Reuben Kapur

  • 4551 Citations
  • 35 h-Index
1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

1991

Analysis of an evolutionarily-conserved function-associated molecule (FAM) on murine natural killer (NK) cells

Acevedo, A., Kapur, R. & Harris, D. T., Jan 1 1991, In : Developmental and Comparative Immunology. 15, SUPPL. 1, p. S106

Research output: Contribution to journalArticle

1992

A species-conserved NK cell antigen receptor is a novel vimentin-like molecule

Harris, D. T., Kapur, R., Frye, C., Acevedo, A., Camenisch, T., Jaso-Friedmann, L. & Evans, D. L., Jan 1 1992, In : Developmental and Comparative Immunology. 16, 5, p. 395-403 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
1994

Evolutionary Conservation of a Human Function‐Associated Molecule on Murine Natural Killer Cells: Expression and Function

KAPUR, R., EVANS, D. L. & HARRIS, D. T., Jul 1994, In : Scandinavian Journal of Immunology. 40, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
1995

An evolutionary conserved target cell antigen along with MHC class I molecules influences susceptibility to murine NK cell lysis

Kapur, R., Evans, D. L. & Harris, D. T., Jan 1 1995, In : Developmental and Comparative Immunology. 19, 4, p. 347-355 9 p.

Research output: Contribution to journalArticle

1996
1 Scopus citations

Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations

Majumdar, M. K., Everett, E. T., Xiao, X., Cooper, R., Langley, K., Kapur, R., Vik, T. & Williams, D. A., Apr 15 1996, In : Blood. 87, 8, p. 3203-3211 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
1997

Overexpression of human stem cell factor impairs melanocyte, mast cell, and thymocyte development: A role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation

Kapur, R., Everett, E. T., Uffman, J., McAndrews-Hill, M., Cooper, R., Ryder, J., Vik, T. & Williams, D. A., Oct 15 1997, In : Blood. 90, 8, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
33 Scopus citations
1998

Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor kinase: Genetic evidence for a differential role in erythropoiesis

Kapur, R., Majumdar, M., Xiao, X., McAndrews-Hill, M., Schindler, K. & Williams, D. A., Feb 1 1998, In : Blood. 91, 3, p. 879-889 11 p.

Research output: Contribution to journalArticle

68 Scopus citations
1999

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

Roberts, A. W., Chaekyun, K., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., Atkinson, S. J., Dinauer, M. C. & Williams, D. A., Feb 1999, In : Immunity. 10, 2, p. 183-196 14 p.

Research output: Contribution to journalArticle

Open Access
452 Scopus citations

The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(117H) mice

Kapur, R., Cooper, R., Xiao, X., Weiss, M. J., Donovan, P. & Williams, D. A., Sep 15 1999, In : Blood. 94, 6, p. 1915-1925 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2000

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F. C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., Jan 1 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations
2001
59 Scopus citations
75 Scopus citations
2002

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F. C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor

Kapur, R., Chandra, S., Cooper, R., McCarthy, J. & Williams, D. A., Aug 15 2002, In : Blood. 100, 4, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations
45 Scopus citations
2003

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype

Chandra, S., Kapur, R., Chuzhanova, N., Summey, V., Prentice, D., Barker, J., Cooper, D. N. & Williams, D. A., Nov 15 2003, In : Blood. 102, 10, p. 3548-3555 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
25 Scopus citations

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F. C., White, H., Wenning, M. J., Orazi, A., Yoder, M. C., Kapur, R. & Ingram, D. A., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genetic evidence for convergence of c-Kit- and α4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

Tan, B. L., Yazicioglu, M. N., Ingram, D., McCarthy, J., Borneo, J., Williams, D. A. & Kapur, R., Jun 15 2003, In : Blood. 101, 12, p. 4725-4732 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F. C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 1 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

153 Scopus citations

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R. J., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M. C., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

c-Kit-Mediated Overlapping and Unique Functional and Biochemical Outcomes via Diverse Signaling Pathways

Hong, L., Munugalavadla, V. & Kapur, R., Feb 1 2004, In : Molecular and cellular biology. 24, 3, p. 1401-1410 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Hiatt, K., Ingram, D. A., Huddleston, H., Spandau, D. F., Kapur, R. & Clapp, D. W., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2005

Enhanced TNF-α-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Werne, A., McKenzie, K. A. W., Kapur, R., Ichijo, H. & Haneline, L. S., Dec 15 2005, In : Blood. 106, 13, p. 4124-4130 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Chan, R. J., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.

Research output: Contribution to journalArticle

121 Scopus citations

K-Ras is essential for normal fetal liver erythropoiesis

Khalaf, W. F., White, H., Wenning, M. J., Orazi, A., Kapur, R. & Ingram, D. A., May 1 2005, In : Blood. 105, 9, p. 3538-3541 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration

Munugalavadla, V., Borneo, J., Ingram, D. A. & Kapur, R., Jul 1 2005, In : Blood. 106, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Repression of c-Kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation

Munugalavadla, V., Dore, L. C., Tan, B. L., Hong, L., Vishnu, M., Weiss, M. J. & Kapur, R., Aug 1 2005, In : Molecular and cellular biology. 25, 15, p. 6747-6759 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Role of c-Kit and erythropoietin receptor in erythropoiesis

Munugalavadla, V. & Kapur, R., Apr 2005, In : Critical Reviews in Oncology/Hematology. 54, 1, p. 63-75 13 p.

Research output: Contribution to journalReview article

93 Scopus citations
2006

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Li, B., Jia, N., Kapur, R. & Chun, K. T., Jun 1 2006, In : Blood. 107, 11, p. 4291-4299 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L. S., White, H., Yang, F. C., Chen, S., Orschell, C., Kapur, R. & Ingram, D. A., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F. C., Oct 1 2006, In : Human molecular genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Regulation of Th2 cytokine expression in NKT cells: Unconventional use of Stat6, GATA-3, and NFAT2

Wang, Z. Y., Kusam, S., Munugalavadla, V., Kapur, R., Brutkiewicz, R. R. & Dent, A. L., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 880-888 9 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Kapur, R., Belladonna, M. L., Kansas, G. S. & Kaplan, M. H., Sep 1 2006, In : Blood. 108, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

122 Scopus citations
2007
29 Scopus citations

IL-4-stimulated NF-κB activity is required for Stat6 DNA binding

Thieu, V. T., Nguyen, E. T., McCarthy, B. P., Bruns, H. A., Kapur, R., Chang, C. H. & Kaplan, M. H., Aug 1 2007, In : Journal of Leukocyte Biology. 82, 2, p. 370-379 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells

Samayawardhena, L. A., Kapur, R. & Craig, A. W. B., May 1 2007, In : Blood. 109, 9, p. 3679-3686 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8322-8331 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors

Borneo, J., Munugalavadla, V., Sims, E. C., Vemula, S., Orschell, C. M., Yoder, M. & Kapur, R., Jul 1 2007, In : Experimental Hematology. 35, 7, p. 1026-1037 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Stat3 and Stat4 direct development of IL-17-secreting Th cells

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O'Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S. & Kaplan, M. H., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4901-4907 7 p.

Research output: Contribution to journalArticle

Open Access
409 Scopus citations
2008

Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells

Orschell, C. M., Borneo, J., Munugalavadla, V., Ma, P., Sims, E., Ramdas, B., Yoder, M. C. & Kapur, R., May 1 2008, In : Experimental Hematology. 36, 5, p. 655-666 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F. C., Jun 15 2008, In : Human molecular genetics. 17, 12, 1 p.

Research output: Contribution to journalComment/debate

KIT associated intracellular tyrosines play an essential role in EpoR co-signaling

Hong, L., Ramdas, B., Chen, J., Harris, C., Wojchowski, D. M. & Kapur, R., Aug 1 2008, In : Cellular Signalling. 20, 8, p. 1513-1520 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins (Journal of Immunology (2007) 179 (8322-8331))

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Mar 1 2008, In : Journal of Immunology. 180, 5, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R. J., Lenz, S. D. & Kapur, R., Mar 1 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F. C. & Kapur, R., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

28 Scopus citations
2009

Distinct roles of stress-activated protein kinases in fanconi anemia type C deficient hematopoiesis

Saadatzadeh, M. R., Bijangi-Vishehsaraei, K., Kapur, R. & Haneline, L. S., Mar 19 2009, In : Blood. 113, 12, p. 2655-2660 6 p.

Research output: Contribution to journalArticle

16 Scopus citations