Raj Vuppalanchi

  • 4049 Citations
  • 31 h-Index
20052020
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Publications 2005 2020

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Article
2020

Quantitative Prediction of CYP3A4- and CYP3A5-Mediated Drug Interactions

Guo, Y., Lucksiri, A., Dickinson, G. L., Vuppalanchi, R. K., Hilligoss, J. K. & Hall, S. D., Jan 1 2020, In : Clinical Pharmacology and Therapeutics. 107, 1, p. 246-256 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Drug Interactions
Midazolam
Ketoconazole
Area Under Curve
2019

Cannabidiol (CBD) Consumption and Perceived Impact on Extrahepatic Symptoms in Patients with Autoimmune Hepatitis

Mathur, K., Vuppalanchi, V., Gelow, K., Vuppalanchi, R. & Lammert, C., Jan 1 2019, In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Open Access
Cannabidiol
Autoimmune Hepatitis
Sleep
Pain
Fatigue

Development and Validation of a Model Consisting of Comorbidity Burden to Calculate Risk of Death Within 6 Months for Patients With Suspected Drug-Induced Liver Injury

Ghabril, M., Gu, J., Yoder, L., Corbito, L., Ringel, A., Beyer, C. D., Vuppalanchi, R., Barnhart, H., Hayashi, P. H. & Chalasani, N., Nov 2019, In : Gastroenterology. 157, 5, p. 1245-1252.e3

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Comorbidity
Confidence Intervals
End Stage Liver Disease
Mortality
6 Citations (Scopus)

Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage

NASH Clinical Research Network, Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Fibrosis
Blood Platelets
Aspartate Aminotransferases
Biopsy
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)

Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis

for the NASH CRN, Jan 1 2019, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Open Access
Fatty Liver
Lipoproteins
LDL Lipoproteins
VLDL Lipoproteins
Placebos

Is Fasting Necessary for Individuals With Nonalcoholic Fatty Liver Disease to Undergo Vibration-Controlled Transient Elastography?

Vuppalanchi, R., Weber, R., Russell, S., Gawrieh, S., Samala, N., Slaven, J. E., Harden, L. & Chalasani, N., Jun 1 2019, In : The American journal of gastroenterology. 114, 6, p. 995-997 3 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Fasting
Meals
Liver
7 Citations (Scopus)
Metformin
Fatty Liver
Fibrosis
Hepatocellular Carcinoma
Transplants

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

REGENERATE Study Investigators, Dec 14 2019, In : The Lancet. 394, 10215, p. 2184-2196 13 p.

Research output: Contribution to journalArticle

Fatty Liver
Placebos
Fibrosis
Therapeutics
6-ethylchenodeoxycholic acid
1 Citation (Scopus)

Older Age and Disease Duration Are Highly Associated with Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis

Dakhoul, L., Jones, K. R., Gawrieh, S., Ghabril, M., McShane, C., Vuppalanchi, R., Vilar-Gomez, E., Nephew, L., Chalasani, N. & Lammert, C., Jan 1 2019, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Autoimmune Hepatitis
Hepatocellular Carcinoma
Fibrosis
Autoimmune Diseases
Medical Records
2 Citations (Scopus)

Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters

Zemel, M. B., Kolterman, O., Rinella, M., Vuppalanchi, R., Flores, O., Barritt, A. S., Siddiqui, M. & Chalasani, N., Jan 1 2019, In : Obesity. 27, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Metformin
Leucine
Randomized Controlled Trials
Sirtuin 1
Comorbidity
3 Citations (Scopus)

Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial

the NASH Clinical Research Network, May 1 2019, In : Alimentary Pharmacology and Therapeutics. 49, 9, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

Open Access
Fatty Liver
Lipoproteins
pioglitazone
E-Selectin
Vitamin E
27 Citations (Scopus)

Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease

NASH Clinical Research Network, Jan 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 1, p. 156-163.e2

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Fibrosis
Liver
ROC Curve
9 Citations (Scopus)
Vitamin E
Fibrosis
Transplants
Survival
Liver
2018
11 Citations (Scopus)

Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis

for the NASH CRN, Mar 1 2018, In : Alimentary Pharmacology and Therapeutics. 47, 5, p. 645-656 12 p.

Research output: Contribution to journalArticle

Fatty Liver
Weight Loss
Weights and Measures
Placebos
Histology
12 Citations (Scopus)

Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience

Cheng, Y. W., Phelps, E., Ganapini, V., Khan, N., Ouyang, F., Xu, H., Khanna, S., Tariq, R., Friedman-Moraco, R. J., Woodworth, M. H., Dhere, T., Kraft, C. S., Kao, D., Smith, J., Le, L., El-Nachef, N., Kaur, N., Kowsika, S., Ehrlich, A., Smith, M. & 8 others, Safdar, N., Ann Misch, E., Allegretti, J. R., Flynn, A., Kassam, Z., Sharfuddin, A., Vuppalanchi, R. & Fischer, M., Jan 1 2018, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Microbiota
Transplants
Organ Transplantation
8 Citations (Scopus)

Liver Stiffness Measurements in Patients with Noncirrhotic Portal Hypertension—The Devil Is in the Details

Vuppalanchi, R., Mathur, K., Pyko, M., Samala, N. & Chalasani, N., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Portal Hypertension
Liver
Fibrosis
Elasticity Imaging Techniques
Portal Vein
40 Citations (Scopus)

Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease

for the NASH Clinical Research Network, Jan 1 2018, In : Hepatology. 67, 1, p. 134-144 11 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Vibration
Liver
Reading
Touch
12 Citations (Scopus)

Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase activation in subjects with non-alcoholic fatty liver disease

Shiffman, M., Freilich, B., Vuppalanchi, R., Watt, K., Chan, J. L., Spada, A., Hagerty, D. T. & Schiff, E., Jan 1 2018, (Accepted/In press) In : Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Caspases
Randomized Controlled Trials
Placebos
Transaminases
Keratin-18
7 Citations (Scopus)

Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease

Chalasani, N., Vuppalanchi, R., Rinella, M., Middleton, M. S., Siddiqui, M. S., Barritt, A. S., Kolterman, O., Flores, O., Alonso, C., Iruarrizaga-Lejarreta, M., Gil-Redondo, R., Sirlin, C. B. & Zemel, M. B., Jun 1 2018, In : Alimentary Pharmacology and Therapeutics. 47, 12, p. 1639-1651 13 p.

Research output: Contribution to journalArticle

Metformin
Leucine
Randomized Controlled Trials
Fats
Placebos
2017
11 Citations (Scopus)
Sleep
Fibrosis
Quality of Life
Muscle Cramp
Actigraphy
13 Citations (Scopus)

Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis

Yang, J. D., Abdelmalek, M. F., Guy, C. D., Gill, R. M., Lavine, J. E., Yates, K., Klair, J., Terrault, N. A., Clark, J. M., Unalp-Arida, A., Diehl, A. M., Suzuki, A., Dasarathy, S., Dasarathy, J., Hawkins, C., McCullough, A. J., Dasarathy, S., McCullough, A. J., Pagadala, M., Pai, R. & 89 others, Sargent, R., Abdelmalek, M. F., Bashir, M., Buie, S., Diehl, A. M., Guy, C., Kigongo, C., Pan, Y. P., Piercy, D., Chalasani, N., Cummings, O. W., Gawrieh, S., Ghabril, M., Marri, S., Ragozzino, L., Sandrasegaran, K., Vuppalanchi, R., King, D., Osmack, P., Siegner, J., Stewart, S., Neuschwander-Tetri, B. A., Torretta, S., Ang, B., Behling, C., Bhatt, A., Loomba, R., Middleton, M., Patton, H., Sirlin, C., Aouizerat, B., Bass, N. M., Brandman, D., Ferrell, L. D., Gill, R., Hameed, B., Ramos, C., Terrault, N., Ungermann, A., Atla, P., Croft, B., Garcia, R., Garcia, S., Sheikh, M., Singh, M., Boyett, S., Carucci, L., Contos, M. J., Kraft, K., Luketic, V. A. C., Puri, P., Sanyal, A. J., Schlosser, J., Siddiqui, M. S., Wolford, B., Ackermann, S., Cooney, S., Coy, D., Gelinas, K., Kowdley, K. V., Lee, M., Pierce, T., Mooney, J., Nelson, J. E., Shaw, C., Siddique, A., Wang, C., Brunt, E. M., Fowler, K., Kleiner, D. E., Grave, G. D., Doo, E. C., Hoofnagle, J. H., Robuck, P. R., Sherker, A., Belt, P., Clark, J. M., Donithan, M., Hallinan, E., Isaacson, M., May, K. P., Miriel, L., Sternberg, A., Tonascia, J., Ünalp-Arida, A., Van Natta, M., Vaughn, I., Wilson, L. & Yates, K., Jan 1 2017, In : Clinical Gastroenterology and Hepatology. 15, 1, p. 127-131.e2

Research output: Contribution to journalArticle

Mallory Bodies
Hormones
Inflammation
Physiological Stress
Hepatocytes
2 Citations (Scopus)
HMGB1 Protein
fatty liver
Liver
pioglitazone
Serum
2016
1 Citation (Scopus)

A not-so-sweet diagnosis: Secondary biliary cirrhosis from a "lollipop" stone

Gromski, M. A., Vuppalanchi, R., Sherman, S. & Fogel, E., 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Bile Duct Diseases
Cholelithiasis
Lithotripsy
Esophageal and Gastric Varices
Biliary Liver Cirrhosis
Liver Neoplasms
MicroRNAs
Fibrosis
Liver
Non-alcoholic Fatty Liver Disease
10 Citations (Scopus)

Febuxostat-induced acute liver injury

Bohm, M., Vuppalanchi, R. & Chalasani, N., 2016, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Gout Suppressants
Chemical and Drug Induced Liver Injury
Liver
Wounds and Injuries
Febuxostat
18 Citations (Scopus)

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Eadon, M., Desta, Z., Levy, K., Decker, B., Pierson, R., Pratt, V., Callaghan, J., Rosenman, M., Carpenter, J., Holmes, A., Mcdonald, C., Benson, E., Patil, A., Vuppalanchi, R., Gufford, B., Dave, N., Robarge, J., Hyder, M., Haas, D., Kreutz, R. & 3 others, Dexter, P., Skaar, T. & Flockhart, D., 2016, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Safety-net Providers
Credentialing
Pharmacogenetics
Vulnerable Populations
Poverty
5 Citations (Scopus)

Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms

the NASH Clinical Research Network, Dec 1 2016, In : Alimentary Pharmacology and Therapeutics. 44, 11-12, p. 1253-1264 12 p.

Research output: Contribution to journalArticle

Fatty Liver
Interleukin-6
Mallory Bodies
Fibrosis
Alleles
13 Citations (Scopus)

Nodular regenerative hyperplasia after treatment with trastuzumab emtansine

Force, J., Saxena, R., Schneider, B., Storniolo, A. M., Sledge, G. W., Chalasani, N. & Vuppalanchi, R., Jan 20 2016, In : Journal of Clinical Oncology. 34, 3, p. e9-e12

Research output: Contribution to journalArticle

Maytansine
Carcinoma, Ductal, Breast
Antibodies, Monoclonal, Humanized
Portal Hypertension
Hyperplasia
8 Citations (Scopus)

Risk of Liver Injury Associated with Green Tea Extract in SLIMQUICK® Weight Loss Products: Results from the DILIN Prospective Study

Zheng, E. X., Rossi, S., Fontana, R. J., Vuppalanchi, R., Hoofnagle, J. H., Khan, I. & Navarro, V. J., May 17 2016, (Accepted/In press) In : Drug Safety. p. 1-6 6 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Tea
Liver
Weight Loss
Prospective Studies
1 Citation (Scopus)
Fatty Liver
Liver Cirrhosis
Fats
Non-alcoholic Fatty Liver Disease
1 Citation (Scopus)

Secondary Sclerosing Cholangitis From Spontaneous Choledochoduodenal Fistula

Gromski, M. A., Fogel, E. & Vuppalanchi, R., 2016, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Fistula
2015
28 Citations (Scopus)

Clinical and histologic features of azithromycin-induced liver injury

Martinez, M. A., Vuppalanchi, R., Fontana, R. J., Stolz, A., Kleiner, D. E., Hayashi, P. H., Gu, J., Hoofnagle, J. H. & Chalasani, N., 2015, In : Clinical Gastroenterology and Hepatology. 13, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

Azithromycin
Liver
Wounds and Injuries
Liver Transplantation
Causality
49 Citations (Scopus)

Drug-induced liver injury

Fisher, K., Vuppalanchi, R. & Saxena, R., Jul 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 7, p. 876-887 12 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Liver
National Library of Medicine (U.S.)
Biopsy
Self Medication

Endoscopic Sedation in Roux-en-Y Gastric Bypass

Vuppalanchi, R., 2015, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Gastric Bypass
Chemical and Drug Induced Liver Injury
Skin
Rivaroxaban
79 Citations (Scopus)
Clostridium Infections
Clostridium difficile
Vancomycin
Colectomy
Colonoscopy
230 Citations (Scopus)

Features and outcomes of 899 patients with drug-induced liver injury: The DILIN prospective study

Chalasani, N., Bonkovsky, H. L., Fontana, R., Lee, W., Stolz, A., Talwalkar, J., Reddy, K. R., Watkins, P. B., Navarro, V., Barnhart, H., Gu, J., Serrano, J., Ahmad, J., Bach, N., Bansal, M., Barnhart, H. X., Beavers, K., Calvo, F. O., Chang, C., Conjeevaram, H. & 56 others, Conner, G., Darling, J., De Boer, Y., Dieterich, D., Dipaola, F., Durazo, F. A., Everhart, J. E., Fontana, R. J., Ghabril, M. S., Goldstein, D., Gopalreddy, V., Grewal, P., Hayashi, P. H., Hoofnagle, J., Kaplowitz, N., Liangpunsakul, S., Lichtman, S., Liu, L., Navarro, V. J., Odin, J., Rossi, S., Russo, M., Schiano, T., Sherker, A. H., Vuppalanchi, R., Zacks, S., Balasco, A., Chesney, K., Corne, A., Cummings, S., Groseclose, G., Hammett, A., Hooker, J., Kesar, V., Mao, S., Marks, K., McFadden, R., Melgoza, Y., Mikhail, S., Milstein, S., Morlan, W., Peacock, V., Rosado, N., Russell, T., Vega, M., Verma, M., Walker, P., Yalamanchili, R., McClanahan-Crowder, M., Galan, K., Chau, T., Ragavan, K., Rostami, H., Puglisi-Scharenbroich, C., Torrance, R. J. & Van Raaphorst, R., Jun 1 2015, In : Gastroenterology. 148, 7, p. 1340-1352.e7

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Prospective Studies
Nitrofurantoin
Liver Diseases
Azithromycin
10 Citations (Scopus)

Herbal dietary supplement associated hepatotoxicity: An upcoming workshop and need for research

Vuppalanchi, R., Navarro, V., Vega, M., Bonkovsky, H. L., Seeff, L. & Serrano, J., Mar 1 2015, In : Gastroenterology. 148, 3, p. 480-482 3 p.

Research output: Contribution to journalArticle

Plant Preparations
Chemical and Drug Induced Liver Injury
Dietary Supplements
Liver Diseases
Education
18 Citations (Scopus)

Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease

Corey, K. E., Vuppalanchi, R., Vos, M., Kohli, R., Molleston, J., Wilson, L., Unalp-Arida, A., Cummings, O., Lavine, J. E. & Chalasani, N., Mar 7 2015, In : Journal of Pediatric Gastroenterology and Nutrition. 60, 3, p. 360-367 8 p.

Research output: Contribution to journalArticle

Dyslipidemias
Histology
Liver
HDL Lipoproteins
Lipoproteins
9 Citations (Scopus)

Individuals with Primary Sclerosing Cholangitis Have Elevated Levels of Biomarkers for Apoptosis but Not Necrosis

Masuoka, H., Vuppalanchi, R., Deppe, R., Bybee, P., Comerford, M., Liangpunsakul, S., Ghabril, M. & Chalasani, N., Dec 1 2015, In : Digestive Diseases and Sciences. 60, 12, p. 3642-3646 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Necrosis
Biomarkers
Apoptosis
HMGB1 Protein
2 Citations (Scopus)

Myths and Mysteries About Staging Hepatic Fibrosis by Fibroscan

Vuppalanchi, R. & Sanyal, A. J., Apr 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 4, p. 780-782 3 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
HDL Lipoproteins
Cholesterol
pioglitazone
Dyslipidemias
Cardiovascular Diseases

Reply

Martinez, M., Tandra, A. & Vuppalanchi, R., Apr 1 2015, In : Hepatology. 61, 4, p. 1436-1437 2 p.

Research output: Contribution to journalArticle

Morpholines
Mesenteric Veins
Thiophenes
Portal Vein
Venous Thrombosis
1 Citation (Scopus)

Reply

Martinez, M., Tandra, A. & Vuppalanchi, R., Jun 1 2015, In : Hepatology. 61, 6, p. 2119-2120 2 p.

Research output: Contribution to journalArticle

Morpholines
Mesenteric Veins
Thiophenes
Portal Vein
Venous Thrombosis

Reply to Martinez-Gonzalez et al

Kahloon, A., Chalasani, N., DeWitt, J., Liangpunsakul, S., Vinayek, R., Vuppalanchi, R., Ghabril, M. & Chiorean, M., Jan 1 2015, In : Digestive Diseases and Sciences. 60, 1, p. 276-277 2 p.

Research output: Contribution to journalArticle

Endoscopic Hemostasis
Tissue Adhesives
Cyanoacrylates
Gastrointestinal Hemorrhage
Esophageal and Gastric Varices
25 Citations (Scopus)

Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis

Bell, L. N., Wulff, J., Comerford, M., Vuppalanchi, R. & Chalasani, N., Jan 1 2015, In : Liver International. 35, 1, p. 263-274 12 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Biliary Liver Cirrhosis
Serum
Control Groups
Metabolome
20 Citations (Scopus)

Severe Drug-Induced Skin and Liver Injury from Rivaroxaban

Barrett, P., Vuppalanchi, R., Masuoka, H. & Chalasani, N., Jun 5 2015, In : Digestive Diseases and Sciences. 60, 6, p. 1856-1858 3 p.

Research output: Contribution to journalArticle

Morpholines
Drug Eruptions
Chemical and Drug Induced Liver Injury
Thiophenes
Drug-Related Side Effects and Adverse Reactions
2014
19 Citations (Scopus)

Drug-induced nodular regenerative hyperplasia

Ghabril, M. & Vuppalanchi, R., 2014, In : Seminars in Liver Disease. 34, 2, p. 240-245 6 p.

Research output: Contribution to journalArticle

Portal Hypertension
Hyperplasia
Pharmaceutical Preparations
Hypersplenism
Anti-Retroviral Agents
18 Citations (Scopus)

Endoscopic therapy with 2-octyl-cyanoacrylate for the treatment of gastric varices

Kahloon, A., Chalasani, N., DeWitt, J., Liangpunsakul, S., Vinayek, R., Vuppalanchi, R., Ghabril, M. & Chiorean, M., 2014, In : Digestive Diseases and Sciences. 59, 9, p. 2178-2183 6 p.

Research output: Contribution to journalArticle

Esophageal and Gastric Varices
Hemorrhage
Cyanoacrylates
Therapeutics
Stomach