & Woo, S. L. C., 2002, In : Diabetes. 51, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Insulin
Gene Expression
Fasting
Therapeutics
Liver
7 Citations (Scopus)

Challenges for gene therapy of type 1 diabetes.

Dong, H., Anthony, K. & Morral, N., Dec 2002, In : Current Gene Therapy. 2, 4, p. 403-414 12 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genetic Therapy
Insulin
Insulin-Secreting Cells
Glucose
151 Citations (Scopus)

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

Morral, N., O'Neal, W. K., Rice, K., Leland, M. M., Piedra, P. A., Aguilar-Córdova, E., Carey, K. D., Beaudet, A. L. & Langston, C., 2002, In : Human Gene Therapy. 13, 1, p. 143-154 12 p.

Research output: Contribution to journalArticle

Papio
Wounds and Injuries
Galactosidases
Endothelium
Liver
2001
33 Citations (Scopus)

Hepatic insulin expression improves glycemic control in type 1 diabetic rats

Dong, H., Morral, N., McEvoy, R., Meseck, M., Thung, S. N. & Woo, S. L. C., 2001, In : Diabetes Research and Clinical Practice. 52, 3, p. 153-163 11 p.

Research output: Contribution to journalArticle

Insulin
Liver
Hyperglycemia
Type 1 Diabetes Mellitus
Hypoglycemia
2000
8 Citations (Scopus)

Analiza mutacji w genie CFTR u pacjentów z rozpoznana mukowiscydoza w Polsce.

Translated title of the contribution: Analysis of mutations in the CFTR gene in patients diagnosed with cystic fibrosis in PolandAznarez, I., Bal, J., Casals, T., Estivill, X., Morral, N., Sands, D., Nunes, V., Sobczyńska-Tomaszewska, A., Tsui, L. C. & Zielenski, J., 2000, In : Medycyna wieku rozwojowego. 4, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

Poland
Cystic Fibrosis
Mutation
Genes
Population
75 Citations (Scopus)

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

O'Neal, W. K., Zhou, H., Morral, N., Langston, C., Parks, R. J., Graham, F. L., Kochanek, S. & Beaudet, A. L., Mar 2000, In : Molecular Medicine. 6, 3, p. 179-195 17 p.

Research output: Contribution to journalArticle

Transgenes
Adenoviridae
Genetic Therapy
Hepatocytes
alpha 1-Antitrypsin
1999
360 Citations (Scopus)

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

Morral, N., O'Neal, W., Rice, K., Leland, M., Kaplan, J., Piedra, P. A., Zhou, H., Parks, R. J., Velji, R., Aguilar-Córdova, E., Wadsworth, S., Graham, F. L., Kochanek, S., Dee Carey, K. & Beaudet, A. L., Oct 26 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12816-12821 6 p.

Research output: Contribution to journalArticle

Papio
Transgenes
Liver
Viral Proteins
Genes
147 Citations (Scopus)

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

Pastore, L., Morral, N., Zhou, H., Garcia, R., Parks, R. J., Kochanek, S., Graham, F. L., Lee, B. & Beaudet, A. L., Jul 20 1999, In : Human Gene Therapy. 10, 11, p. 1773-1781 9 p.

Research output: Contribution to journalArticle

Transgenes
Inbred C3H Mouse
Liver
Antibody Formation
Albumins
1998
526 Citations (Scopus)

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

Schiedner, G., Morral, N., Parks, R. J., Wu, Y., Koopmans, S. C., Langston, C., Graham, F. L., Beaudet, A. L. & Kochanek, S., 1998, In : Nature Genetics. 18, 2, p. 180-183 4 p.

Research output: Contribution to journalArticle

Adenoviridae
Viral Proteins
Gene Expression
DNA
Genes
220 Citations (Scopus)

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of α1-antitrypsin with negligible toxicity

Morral, N., Parks, R. J., Zhou, H., Langston, C., Schiedner, G., Quinones, J., Graham, F. L., Kochanek, S. & Beaudet, A. L., Dec 10 1998, In : Human Gene Therapy. 9, 18, p. 2709-2716 8 p.

Research output: Contribution to journalArticle

DNA
Viral Proteins
Genetic Therapy
Genes
Hepatocytes
101 Citations (Scopus)

Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing α1-antitrypsin after systemic delivery

O'Neal, W. K., Zhou, H., Morral, N., Aguilar-Cordova, E., Pestaner, J., Langston, C., Mull, B., Wang, Y., Beaudet, A. L. & Lee, B., Jul 20 1998, In : Human Gene Therapy. 9, 11, p. 1587-1598 12 p.

Research output: Contribution to journalArticle

Toxicology
Hepatocytes
Viral Genes
Inbred C3H Mouse
Liver Function Tests
1997
152 Citations (Scopus)

Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors

Morral, N., O'Neal, W., Zhou, H., Langston, C. & Beaudet, A., Jul 1 1997, In : Human Gene Therapy. 8, 10, p. 1275-1286 12 p.

Research output: Contribution to journalArticle

Inbred CBA Mouse
Viral Proteins
Inbred C57BL Mouse
Reporter Genes
Galactosidases
1996
31 Citations (Scopus)

CFTR haplotypic variability far normal and mutant genes in cystic fibrosis families from southern France

Claustres, M., Desgeorges, M., Moine, P., Morral, N. & Estivill, X., 1996, In : Human Genetics. 98, 3, p. 336-344 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
France
Mutation
Haplotypes
80 Citations (Scopus)

Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

Zhou, H., O'Neal, W., Morral, N. & Beaudet, A. L., Oct 1996, In : Journal of Virology. 70, 10, p. 7030-7038 9 p.

Research output: Contribution to journalArticle

Adenoviridae
cell lines
Cell Line
Viruses
viruses
1 Citation (Scopus)

Erratum: Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphic CFTR DNA markers (Human Mutation (1996) 8 (149-159))

Morral, N., Dork, T., Llevadot, R., Dziadek, V., Mercier, B., Ferec, C., Costes, B. B., Girodon, E., Zielenski, J., Tsui, L. C., Tummler, B. & Estivill, X., 1996, In : Human Mutation. 8, 3, p. 295 1 p.

Research output: Contribution to journalArticle

Genetic Markers
Cystic Fibrosis
Haplotypes
Mutation
48 Citations (Scopus)

Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphic CFTR DNA markers

Morral, N., Dörk, T., Llevadot, R., Dziadek, V., Mercier, B., Férec, C., Costes, B., Girodon, E., Zielenski, J., Tsui, L. C., Tümmler, B. & Estivill, X., 1996, In : Human Mutation. 8, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

Genetic Markers
Cystic Fibrosis
Haplotypes
Mutation
Chromosomes
1995
16 Citations (Scopus)

Analysis of microsatellites by direct blotting electrophoresis and chemiluminescence detection

Mekus, F., Dork, T., Deufel, T., Morral, N. & Tummler, B., 1995, In : Electrophoresis. 16, 10, p. 1886-1888 3 p.

Research output: Contribution to journalArticle

Chemiluminescence
Polymerase chain reaction
Luminescence
Electrophoresis
Microsatellite Repeats
13 Citations (Scopus)

Identical intragenic microsatellite haplotype found in cystic fibrosis chromosomes bearing mutation G551D in Irish, English, Scottish, Breton and Czech Patients

Cashman, S. M., Patino, A., Martinez, A., Garcia-Delgado, M., Miedzybrodzka, Z., Schwarz, M., Shrimpton, A., Ferec, C., Raguenes, O., Macek, M., Morral, N. & De Arce, M., 1995, In : Human Heredity. 45, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Microsatellite Repeats
Haplotypes
Chromosomes
Mutation
1994
64 Citations (Scopus)

Analysis of the CFTR gene confirms the high genetic heterogeneity of the Spanish population: 43 mutations account for only 78% of CF chromosomes

Chillón, M., Casals, T., Giménez, J., Ramos, M. D., Palacio, A., Morral, N., Estivill, X. & Nunes, V., Apr 1994, In : Human Genetics. 93, 4, p. 447-451 5 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Chromosomes
Mutation
Population
Genes
31 Citations (Scopus)

Complete detection of mutations in cystic fibrosis patients of Native American origin

Mercier, B., Raguénès, O., Estivill, X., Morral, N., Kaplan, G. C., McClure, M., Grebe, T. A., Kessler, D., Pignatti, P. F., Marigo, C., Bombieri, C., Audrézet, M. P., Verlingue, C. & Férec, C., Dec 1994, In : Human Genetics. 94, 6, p. 629-632 4 p.

Research output: Contribution to journalArticle

North American Indians
Cystic Fibrosis
Mutation
Chromosomes
Haplotypes
28 Citations (Scopus)

Cystic fibrosis in a low-incidence population: two major mutations in Finland

Kere, J., Estivill, X., Chillón, M., Morral, N., Numes, V., Norio, R., Savilahti, E. & de la Chapelle, A., Feb 1994, In : Human Genetics. 93, 2, p. 162-166 5 p.

Research output: Contribution to journalArticle

Finland
Cystic Fibrosis
Mutation
Incidence
Population
25 Citations (Scopus)

Independent origins of cystic fibrosis mutations R334W, R347P, R1162X, and 3849+10kbC→T provide evidence of mutation recurrence in the CFTR gene

Morral, N., Llevadot, R., Casals, T., Gasparini, P., Macek, M., Dörk, T. & Estivill, X., Nov 1994, In : American Journal of Human Genetics. 55, 5, p. 890-898 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Recurrence
Mutation
Genes
Microsatellite Repeats
5 Citations (Scopus)

Reply to — Age of the ΔF508 cystic fibrosis mutation

Estivill, X., Morral, N. & Bertranpetit, J., 1994, In : Nature Genetics. 8, 3, p. 216-218 3 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Mutation
270 Citations (Scopus)

The origin of the major cystic fibrosis mutation (ΔF508) in European populations

Morral, N., Bertranpetit, J., Estivill, X., Nunes, V., Casals, T., Giménez, J., Reis, A., Varon-Mateeva, R., Macek, M., Kalaydjieva, L., Angelicheva, D., Dancheva, R., Romeo, G., Russo, M. P., Garnerone, S., Restagno, G., Ferrari, M., Magnani, C., Claustres, M., Desgeorges, M. & 11 others, Schwartz, M., Schwarz, M., Dallapiccola, B., Novelli, G., Ferec, C., De Arce, M., Nemeti, M., Kere, J., Anvret, M., Dahl, N. & Kadasi, L., Jun 1994, In : Nature Genetics. 7, 2, p. 169-175 7 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Mutation
Chromosomes
Population
Microsatellite Repeats
1993
38 Citations (Scopus)

Cystic fibrosis in Spain: high frequency of mutation G542X in the Mediterranean coastal area

Casals, T., Nunes, V., Palacio, A., Giménez, J., Gaona, A., Ibáñez, N., Morral, N. & Estivill, X., Mar 1993, In : Human Genetics. 91, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

Mutation Rate
Cystic Fibrosis
Spain
Mutation
Haplotypes
77 Citations (Scopus)

Microsatellite haplotypes for cystic fibrosis: Mutation frameworks and evolutionary tracers

Morral, N., Nunes, V., Casals, T., Chillón, M., Giménez, J., Bertranpetit, J. & Estivill, X., Jul 1993, In : Human Molecular Genetics. 2, 7, p. 1015-1022 8 p.

Research output: Contribution to journalArticle

Microsatellites
Fibrosis
Haplotype
Chromosomes
Cystic Fibrosis
26 Citations (Scopus)

Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): Identification of a 50 kilobase deletion

Morral, N., Nunes, V., Casals, T., Cobos, N., Asensio, O., Dapena, J. & Estivill, X., Jun 1993, In : Human Molecular Genetics. 2, 6, p. 677-681 5 p.

Research output: Contribution to journalArticle

Microsatellites
Fibrosis
Cystic Fibrosis
Regulator
Microsatellite Repeats
1992
25 Citations (Scopus)

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

Morral, N., Girbau, E., Zielenski, J., Nunes, V., Casals, T., Tsui, L. C. & Estivill, X., Jan 1992, In : Human Genetics. 88, 3, p. 356 1 p.

Research output: Contribution to journalArticle

Dinucleotide Repeats
Cystic Fibrosis Transmembrane Conductance Regulator
Regulator Genes
Microsatellite Repeats
Introns
52 Citations (Scopus)

Molecular cloning and analysis of a yeast protein phosphatase with an unusual amino-terminal region

Posas, F., Casamayor, A., Morral, N. & Ariño, J., Jun 15 1992, In : Journal of Biological Chemistry. 267, 17, p. 11734-11740 7 p.

Research output: Contribution to journalArticle

Fungal Proteins
Cloning
Phosphoprotein Phosphatases
Molecular Cloning
Genes
66 Citations (Scopus)

Multiplex PCR amplification of three microsatellites within the CFTR gene

Morral, N. & Estivill, X., 1992, In : Genomics. 13, 4, p. 1362-1364 3 p.

Research output: Contribution to journalArticle

Multiplex Polymerase Chain Reaction
Microsatellite Repeats
Cystic Fibrosis Transmembrane Conductance Regulator
Regulator Genes
Cystic Fibrosis
1991
29 Citations (Scopus)

A tetranucleotide repeat polymorphism in the cystic fibrosis gene

Gasparini, P., Dognini, M., Bonizzato, A., Pignatti, P. F., Morral, N. & Estivill, X., 1991, In : Human Genetics. 86, 6, p. 625 1 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Regulator Genes
Cystic Fibrosis
Microsatellite Repeats
Genes