Rebecca Chan

  • 2584 Citations
  • 26 h-Index
1992 …2018
If you made any changes in Pure, your changes will be visible here soon.

Publications 1994 2018

  • 2584 Citations
  • 26 h-Index
  • 77 Article
  • 1 Comment/debate
  • 1 Letter
Article
2 Citations (Scopus)

12-O-Tetradecanoylphorbol-13-acetate in acute myeloid leukemia

Chan, R. & Cripe, L., Oct 2005, In : Leukemia Research. 29, 10, p. 1107-1108 2 p.

Research output: Contribution to journalArticle

Immediate-Early Proteins
Cell Cycle Proteins
Protein Tyrosine Phosphatases
Myeloid Leukemia
Phosphoprotein Phosphatases
20 Citations (Scopus)

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

Yang, Z., Li, Y., Yin, F. & Chan, R., Oct 2008, In : Experimental Hematology. 36, 10, p. 1285-1296 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cell Survival
Cell Cycle
Juvenile Myelomonocytic Leukemia
Apoptosis Regulatory Proteins
75 Citations (Scopus)

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

Chan, R., Johnson, S. A., Li, Y., Yoder, M. & Feng, G. S., Sep 15 2003, In : Blood. 102, 6, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Hematopoiesis
Embryonic Stem Cells
Stem cells
Cell Differentiation
11 Citations (Scopus)

A direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene

Chan, R., Stewart, M. J. & Crabb, D., Apr 1997, In : Molecular Brain Research. 45, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

Nucleic Acid Repetitive Sequences
Exons
Genes
Retinoid X Receptors
Sequence Deletion
13 Citations (Scopus)
Asian Americans
Pathology
Alcoholics
Gene Frequency
African Americans
25 Citations (Scopus)

AML1-FOG2 fusion protein in myelodysplasia

Chan, E. M., Comer, E. M., Brown, F. C., Richkind, K. E., Holmes, M. L., Chong, B. H., Shiffman, R., Zhang, D. E., Slovak, M. L., Willman, C. L., Noguchi, C. T., Li, Y., Heiber, D. J., Kwan, L., Chan, R., Vance, G., Ramsey, H. C. & Hromas, R. A., Jun 1 2005, In : Blood. 105, 11, p. 4523-4526 4 p.

Research output: Contribution to journalArticle

Core Binding Factors
Acute Myeloid Leukemia
Fusion reactions
Electric fuses
Genes
53 Citations (Scopus)

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F. C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

Bone Resorption
Mitogen-Activated Protein Kinases
Bone and Bones
Urine
Costello Syndrome
12 Citations (Scopus)

Chemical Modification and Site-Directed Mutagenesis Studies of Rat 3-Hydroxyisobutyrate Dehydrogenase

Hawes, J. W., Crabb, D., Chan, R., Harris, R. & Rougraff, P. M., Sep 1 1995, In : Biochemistry. 34, 13, p. 4231-4237 7 p.

Research output: Contribution to journalArticle

3-hydroxyisobutyrate dehydrogenase
Mutagenesis
Chemical modification
Site-Directed Mutagenesis
Rats
14 Citations (Scopus)

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia

Niemeyer, C. M., Loh, M. L., Cseh, A., Cooper, T., Dvorak, C. C., Chan, R., Xicoy, B., Germing, U., Kojima, S., Manabe, A., Dworzak, M., De Moerloose, B., Starý, J., Smith, O. P., Masetti, R., Catala, A., Bergstraesser, E., Ussowicz, M., Fabri, O., Baruchel, A. & 7 others, Cavé, H., Zwaan, M., Locatelli, F., Hasle, H., Van Den Heuvel-Eibrink, M. M., Flotho, C. & Yoshimi, A., 2015, In : Haematologica. 100, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Clinical Trials
Hematopoietic Stem Cell Transplantation
Therapeutics
Phase II Clinical Trials
1 Citation (Scopus)
Chloramphenicol O-Acetyltransferase
Phorbol Esters
Colforsin
Dexamethasone
Calcium
69 Citations (Scopus)

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis

Li, D., Hallett, M. A., Zhu, W., Rubart-von der Lohe, M., Liu, Y., Yang, Z., Chen, H., Haneline, L., Chan, R., Schwartz, R. J., Field, L., Atkinson, S. J. & Shou, W., Jan 15 2011, In : Development (Cambridge). 138, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

Morphogenesis
Actin Cytoskeleton
Actins
Double Outlet Right Ventricle
Gastrulation
5 Citations (Scopus)

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factors
Interleukin-3
Hematopoiesis
Granulocytes
Experimental Leukemias
10 Citations (Scopus)

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 1 2016, In : PLoS One. 11, 8, e0161341.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Chelation Therapy
iron overload
Iron Overload
chelation

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Kapur, R., Chan, R. & Yang, F. C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Medical Genetics
Osteoclasts
Molecular Biology
28 Citations (Scopus)
Systemic Mastocytosis
GTP Phosphohydrolases
Acute Myeloid Leukemia
Phosphotransferases
Hematopoietic Stem Cells
10 Citations (Scopus)

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Goodwin, C. B., Yang, Z., Yin, F., Yu, M. & Chan, R., Jul 1 2012, In : Haematologica. 97, 7, p. 1042-1047 6 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
Phosphatidylinositol 3-Kinases
Hypersensitivity
Juvenile Myelomonocytic Leukemia
1 Citation (Scopus)

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F. C. & Chan, R., Jul 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Protein Kinases
Hypersensitivity
Bone Marrow
KSR-1 protein kinase
5 Citations (Scopus)

Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on shp2 phosphatase function

Broxmeyer, H., Etienne-Julan, M., Gotoh, A., Braun, S. E., Lu, L., Cooper, S., Feng, G. S., Li, X. J. & Chan, R., Mar 15 2013, In : Stem Cells and Development. 22, 6, p. 998-1006 9 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Myeloid Progenitor Cells
Fetal Blood
Phosphoric Monoester Hydrolases
Blood Cells
1 Citation (Scopus)

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

Tarnawsky, S. P., Yu, W. M., Qu, C. K., Chan, R. & Yoder, M., Apr 24 2018, In : Oncotarget. 9, 31, p. 21831-21843 13 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
T-Lymphocytes
Neoplasms
Extramedullary Hematopoiesis
T-Cell Leukemia
17 Citations (Scopus)

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

Cai, S., Wang, H., Bailey, B., Ernstberger, A., Juliar, B. E., Sinn, A. L., Chan, R., Jones, D. R., Mayo, L., Baluyut, A. R., Goebel, W. & Pollok, K., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

Bone Marrow
Heterografts
Therapeutics
temozolomide
Hematopoiesis
117 Citations (Scopus)

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Chan, R., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Mutation
Juvenile Myelomonocytic Leukemia
Macrophages
2 Citations (Scopus)

Identification of trans-acting factors by electrophoretic mobility shift assay.

Chan, R., You, M. & Feng, G. S., 2004, In : Methods in molecular biology (Clifton, N.J.). 249, p. 7-20 14 p.

Research output: Contribution to journalArticle

Trans-Activators
Electrophoretic Mobility Shift Assay
Nuclear Proteins
Protein Binding
Signal Transduction
48 Citations (Scopus)

Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells

Zhong, L., Li, W., Yang, Z., Qing, K., Tan, M., Hansen, J., Li, Y., Chen, L., Chan, R., Bischof, D., Maina, N., Weigel-Kelley, K. A., Zhao, W., Larsen, S. H., Yoder, M., Shou, W. & Srivastava, A., Dec 2004, In : Human Gene Therapy. 15, 12, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

Dependovirus
Cell Nucleus Active Transport
Hydroxyurea
Virion
Genome
23 Citations (Scopus)

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants

Yang, Z., Kondo, T., Voorhorst, C. S., Nabinger, S. C., Ndong, L., Yin, F., Chan, E. M., Yu, M., Würstlin, O., Kratz, C. P., Niemeyer, C. M., Flotho, C., Hashino, E. & Chan, R., Aug 2009, In : Molecular and Cellular Biology. 29, 16, p. 4376-4393 18 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Macrophage Colony-Stimulating Factor Receptors
NIH 3T3 Cells
Chromatin Immunoprecipitation
Zinc Fingers
13 Citations (Scopus)

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

Liu, W., Yu, W. M., Zhang, J., Chan, R., Loh, M. L., Zhang, Z., Bunting, K. D. & Qu, C. K., Jun 1 2017, In : Leukemia. 31, 6, p. 1415-1422 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Juvenile Myelomonocytic Leukemia
Mutation
Myeloid Cells
Sirolimus
184 Citations (Scopus)

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M., Robling, A., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H., Vidal, R., Chan, R., Goodwin, C. B., Hui, S., Peacock, M. & White, K., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46

Research output: Contribution to journalArticle

Iron
Phenotype
Diet
fibroblast growth factor 23
Autosomal Dominant Hypophosphatemic Rickets
6 Citations (Scopus)

JMML patient-derived iPSCs induce new hypotheses.

Chan, R. & Yoder, M., Jun 13 2013, In : Blood. 121, 24, p. 4815-4817 3 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Induced Pluripotent Stem Cells
Stem cells
Blood
90 Citations (Scopus)

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

Chan, R., Cooper, T., Kratz, C. P., Weiss, B. & Loh, M. L., Mar 2009, In : Leukemia Research. 33, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
SEER Program
Myeloproliferative Disorders
Inborn Genetic Diseases
Incidence
5 Citations (Scopus)

Kinase suppressor of ras (ksr1) modulates multiple kit-ligand-dependent mast cell functions

Chen, M., Burgin, S., Staser, K., He, Y., Li, X., Robinson, M., Jiang, L., Chan, R., Ingram, D. & Clapp, D., Oct 2011, In : Experimental Hematology. 39, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Mast Cells
Mitogen-Activated Protein Kinases
Proteins
p21-Activated Kinases
5 Citations (Scopus)

Mammalian 3-hydroxyisobutyrate dehydrogenase

Hawes, J. W., Crabb, D., Chan, R., Rougraff, P. M., Paxton, R. & Harris, R., 2000, In : Methods in Enzymology. 324, p. 218-228 11 p.

Research output: Contribution to journalArticle

3-hydroxyisobutyrate dehydrogenase
3 Citations (Scopus)

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Tarnawsky, S. P., Chan, R. J. & Chan, R., Oct 2 2017, In : Journal of Clinical Investigation. 127, 10, p. 3652-3656 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Myeloid Leukemia
Hematopoietic Stem Cells
Infant, Newborn, Diseases
Pediatrics
20 Citations (Scopus)

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H., Nakshatri, H. & Gabig, T. G., Dec 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Zinc Fingers
Transcription Factors
Acute Myeloid Leukemia
Nuclear Receptor Coactivator 1
202 Citations (Scopus)

Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4

Li, Y., McClintick, J., Zhong, L., Edenberg, H., Yoder, M. & Chan, R., Jan 15 2005, In : Blood. 105, 2, p. 635-637 3 p.

Research output: Contribution to journalArticle

Zinc Fingers
Embryonic Stem Cells
Stem cells
Leukemia Inhibitory Factor
Zinc
16 Citations (Scopus)

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Chen, L., Chen, W., Mysliwski, M., Serio, J., Ropa, J., Abulwerdi, F. A., Chan, R., Patel, J. P., Tallman, M. S., Paietta, E., Melnick, A., Levine, R. L., Abdel-Wahab, O., Nikolovska-Coleska, Z. & Muntean, A. G., Jun 9 2015, In : Leukemia. 29, 6, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Stem Cells
Mutation
Non-Receptor Protein Tyrosine Phosphatases
38 Citations (Scopus)

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R., Zhang, Z-Y., Fu, X. Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Noonan Syndrome
Bearings (structural)
Cells
Defects
12 Citations (Scopus)

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R., Wang, L., Carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M., 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

Fetal Blood
Ligands
Stromal Cells
Blood Vessels
Notch Receptors
3 Citations (Scopus)

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Embryonic Stem Cells
Stromal Cells
Embryoid Bodies
Endoderm

On physician-assisted suicide.

Chan, R., 2002, In : The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. 65, 2, p. 49-50 2 p.

Research output: Contribution to journalArticle

Attitude to Death
Right to Die
Choice Behavior
Assisted Suicide
Terminally Ill
56 Citations (Scopus)

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. & Dagher, P., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

Inflammation
Kidney
Wounds and Injuries
Leukocytes
Anti-Inflammatory Agents
1 Citation (Scopus)

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Myeloid Cells
Juvenile Myelomonocytic Leukemia
Splenomegaly
B-Cell Chronic Lymphocytic Leukemia
22 Citations (Scopus)

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Phosphatidylinositol 3-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Catalytic Domain
84 Citations (Scopus)

Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma

Ganjoo, K. N., Chan, R., Sharma, M. & Einhorn, L., Nov 1999, In : Journal of Clinical Oncology. 17, 11, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

Seminoma
Positron-Emission Tomography
Drug Therapy
14 Citations (Scopus)

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S. & Chan, R., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3894-3909 16 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Respiratory Burst
Macrophages
Phosphoric Monoester Hydrolases
Bearings (structural)
184 Citations (Scopus)

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Chan, R. & Feng, G. S., Feb 1 2007, In : Blood. 109, 3, p. 862-867 6 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Phosphoric Monoester Hydrolases
Tyrosine
Tumors
Leukemia
37 Citations (Scopus)

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Karpur, R., Chan, R. & Yang, F. C., Apr 1 2008, In : Human Molecular Genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Osteoclasts
rho GTP-Binding Proteins
Bone Resorption
Osteoporosis

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. & Kapur, R., Jan 1 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Mutation
Juvenile Myelomonocytic Leukemia
Neoplasms
Haploinsufficiency
Acute Myeloid Leukemia
25 Citations (Scopus)

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation

Zou, G. M., Chan, R., Shelley, W. C. & Yoder, M., Mar 2006, In : Stem Cells. 24, 3, p. 587-594 8 p.

Research output: Contribution to journalArticle

Hemangioblasts
Embryonic Stem Cells
Small Interfering RNA
Fibroblast Growth Factor 2
SH2 Domain-Containing Protein Tyrosine Phosphatases
27 Citations (Scopus)

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H., Liu, Y., Chan, R. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Chemical activation
Transcription
Acute Myeloid Leukemia
Neoplasms
11 Citations (Scopus)

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Myeloproliferative Disorders
Bone Marrow Cells
Biochemical Phenomena
Transplantation
54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. & Kapur, R., Sep 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia