Rebecca Chan

  • 2779 Citations
  • 27 h-Index
1992 …2018

Research output per year

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2018

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

Tarnawsky, S. P., Yu, W. M., Qu, C. K., Chan, R. J. & Yoder, M. C., Apr 24 2018, In : Oncotarget. 9, 31, p. 21831-21843 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. J. & Kapur, R., 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

2017

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

Liu, W., Yu, W. M., Zhang, J., Chan, R. J., Loh, M. L., Zhang, Z., Bunting, K. D. & Qu, C. K., Jun 1 2017, In : Leukemia. 31, 6, p. 1415-1422 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia

Tarnawsky, S. P., Kobayashi, M., Chan, R. J. & Yode, M. C., Jan 1 2017, In : Journal of Clinical Investigation. 127, 10, p. 3652-3656 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice

Tarnawsky, S. P., Yoshimoto, M., Deng, L., Chan, R. J. & Yoder, M. C., Dec 2017, In : Developmental Dynamics. 246, 12, p. 1001-1014 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H. J., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R. J., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 2016, In : PloS one. 11, 8, e0161341.

Research output: Contribution to journalArticle

11 Scopus citations

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R. J., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. J. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia

Niemeyer, C. M., Loh, M. L., Cseh, A., Cooper, T., Dvorak, C. C., Chan, R., Xicoy, B., Germing, U., Kojima, S., Manabe, A., Dworzak, M., De Moerloose, B., Starý, J., Smith, O. P., Masetti, R., Catala, A., Bergstraesser, E., Ussowicz, M., Fabri, O., Baruchel, A. & 7 others, Cavé, H., Zwaan, M., Locatelli, F., Hasle, H., Van Den Heuvel-Eibrink, M. M., Flotho, C. & Yoshimi, A., 2015, In : Haematologica. 100, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

Chen, L., Chen, W., Mysliwski, M., Serio, J., Ropa, J., Abulwerdi, F. A., Chan, R. J., Patel, J. P., Tallman, M. S., Paietta, E., Melnick, A., Levine, R. L., Abdel-Wahab, O., Nikolovska-Coleska, Z. & Muntean, A. G., Jun 9 2015, In : Leukemia. 29, 6, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Notch ligand Delta-like 1 promotes invivo vasculogenesis in human cord blood-derived endothelial colony forming cells

Kim, H., Huang, L., Critser, P. J., Yang, Z., Chan, R. J., Wang, L., carlesso, N., Voytik-Harbin, S. L., Bernstein, I. D. & Yoder, M. C., Jan 1 2015, In : Cytotherapy. 17, 5, p. 579-592 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst

Li, X. J., Oodwin, C. B. G., Nabinger, S. C., Richine, B. M., Yang, Z., Hanenberg, H., Ohnishi, H., Matozaki, T., Feng, G. S. & Chan, R. J., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 3894-3909 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H. J., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R. J., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PloS one. 10, 1, e0117435.

Research output: Contribution to journalArticle

26 Scopus citations
2014

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R. J., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D. & Zhang, Z. Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

58 Scopus citations
2013

Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on shp2 phosphatase function

Broxmeyer, H. E., Etienne-Julan, M., Gotoh, A., Braun, S. E., Lu, L., Cooper, S., Feng, G. S., Li, X. J. & Chan, R. J., Mar 15 2013, In : Stem cells and development. 22, 6, p. 998-1006 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

p53 is renoprotective after ischemic kidney injury by reducing inflammation

Sutton, T. A., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. J. & Dagher, P. C., Dec 28 2013, In : Journal of the American Society of Nephrology. 24, 1, p. 113-124 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z. Y., Kapur, R. & Chan, R. J., Feb 1 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF

Goodwin, C. B., Yang, Z., Yin, F., Yu, M. & Chan, R. J., Jul 1 2012, In : Haematologica. 97, 7, p. 1042-1047 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R. J., Zhang, Z. Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
2011

Bone resorption in syndromes of the Ras/MAPK pathway

Stevenson, D., Schwarz, E., Carey, J., Viskochil, D., Hanson, H., Bauer, S., Cindy Weng, H. Y., Greene, T., Reinker, K., Swensen, J., Chan, R., Yang, F. C., Senbanjo, L., Yang, Z., Mao, R. & Pasquali, M., Dec 2011, In : Clinical Genetics. 80, 6, p. 566-573 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis

Li, D., Hallett, M. A., Zhu, W., Rubart, M., Liu, Y., Yang, Z., Chen, H., Haneline, L. S., Chan, R. J., Schwartz, R. J., Field, L. J., Atkinson, S. J. & Shou, W., Jan 15 2011, In : Development. 138, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Yang, Z., Chen, M., Sitarski, S. A., Saadatzadeh, T., Yin, F., Yu, M., Yang, F. C. & Chan, R. J., Jul 1 2011, In : Leukemia Research. 35, 7, p. 961-964 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

Cai, S., Wang, H., Bailey, B., Ernstberger, A., Juliar, B. E., Sinn, A. L., Chan, R. J., Jones, D. R., Mayo, L. D., Baluyut, A. R., Goebel, W. S. & Pollok, K. E., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M. R., Robling, A. G., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H. J., Vidal, R., Chan, R. J., Goodwin, C. B., Hui, S. L., Peacock, M. & White, K. E., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. E1146-E1155

Research output: Contribution to journalArticle

207 Scopus citations

Kinase suppressor of ras (ksr1) modulates multiple kit-ligand-dependent mast cell functions

Chen, M., Burgin, S., Staser, K., He, Y., Li, X., Robinson, M., Jiang, L., Chan, R. J., Ingram, D. & Clapp, D. W., Oct 1 2011, In : Experimental Hematology. 39, 10, p. 969-976 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

SHP2 is a target of the immunosuppressant tautomycetin

Liu, S., Yu, Z., Yu, X., Huang, S. X., Luo, Y., Wu, L., Shen, W., Yang, Z., Wang, L., Gunawan, A. M., Chan, R. J., Shen, B. & Zhang, Z. Y., Jan 28 2011, In : Chemistry and Biology. 18, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases

Ranahan, W. P., Han, Z., Smith-Kinnaman, W., Nabinger, S. C., Heller, B., Herbert, B. S., Chan, R. & Wells, C. D., Mar 15 2011, In : Cancer Research. 71, 6, p. 2203-2211 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: A study of the Hoosier Oncology Group

Sayar, H., Chan, R. J., Orschell, C. M., Chan, E. M., Yu, Z., Hood, D., Plett, A., Yang, Z., Hui, C. L., Nabinger, S. C., Kohlbacher, K. J., West, E. S., Walter, A., Sampson, C., Wu, J. & Cripe, L. D., Aug 1 2011, In : Leukemia Research. 35, 8, p. 1108-1110 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3

Kondo, T., Matsuoka, A. J., Shimomura, A., Koehler, K. R., Chan, R. J., Miller, J. M., Srour, E. F. & Hashino, E., May 1 2011, In : STEM CELLS. 29, 5, p. 836-846 11 p.

Research output: Contribution to journalArticle

64 Scopus citations
2010

Salicylic acid based small molecule inhibitor for the oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

Zhang, X., He, Y., Liu, S., Yu, Z., Jiang, Z. X., Yang, Z., Dong, Y., Nabinger, S. C., Wu, L., Gunawan, A. M., Wang, L., Chan, R. J. & Zhang, Z. Y., Mar 25 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2482-2493 12 p.

Research output: Contribution to journalArticle

117 Scopus citations

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

Zhou, B., He, Y., Zhang, X., Xu, J., Luo, Y., Wang, Y., Franzblau, S. G., Yang, Z., Chan, R. J., Liu, Y., Zheng, J. & Zhang, Z. Y., Mar 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 10, p. 4573-4578 6 p.

Research output: Contribution to journalArticle

148 Scopus citations
2009

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants

Yang, Z., Kondo, T., Voorhorst, C. S., Nabinger, S. C., Ndong, L., Yin, F., Chan, E. M., Yu, M., Würstlin, O., Kratz, C. P., Niemeyer, C. M., Flotho, C., Hashino, E. & Chan, R. J., Aug 1 2009, In : Molecular and cellular biology. 29, 16, p. 4376-4393 18 p.

Research output: Contribution to journalArticle

25 Scopus citations

Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

Chan, R. J., Cooper, T., Kratz, C. P., Weiss, B. & Loh, M. L., Mar 2009, In : Leukemia Research. 33, 3, p. 355-362 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R. J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R. M., Zhang, Z. Y., Fu, X. Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Novel method of murine embryonic stem cell-derived osteoclast development

Goodman, M. L., Chen, S., Yang, F. C. & Chan, R. J., Jan 1 2009, In : Stem Cells and Development. 18, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2008

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival

Yang, Z., Li, Y., Yin, F. & Chan, R. J., Oct 1 2008, In : Experimental Hematology. 36, 10, p. 1285-1296 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Karpur, R., Chan, R. J. & Yang, F. C., Apr 1 2008, In : Human molecular genetics. 17, 7, p. 936-948 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R. J., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
26 Scopus citations
2007
29 Scopus citations

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R. J., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H. S., Nakshatri, H. & Gabig, T. G., Dec 1 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2006

Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation

Zou, G. M., Chan, R. J., Shelley, W. C. & Yoder, M. C., Mar 1 2006, In : STEM CELLS. 24, 3, p. 587-594 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal

Chan, R. J., Li, Y., Hass, M. N., Walter, A., Voorhorst, C. S., Shelley, W. C., Yang, Z., Orschell, C. M. & Yoder, M. C., Sep 2006, In : Experimental Hematology. 34, 9, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

The role of Hex in hemangioblast and hematopoietic development.

Chan, R. J., Hromas, R. & Yoder, M. C., 2006, In : Methods in molecular biology (Clifton, N.J.). 330, p. 123-133 11 p.

Research output: Contribution to journalArticle

4 Scopus citations