Peter Roach

  • 12131 Citations
  • 57 h-Index
1970 …2021

Research output per year

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Publications

  • 12131 Citations
  • 57 h-Index
  • 192 Article
  • 17 Review article
  • 8 Comment/debate
  • 5 Chapter
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Article
2020

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Young, L. E. A., Brizzee, C. O., Macedo, J. K. A., Murphy, R. D., Contreras, C. J., DePaoli-Roach, A. A., Roach, P. J., Gentry, M. S. & Sun, R. C., Feb 15 2020, In : Carbohydrate Polymers. 230, 115651.

Research output: Contribution to journalArticle

2019

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

Mayeuf-Louchart, A., Lancel, S., Sebti, Y., Pourcet, B., Loyens, A., Delhaye, S., Duhem, C., Beauchamp, J., Ferri, L., Thorel, Q., Boulinguiez, A., Zecchin, M., Dubois-Chevalier, J., Eeckhoute, J., Vaughn, L. T., Roach, P. J., Dani, C., Pederson, B. A., Vincent, S. D., Staels, B. & 1 others, Duez, H., Nov 5 2019, In : Cell Reports. 29, 6, p. 1410-1418.e6

Research output: Contribution to journalArticle

Open Access

Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion

Brewer, M. K., Uittenbogaard, A., Austin, G. L., Segvich, D. M., DePaoli-Roach, A., Roach, P. J., McCarthy, J. J., Simmons, Z. R., Brandon, J. A., Zhou, Z., Zeller, J., Young, L. E. A., Sun, R. C., Pauly, J. R., Aziz, N. M., Hodges, B. L., McKnight, T. R., Armstrong, D. D. & Gentry, M. S., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 689-705.e6

Research output: Contribution to journalArticle

4 Scopus citations
2017

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Irimia, J. M., Meyer, C. M., Segvich, D. M., Surendran, S., De Paoli-Roach, A., Morral, N. & Roach, P., 2017, In : Journal of Biological Chemistry. 292, 25, p. 10455-10464 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Novel method for detection of glycogen in cells

Skurat, A., Segvich, D. M., De Paoli-Roach, A. & Roach, P., May 1 2017, In : Glycobiology. 27, 5, p. 416-424 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation

Mahalingan, K. K., Baskaran, S., De Paoli-Roach, A., Roach, P. & Hurley, T., Jan 10 2017, In : Biochemistry. 56, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation

Scheffler, T. L., Park, S., Roach, P. J. & Gerrard, D. E., Jun 1 2016, In : Physiological reports. 4, 11, e12802.

Research output: Contribution to journalArticle

6 Scopus citations

Incorporation of phosphate into glycogen by glycogen synthase

Contreras, C. J., Segvich, D. M., Mahalingan, K., Chikwana, V. M., Kirley, T. L., Hurley, T. D., DePaoli-Roach, A. A. & Roach, P. J., May 1 2016, In : Archives of Biochemistry and Biophysics. 597, p. 21-29 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes

Ruchti, E., Roach, P. J., DePaoli-Roach, A. A., Magistretti, P. J. & Allaman, I., Dec 1 2016, In : IBRO Reports. 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease

DePaoli-Roach, A. A., Contreras, C. J., Segvich, D. M., Heiss, C., Ishihara, M., Azadi, P. & Roach, P. J., Jan 1 2015, In : Journal of Biological Chemistry. 290, 2, p. 841-850 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Glycogen phosphorylation and Lafora disease

Roach, P., Dec 1 2015, In : Molecular Aspects of Medicine. 46, p. 78-84 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice

Irimia, J. M., Tagliabracci, V. S., Meyer, C. M., Segvich, D. M., Depaoli-Roach, A. A. & Roach, P. J., Sep 11 2015, In : Journal of Biological Chemistry. 290, 37, p. 22686-22698 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding

Coate, K. C., Kraft, G., Moore, M. C., Smith, M. S., Ramnanan, C., Irimia, J. M., Roach, P. J., Farmer, B., Neal, D. W., Williams, P. & Cherrington, A. D., Jul 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 2, p. E151-E160

Research output: Contribution to journalArticle

11 Scopus citations

Protein degradation and quality control in cells from laforin and malin knockout mice

Garyali, P., Segvich, D. M., Depaoli-Roach, A. A. & Roach, P. J., Jul 25 2014, In : Journal of Biological Chemistry. 289, 30, p. 20606-20614 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

Ruiz, R., Jideonwo, V., Ahn, M., Surendran, S., Tagliabracci, V. S., Hou, Y., Gamble, A., Kerner, J., Irimia-Dominguez, J. M., Puchowicz, M. A., DePaoli-Roach, A., Hoppel, C., Roach, P. & Morral, N., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 5510-5517 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
2013

Hepatic glucose metabolism in late pregnancy normal versus high-fat and -fructose diet

Coate, K. C., Smith, M. S., Shiota, M., Irimia, J. M., Roach, P. J., Farmer, B., Williams, P. E. & Moore, M. C., Mar 1 2013, In : Diabetes. 62, 3, p. 753-761 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inhibiting glycogen synthesis prevents lafora disease in a mouse model

Pederson, B. A., Turnbull, J., Epp, J. R., Weaver, S. A., Zhao, X., Pencea, N., Roach, P. J., Frankland, P. W., Ackerley, C. A. & Minassian, B. A., Aug 1 2013, In : Annals of Neurology. 74, 2, p. 297-300 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion

Winnick, J. J., An, Z., Kraft, G., Ramnanan, C. J., Irimia, J. M., Smith, M., Lautz, M., Roach, P. J. & Cherrington, A. D., Jan 1 2013, In : Diabetes. 62, 1, p. 96-101 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs

Coate, K. C., Kraft, G., Irimia, J. M., Smith, M. S., Farmer, B., Neal, D. W., Roach, P. J., Shiota, M. & Cherrington, A. D., Feb 1 2013, In : Diabetes. 62, 2, p. 392-400 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase

Chikwana, V. M., Khanna, M., Baskaran, S., Tagliabracci, V. S., Contreras, C. J., DePaoli-Roach, A., Roach, P. J. & Hurley, T. D., Dec 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 52, p. 20976-20981 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo

An, Z., Winnick, J. J., Moore, M. C., Farmer, B., Smith, M., Irimia, J. M., Roach, P. J. & Cherrington, A. D., Oct 1 2012, In : Diabetes. 61, 10, p. 2433-2441 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity

DePaoli-Roach, A. A., Segvich, D. M., Meyer, C. M., Rahimi, Y., Worby, C. A., Gentry, M. S. & Roach, P. J., Apr 1 2012, In : Human molecular genetics. 21, 7, p. 1604-1610 7 p., ddr598.

Research output: Contribution to journalArticle

15 Scopus citations
2011

Are there errors in glycogen biosynthesis and is laforin a repair enzyme?

Roach, P. J., Oct 20 2011, In : FEBS Letters. 585, 20, p. 3216-3218 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver

Winnick, J. J., An, Z., Ramnanan, C. J., Smith, M., Irimia, J. M., Neal, D. W., Moore, M. C., Roach, P. J. & Cherrington, A. D., Feb 1 2011, In : Diabetes. 60, 2, p. 398-407 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen

Baskaran, S., Chikwana, V. M., Contreras, C. J., Davis, K. D., Wilson, W. A., DePaoli-Roach, A. A., Roach, P. J. & Hurley, T. D., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 33999-34006 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phosphate incorporation during glycogen synthesis and Lafora disease

Tagliabracci, V. S., Heiss, C., Karthik, C., Contreras, C. J., Glushka, J., Ishihara, M., Azadi, P., Hurley, T. D., Depaoli-Roach, A. A. & Roach, P. J., Mar 2 2011, In : Cell Metabolism. 13, 3, p. 274-282 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

PTG depletion removes lafora bodies and rescues the fatal epilepsy of lafora disease

Turnbull, J., DePaoli-Roach, A. A., Zhao, X., Cortez, M. A., Pencea, N., Tiberia, E., Piliguian, M., Roach, P. J., Wang, P., Ackerley, C. A. & Minassian, B. A., Apr 1 2011, In : PLoS Genetics. 7, 4, e1002037.

Research output: Contribution to journalArticle

64 Scopus citations
92 Scopus citations
2010

A soluble guanylate cyclase-dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo

An, Z., Winnick, J. J., Farmer, B., Neal, D., Lautz, M., Irimia, J. M., Roach, P. J. & Cherrington, A. D., Dec 1 2010, In : Diabetes. 59, 12, p. 2999-3007 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Genetic depletion of the malin e3 ubiquitin ligase in mice leads to Lafora bodies and the accumulation of insoluble laforin

DePaoli-Roach, A. A., Tagliabracci, V. S., Segvich, D. M., Meyer, C. M., Irimia, J. M. & Roach, P. J., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25372-25381 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice

Irimia, J. M., Meyer, C. M., Peper, C. L., Zhai, L., Bock, C. B., Previs, S. F., McGuinness, O. P., DePaoli-Roach, A. & Roach, P. J., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12851-12861 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs

Rivera, N., Ramnanan, C. J., An, Z., Farmer, T., Smith, M., Farmer, B., Irimia, J. M., Snead, W., Lautz, M., Roach, P. J. & Cherrington, A. D., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4425-4435 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo

Ramnanan, C. J., Edgerton, D. S., Rivera, N., Irimia-Dominguez, J., Farmer, B., Neal, D. W., Lautz, M., Donahue, E. P., Meyer, C. M., Roach, P. J. & Cherrington, A. D., Jun 1 2010, In : Diabetes. 59, 6, p. 1302-1311 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism

Jiang, S., Heller, B., Tagliabracci, V. S., Zhai, L., Irimia, J. M., DePaoli-Roach, A. A., Wells, C. D., Skurat, A. V. & Roach, P. J., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34960-34971 12 p.

Research output: Contribution to journalArticle

71 Scopus citations
48 Scopus citations

The subcellular localization of yeast glycogen synthase is dependent upon glycogen content

Wilson, W. A., Boyer, M. P., Davis, K. D., Burke, M. & Roach, P. J., May 1 2010, In : Canadian Journal of Microbiology. 56, 5, p. 408-420 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene

Heyen, C. A., Tagliabracci, V. S., Zhai, L. & Roach, P. J., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1414-1418 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Restoration of muscle functionality by genetic suppression of glycogen synthesis in a murine model of Pompe disease

Douillard-Guilloux, G., Raben, N., Takikita, S., Ferry, A., Vignaud, A., Guillet-Deniau, I., Favier, M., Thurberg, B. L., Roach, P. J., Caillaud, C. & Richard, E., Dec 3 2009, In : Human molecular genetics. 19, 4, p. 684-696 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2008

Abnormal metabolism of glycogen phosphate as a cause for Lafora disease

Tagliabracci, V. S., Girard, J. M., Segvich, D., Meyer, C., Turnbull, J., Zhao, X., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 5 2008, In : Journal of Biological Chemistry. 283, 49, p. 33816-33825 10 p.

Research output: Contribution to journalArticle

114 Scopus citations

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

Savage, D. B., Zhai, L., Ravikumar, B., Cheol, S. C., Snaar, J. E., McGuire, A. C., Wou, S. E., Medina-Gomez, G., Kim, S., Bock, C. B., Segvich, D. M., Vidal-Puig, A., Wareham, N. J., Shulman, G. I., Karpe, F., Taylor, R., Pederson, B. A., Roach, P. J., O'Rahilly, S. & DePaoli-Roach, A. A., Jan 1 2008, In : PLoS Medicine. 5, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2007

Glycogen metabolism in tissues from a mouse model of Lafora disease

Wang, W., Lohi, H., Skurat, A. V., DePaoli-Roach, A. A., Minassian, B. A. & Roach, P. J., Jan 15 2007, In : Archives of Biochemistry and Biophysics. 457, 2, p. 264-269 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

Tagliabracci, V. S., Turnbull, J., Wang, W., Girard, J. M., Zhao, X., Skurat, A. V., Delgado-Escueta, A. V., Minassian, B. A., DePaoli-Roach, A. A. & Roach, P. J., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19262-19266 5 p.

Research output: Contribution to journalArticle

135 Scopus citations
2006

Direct detection of glycogenin reaction products during glycogen initiation

Hurley, T. D., Walls, C., Bennett, J. R., Roach, P. J. & Wang, M., Sep 22 2006, In : Biochemical and Biophysical Research Communications. 348, 2, p. 374-378 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Gene expression profiling of mice with genetically modified muscle glycogen content

Parker, G. E., Pederson, B. A., Obayashi, M., Schroeder, J. M., Harris, R. A. & Roach, P. J., Apr 1 2006, In : Biochemical Journal. 395, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Interaction between glycogenin and glycogen synthase

Skurat, A. V., Dietrich, A. D. & Roach, P. J., Dec 1 2006, In : Archives of Biochemistry and Biophysics. 456, 1, p. 93-97 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Relationship between glycogen accumulation and the laforin dual specificity phosphatase

Wang, W., Parker, G. E., Skurat, A. V., Raben, N., DePaoli-Roach, A. A. & Roach, P. J., Nov 24 2006, In : Biochemical and Biophysical Research Communications. 350, 3, p. 588-592 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2005

Biochemical characterization of Neurospora crassa glycogenin (GNN), the self-glucosylating initiator of glycogen synthesis

De Paula, R. M., Wilson, W. A., Roach, P. J., Terenzi, H. F. & Bertolini, M. C., Apr 11 2005, In : FEBS Letters. 579, 10, p. 2208-2214 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Control of mammalian glycogen synthase by PAS kinase

Wilson, W. A., Skurat, A. V., Probst, B., De Paoli-Roach, A., Roach, P. J. & Rutter, J., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16596-16601 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise

Pederson, B. A., Cope, C. M., Schroeder, J. M., Smith, M. W., Irimia, J. M., Thurberg, B. L., DePaoli-Roach, A. A. & Roach, P. J., Apr 29 2005, In : Journal of Biological Chemistry. 280, 17, p. 17260-17265 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Glucose metabolism in mice lacking muscle glycogen synthase

Pederson, B. A., Schroeder, J. M., Parker, G. E., Smith, M. W., DePaoli-Roach, A. A. & Roach, P. J., Dec 1 2005, In : Diabetes. 54, 12, p. 3466-3473 8 p.

Research output: Contribution to journalArticle

75 Scopus citations