Rebecca Chan

  • 2617 Citations
  • 27 h-Index
1992 …2018
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Publications 1994 2018

  • 2617 Citations
  • 27 h-Index
  • 77 Article
  • 1 Comment/debate
  • 1 Letter
Article
4 Citations (Scopus)

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

Phagocytosis
Reactive Oxygen Species
Neutrophils
Complement Receptors
Methicillin Resistance
38 Citations (Scopus)

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R., Zhang, Z-Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Bearings (structural)
Systemic Mastocytosis
Phosphatidylinositol 3-Kinases
Oncogenes
15 Citations (Scopus)

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Hematopoietic Stem Cells
Leukemia
Maintenance
Oncogene Fusion
107 Citations (Scopus)

Salicylic acid based small molecule inhibitor for the oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z. X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. & Zhang, Z-Y., Mar 25 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

SH2 Domain-Containing Protein Tyrosine Phosphatases
Protein Phosphatase 2
Protein Tyrosine Phosphatases
Salicylic Acid
Intercellular Signaling Peptides and Proteins
35 Citations (Scopus)

Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to Improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo

Zhong, L., Chen, L., Li, Y., Qing, K., Weigel-Kelley, K. A., Chan, R., Yoder, M. & Srivastava, A., Nov 2004, In : Molecular Therapy. 10, 5, p. 950-957 8 p.

Research output: Contribution to journalArticle

Non-Receptor Type 2 Protein Tyrosine Phosphatase
Helper Viruses
Dependovirus
Hepatocytes
Coinfection
3 Citations (Scopus)
Polymerase chain reaction
Transcription
Reverse Transcription
Complementary DNA
Polymerase Chain Reaction
22 Citations (Scopus)

Shp2 function in hematopoietic stem cell biology and leukemogenesis

Nabinger, S. C. & Chan, R., Jul 2012, In : Current Opinion in Hematology. 19, 4, p. 273-279 7 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Cell Biology
Leukemia
Hematopoiesis
Noonan Syndrome
19 Citations (Scopus)

Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal

Chan, R., Li, Y., Hass, M. N., Walter, A., Voorhorst, C. S., Shelley, W. C., Yang, Z., Orschell, C. & Yoder, M., Sep 2006, In : Experimental Hematology. 34, 9, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Transplantation
Cell Cycle
Leukemia
Stem Cells
28 Citations (Scopus)

SHP2 is a target of the immunosuppressant tautomycetin

Liu, S., Yu, Z., Yu, X., Huang, S. X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R., Shen, B. & Zhang, Z-Y., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Non-Receptor Type 11 Protein Tyrosine Phosphatase
Noonan Syndrome
Transplantation (surgical)
Phosphorylation
123 Citations (Scopus)

Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis

Palis, J., Chan, R., Koniski, A., Patel, R., Starr, M. & Yoder, M., Apr 10 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

Embryonic Development
Yolk Sac
Somites
Gastrulation
Embryonic Structures
8 Citations (Scopus)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Jun 3 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
Syk Kinase
18 Citations (Scopus)

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PLoS One. 10, 1, e0117435.

Research output: Contribution to journalArticle

ferritin
Ferritins
Knockout Mice
homeostasis
Homeostasis
141 Citations (Scopus)

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R., Liu, Y., Zheng, J. & Zhang, Z-Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Mycobacterium
Phosphoric Monoester Hydrolases
Macrophages
Click Chemistry
2 Citations (Scopus)

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Myeloproliferative Disorders
Enzyme Inhibitors
Neoplasms
29 Citations (Scopus)

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B-S., Chan, R. & Wells, C., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Extracellular Signal-Regulated MAP Kinases
Breast
Epithelial Cells
69 Citations (Scopus)

The homeoprotein Hex is required for hemangioblast differentiation

Guo, Y., Chan, R., Ramsey, H., Li, W., Xie, X., Shelley, W. C., Martinez-Barbera, J. P., Bort, B., Zaret, K., Yoder, M. & Hromas, R., Oct 1 2003, In : Blood. 102, 7, p. 2428-2435 8 p.

Research output: Contribution to journalArticle

Hemangioblasts
Homeodomain Proteins
Endothelial cells
Endothelial Cells
Homeobox Genes
20 Citations (Scopus)

The multiple facets of hematopoietic stem cells.

Chan, R. & Yoder, M., Jul 2004, In : Curr Neurovasc Res. 1, 3, p. 197-206 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Hematopoietic System
Hemangioblasts
Bone Marrow Diseases
Endoderm
16 Citations (Scopus)

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Phosphatidylinositol 3-Kinases
Mast Cells
Chemical activation
Tissue
22 Citations (Scopus)

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G., Boswell, H., Zhang, Z-Y., Kapur, R. & Chan, R., Feb 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Acute Myeloid Leukemia
Bone Marrow
Vascular Endothelial Growth Factor Receptor-1
Receptor Protein-Tyrosine Kinases
51 Citations (Scopus)

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R., Kapur, R., Wells, C. & Zhang, Z-Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Carboxylic Acids
Leukemia
SH2 Domain-Containing Protein Tyrosine Phosphatases
Breast Neoplasms
4 Citations (Scopus)

The role of Hex in hemangioblast and hematopoietic development.

Chan, R., Hromas, R. & Yoder, M., 2006, In : Methods in molecular biology (Clifton, N.J.). 330, p. 123-133 11 p.

Research output: Contribution to journalArticle

Hemangioblasts
Embryonic Stem Cells
Colony-Forming Units Assay
Homeobox Genes
Hematopoiesis
7 Citations (Scopus)

Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: A study of the Hoosier Oncology Group

Sayar, H., Chan, R., Orschell, C., Chan, E. M., Yu, Z., Hood, D., Plett, A., Yang, Z., Hui, C. L., Nabinger, S. C., Kohlbacher, K. J., West, E. S., Walter, A., Sampson, C., Wu, J. & Cripe, L., Aug 2011, In : Leukemia Research. 35, 8, p. 1108-1110 3 p.

Research output: Contribution to journalArticle

Azacitidine
Myelodysplastic Syndromes
Apoptosis
Erythropoiesis
Transferases
10 Citations (Scopus)
Thrombopoietin
Leukemia Inhibitory Factor
Sequence Deletion
Embryonic Stem Cells
Stem cells
17 Citations (Scopus)

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Thrombopoietin
Yolk Sac
Erythropoiesis
Cell growth
Growth
23 Citations (Scopus)
Embryonic Stem Cells
Neurons
Genes
Sensory Ganglia
T-Cell Leukemia
60 Citations (Scopus)

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Kondo, T., Matsuoka, A. J., Shimomura, A., Koehler, K. R., Chan, R., Miller, J. M., Srour, E. & Hashino, E., May 2011, In : Stem Cells. 29, 5, p. 836-846 11 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Mesenchymal Stromal Cells
Transcription Factor 7-Like 1 Protein
Neurons
Transcription Factor 7-Like 2 Protein
2 Citations (Scopus)

Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice

Tarnawsky, S. P., Yoshimoto, M., Deng, L., Chan, R. & Yoder, M., Dec 1 2017, In : Developmental Dynamics. 246, 12, p. 1001-1014 14 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Yolk Sac
Neoplasms
Hematopoiesis
Granulocyte-Macrophage Colony-Stimulating Factor
Comment/debate

Cleaning up the environment in juvenile myelomonocytic leukemia

Deng, L. & Chan, R., 2017, In : Translational Cancer Research. 6, p. S36-S38

Research output: Contribution to journalComment/debate

Juvenile Myelomonocytic Leukemia
Letter
28 Citations (Scopus)

Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Clinkenbeard, E. L., Hanudel, M. R., Stayrook, K. R., Appaiah, H. N., Farrow, E. G., Cass, T. A., Summers, L. J., Ip, C. S., Hum, J. M., Thomas, J. C., Ivan, M., Richine, B. M., Chan, R., Clemens, T. L., Schipani, E., Sabbagh, Y., Xu, L., Srour, E., Alvarez, M. B., Kacena, M. & 4 others, Salusky, I. B., Ganz, T., Nemeth, E. & White, K., Oct 27 2017, In : Haematologica. 102, 11, p. e427-e430

Research output: Contribution to journalLetter

Erythropoietin
Bone Marrow
Bone and Bones
fibroblast growth factor 23