Rebecca Chan

  • 2741 Citations
  • 27 h-Index
1992 …2018

Research output per year

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Publications

Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice

Tarnawsky, S. P., Yoshimoto, M., Deng, L., Chan, R. J. & Yoder, M. C., Dec 2017, In : Developmental Dynamics. 246, 12, p. 1001-1014 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Kondo, T., Matsuoka, A. J., Shimomura, A., Koehler, K. R., Chan, R. J., Miller, J. M., Srour, E. F. & Hashino, E., May 1 2011, In : STEM CELLS. 29, 5, p. 836-846 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
26 Scopus citations

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R. J., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M. C., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
10 Scopus citations

Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: A study of the Hoosier Oncology Group

Sayar, H., Chan, R. J., Orschell, C. M., Chan, E. M., Yu, Z., Hood, D., Plett, A., Yang, Z., Hui, C. L., Nabinger, S. C., Kohlbacher, K. J., West, E. S., Walter, A., Sampson, C., Wu, J. & Cripe, L. D., Aug 1 2011, In : Leukemia Research. 35, 8, p. 1108-1110 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

The role of Hex in hemangioblast and hematopoietic development.

Chan, R. J., Hromas, R. & Yoder, M. C., 2006, In : Methods in molecular biology (Clifton, N.J.). 330, p. 123-133 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D. & Zhang, Z. Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

57 Scopus citations

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z. Y., Kapur, R. & Chan, R. J., Feb 1 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

The multiple facets of hematopoietic stem cells.

Chan, R. J. & Yoder, M. C., Jul 2004, In : Current neurovascular research. 1, 3, p. 197-206 10 p.

Research output: Contribution to journalReview article

20 Scopus citations

The homeoprotein Hex is required for hemangioblast differentiation

Guo, Y., Chan, R., Ramsey, H., Li, W., Xie, X., Shelley, W. C., Martinez-Barbera, J. P., Bort, B., Zaret, K., Yoder, M. & Hromas, R., Oct 1 2003, In : Blood. 102, 7, p. 2428-2435 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B. S., Chan, R. & Wells, C. D., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., Jan 1 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalEditorial

Open Access
2 Scopus citations

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R. J., Liu, Y., Zheng, J. & Zhang, Z. Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

144 Scopus citations

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H. J., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R. J., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PloS one. 10, 1, e0117435.

Research output: Contribution to journalArticle

24 Scopus citations

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Oct 1 2016, In : Leukemia. 30, 10, p. 2094-2097 4 p.

Research output: Contribution to journalLetter

8 Scopus citations

Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis

Palis, J., Chan, R. J., Koniski, A., Patel, R., Starr, M. & Yoder, M. C., Apr 10 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

127 Scopus citations

SHP2 is a target of the immunosuppressant tautomycetin

Liu, S., Yu, Z., Yu, X., Huang, S. X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R. J., Shen, B. & Zhang, Z. Y., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal

Chan, R. J., Li, Y., Hass, M. N., Walter, A., Voorhorst, C. S., Shelley, W. C., Yang, Z., Orschell, C. M. & Yoder, M. C., Sep 2006, In : Experimental Hematology. 34, 9, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Shp2 function in hematopoietic stem cell biology and leukemogenesis

Nabinger, S. C. & Chan, R. J., Jul 1 2012, In : Current opinion in hematology. 19, 4, p. 273-279 7 p.

Research output: Contribution to journalReview article

22 Scopus citations
3 Scopus citations

Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to Improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo

Zhong, L., Chen, L., Li, Y., Qing, K., Weigel-Kelley, K. A., Chan, R. J., Yoder, M. C. & Srivastava, A., Nov 1 2004, In : Molecular Therapy. 10, 5, p. 950-957 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Salicylic acid based small molecule inhibitor for the oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z. X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. J. & Zhang, Z. Y., Mar 25 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R. J., Zhang, Z. Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R. J., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R. J., Lenz, S. D. & Kapur, R., Mar 1 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation

Zou, G. M., Chan, R. J., Shelley, W. C. & Yoder, M. C., Mar 1 2006, In : STEM CELLS. 24, 3, p. 587-594 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. & Kapur, R., Jan 1 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F. C., Apr 1 2008, In : Human molecular genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Chan, R. J. & Feng, G. S., Feb 1 2007, In : Blood. 109, 3, p. 862-867 6 p.

Research output: Contribution to journalReview article

195 Scopus citations

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S. & Chan, R. J., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3894-3909 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma

Ganjoo, K. N., Chan, R. J., Sharma, M. & Einhorn, L. H., Nov 1999, In : Journal of Clinical Oncology. 17, 11, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

84 Scopus citations

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R. J., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T. A., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. J. & Dagher, P. C., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

On physician-assisted suicide.

Chan, R. J., Jan 1 2002, In : The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. 65, 2, p. 49-50 2 p.

Research output: Contribution to journalComment/debate

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R. J., Wang, L., carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M. C., Jan 1 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R. J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R. M., Zhang, Z. Y., Fu, X. Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Chen, L., Chen, W., Mysliwski, M., Serio, J., Ropa, J., Abulwerdi, F. A., Chan, R. J., Patel, J. P., Tallman, M. S., Paietta, E., Melnick, A., Levine, R. L., Abdel-Wahab, O., Nikolovska-Coleska, Z. & Muntean, A. G., Jun 9 2015, In : Leukemia. 29, 6, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4

Li, Y., McClintick, J., Zhong, L., Edenberg, H. J., Yoder, M. C. & Chan, R. J., Jan 15 2005, In : Blood. 105, 2, p. 635-637 3 p.

Research output: Contribution to journalArticle

207 Scopus citations

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R. J., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H. S., Nakshatri, H. & Gabig, T. G., Dec 1 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Tarnawsky, S. P., Kobayashi, M., Chan, R. J. & Yode, M. C., Jan 1 2017, In : Journal of Clinical Investigation. 127, 10, p. 3652-3656 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mammalian 3-hydroxyisobutyrate dehydrogenase

Hawes, J. W., Crabb, D. W., Chan, R. J., Rougraff, P. M., Paxton, R. & Harris, R. A., Jan 1 2000, In : Methods in Enzymology. 324, p. 218-228 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Kinase suppressor of ras (ksr1) modulates multiple kit-ligand-dependent mast cell functions

Chen, M., Burgin, S., Staser, K., He, Y., Li, X., Robinson, M., Jiang, L., Chan, R. J., Ingram, D. & Clapp, D. W., Oct 1 2011, In : Experimental Hematology. 39, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

Chan, R. J., Cooper, T., Kratz, C. P., Weiss, B. & Loh, M. L., Mar 1 2009, In : Leukemia Research. 33, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

97 Scopus citations