Rebecca Chan

  • 2584 Citations
  • 26 h-Index
1992 …2018
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Publications 1994 2018

  • 2584 Citations
  • 26 h-Index
  • 77 Article
  • 1 Comment/debate
  • 1 Letter
2008
11 Citations (Scopus)

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Myeloproliferative Disorders
Bone Marrow Cells
Biochemical Phenomena
Transplantation
23 Citations (Scopus)
Embryonic Stem Cells
Neurons
Genes
Sensory Ganglia
T-Cell Leukemia
2007
28 Citations (Scopus)
Systemic Mastocytosis
GTP Phosphohydrolases
Acute Myeloid Leukemia
Phosphotransferases
Hematopoietic Stem Cells
20 Citations (Scopus)

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H., Nakshatri, H. & Gabig, T. G., Dec 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Zinc Fingers
Transcription Factors
Acute Myeloid Leukemia
Nuclear Receptor Coactivator 1
184 Citations (Scopus)

PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

Chan, R. & Feng, G. S., Feb 1 2007, In : Blood. 109, 3, p. 862-867 6 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Phosphoric Monoester Hydrolases
Tyrosine
Tumors
Leukemia
2006
25 Citations (Scopus)

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation

Zou, G. M., Chan, R., Shelley, W. C. & Yoder, M., Mar 2006, In : Stem Cells. 24, 3, p. 587-594 8 p.

Research output: Contribution to journalArticle

Hemangioblasts
Embryonic Stem Cells
Small Interfering RNA
Fibroblast Growth Factor 2
SH2 Domain-Containing Protein Tyrosine Phosphatases
19 Citations (Scopus)

Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal

Chan, R., Li, Y., Hass, M. N., Walter, A., Voorhorst, C. S., Shelley, W. C., Yang, Z., Orschell, C. & Yoder, M., Sep 2006, In : Experimental Hematology. 34, 9, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Transplantation
Cell Cycle
Leukemia
Stem Cells
4 Citations (Scopus)

The role of Hex in hemangioblast and hematopoietic development.

Chan, R., Hromas, R. & Yoder, M., 2006, In : Methods in molecular biology (Clifton, N.J.). 330, p. 123-133 11 p.

Research output: Contribution to journalArticle

Hemangioblasts
Embryonic Stem Cells
Colony-Forming Units Assay
Homeobox Genes
Hematopoiesis
2005
2 Citations (Scopus)

12-O-Tetradecanoylphorbol-13-acetate in acute myeloid leukemia

Chan, R. & Cripe, L., Oct 2005, In : Leukemia Research. 29, 10, p. 1107-1108 2 p.

Research output: Contribution to journalArticle

Immediate-Early Proteins
Cell Cycle Proteins
Protein Tyrosine Phosphatases
Myeloid Leukemia
Phosphoprotein Phosphatases
25 Citations (Scopus)

AML1-FOG2 fusion protein in myelodysplasia

Chan, E. M., Comer, E. M., Brown, F. C., Richkind, K. E., Holmes, M. L., Chong, B. H., Shiffman, R., Zhang, D. E., Slovak, M. L., Willman, C. L., Noguchi, C. T., Li, Y., Heiber, D. J., Kwan, L., Chan, R., Vance, G., Ramsey, H. C. & Hromas, R. A., Jun 1 2005, In : Blood. 105, 11, p. 4523-4526 4 p.

Research output: Contribution to journalArticle

Core Binding Factors
Acute Myeloid Leukemia
Fusion reactions
Electric fuses
Genes
117 Citations (Scopus)

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Chan, R., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Mutation
Juvenile Myelomonocytic Leukemia
Macrophages
202 Citations (Scopus)

Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4

Li, Y., McClintick, J., Zhong, L., Edenberg, H., Yoder, M. & Chan, R., Jan 15 2005, In : Blood. 105, 2, p. 635-637 3 p.

Research output: Contribution to journalArticle

Zinc Fingers
Embryonic Stem Cells
Stem cells
Leukemia Inhibitory Factor
Zinc
2004
2 Citations (Scopus)

Identification of trans-acting factors by electrophoretic mobility shift assay.

Chan, R., You, M. & Feng, G. S., 2004, In : Methods in molecular biology (Clifton, N.J.). 249, p. 7-20 14 p.

Research output: Contribution to journalArticle

Trans-Activators
Electrophoretic Mobility Shift Assay
Nuclear Proteins
Protein Binding
Signal Transduction
48 Citations (Scopus)

Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells

Zhong, L., Li, W., Yang, Z., Qing, K., Tan, M., Hansen, J., Li, Y., Chen, L., Chan, R., Bischof, D., Maina, N., Weigel-Kelley, K. A., Zhao, W., Larsen, S. H., Yoder, M., Shou, W. & Srivastava, A., Dec 2004, In : Human Gene Therapy. 15, 12, p. 1207-1218 12 p.

Research output: Contribution to journalArticle

Dependovirus
Cell Nucleus Active Transport
Hydroxyurea
Virion
Genome
35 Citations (Scopus)

Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to Improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo

Zhong, L., Chen, L., Li, Y., Qing, K., Weigel-Kelley, K. A., Chan, R., Yoder, M. & Srivastava, A., Nov 2004, In : Molecular Therapy. 10, 5, p. 950-957 8 p.

Research output: Contribution to journalArticle

Non-Receptor Type 2 Protein Tyrosine Phosphatase
Helper Viruses
Dependovirus
Hepatocytes
Coinfection
20 Citations (Scopus)

The multiple facets of hematopoietic stem cells.

Chan, R. & Yoder, M., Jul 2004, In : Curr Neurovasc Res. 1, 3, p. 197-206 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Hematopoietic System
Hemangioblasts
Bone Marrow Diseases
Endoderm
2003
75 Citations (Scopus)

A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

Chan, R., Johnson, S. A., Li, Y., Yoder, M. & Feng, G. S., Sep 15 2003, In : Blood. 102, 6, p. 2074-2080 7 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Hematopoiesis
Embryonic Stem Cells
Stem cells
Cell Differentiation
69 Citations (Scopus)

The homeoprotein Hex is required for hemangioblast differentiation

Guo, Y., Chan, R., Ramsey, H., Li, W., Xie, X., Shelley, W. C., Martinez-Barbera, J. P., Bort, B., Zaret, K., Yoder, M. & Hromas, R., Oct 1 2003, In : Blood. 102, 7, p. 2428-2435 8 p.

Research output: Contribution to journalArticle

Hemangioblasts
Homeodomain Proteins
Endothelial cells
Endothelial Cells
Homeobox Genes
17 Citations (Scopus)

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Thrombopoietin
Yolk Sac
Erythropoiesis
Cell growth
Growth
2002

On physician-assisted suicide.

Chan, R., 2002, In : The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. 65, 2, p. 49-50 2 p.

Research output: Contribution to journalArticle

Attitude to Death
Right to Die
Choice Behavior
Assisted Suicide
Terminally Ill
10 Citations (Scopus)
Thrombopoietin
Leukemia Inhibitory Factor
Sequence Deletion
Embryonic Stem Cells
Stem cells
2001
122 Citations (Scopus)

Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis

Palis, J., Chan, R., Koniski, A., Patel, R., Starr, M. & Yoder, M., Apr 10 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 8, p. 4528-4533 6 p.

Research output: Contribution to journalArticle

Embryonic Development
Yolk Sac
Somites
Gastrulation
Embryonic Structures
2000
5 Citations (Scopus)

Mammalian 3-hydroxyisobutyrate dehydrogenase

Hawes, J. W., Crabb, D., Chan, R., Rougraff, P. M., Paxton, R. & Harris, R., 2000, In : Methods in Enzymology. 324, p. 218-228 11 p.

Research output: Contribution to journalArticle

3-hydroxyisobutyrate dehydrogenase
1999
84 Citations (Scopus)

Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma

Ganjoo, K. N., Chan, R., Sharma, M. & Einhorn, L., Nov 1999, In : Journal of Clinical Oncology. 17, 11, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

Seminoma
Positron-Emission Tomography
Drug Therapy
1997
11 Citations (Scopus)

A direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene

Chan, R., Stewart, M. J. & Crabb, D., Apr 1997, In : Molecular Brain Research. 45, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

Nucleic Acid Repetitive Sequences
Exons
Genes
Retinoid X Receptors
Sequence Deletion
1996
1 Citation (Scopus)
Chloramphenicol O-Acetyltransferase
Phorbol Esters
Colforsin
Dexamethasone
Calcium
1995
12 Citations (Scopus)

Chemical Modification and Site-Directed Mutagenesis Studies of Rat 3-Hydroxyisobutyrate Dehydrogenase

Hawes, J. W., Crabb, D., Chan, R., Harris, R. & Rougraff, P. M., Sep 1 1995, In : Biochemistry. 34, 13, p. 4231-4237 7 p.

Research output: Contribution to journalArticle

3-hydroxyisobutyrate dehydrogenase
Mutagenesis
Chemical modification
Site-Directed Mutagenesis
Rats
1994
13 Citations (Scopus)
Asian Americans
Pathology
Alcoholics
Gene Frequency
African Americans
3 Citations (Scopus)
Polymerase chain reaction
Transcription
Reverse Transcription
Complementary DNA
Polymerase Chain Reaction