Rebecca Chan

  • 2500 Citations
  • 25 h-Index
1992 …2018
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Publications 1994 2018

  • 2500 Citations
  • 25 h-Index
  • 77 Article
  • 1 Comment/debate
  • 1 Letter
2018
1 Citation (Scopus)

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

Tarnawsky, S. P., Yu, W. M., Qu, C. K., Chan, R. & Yoder, M., Apr 24 2018, In : Oncotarget. 9, 31, p. 21831-21843 13 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
T-Lymphocytes
Neoplasms
Extramedullary Hematopoiesis
T-Cell Leukemia

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. & Kapur, R., Jan 1 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Mutation
Juvenile Myelomonocytic Leukemia
Neoplasms
Haploinsufficiency
Acute Myeloid Leukemia
2017

Cleaning up the environment in juvenile myelomonocytic leukemia

Deng, L. & Chan, R., 2017, In : Translational Cancer Research. 6, p. S36-S38

Research output: Contribution to journalComment/debate

Juvenile Myelomonocytic Leukemia
5 Citations (Scopus)

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factors
Interleukin-3
Hematopoiesis
Granulocytes
Experimental Leukemias
22 Citations (Scopus)

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Clinkenbeard, E. L., Hanudel, M. R., Stayrook, K. R., Appaiah, H. N., Farrow, E. G., Cass, T. A., Summers, L. J., Ip, C. S., Hum, J. M., Thomas, J. C., Ivan, M., Richine, B. M., Chan, R., Clemens, T. L., Schipani, E., Sabbagh, Y., Xu, L., Srour, E., Alvarez, M. B., Kacena, M. & 4 others, Salusky, I. B., Ganz, T., Nemeth, E. & White, K., Oct 27 2017, In : Haematologica. 102, 11, p. e427-e430

Research output: Contribution to journalLetter

Erythropoietin
Bone Marrow
Bone and Bones
fibroblast growth factor 23
13 Citations (Scopus)

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

Liu, W., Yu, W. M., Zhang, J., Chan, R., Loh, M. L., Zhang, Z., Bunting, K. D. & Qu, C. K., Jun 1 2017, In : Leukemia. 31, 6, p. 1415-1422 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Juvenile Myelomonocytic Leukemia
Mutation
Myeloid Cells
Sirolimus
2 Citations (Scopus)

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Tarnawsky, S. P., Chan, R. J. & Chan, R., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3652-3656 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Myeloid Leukemia
Hematopoietic Stem Cells
Infant, Newborn, Diseases
Pediatrics
1 Citation (Scopus)

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Myeloid Cells
Juvenile Myelomonocytic Leukemia
Splenomegaly
B-Cell Chronic Lymphocytic Leukemia
1 Citation (Scopus)

Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice

Tarnawsky, S. P., Yoshimoto, M., Deng, L., Chan, R. & Yoder, M., Dec 1 2017, In : Developmental Dynamics. 246, 12, p. 1001-1014 14 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Yolk Sac
Neoplasms
Hematopoiesis
Granulocyte-Macrophage Colony-Stimulating Factor
2016
9 Citations (Scopus)

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 1 2016, In : PLoS One. 11, 8, e0161341.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Chelation Therapy
iron overload
Iron Overload
chelation
4 Citations (Scopus)

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

Phagocytosis
Reactive Oxygen Species
Neutrophils
Complement Receptors
Methicillin Resistance
14 Citations (Scopus)

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Hematopoietic Stem Cells
Leukemia
Maintenance
Oncogene Fusion
6 Citations (Scopus)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z-Y., Boswell, H., Kapur, R. & Chan, R., Jun 3 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
Syk Kinase
2015
11 Citations (Scopus)

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia

Niemeyer, C. M., Loh, M. L., Cseh, A., Cooper, T., Dvorak, C. C., Chan, R., Xicoy, B., Germing, U., Kojima, S., Manabe, A., Dworzak, M., De Moerloose, B., Starý, J., Smith, O. P., Masetti, R., Catala, A., Bergstraesser, E., Ussowicz, M., Fabri, O., Baruchel, A. & 7 others, Cavé, H., Zwaan, M., Locatelli, F., Hasle, H., Van Den Heuvel-Eibrink, M. M., Flotho, C. & Yoshimi, A., 2015, In : Haematologica. 100, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Clinical Trials
Hematopoietic Stem Cell Transplantation
Therapeutics
Phase II Clinical Trials
15 Citations (Scopus)

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Chen, L., Chen, W., Mysliwski, M., Serio, J., Ropa, J., Abulwerdi, F. A., Chan, R., Patel, J. P., Tallman, M. S., Paietta, E., Melnick, A., Levine, R. L., Abdel-Wahab, O., Nikolovska-Coleska, Z. & Muntean, A. G., Jun 9 2015, In : Leukemia. 29, 6, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Stem Cells
Mutation
Non-Receptor Protein Tyrosine Phosphatases
12 Citations (Scopus)

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R., Wang, L., Carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M., 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

Fetal Blood
Ligands
Stromal Cells
Blood Vessels
Notch Receptors
12 Citations (Scopus)

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S. & Chan, R., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3894-3909 16 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Respiratory Burst
Macrophages
Phosphoric Monoester Hydrolases
Bearings (structural)
16 Citations (Scopus)

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PLoS One. 10, 1, e0117435.

Research output: Contribution to journalArticle

ferritin
Ferritins
Knockout Mice
homeostasis
Homeostasis
2014
20 Citations (Scopus)

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Phosphatidylinositol 3-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Catalytic Domain
24 Citations (Scopus)

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H., Liu, Y., Chan, R. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Chemical activation
Transcription
Acute Myeloid Leukemia
Neoplasms
48 Citations (Scopus)

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R., Kapur, R., Wells, C. & Zhang, Z-Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Carboxylic Acids
Leukemia
SH2 Domain-Containing Protein Tyrosine Phosphatases
Breast Neoplasms
2013
5 Citations (Scopus)

Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on shp2 phosphatase function

Broxmeyer, H., Etienne-Julan, M., Gotoh, A., Braun, S. E., Lu, L., Cooper, S., Feng, G. S., Li, X. J. & Chan, R., Mar 15 2013, In : Stem Cells and Development. 22, 6, p. 998-1006 9 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Myeloid Progenitor Cells
Fetal Blood
Phosphoric Monoester Hydrolases
Blood Cells
6 Citations (Scopus)

JMML patient-derived iPSCs induce new hypotheses.

Chan, R. & Yoder, M., Jun 13 2013, In : Blood. 121, 24, p. 4815-4817 3 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Induced Pluripotent Stem Cells
Stem cells
Blood
56 Citations (Scopus)

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. & Dagher, P., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

Inflammation
Kidney
Wounds and Injuries
Leukocytes
Anti-Inflammatory Agents
20 Citations (Scopus)

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G., Boswell, H., Zhang, Z-Y., Kapur, R. & Chan, R., Feb 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Acute Myeloid Leukemia
Bone Marrow
Vascular Endothelial Growth Factor Receptor-1
Receptor Protein-Tyrosine Kinases
2012
9 Citations (Scopus)

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Goodwin, C. B., Yang, Z., Yin, F., Yu, M. & Chan, R., Jul 1 2012, In : Haematologica. 97, 7, p. 1042-1047 6 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
Phosphatidylinositol 3-Kinases
Hypersensitivity
Juvenile Myelomonocytic Leukemia
37 Citations (Scopus)

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R., Zhang, Z-Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Bearings (structural)
Systemic Mastocytosis
Phosphatidylinositol 3-Kinases
Oncogenes
19 Citations (Scopus)

Shp2 function in hematopoietic stem cell biology and leukemogenesis

Nabinger, S. C. & Chan, R., Jul 2012, In : Current Opinion in Hematology. 19, 4, p. 273-279 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cell Biology
Leukemia
Hematopoiesis
Noonan Syndrome
2 Citations (Scopus)

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Myeloproliferative Disorders
Enzyme Inhibitors
Neoplasms
2011
49 Citations (Scopus)

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F. C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

Bone Resorption
Mitogen-Activated Protein Kinases
Bone and Bones
Urine
Costello Syndrome
67 Citations (Scopus)

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis

Li, D., Hallett, M. A., Zhu, W., Rubart-von der Lohe, M., Liu, Y., Yang, Z., Chen, H., Haneline, L., Chan, R., Schwartz, R. J., Field, L., Atkinson, S. J. & Shou, W., Jan 15 2011, In : Development (Cambridge). 138, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

Morphogenesis
Actin Cytoskeleton
Actins
Double Outlet Right Ventricle
Gastrulation
1 Citation (Scopus)

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F. C. & Chan, R., Jul 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Protein Kinases
Hypersensitivity
Bone Marrow
KSR-1 protein kinase
17 Citations (Scopus)

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

Cai, S., Wang, H., Bailey, B., Ernstberger, A., Juliar, B. E., Sinn, A. L., Chan, R., Jones, D. R., Mayo, L., Baluyut, A. R., Goebel, W. & Pollok, K., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

Bone Marrow
Heterografts
Therapeutics
temozolomide
Hematopoiesis
162 Citations (Scopus)

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M., Robling, A., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H., Vidal, R., Chan, R., Goodwin, C. B., Hui, S., Peacock, M. & White, K., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46

Research output: Contribution to journalArticle

Iron
Phenotype
Diet
fibroblast growth factor 23
Autosomal Dominant Hypophosphatemic Rickets
5 Citations (Scopus)

Kinase suppressor of ras (ksr1) modulates multiple kit-ligand-dependent mast cell functions

Chen, M., Burgin, S., Staser, K., He, Y., Li, X., Robinson, M., Jiang, L., Chan, R., Ingram, D. & Clapp, D., Oct 2011, In : Experimental Hematology. 39, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Mast Cells
Mitogen-Activated Protein Kinases
Proteins
p21-Activated Kinases
54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. & Kapur, R., Sep 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia
27 Citations (Scopus)

SHP2 is a target of the immunosuppressant tautomycetin

Liu, S., Yu, Z., Yu, X., Huang, S. X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R., Shen, B. & Zhang, Z-Y., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Non-Receptor Type 11 Protein Tyrosine Phosphatase
Noonan Syndrome
Transplantation (surgical)
Phosphorylation
28 Citations (Scopus)

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B-S., Chan, R. & Wells, C., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Extracellular Signal-Regulated MAP Kinases
Breast
Epithelial Cells
14 Citations (Scopus)

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Phosphatidylinositol 3-Kinases
Mast Cells
Chemical activation
Tissue
7 Citations (Scopus)

Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: A study of the Hoosier Oncology Group

Sayar, H., Chan, R., Orschell, C., Chan, E. M., Yu, Z., Hood, D., Plett, A., Yang, Z., Hui, C. L., Nabinger, S. C., Kohlbacher, K. J., West, E. S., Walter, A., Sampson, C., Wu, J. & Cripe, L., Aug 2011, In : Leukemia Research. 35, 8, p. 1108-1110 3 p.

Research output: Contribution to journalArticle

Azacitidine
Myelodysplastic Syndromes
Apoptosis
Erythropoiesis
Transferases
57 Citations (Scopus)

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Kondo, T., Matsuoka, A. J., Shimomura, A., Koehler, K. R., Chan, R., Miller, J. M., Srour, E. & Hashino, E., May 2011, In : Stem Cells. 29, 5, p. 836-846 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Mesenchymal Stromal Cells
Transcription Factor 7-Like 1 Protein
Neurons
Transcription Factor 7-Like 2 Protein
2010
102 Citations (Scopus)

Salicylic acid based small molecule inhibitor for the oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z. X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. & Zhang, Z-Y., Mar 25 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

SH2 Domain-Containing Protein Tyrosine Phosphatases
Protein Phosphatase 2
Protein Tyrosine Phosphatases
Salicylic Acid
Intercellular Signaling Peptides and Proteins
139 Citations (Scopus)

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R., Liu, Y., Zheng, J. & Zhang, Z-Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium
Phosphoric Monoester Hydrolases
Macrophages
Click Chemistry
2009
23 Citations (Scopus)

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants

Yang, Z., Kondo, T., Voorhorst, C. S., Nabinger, S. C., Ndong, L., Yin, F., Chan, E. M., Yu, M., Würstlin, O., Kratz, C. P., Niemeyer, C. M., Flotho, C., Hashino, E. & Chan, R., Aug 2009, In : Molecular and Cellular Biology. 29, 16, p. 4376-4393 18 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Macrophage Colony-Stimulating Factor Receptors
NIH 3T3 Cells
Chromatin Immunoprecipitation
Zinc Fingers
88 Citations (Scopus)

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

Chan, R., Cooper, T., Kratz, C. P., Weiss, B. & Loh, M. L., Mar 2009, In : Leukemia Research. 33, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
SEER Program
Myeloproliferative Disorders
Inborn Genetic Diseases
Incidence
38 Citations (Scopus)

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R., Zhang, Z-Y., Fu, X. Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Noonan Syndrome
Bearings (structural)
Cells
Defects
3 Citations (Scopus)

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Embryonic Stem Cells
Stromal Cells
Embryoid Bodies
Endoderm
2008
19 Citations (Scopus)

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

Yang, Z., Li, Y., Yin, F. & Chan, R., Oct 2008, In : Experimental Hematology. 36, 10, p. 1285-1296 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cell Survival
Cell Cycle
Juvenile Myelomonocytic Leukemia
Apoptosis Regulatory Proteins

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Kapur, R., Chan, R. & Yang, F. C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Medical Genetics
Osteoclasts
Molecular Biology
37 Citations (Scopus)

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Karpur, R., Chan, R. & Yang, F. C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Osteoclasts
rho GTP-Binding Proteins
Bone Resorption
Osteoporosis