Reuben Kapur

  • 4149 Citations
  • 35 h-Index
1991 …2019
If you made any changes in Pure, your changes will be visible here soon.

Publications 1991 2019

  • 4149 Citations
  • 35 h-Index
  • 125 Article
  • 3 Review article
  • 2 Letter
  • 1 Editorial
2019
2 Citations (Scopus)

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M., Waisman, A., Rad, R., Schotta, G., Huehn, J. & 2 others, Kallies, A. & Korn, T., Feb 12 2019, In : Cell Reports. 26, 7, p. 1854-1868.e5

Research output: Contribution to journalArticle

Methylation
T-cells
Methyltransferases
Regulatory T-Lymphocytes
Interleukin-6

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H., Sandusky, G., Mayo, L., Kapur, R. & Liu, Y., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Leukemia
Cell Self Renewal
2018

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Prudent, R., Demoncheaux, N., Diemer, H., Collin-Faure, V., Kapur, R., Paublant, F., Lafanechère, L., Cianférani, S. & Rabilloud, T., Dec 1 2018, In : PLoS One. 13, 12, e0208979.

Research output: Contribution to journalArticle

Lim Kinases
Actin Depolymerizing Factors
Phosphorylation
Myeloid Cells
Proteomics
1 Citation (Scopus)

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Mutation
Epigenetic Repression
Histone Deacetylase Inhibitors
Chromatin Assembly and Disassembly
3 Citations (Scopus)

Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

Chen, S., Gao, R., Yao, C., Kobayashi, M., Liu, S. Z., Yoder, M., Broxmeyer, H., Kapur, R., Boswell, H., Mayo, L. & Liu, Y., Mar 1 2018, In : Leukemia. 32, 3, p. 850-854 5 p.

Research output: Contribution to journalLetter

Hematopoietic Stem Cells
DNA Damage
10 Citations (Scopus)

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M., Sandusky, G., Mohseni, M., Williams, A., Henao-Mejia, J. & Kapur, R., Jan 1 2018, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Hematopoiesis
Hematopoietic Stem Cells
Interleukin-6
Long Noncoding RNA
Myeloid Cells
2 Citations (Scopus)

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI insight. 3, 4

Research output: Contribution to journalArticle

Open Access
Myeloid Cells
Phosphatidylinositol 3-Kinases
Epigenomics
Ascorbic Acid
Azacitidine
3 Citations (Scopus)

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M., Filippi, M. D., Broxmeyer, H. & Kapur, R., Dec 1 2018, In : Nature Communications. 9, 1, 3518.

Research output: Contribution to journalArticle

anemias
Erythropoiesis
Erythropoietin
Epigenomics
Anemia

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. & Kapur, R., Jan 1 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Mutation
Juvenile Myelomonocytic Leukemia
Neoplasms
Haploinsufficiency
Acute Myeloid Leukemia
1 Citation (Scopus)

The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation

Kurkewich, J. L., Boucher, A., Klopfenstein, N., Baskar, R., Kapur, R. & Dahl, R., Jan 1 2018, (Accepted/In press) In : Experimental Hematology.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
MicroRNAs
Cell Differentiation
Knockout Mice
Transplantation
2017
5 Citations (Scopus)

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factors
Interleukin-3
Hematopoiesis
Granulocytes
Experimental Leukemias
2 Citations (Scopus)

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells

Metts, J., Bradley, H. L., Wang, Z., Shah, N. P., Kapur, R., Arbiser, J. L. & Bunting, K. D., Dec 1 2017, In : Scientific Reports. 7, 1, 4447.

Research output: Contribution to journalArticle

Imipramine
Myeloid Cells
Acute Myeloid Leukemia
STAT5 Transcription Factor
NADPH Oxidase
1 Citation (Scopus)

Kinase inhibitors in clinical practice: An expanding world

Pandey, R. & Kapur, R., 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Immune System Diseases
Phosphotransferases
19 Citations (Scopus)

LIM kinases: Cofilin and beyond

Prunier, C., Prudent, R., Kapur, R., Sadoul, K. & Lafanechère, L., 2017, In : Oncotarget. 8, 25, p. 41749-41763 15 p.

Research output: Contribution to journalReview article

Lim Kinases
Actin Depolymerizing Factors
Microtubules
Animal Disease Models
Cytoskeleton
6 Citations (Scopus)

P190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

Hinge, A., Xu, J., Javier, J., Mose, E., Kumar, S., Kapur, R., Srour, E., Malik, P., Aronow, B. J. & Filippi, M. D., Feb 8 2017, In : Nature Communications. 8, 14382.

Research output: Contribution to journalArticle

stem cells
Hematopoietic Stem Cells
stems
p38 Mitogen-Activated Protein Kinases
Cytokines
1 Citation (Scopus)

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice

Chen, S., Gao, R., Kobayashi, M., Yu, H., Yao, C., Kapur, R., Yoder, M. & Liu, Y., Jan 1 2017, In : Experimental Hematology. 45, p. 74-84 11 p.

Research output: Contribution to journalArticle

Human Activities
Pharmacology
Fetal Blood
Hematopoietic Stem Cells
Blood Cells
1 Citation (Scopus)

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Myeloid Cells
Juvenile Myelomonocytic Leukemia
Splenomegaly
B-Cell Chronic Lymphocytic Leukemia
3 Citations (Scopus)

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H., Yoder, M., Kapur, R., Mulloy, J. C., Zhang, Z-Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
6 Citations (Scopus)

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M., Kapur, R., Kaplan, M., Daniel Lacorazza, H., Zhang, Z-Y. & Liu, Y., Apr 1 2017, In : Stem Cells. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Hematopoietic Stem Cells
T-Lymphocytes
Cell Differentiation
Stem Cell Factor
9 Citations (Scopus)

Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia

Ghosh, J. & Kapur, R., Jun 1 2017, In : Experimental Hematology. 50, p. 13-21 9 p.

Research output: Contribution to journalReview article

Hematopoietic Stem Cells
Acute Myeloid Leukemia
Leukemia
Stem Cells
Ribosomal Proteins
5 Citations (Scopus)

Role of SHP2 in hematopoiesis and leukemogenesis

Pandey, R., Saxena, M. & Kapur, R., Mar 16 2017, (Accepted/In press) In : Current Opinion in Hematology.

Research output: Contribution to journalArticle

Hematopoiesis
Non-Receptor Type 11 Protein Tyrosine Phosphatase
src Homology Domains
Receptor Protein-Tyrosine Kinases
Cell Surface Receptors
14 Citations (Scopus)

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Ramadan, A., Griesenauer, B., Adom, D., Kapur, R., Hanenberg, H., Liu, C., Kaplan, M. & Paczesny, S., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3577-3596 20 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Immunity
Graft vs Host Disease
Transplants
Leukemia
2016
12 Citations (Scopus)

LIM kinase inhibitor Pyr1 reduces the growth and metastatic load of breast cancers

Prunier, C., Josserand, V., Vollaire, J., Beerling, E., Petropoulos, C., Destaing, O., Montemagno, C., Hurbin, A., Prudent, R., De Koning, L., Kapur, R., Cohen, P. A., Albiges-Rizo, C., Coll, J. L., Van Rheenen, J., Billaud, M. & Lafanechère, L., Jun 15 2016, In : Cancer Research. 76, 12, p. 3541-3552 12 p.

Research output: Contribution to journalArticle

Lim Kinases
Breast Neoplasms
Growth
Microtubules
Neoplasms

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J. & Kapur, R., Dec 1 2016, In : Current Stem Cell Reports. 2, 4, p. 368-378 11 p.

Research output: Contribution to journalReview article

1-Phosphatidylinositol 4-Kinase
Hematopoietic Stem Cells
Leukemia
Stem Cells
Maintenance
5 Citations (Scopus)

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

Lim Kinases
Mast Cells
Actins
Growth
Bone Marrow
4 Citations (Scopus)

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

Phagocytosis
Reactive Oxygen Species
Neutrophils
Complement Receptors
Methicillin Resistance
14 Citations (Scopus)

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6 Kinases
Hematopoietic Stem Cells
Leukemia
Maintenance
Oncogene Fusion
21 Citations (Scopus)

Sepsis induces hematopoietic stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88

Zhang, H., Rodriguez, S., Wang, L., Wang, S., Serezani, H., Kapur, R., Cardoso, A. A. & Carlesso, N., Jun 14 2016, In : Stem Cell Reports. 6, 6, p. 940-956 17 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Toll-Like Receptor 4
Sepsis
Chemical activation
6 Citations (Scopus)

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z-Y., Boswell, H., Kapur, R. & Chan, R., Jun 3 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Phosphoric Monoester Hydrolases
Acute Myeloid Leukemia
Syk Kinase
3 Citations (Scopus)

Targeting LIM kinases in taxane resistant tumors

Prunier, C., Kapur, R. & Lafanechère, L., Aug 1 2016, In : Oncotarget. 7, 32, p. 50816-50817 2 p.

Research output: Contribution to journalEditorial

Lim Kinases
Neoplasms
taxane
2015
9 Citations (Scopus)

Bmi1 promotes erythroid development through regulating ribosome biogenesis

Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M., Wek, R., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : Stem Cells. 33, 3, p. 925-938 14 p.

Research output: Contribution to journalArticle

Diamond-Blackfan Anemia
Ribosomes
Erythroid Precursor Cells
Ribosomal Proteins
Hematopoietic Stem Cells
105 Citations (Scopus)

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Broustovetski, N., Srour, E., Lee, M. R., Messina-Graham, S., Haas, D., Falah, N., Kapur, R., Pelus, L., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Stem cells
Shock
Oxygen
2 Citations (Scopus)

Erratum: Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of rho-associated kinase via the Cxcl12/Cxcr4 signaling axis (Journal of Biological Chemistry)

Onishi, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28356 1 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Genes
Proteins
10 Citations (Scopus)

Mastocytosis- a mutated KIT receptor induced myeloproliferative disorder

Chatterjee, A., Ghosh, J. & Kapur, R., 2015, In : Oncotarget. 6, 21, p. 18250-18264 15 p.

Research output: Contribution to journalArticle

Mastocytosis
Myeloproliferative Disorders
Mutation
Epigenomics
Systemic Mastocytosis
7 Citations (Scopus)

Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation

Bessler, W. K., Kim, G., Hudson, F. Z., Mund, J. A., Mali, R., Menon, K., Kapur, R., Clapp, D., Ingram, D. & Stansfield, B. K., Aug 17 2015, In : Human Molecular Genetics. 25, 6, p. 1129-1139 11 p., ddv635.

Research output: Contribution to journalArticle

Neointima
Chemokine CCL2
Neurofibromatosis 1
Monocytes
Macrophages
57 Citations (Scopus)

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Zhang, J., Ramadan, A. M., Griesenauer, B., Li, W., Turner, M. J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B. R., Tawara, I. & Paczesny, S., Oct 7 2015, In : Science Translational Medicine. 7, 308, 308ra160.

Research output: Contribution to journalArticle

Graft vs Host Disease
T-Lymphocytes
Membranes
Interleukin-17
Interleukin-23
9 Citations (Scopus)

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms

Pandey, R. & Kapur, R., Jun 11 2015, In : Molecular Cancer. 14, 1, 118.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Protein-Tyrosine Kinases
Mutation
Neoplasms
Phosphotransferases
2014
36 Citations (Scopus)

Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development

Kobayashi, M., Shelley, W. C., Seo, W., Vemula, S., Lin, Y., Liu, Y., Kapur, R., Taniuchi, I. & Yoshimoto, M., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12151-12156 6 p.

Research output: Contribution to journalArticle

Core Binding Factor beta Subunit
B-Lymphoid Precursor Cells
Hematopoietic Stem Cells
Embryonic Structures
Liver
8 Citations (Scopus)

Global microRNA expression is essential for murine mast cell development invivo

Oh, S. Y., Brandal, S., Kapur, R., Zhu, Z. & Takemoto, C. M., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 919-923 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Mast Cells
Immunoglobulin E
Ribonuclease III
Connective Tissue Cells
4 Citations (Scopus)

Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the rho-associated kinase via the Cxcl12/Cxcr4 signaling axis

Onish, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 7 2014, In : Journal of Biological Chemistry. 289, 45, p. 31053-31065 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Chemotaxis
Down-Regulation
Genes
Mutation
91 Citations (Scopus)

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamocka, M., Mu, J., Chen, D. Z., Srour, E., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T., Boswell, H., Manshouri, T., Verstovsek, S., Yoder, M., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

Hematopoiesis
Bone Marrow
Cytokines
Myeloproliferative Disorders
MicroRNAs
10 Citations (Scopus)

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Sharma, N., Everingham, S., Zeng, L. F., Zhang, Z-Y., Kapur, R. & Craig, A. W. B., 2014, In : Oncotarget. 5, 15, p. 6130-6141 12 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Systemic Mastocytosis
Disease Progression
Cell Survival
Mast-Cell Leukemia
20 Citations (Scopus)

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

Juvenile Myelomonocytic Leukemia
Phosphatidylinositol 3-Kinase
Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Catalytic Domain
21 Citations (Scopus)

PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal

Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L., Yoder, M., Kapur, R., Zhang, Z-Y. & Liu, Y., 2014, In : Stem Cells. 32, 7, p. 1956-1967 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Phosphoric Monoester Hydrolases
Stem Cell Factor
Protein Tyrosine Phosphatases
Cell Proliferation
12 Citations (Scopus)

Ras-mek-erk signaling regulates Nf1 heterozygous neointima formation

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B. D., Kapur, R. & Ingram, D., Jan 2014, In : American Journal of Pathology. 184, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

Neointima
Neurofibromatosis 1
Neurofibromin 1
Tunica Intima
Phosphotransferases
24 Citations (Scopus)

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H., Liu, Y., Chan, R. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Chemical activation
Transcription
Acute Myeloid Leukemia
Neoplasms
17 Citations (Scopus)

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS One. 9, 3, e90758.

Research output: Contribution to journalArticle

doxorubicin
Doxorubicin
protective effect
reactive oxygen species
Reactive Oxygen Species
6 Citations (Scopus)

Role of Rho kinases in abnormal and normal hematopoiesis

Mali, R. S., Kapur, S. & Kapur, R., 2014, In : Current Opinion in Hematology. 21, 4, p. 271-275 5 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Hematopoiesis
Lim Kinases
Myosin-Light-Chain Phosphatase
Growth
7 Citations (Scopus)

SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis

Sharma, N., Everingham, S., Ramdas, B., Kapur, R. & Craig, A. W. B., May 15 2014, In : Journal of Immunology. 192, 10, p. 4859-4866 8 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Stem Cell Factor
Chemotaxis
Mast Cells
Phosphorylation
48 Citations (Scopus)

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R., Kapur, R., Wells, C. & Zhang, Z-Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Carboxylic Acids
Leukemia
SH2 Domain-Containing Protein Tyrosine Phosphatases
Breast Neoplasms