Rebecca Chan

  • 2779 Citations
  • 27 h-Index
1992 …2018

Research output per year

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Publications

12-O-Tetradecanoylphorbol-13-acetate in acute myeloid leukemia

Chan, R. J. & Cripe, L. D., Oct 1 2005, In : Leukemia Research. 29, 10, p. 1107-1108 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

Yang, Z., Li, Y., Yin, F. & Chan, R. J., Oct 1 2008, In : Experimental Hematology. 36, 10, p. 1285-1296 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

Chan, R. J., Johnson, S. A., Li, Y., Yoder, M. C. & Feng, G. S., Sep 15 2003, In : Blood. 102, 6, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

A direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene

Chan, R. M., Stewart, M. J. & Crabb, D. W., Apr 1 1997, In : Molecular Brain Research. 45, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
13 Scopus citations

AML1-FOG2 fusion protein in myelodysplasia

Chan, E. M., Comer, E. M., Brown, F. C., Richkind, K. E., Holmes, M. L., Chong, B. H., Shiffman, R., Zhang, D. E., Slovak, M. L., Willman, C. L., Noguchi, C. T., Li, Y., Heiber, D. J., Kwan, L., Chan, R. J., Vance, G. H., Ramsey, H. C. & Hromas, R. A., Jun 1 2005, In : Blood. 105, 11, p. 4523-4526 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F. C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Chemical Modification and Site-Directed Mutagenesis Studies of Rat 3-Hydroxyisobutyrate Dehydrogenase

Hawes, J. W., Crabb, D. W., Chan, R. M., Harris, R. A. & Rougraff, P. M., Sep 1 1995, In : Biochemistry. 34, 13, p. 4231-4237 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cleaning up the environment in juvenile myelomonocytic leukemia

Deng, L. & Chan, R. J., Jan 1 2017, In : Translational Cancer Research. 6, p. S36-S38

Research output: Contribution to journalComment/debate

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia

Niemeyer, C. M., Loh, M. L., Cseh, A., Cooper, T., Dvorak, C. C., Chan, R., Xicoy, B., Germing, U., Kojima, S., Manabe, A., Dworzak, M., De Moerloose, B., Starý, J., Smith, O. P., Masetti, R., Catala, A., Bergstraesser, E., Ussowicz, M., Fabri, O., Baruchel, A. & 7 others, Cavé, H., Zwaan, M., Locatelli, F., Hasle, H., Van Den Heuvel-Eibrink, M. M., Flotho, C. & Yoshimi, A., 2015, In : Haematologica. 100, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
1 Scopus citations

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis

Li, D., Hallett, M. A., Zhu, W., Rubart, M., Liu, Y., Yang, Z., Chen, H., Haneline, L. S., Chan, R. J., Schwartz, R. J., Field, L. J., Atkinson, S. J. & Shou, W., Jan 15 2011, In : Development. 138, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H. J., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R. J., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 2016, In : PloS one. 11, 8, e0161341.

Research output: Contribution to journalArticle

11 Scopus citations

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F. C., Jun 15 2008, In : Human molecular genetics. 17, 12, 1 p.

Research output: Contribution to journalComment/debate

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Clinkenbeard, E. L., Hanudel, M. R., Stayrook, K. R., Appaiah, H. N., Farrow, E. G., Cass, T. A., Summers, L. J., Ip, C. S., Hum, J. M., Thomas, J. C., Ivan, M., Richine, B. M., Chan, R. J., Clemens, T. L., Schipani, E., Sabbagh, Y., Xu, L., Srour, E. F., Alvarez, M. B., Kacena, M. A. & 4 others, Salusky, I. B., Ganz, T., Nemeth, E. & White, K. E., Oct 27 2017, In : Haematologica. 102, 11, p. e427-e430

Research output: Contribution to journalLetter

36 Scopus citations
29 Scopus citations

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Goodwin, C. B., Yang, Z., Yin, F., Yu, M. & Chan, R. J., Jul 1 2012, In : Haematologica. 97, 7, p. 1042-1047 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F. C. & Chan, R. J., Jul 1 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on shp2 phosphatase function

Broxmeyer, H. E., Etienne-Julan, M., Gotoh, A., Braun, S. E., Lu, L., Cooper, S., Feng, G. S., Li, X. J. & Chan, R. J., Mar 15 2013, In : Stem cells and development. 22, 6, p. 998-1006 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

Tarnawsky, S. P., Yu, W. M., Qu, C. K., Chan, R. J. & Yoder, M. C., Apr 24 2018, In : Oncotarget. 9, 31, p. 21831-21843 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

Cai, S., Wang, H., Bailey, B., Ernstberger, A., Juliar, B. E., Sinn, A. L., Chan, R. J., Jones, D. R., Mayo, L. D., Baluyut, A. R., Goebel, W. S. & Pollok, K. E., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Chan, R. J., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.

Research output: Contribution to journalArticle

121 Scopus citations

Identification of trans-acting factors by electrophoretic mobility shift assay.

Chan, R. J., You, M. & Feng, G. S., 2004, In : Methods in molecular biology (Clifton, N.J.). 249, p. 7-20 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells

Zhong, L., Li, W., Yang, Z., Qing, K., Tan, M., Hansen, J., Li, Y., Chen, L., Chan, R. J., Bischof, D., Maina, N., Weigel-Kelley, K. A., Zhao, W., Larsen, S. H., Yoder, M. C., Shou, W. & Srivastava, A., Dec 2004, In : Human gene therapy. 15, 12, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants

Yang, Z., Kondo, T., Voorhorst, C. S., Nabinger, S. C., Ndong, L., Yin, F., Chan, E. M., Yu, M., Würstlin, O., Kratz, C. P., Niemeyer, C. M., Flotho, C., Hashino, E. & Chan, R. J., Aug 1 2009, In : Molecular and cellular biology. 29, 16, p. 4376-4393 18 p.

Research output: Contribution to journalArticle

25 Scopus citations

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

Liu, W., Yu, W. M., Zhang, J., Chan, R. J., Loh, M. L., Zhang, Z., Bunting, K. D. & Qu, C. K., Jun 1 2017, In : Leukemia. 31, 6, p. 1415-1422 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M. R., Robling, A. G., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H. J., Vidal, R., Chan, R. J., Goodwin, C. B., Hui, S. L., Peacock, M. & White, K. E., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. E1146-E1155

Research output: Contribution to journalArticle

207 Scopus citations

JMML patient-derived iPSCs induce new hypotheses

Chan, R. J. & Yoder, M. C., Jun 13 2013, In : Blood. 121, 24, p. 4815-4817 3 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

Chan, R. J., Cooper, T., Kratz, C. P., Weiss, B. & Loh, M. L., Mar 1 2009, In : Leukemia Research. 33, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Kinase suppressor of ras (ksr1) modulates multiple kit-ligand-dependent mast cell functions

Chen, M., Burgin, S., Staser, K., He, Y., Li, X., Robinson, M., Jiang, L., Chan, R. J., Ingram, D. & Clapp, D. W., Oct 1 2011, In : Experimental Hematology. 39, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mammalian 3-hydroxyisobutyrate dehydrogenase

Hawes, J. W., Crabb, D. W., Chan, R. J., Rougraff, P. M., Paxton, R. & Harris, R. A., Jan 1 2000, In : Methods in Enzymology. 324, p. 218-228 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Tarnawsky, S. P., Kobayashi, M., Chan, R. J. & Yode, M. C., Jan 1 2017, In : Journal of Clinical Investigation. 127, 10, p. 3652-3656 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R. J., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H. S., Nakshatri, H. & Gabig, T. G., Dec 1 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4

Li, Y., McClintick, J., Zhong, L., Edenberg, H. J., Yoder, M. C. & Chan, R. J., Jan 15 2005, In : Blood. 105, 2, p. 635-637 3 p.

Research output: Contribution to journalArticle

207 Scopus citations

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Chen, L., Chen, W., Mysliwski, M., Serio, J., Ropa, J., Abulwerdi, F. A., Chan, R. J., Patel, J. P., Tallman, M. S., Paietta, E., Melnick, A., Levine, R. L., Abdel-Wahab, O., Nikolovska-Coleska, Z. & Muntean, A. G., Jun 9 2015, In : Leukemia. 29, 6, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R. J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R. M., Zhang, Z. Y., Fu, X-Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R. J., Wang, L., carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M. C., Jan 1 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

On physician-assisted suicide.

Chan, R. J., Jan 1 2002, In : The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. 65, 2, p. 49-50 2 p.

Research output: Contribution to journalComment/debate

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T. A., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. J. & Dagher, P. C., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R. J., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma

Ganjoo, K. N., Chan, R. J., Sharma, M. & Einhorn, L. H., Nov 1999, In : Journal of Clinical Oncology. 17, 11, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

84 Scopus citations

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S. & Chan, R. J., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3894-3909 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Chan, R. J. & Feng, G. S., Feb 1 2007, In : Blood. 109, 3, p. 862-867 6 p.

Research output: Contribution to journalReview article

199 Scopus citations

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F. C., Apr 1 2008, In : Human molecular genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. J. & Kapur, R., 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation

Zou, G. M., Chan, R. J., Shelley, W. C. & Yoder, M. C., Mar 1 2006, In : STEM CELLS. 24, 3, p. 587-594 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

33 Scopus citations