Peter Roach

  • 11857 Citations
  • 56 h-Index
1970 …2021
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Publications 1970 2018

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2017
10 Citations (Scopus)

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Irimia, J. M., Meyer, C. M., Segvich, D. M., Surendran, S., De Paoli-Roach, A., Morral, N. & Roach, P., 2017, In : Journal of Biological Chemistry. 292, 25, p. 10455-10464 10 p.

Research output: Contribution to journalArticle

Liver Glycogen
Insulin Resistance
Insulin
Liver
Phosphorylation
5 Citations (Scopus)

Novel method for detection of glycogen in cells

Skurat, A., Segvich, D. M., De Paoli-Roach, A. & Roach, P., May 1 2017, In : Glycobiology. 27, 5, p. 416-424 9 p.

Research output: Contribution to journalArticle

Glycogen
Glycogen Storage Disease Type II
Glycogen Storage Disease
Glucans
Metabolism
2 Citations (Scopus)

Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation

Mahalingan, K. K., Baskaran, S., De Paoli-Roach, A., Roach, P. & Hurley, T., Jan 10 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Phosphorylation
Yeast
Oxidation-Reduction
Yeasts
2016
6 Citations (Scopus)

Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation

Scheffler, T. L., Park, S., Roach, P. & Gerrard, D. E., Jun 1 2016, In : Physiological Reports. 4, 11, e12802.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Glycogen
Swine
Glycogen Synthase
Muscles
8 Citations (Scopus)

Incorporation of phosphate into glycogen by glycogen synthase

Contreras, C. J., Segvich, D. M., Mahalingan, K., Chikwana, V. M., Kirley, T. L., Hurley, T., De Paoli-Roach, A. & Roach, P., May 1 2016, In : Archives of Biochemistry and Biophysics. 597, p. 21-29 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Phosphates
Phosphorylation
Uridine Diphosphate
4 Citations (Scopus)

Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes

Ruchti, E., Roach, P., De Paoli-Roach, A., Magistretti, P. J. & Allaman, I., Dec 1 2016, In : IBRO Reports. 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

Protein Transport
Glycogen
Astrocytes
Down-Regulation
Adenoviridae
19 Citations (Scopus)

Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease

De Paoli-Roach, A., Contreras, C. J., Segvich, D. M., Heiss, C., Ishihara, M., Azadi, P. & Roach, P., Jan 1 2015, In : Journal of Biological Chemistry. 290, 2, p. 841-850 10 p.

Research output: Contribution to journalArticle

Lafora Disease
Progressive Myoclonic Epilepsy
Glycogen
Phosphorylation
Phosphates
26 Citations (Scopus)

Glycogen phosphorylation and Lafora disease

Roach, P., Dec 1 2015, In : Molecular Aspects of Medicine. 46, p. 78-84 7 p.

Research output: Contribution to journalArticle

Lafora Disease
Phosphorylation
Glycogen
Phosphates
Glucose
10 Citations (Scopus)

Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice

Irimia, J. M., Tagliabracci, V. S., Meyer, C. M., Segvich, D. M., De Paoli-Roach, A. & Roach, P., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22686-22698 13 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Knockout Mice
Muscle
Phosphates
2014
11 Citations (Scopus)

Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding

Coate, K. C., Kraft, G., Moore, M. C., Smith, M. S., Ramnanan, C., Irimia, J. M., Roach, P., Farmer, B., Neal, D. W., Williams, P. & Cherrington, A. D., Jul 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 2

Research output: Contribution to journalArticle

Fructose
Fats
Glucose
Liver
Glucokinase
20 Citations (Scopus)

Protein degradation and quality control in cells from laforin and malin knockout mice

Garyali, P., Segvich, D. M., De Paoli-Roach, A. & Roach, P., Jul 25 2014, In : Journal of Biological Chemistry. 289, 30, p. 20606-20614 9 p.

Research output: Contribution to journalArticle

Glycogen
Knockout Mice
Quality Control
Proteolysis
Quality control
43 Citations (Scopus)

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., De Paoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 1
Glycogen
Gene expression
Liver
Gene Expression
2013
9 Citations (Scopus)

Hepatic glucose metabolism in late pregnancy normal versus high-fat and -fructose diet

Coate, K. C., Smith, M. S., Shiota, M., Irimia, J. M., Roach, P., Farmer, B., Williams, P. E. & Moore, M. C., Mar 2013, In : Diabetes. 62, 3, p. 753-761 9 p.

Research output: Contribution to journalArticle

High Fat Diet
Fructose
Glucose
Pregnancy
Liver
36 Citations (Scopus)

Inhibiting glycogen synthesis prevents lafora disease in a mouse model

Pederson, B. A., Turnbull, J., Epp, J. R., Weaver, S. A., Zhao, X., Pencea, N., Roach, P., Frankland, P. W., Ackerley, C. A. & Minassian, B. A., Aug 2013, In : Annals of Neurology. 74, 2, p. 297-300 4 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Progressive Myoclonic Epilepsy
Seizures
Brain
7 Citations (Scopus)

Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion

Winnick, J. J., An, Z., Kraft, G., Ramnanan, C. J., Irimia, J. M., Smith, M., Lautz, M., Roach, P. & Cherrington, A. D., Jan 2013, In : Diabetes. 62, 1, p. 96-101 6 p.

Research output: Contribution to journalArticle

Liver Glycogen
Hyperinsulinism
Glycogen
Glucose
Insulin
19 Citations (Scopus)

Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs

Coate, K. C., Kraft, G., Irimia, J. M., Smith, M. S., Farmer, B., Neal, D. W., Roach, P., Shiota, M. & Cherrington, A. D., Feb 2013, In : Diabetes. 62, 2, p. 392-400 9 p.

Research output: Contribution to journalArticle

Portal Vein
Fructose
Fats
Dogs
Glucose
13 Citations (Scopus)

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., De Paoli-Roach, A., Roach, P. & Hurley, T., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Phosphates
Uridine Diphosphate
Glucose
2012
3 Citations (Scopus)

A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo

An, Z., Winnick, J. J., Moore, M. C., Farmer, B., Smith, M., Irimia, J. M., Roach, P. & Cherrington, A. D., Oct 2012, In : Diabetes. 61, 10, p. 2433-2441 9 p.

Research output: Contribution to journalArticle

Cyclic GMP
Glucose
Liver
AMP-Activated Protein Kinases
Glucose Clamp Technique
267 Citations (Scopus)

Glycogen and its metabolism: Some new developments and old themes

Roach, P., De Paoli-Roach, A., Hurley, T. & Tagliabracci, V. S., Feb 1 2012, In : Biochemical Journal. 441, 3, p. 763-787 25 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Glycogen Synthase
Epinephrine
Lafora Disease
15 Citations (Scopus)

Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity

De Paoli-Roach, A., Segvich, D. M., Meyer, C. M., Rahimi, Y., Worby, C. A., Gentry, M. S. & Roach, P., Apr 2012, In : Human Molecular Genetics. 21, 7, p. 1604-1610 7 p., ddr598.

Research output: Contribution to journalArticle

Knockout Mice
Insulin Resistance
Lafora Disease
Glucose
Insulin
2011
76 Citations (Scopus)

AMPK → ULK1 → autophagy

Roach, P., Aug 2011, In : Molecular and Cellular Biology. 31, 15, p. 3082-3084 3 p.

Research output: Contribution to journalArticle

Intracellular Signaling Peptides and Proteins
TOR Serine-Threonine Kinases
AMP-Activated Protein Kinases
Protein-Serine-Threonine Kinases
Autophagy
17 Citations (Scopus)

Are there errors in glycogen biosynthesis and is laforin a repair enzyme?

Roach, P., Oct 20 2011, In : FEBS Letters. 585, 20, p. 3216-3218 3 p.

Research output: Contribution to journalArticle

Biosynthesis
Glycogen
Repair
Phosphates
Lafora Disease
14 Citations (Scopus)

Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver

Winnick, J. J., An, Z., Ramnanan, C. J., Smith, M., Irimia, J. M., Neal, D. W., Moore, M. C., Roach, P. & Cherrington, A. D., Feb 2011, In : Diabetes. 60, 2, p. 398-407 10 p.

Research output: Contribution to journalArticle

Liver Glycogen
AMP-Activated Protein Kinases
Glycogen
Fructose
Insulin
19 Citations (Scopus)

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen

Baskaran, S., Chikwana, V. M., Contreras, C. J., Davis, K. D., Wilson, W. A., De Paoli-Roach, A., Roach, P. & Hurley, T., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 33999-34006 8 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Binding Sites
Yeast
Mutation
73 Citations (Scopus)

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T., De Paoli-Roach, A. & Roach, P., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Phosphates
Progressive Myoclonic Epilepsy
Uridine Diphosphate Glucose
63 Citations (Scopus)

PTG depletion removes lafora bodies and rescues the fatal epilepsy of lafora disease

Turnbull, J., De Paoli-Roach, A., Zhao, X., Cortez, M. A., Pencea, N., Tiberia, E., Piliguian, M., Roach, P., Wang, P., Ackerley, C. A. & Minassian, B. A., Apr 2011, In : PLoS Genetics. 7, 4, e1002037.

Research output: Contribution to journalArticle

Lafora Disease
epilepsy
Protein Phosphatase 1
Epilepsy
glycogen
1 Citation (Scopus)

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism (Journal of Biological Chemistry (2010) 285, (34960-34971))

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., De Paoli-Roach, A., Wells, C., Skurat, A. & Roach, P., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39673 1 p.

Research output: Contribution to journalArticle

Glycogen
Starch
Protein Domains
89 Citations (Scopus)
Glycogen
Metabolism
Starch
Proteins
Autophagy
2010
7 Citations (Scopus)

A soluble guanylate cyclase-dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo

An, Z., Winnick, J. J., Farmer, B., Neal, D., Lautz, M., Irimia, J. M., Roach, P. & Cherrington, A. D., Dec 2010, In : Diabetes. 59, 12, p. 2999-3007 9 p.

Research output: Contribution to journalArticle

Nitric Oxide
Glucose
Liver
Glucagon
Hyperglycemia
76 Citations (Scopus)

Genetic depletion of the malin e3 ubiquitin ligase in mice leads to Lafora bodies and the accumulation of insoluble laforin

De Paoli-Roach, A., Tagliabracci, V. S., Segvich, D. M., Meyer, C. M., Irimia, J. M. & Roach, P., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25372-25381 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Glycogen
Brain
Lafora Disease
Muscle
43 Citations (Scopus)

Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice

Irimia, J. M., Meyer, C. M., Peper, C. L., Zhai, L., Bock, C. B., Previs, S. F., McGuinness, O. P., De Paoli-Roach, A. & Roach, P., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12851-12861 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Liver Glycogen
Glucose Intolerance
Knockout Mice
Glucose
4 Citations (Scopus)

Insights into the mechanism of polysaccharide dephosphorylation by a glucan phosphatase

Tagliabracci, V. S. & Roach, P., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15312-15313 2 p.

Research output: Contribution to journalArticle

Non-Receptor Protein Tyrosine Phosphatases
Molecular Sequence Data
Carbohydrate Sequence
Dual-Specificity Phosphatases
Arabidopsis Proteins
25 Citations (Scopus)

Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs

Rivera, N., Ramnanan, C. J., An, Z., Farmer, T., Smith, M., Farmer, B., Irimia, J. M., Snead, W., Lautz, M., Roach, P. & Cherrington, A. D., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4425-4435 11 p.

Research output: Contribution to journalArticle

Glucagon
Hypoglycemia
Dogs
Insulin
Liver
56 Citations (Scopus)

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo

Ramnanan, C. J., Edgerton, D. S., Rivera, N., Irimia-Dominguez, J., Farmer, B., Neal, D. W., Lautz, M., Donahue, E. P., Meyer, C. M., Roach, P. & Cherrington, A. D., Jun 2010, In : Diabetes. 59, 6, p. 1302-1311 10 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Glycogen
Insulin
Glucose
Liver
171 Citations (Scopus)

Regulation of glycogen metabolism in yeast and bacteria

Wilson, W. A., Roach, P., Montero, M., Baroja-Fernández, E., Muñoz, F. J., Eydallin, G., Viale, A. M. & Pozueta-Romero, J., Nov 2010, In : FEMS Microbiology Reviews. 34, 6, p. 952-985 34 p.

Research output: Contribution to journalArticle

Glycogen
Yeasts
Bacteria
Biological Phenomena
Starvation
70 Citations (Scopus)

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., De Paoli-Roach, A., Wells, C., Skurat, A. & Roach, P., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34960-34971 12 p.

Research output: Contribution to journalArticle

Glycogen
Metabolism
Starch
Proteins
Lysosomal-Associated Membrane Protein 1
48 Citations (Scopus)
Glycogen Synthase
Glucose-6-Phosphate
Phosphorylation
Enzymes
Inteins
9 Citations (Scopus)

The subcellular localization of yeast glycogen synthase is dependent upon glycogen content

Wilson, W. A., Boyer, M. P., Davis, K. D., Burke, M. & Roach, P., May 2010, In : Canadian Journal of Microbiology. 56, 5, p. 408-420 13 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Glycogen
Yeasts
Green Fluorescent Proteins
Cytoplasm
2009
14 Citations (Scopus)

Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene

Heyen, C. A., Tagliabracci, V. S., Zhai, L. & Roach, P., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1414-1418 5 p.

Research output: Contribution to journalArticle

Pyrophosphatases
Uridine Diphosphate Glucose
Genes
Adenosine Diphosphate Ribose
Uridine Monophosphate
27 Citations (Scopus)

Restoration of muscle functionality by genetic suppression of glycogen synthesis in a murine model of Pompe disease

Douillard-Guilloux, G., Raben, N., Takikita, S., Ferry, A., Vignaud, A., Guillet-Deniau, I., Favier, M., Thurberg, B. L., Roach, P., Caillaud, C. & Richard, E., Dec 3 2009, In : Human Molecular Genetics. 19, 4, p. 684-696 13 p., ddp535.

Research output: Contribution to journalArticle

Glycogen Storage Disease Type II
Genetic Suppression
Glycogen
Muscles
Glycogen Synthase
2008
114 Citations (Scopus)

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

Tagliabracci, V. S., Girard, J. M., Segvich, D., Meyer, C., Turnbull, J., Zhao, X., Minassian, B. A., De Paoli-Roach, A. & Roach, P., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 33816-33825 10 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Metabolism
Phosphates
Phosphorylation
23 Citations (Scopus)

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

Savage, D. B., Zhai, L., Ravikumar, B., Cheol, S. C., Snaar, J. E., McGuire, A. C., Wou, S. E., Medina-Gomez, G., Kim, S., Bock, C. B., Segvich, D. M., Vidal-Puig, A., Wareham, N. J., Shulman, G. I., Karpe, F., Taylor, R., Pederson, B. A., Roach, P., O'Rahilly, S. & De Paoli-Roach, A., Jan 2008, In : PLoS Medicine. 5, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Glycogen
Muscles
Glycogen Synthase
Mutation
Skeletal Muscle

Correction: A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

David, B. S., Zhai, L., Ravikumar, B., Choi, C. S., Snaar, J. E., McGuire, A. C., Wou, S. E., Medina-Gomez, G., Kim, S., Bock, C. B., Segvich, D. M., Solanky, B., Deelchand, D., Vidal-Puig, A., Wareham, N. J., Shulman, G. I., Karpe, F., Taylor, R., Pederson, B. A., Roach, P. & 2 others, O'Rahilly, S. & De Paoli-Roach, A., Dec 2008, In : PLoS Medicine. 5, 12, p. 1776 1 p.

Research output: Contribution to journalArticle

Glycogen
Muscle
Muscles
2007
30 Citations (Scopus)

Glycogen metabolism in tissues from a mouse model of Lafora disease

Wang, W., Lohi, H., Skurat, A., De Paoli-Roach, A., Minassian, B. A. & Roach, P., Jan 15 2007, In : Archives of Biochemistry and Biophysics. 457, 2, p. 264-269 6 p.

Research output: Contribution to journalArticle

Lafora Disease
Glycogen
Metabolism
Glycogen Synthase
Enzyme activity
135 Citations (Scopus)

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

Tagliabracci, V. S., Turnbull, J., Wang, W., Girard, J. M., Zhao, X., Skurat, A., Delgado-Escueta, A. V., Minassian, B. A., De Paoli-Roach, A. & Roach, P., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19262-19266 5 p.

Research output: Contribution to journalArticle

Glycogen
Phosphoric Monoester Hydrolases
Phosphorylation
Lafora Disease
Phosphates
2006
11 Citations (Scopus)

Direct detection of glycogenin reaction products during glycogen initiation

Hurley, T., Walls, C., Bennett, J. R., Roach, P. & Wang, M., Sep 22 2006, In : Biochemical and Biophysical Research Communications. 348, 2, p. 374-378 5 p.

Research output: Contribution to journalArticle

Glycogen
Reaction products
Assays
1,4-alpha-Glucan Branching Enzyme
Glucose
19 Citations (Scopus)

Gene expression profiling of mice with genetically modified muscle glycogen content

Parker, G. E., Pederson, B. A., Obayashi, M., Schroeder, J. M., Harris, R. & Roach, P., Apr 1 2006, In : Biochemical Journal. 395, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Glycogen
Gene expression
Muscle
Muscles
19 Citations (Scopus)

Interaction between glycogenin and glycogen synthase

Skurat, A., Dietrich, A. D. & Roach, P., Dec 1 2006, In : Archives of Biochemistry and Biophysics. 456, 1, p. 93-97 5 p.

Research output: Contribution to journalArticle

Glycogen Synthase
Muscle
Skeletal Muscle
Phosphorylation
glycogenin
16 Citations (Scopus)

Relationship between glycogen accumulation and the laforin dual specificity phosphatase

Wang, W., Parker, G. E., Skurat, A., Raben, N., De Paoli-Roach, A. & Roach, P., Nov 24 2006, In : Biochemical and Biophysical Research Communications. 350, 3, p. 588-592 5 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Glycogen
Muscle
Muscles
Lafora Disease