Rebecca Chan

  • 2597 Citations
  • 26 h-Index
1992 …2018
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Publications 1994 2018

  • 2597 Citations
  • 26 h-Index
  • 77 Article
  • 1 Comment/debate
  • 1 Letter
2 Citations (Scopus)

Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice

Tarnawsky, S. P., Yoshimoto, M., Deng, L., Chan, R. & Yoder, M., Dec 1 2017, In : Developmental Dynamics. 246, 12, p. 1001-1014 14 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Yolk Sac
Neoplasms
Hematopoiesis
Granulocyte-Macrophage Colony-Stimulating Factor
60 Citations (Scopus)

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Kondo, T., Matsuoka, A. J., Shimomura, A., Koehler, K. R., Chan, R., Miller, J. M., Srour, E. & Hashino, E., May 2011, In : Stem Cells. 29, 5, p. 836-846 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Mesenchymal Stromal Cells
Transcription Factor 7-Like 1 Protein
Neurons
Transcription Factor 7-Like 2 Protein
23 Citations (Scopus)
Embryonic Stem Cells
Neurons
Genes
Sensory Ganglia
T-Cell Leukemia
17 Citations (Scopus)

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Thrombopoietin
Yolk Sac
Erythropoiesis
Cell growth
Growth
10 Citations (Scopus)
Thrombopoietin
Leukemia Inhibitory Factor
Sequence Deletion
Embryonic Stem Cells
Stem cells
7 Citations (Scopus)

Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: A study of the Hoosier Oncology Group

Sayar, H., Chan, R., Orschell, C., Chan, E. M., Yu, Z., Hood, D., Plett, A., Yang, Z., Hui, C. L., Nabinger, S. C., Kohlbacher, K. J., West, E. S., Walter, A., Sampson, C., Wu, J. & Cripe, L., Aug 2011, In : Leukemia Research. 35, 8, p. 1108-1110 3 p.

Research output: Contribution to journalArticle

Azacitidine
Myelodysplastic Syndromes
Apoptosis
Erythropoiesis
Transferases
4 Citations (Scopus)

The role of Hex in hemangioblast and hematopoietic development.

Chan, R., Hromas, R. & Yoder, M., 2006, In : Methods in molecular biology (Clifton, N.J.). 330, p. 123-133 11 p.

Research output: Contribution to journalArticle

Hemangioblasts
Embryonic Stem Cells
Colony-Forming Units Assay
Homeobox Genes
Hematopoiesis
51 Citations (Scopus)

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R., Kapur, R., Wells, C. & Zhang, Z-Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Carboxylic Acids
Leukemia
SH2 Domain-Containing Protein Tyrosine Phosphatases
Breast Neoplasms
21 Citations (Scopus)

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G., Boswell, H., Zhang, Z-Y., Kapur, R. & Chan, R., Feb 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Acute Myeloid Leukemia
Bone Marrow
Vascular Endothelial Growth Factor Receptor-1
Receptor Protein-Tyrosine Kinases
16 Citations (Scopus)

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Phosphatidylinositol 3-Kinases
Mast Cells
Chemical activation
Tissue
20 Citations (Scopus)

The multiple facets of hematopoietic stem cells.

Chan, R. & Yoder, M., Jul 2004, In : Curr Neurovasc Res. 1, 3, p. 197-206 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Hematopoietic System
Hemangioblasts
Bone Marrow Diseases
Endoderm
69 Citations (Scopus)

The homeoprotein Hex is required for hemangioblast differentiation

Guo, Y., Chan, R., Ramsey, H., Li, W., Xie, X., Shelley, W. C., Martinez-Barbera, J. P., Bort, B., Zaret, K., Yoder, M. & Hromas, R., Oct 1 2003, In : Blood. 102, 7, p. 2428-2435 8 p.

Research output: Contribution to journalArticle

Hemangioblasts
Homeodomain Proteins
Endothelial cells
Endothelial Cells
Homeobox Genes
29 Citations (Scopus)

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B-S., Chan, R. & Wells, C., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Extracellular Signal-Regulated MAP Kinases
Breast
Epithelial Cells
2 Citations (Scopus)

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Myeloproliferative Disorders
Enzyme Inhibitors
Neoplasms
141 Citations (Scopus)

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R., Liu, Y., Zheng, J. & Zhang, Z-Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium
Phosphoric Monoester Hydrolases
Macrophages
Click Chemistry
17 Citations (Scopus)

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PLoS One. 10, 1, e0117435.

Research output: Contribution to journalArticle

ferritin
Ferritins
Knockout Mice
homeostasis
Homeostasis
8 Citations (Scopus)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Jun 3 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
Syk Kinase
122 Citations (Scopus)

Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis

Palis, J., Chan, R., Koniski, A., Patel, R., Starr, M. & Yoder, M., Apr 10 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

Embryonic Development
Yolk Sac
Somites
Gastrulation
Embryonic Structures
28 Citations (Scopus)

SHP2 is a target of the immunosuppressant tautomycetin

Liu, S., Yu, Z., Yu, X., Huang, S. X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R., Shen, B. & Zhang, Z-Y., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Non-Receptor Type 11 Protein Tyrosine Phosphatase
Noonan Syndrome
Transplantation (surgical)
Phosphorylation
19 Citations (Scopus)

Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal

Chan, R., Li, Y., Hass, M. N., Walter, A., Voorhorst, C. S., Shelley, W. C., Yang, Z., Orschell, C. & Yoder, M., Sep 2006, In : Experimental Hematology. 34, 9, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Transplantation
Cell Cycle
Leukemia
Stem Cells
22 Citations (Scopus)

Shp2 function in hematopoietic stem cell biology and leukemogenesis

Nabinger, S. C. & Chan, R., Jul 2012, In : Current Opinion in Hematology. 19, 4, p. 273-279 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cell Biology
Leukemia
Hematopoiesis
Noonan Syndrome
3 Citations (Scopus)
Polymerase chain reaction
Transcription
Reverse Transcription
Complementary DNA
Polymerase Chain Reaction
35 Citations (Scopus)

Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to Improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo

Zhong, L., Chen, L., Li, Y., Qing, K., Weigel-Kelley, K. A., Chan, R., Yoder, M. & Srivastava, A., Nov 2004, In : Molecular Therapy. 10, 5, p. 950-957 8 p.

Research output: Contribution to journalArticle

Non-Receptor Type 2 Protein Tyrosine Phosphatase
Helper Viruses
Dependovirus
Hepatocytes
Coinfection
107 Citations (Scopus)

Salicylic acid based small molecule inhibitor for the oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z. X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. & Zhang, Z-Y., Mar 25 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

SH2 Domain-Containing Protein Tyrosine Phosphatases
Protein Phosphatase 2
Protein Tyrosine Phosphatases
Salicylic Acid
Intercellular Signaling Peptides and Proteins
14 Citations (Scopus)

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Hematopoietic Stem Cells
Leukemia
Maintenance
Oncogene Fusion
38 Citations (Scopus)

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R., Zhang, Z-Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Bearings (structural)
Systemic Mastocytosis
Phosphatidylinositol 3-Kinases
Oncogenes
4 Citations (Scopus)

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

Phagocytosis
Reactive Oxygen Species
Neutrophils
Complement Receptors
Methicillin Resistance
54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. & Kapur, R., Sep 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia
11 Citations (Scopus)

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Myeloproliferative Disorders
Bone Marrow Cells
Biochemical Phenomena
Transplantation
27 Citations (Scopus)

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H., Liu, Y., Chan, R. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Chemical activation
Transcription
Acute Myeloid Leukemia
Neoplasms
24 Citations (Scopus)

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation

Zou, G. M., Chan, R., Shelley, W. C. & Yoder, M., Mar 2006, In : Stem Cells. 24, 3, p. 587-594 8 p.

Research output: Contribution to journalArticle

Hemangioblasts
Embryonic Stem Cells
Small Interfering RNA
Fibroblast Growth Factor 2
SH2 Domain-Containing Protein Tyrosine Phosphatases

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. & Kapur, R., Jan 1 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Mutation
Juvenile Myelomonocytic Leukemia
Neoplasms
Haploinsufficiency
Acute Myeloid Leukemia
37 Citations (Scopus)

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Karpur, R., Chan, R. & Yang, F. C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Osteoclasts
rho GTP-Binding Proteins
Bone Resorption
Osteoporosis
186 Citations (Scopus)

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Chan, R. & Feng, G. S., Feb 1 2007, In : Blood. 109, 3, p. 862-867 6 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Phosphoric Monoester Hydrolases
Tyrosine
Tumors
Leukemia
14 Citations (Scopus)

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S. & Chan, R., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3894-3909 16 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Respiratory Burst
Macrophages
Phosphoric Monoester Hydrolases
Bearings (structural)
84 Citations (Scopus)

Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma

Ganjoo, K. N., Chan, R., Sharma, M. & Einhorn, L., Nov 1999, In : Journal of Clinical Oncology. 17, 11, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

Seminoma
Positron-Emission Tomography
Drug Therapy
22 Citations (Scopus)

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Phosphatidylinositol 3-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Catalytic Domain
1 Citation (Scopus)

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Myeloid Cells
Juvenile Myelomonocytic Leukemia
Splenomegaly
B-Cell Chronic Lymphocytic Leukemia
56 Citations (Scopus)

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. & Dagher, P., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

Inflammation
Kidney
Wounds and Injuries
Leukocytes
Anti-Inflammatory Agents

On physician-assisted suicide.

Chan, R., 2002, In : The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. 65, 2, p. 49-50 2 p.

Research output: Contribution to journalArticle

Attitude to Death
Right to Die
Choice Behavior
Assisted Suicide
Terminally Ill
3 Citations (Scopus)

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Embryonic Stem Cells
Stromal Cells
Embryoid Bodies
Endoderm
12 Citations (Scopus)

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R., Wang, L., Carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M., 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

Fetal Blood
Ligands
Stromal Cells
Blood Vessels
Notch Receptors
38 Citations (Scopus)

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R., Zhang, Z-Y., Fu, X. Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Noonan Syndrome
Bearings (structural)
Cells
Defects
16 Citations (Scopus)

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Chen, L., Chen, W., Mysliwski, M., Serio, J., Ropa, J., Abulwerdi, F. A., Chan, R., Patel, J. P., Tallman, M. S., Paietta, E., Melnick, A., Levine, R. L., Abdel-Wahab, O., Nikolovska-Coleska, Z. & Muntean, A. G., Jun 9 2015, In : Leukemia. 29, 6, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Stem Cells
Mutation
Non-Receptor Protein Tyrosine Phosphatases
203 Citations (Scopus)

Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4

Li, Y., McClintick, J., Zhong, L., Edenberg, H. J., Yoder, M. C. & Chan, R. J., Jan 15 2005, In : Blood. 105, 2, p. 635-637 3 p.

Research output: Contribution to journalArticle

Zinc Fingers
Embryonic Stem Cells
Stem cells
Leukemia Inhibitory Factor
Zinc
20 Citations (Scopus)

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H., Nakshatri, H. & Gabig, T. G., Dec 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Zinc Fingers
Transcription Factors
Acute Myeloid Leukemia
Nuclear Receptor Coactivator 1
3 Citations (Scopus)

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Tarnawsky, S. P., Chan, R. J. & Chan, R., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3652-3656 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Myeloid Leukemia
Hematopoietic Stem Cells
Infant, Newborn, Diseases
Pediatrics
5 Citations (Scopus)

Mammalian 3-hydroxyisobutyrate dehydrogenase

Hawes, J. W., Crabb, D., Chan, R., Rougraff, P. M., Paxton, R. & Harris, R., 2000, In : Methods in Enzymology. 324, p. 218-228 11 p.

Research output: Contribution to journalArticle

3-hydroxyisobutyrate dehydrogenase
5 Citations (Scopus)

Kinase suppressor of ras (ksr1) modulates multiple kit-ligand-dependent mast cell functions

Chen, M., Burgin, S., Staser, K., He, Y., Li, X., Robinson, M., Jiang, L., Chan, R., Ingram, D. & Clapp, D., Oct 2011, In : Experimental Hematology. 39, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Mast Cells
Mitogen-Activated Protein Kinases
Proteins
p21-Activated Kinases
92 Citations (Scopus)

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

Chan, R., Cooper, T., Kratz, C. P., Weiss, B. & Loh, M. L., Mar 2009, In : Leukemia Research. 33, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
SEER Program
Myeloproliferative Disorders
Inborn Genetic Diseases
Incidence