Nuria Morral

  • 3392 Citations
  • 29 h-Index
1989 …2018

Research output per year

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Publications

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Article

Accurate single-day titration of adenovirus vectors based on equivalence of protein VII nuclear dots and infectious particles

Walkiewicz, M. P., Morral, N. & Engel, D. A., Aug 1 2009, In : Journal of Virological Methods. 159, 2, p. 251-258 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes

Morral, N., McEvoy, R., Dong, H., Meseck, M., Altomonte, J., Thung, S. & Woo, S. L. C., Sep 27 2002, In : Human Gene Therapy. 13, 13, p. 1561-1570 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

Morral, N., O'Neal, W., Rice, K., Leland, M., Kaplan, J., Piedra, P. A., Zhou, H., Parks, R. J., Velji, R., Aguilar-Córdova, E., Wadsworth, S., Graham, F. L., Kochanek, S., Dee Carey, K. & Beaudet, A. L., Oct 26 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12816-12821 6 p.

Research output: Contribution to journalArticle

364 Scopus citations

Analiza mutacji w genie CFTR u pacjentów z rozpoznana mukowiscydoza w Polsce.

Translated title of the contribution: Analysis of mutations in the CFTR gene in patients diagnosed with cystic fibrosis in PolandAznarez, I., Bal, J., Casals, T., Estivill, X., Moral, N., Sands, D., Nunes, V., Sobczyńska-Tomaszewska, A., Tsui, L. C. & Zielenski, J., Jan 1 2000, In : Medycyna wieku rozwojowego. 4, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Analysis of microsatellites by direct blotting electrophoresis and chemiluminescence detection

Mekus, F., Dörk, T., Deufel, T., Morral, N. & Tümmler, B., 1995, In : ELECTROPHORESIS. 16, 1, p. 1886-1888 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Analysis of the CFTR gene confirms the high genetic heterogeneity of the Spanish population: 43 mutations account for only 78% of CF chromosomes

Chillón, M., Casals, T., Giménez, J., Ramos, M. D., Palacio, A., Morral, N., Estivill, X. & Nunes, V., Apr 1 1994, In : Human genetics. 93, 4, p. 447-451 5 p.

Research output: Contribution to journalArticle

66 Scopus citations

Aplicación del método de la reacción en cadena de la polimerasa al análisis genético de la fibrosis quística.

Translated title of the contribution: Use of the polymerase chain reaction technic in the genetic analysis of cystic fibrosisChillón, M., Casals, T., Giménez, F. J., Badía, H., Morral, N., Bosch, A., Nunes, V. & Estivill, X., Mar 31 1990, In : Medicina clinica. 94, 12, p. 444-447 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

A tetranucleotide repeat polymorphism in the cystic fibrosis gene

Gasparini, P., Dognini, M., Bonizzato, A., Pignatti, P. F., Morral, N. & Estivill, X., Apr 1991, In : Human Genetics. 86, 6, p. 625 1 p.

Research output: Contribution to journalArticle

29 Scopus citations

Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats

Dong, H., Altomonte, J., Morral, N., Meseck, M., Thung, S. N. & Woo, S. L. C., Jan 1 2002, In : Diabetes. 51, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

CA GT Microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover

Morral, N., Nunes, V., Casals, T. & Estivill, X., Jul 1991, In : Genomics. 10, 3, p. 692-698 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

CFTR haplotypic variability far normal and mutant genes in cystic fibrosis families from southern France

Claustres, M., Desgeorges, M., Moine, P., Morral, N. & Estivill, X., Aug 20 1996, In : Human genetics. 98, 3, p. 336-344 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies

Park, J. S., Surendran, S., Kamendulis, L. M. & Morral, N., Jan 20 2011, In : BMC Research Notes. 4, 8.

Research output: Contribution to journalArticle

18 Scopus citations

Complete detection of mutations in cystic fibrosis patients of Native American origin

Mercier, B., Raguénès, O., Estivill, X., Morral, N., Kaplan, G. C., McClure, M., Grebe, T. A., Kessler, D., Pignatti, P. F., Marigo, C., Bombieri, C., Audrézet, M. P., Verlingue, C. & Férec, C., Dec 1 1994, In : Human Genetics. 94, 6, p. 629-632 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules

Ahn, M., Witting, S. R., Ruiz, R., Saxena, R. & Morral, N., Dec 1 2011, In : Human Gene Therapy. 22, 12, p. 1483-1497 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cystic fibrosis in a low-incidence population: two major mutations in Finland

Kere, J., Estivill, X., Chillón, M., Morral, N., Numes, V., Norio, R., Savilahti, E. & de la Chapelle, A., Feb 1 1994, In : Human Genetics. 93, 2, p. 162-166 5 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cystic fibrosis in Spain: high frequency of mutation G542X in the Mediterranean coastal area

Casals, T., Nunes, V., Palacio, A., Giménez, J., Gaona, A., Ibáñez, N., Morral, N. & Estivill, X., Mar 1 1993, In : Human genetics. 91, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

Zhou, H., O'Neal, W., Morral, N. & Beaudet, A. L., Oct 1996, In : Journal of virology. 70, 10, p. 7030-7038 9 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

Morral, N., Girbau, E., Zielenski, J., Nunes, V., Casals, T., Tsui, L. C. & Estivill, X., Jan 1 1992, In : Human genetics. 88, 3, 1 p.

Research output: Contribution to journalArticle

25 Scopus citations

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver

Morral, N., Edenberg, H. J., Witting, S. R., Altomonte, J., Chu, T. & Brown, M., Jul 1 2007, In : Journal of Lipid Research. 48, 7, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice

Mansouri, A., Pacheco-López, G., Ramachandran, D., Arnold, M., Leitner, C., Prip-Buus, C., Langhans, W. & Morral, N., Jan 15 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 2, p. R131-R137

Research output: Contribution to journalArticle

2 Scopus citations

Gene targets of mouse miR-709: Regulation of distinct pools

Surendran, S., Jideonwo, V. N., Merchun, C., Ahn, M., Murray, J., Ryan, J., Dunn, K. W., Kota, J. & Morral, N., Jan 8 2016, In : Scientific reports. 6, 18958.

Research output: Contribution to journalArticle

2 Scopus citations

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

Schiedner, G., Morral, N., Parks, R. J., Wu, Y., Koopmans, S. C., Langston, C., Graham, F. L., Beaudet, A. L. & Kochanek, S., Mar 4 1998, In : Nature genetics. 18, 2, p. 180-183 4 p.

Research output: Contribution to journalArticle

533 Scopus citations

Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphic CFTR DNA markers

Morral, N., Dörk, T., Llevadot, R., Dziadek, V., Mercier, B., Férec, C., Costes, B., Girodon, E., Zielenski, J., Tsui, L. C., Tümmler, B. & Estivill, X., Aug 22 1996, In : Human Mutation. 8, 2, p. 149-159 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response

Witting, S. R., Brown, M., Saxena, R., Nabinger, S. & Morral, N., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 2120-2128 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hepatic insulin expression improves glycemic control in type 1 diabetic rats

Dong, H., Morral, N., McEvoy, R., Meseck, M., Thung, S. N. & Woo, S. L. C., May 10 2001, In : Diabetes Research and Clinical Practice. 52, 3, p. 153-163 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of α1-antitrypsin with negligible toxicity

Morral, N., Parks, R. J., Zhou, H., Langston, C., Schiedner, G., Quinones, J., Graham, F. L., Kochanek, S. & Beaudet, A. L., Dec 10 1998, In : Human Gene Therapy. 9, 18, p. 2709-2716 8 p.

Research output: Contribution to journalArticle

223 Scopus citations

Identical intragenic microsatellite haplotype found in cystic fibrosis chromosomes bearing mutation G551D in Irish, English, Scottish, Breton and Czech Patients

Cashman, S. M., Patino, A., Martinez, A., Garcia-Delgado, M., Miedzybrodzka, Z., Schwarz, M., Shrimpton, A., Ferec, C., Raguenes, O., Macek, M., Morral, N. & De Arce, M., Jan 1 1995, In : Human Heredity. 45, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors

Morral, N., O'Neal, W., Zhou, H., Langston, C. & Beaudet, A., Jul 1 1997, In : Human gene therapy. 8, 10, p. 1275-1286 12 p.

Research output: Contribution to journalArticle

152 Scopus citations

Impact of silencing hepatic SREBP-1 on insulin signaling

Jideonwo, V., Hou, Y., Ahn, M., Surendran, S. & Morral, N., May 2018, In : PloS one. 13, 5, e0196704.

Research output: Contribution to journalArticle

2 Scopus citations

Independent origins of cystic fibrosis mutations R334W, R347P, R1162X, and 3489+10kbC→T provide evidence of mutation recurrence in the CFTR gene

Morral, N., Llevadot, R., Casals, T., Gasparini, P., Macek, M., Dork, T. & Estivill, X., Jan 1 1994, In : American Journal of Human Genetics. 55, 5, p. 890-898 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Irimia, J. M., Meyer, C. M., Segvich, D. M., Surendran, S., Depaoli-Roach, A. A., Morral, N. & Roach, P. J., Jun 23 2017, In : Journal of Biological Chemistry. 292, 25, p. 10455-10464 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

Morral, N., O’Neal, W. K., Rice, K., Leland, M. M., Piedra, P. A., Aguilar-CɃrdova, E., Carey, K. D., Beaudet, A. L. & Langston, C., Jan 1 2002, In : Human gene therapy. 13, 1, p. 143-154 12 p.

Research output: Contribution to journalArticle

151 Scopus citations

Microsatellite haplotypes for cystic fibrosis: Mutation frameworks and evolutionary tracers

Morral, N., Nunes, V., Casals, T., Chillón, M., Giménez, J., Bertranpetit, J. & Estivill, X., Jul 1 1993, In : Human molecular genetics. 2, 7, p. 1015-1022 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Molecular cloning and analysis of a yeast protein phosphatase with an unusual amino-terminal region

Posas, F., Casamayor, A., Morral, N. & Arino, J., Jan 1 1992, In : Journal of Biological Chemistry. 267, 17, p. 11734-11740 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Multiplex PCR amplification of three microsatellites within the CFTR gene

Morral, N. & Estivill, X., Aug 1992, In : Genomics. 13, 4, p. 1362-1364 3 p.

Research output: Contribution to journalArticle

66 Scopus citations

Reply to — Age of the ΔF508 cystic fibrosis mutation

Estivill, X., Morral, N. & Bertranpetit, J., 1994, In : Nature Genetics. 8, 3, p. 216-218 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors

Ruiz, R., Witting, S. R., Saxena, R. & Morral, N., Jan 1 2009, In : Human gene therapy. 20, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., DePaoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

The origin of the major cystic fibrosis mutation (ΔF508) in European populations

Morral, N., Bertranpetit, J., Estivill, X., Nunes, V., Casals, T., Giménez, J., Reis, A., Varon-Mateeva, R., Macek, M., Kalaydjieva, L., Angelicheva, D., Dancheva, R., Romeo, G., Russo, M. P., Garnerone, S., Restagno, G., Ferrari, M., Magnani, C., Claustres, M., Desgeorges, M. & 11 others, Schwartz, M., Schwarz, M., Dallapiccola, B., Novelli, G., Ferec, C., De Arce, M., Nemeti, M., Kere, J., Anvret, M., Dahl, N. & Kadasi, L., Jun 1994, In : Nature genetics. 7, 2, p. 169-175 7 p.

Research output: Contribution to journalArticle

276 Scopus citations

The search for South European cystic fibrosis mutations: Identification of two new mutations, four variants, and intronic sequences

Gasparini, P., Nunes, V., Savoia, A., Dognini, M., Morral, N., Gaona, A., Bonizzato, A., Chillon, M., Sangiuolo, F., Novelli, G., Dallapiccola, B., Pignatt, P. F. & Estivill, X., May 1991, In : Genomics. 10, 1, p. 193-200 8 p.

Research output: Contribution to journalArticle

92 Scopus citations

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

O'Neal, W. K., Zhou, H., Morral, N., Langston, C., Parks, R. J., Graham, F. L., Kochanek, S. & Beaudet, A. L., Mar 2000, In : Molecular medicine (Cambridge, Mass.). 6, 3, p. 179-195 17 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing α1-antitrypsin after systemic delivery

O'Neal, W. K., Zhou, H., Morral, N., Aguilar-Cordova, E., Pestaner, J., Langston, C., Mull, B., Wang, Y., Beaudet, A. L. & Lee, B., Jul 20 1998, In : Human gene therapy. 9, 11, p. 1587-1598 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Transcription releases protein VII from adenovirus chromatin

Chen, J., Morral, N. & Engel, D. A., Dec 20 2007, In : Virology. 369, 2, p. 411-422 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): Identification of a 50 kilobase deletion

Morral, N., Nunes, V., Casals, T., Cobos, N., Asensio, O., Dapena, J. & Estivill, X., Jun 1 1993, In : Human molecular genetics. 2, 6, p. 677-681 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

Pastore, L., Morral, N., Zhou, H., Garcia, R., Parks, R. J., Kochanek, S., Graham, F. L., Lee, B. & Beaudet, A. L., Jul 20 1999, In : Human gene therapy. 10, 11, p. 1773-1781 9 p.

Research output: Contribution to journalArticle

148 Scopus citations

Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors

Ahn, M., Gamble, A., Witting, S. R., Magrisso, J., Surendran, S., Obici, S. & Morral, N., Feb 1 2013, In : Human Gene Therapy Methods. 24, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

6 Scopus citations