Reuben Kapur

  • 4635 Citations
  • 36 h-Index
1991 …2020

Research output per year

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Publications

2010

Essential role for focal adhesion kinase in regulating stress hematopoiesis

Vemula, S., Ramdas, B., Hanneman, P., Martin, J., Beggs, H. E. & Kapur, R., Nov 18 2010, In : Blood. 116, 20, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Lasater, E. A., Li, F., Bessler, W. K., Estes, M. L., Vemula, S., Hingtgen, C. M., Dinauer, M. C., Kapur, R., Conway, S. J. & Ingram, D. A., Mar 1 2010, In : Journal of Clinical Investigation. 120, 3, p. 859-870 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 1 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

86 Scopus citations
2011

Balanced interactions between Lyn, the p85α Regulatory Subunit of Class I A phosphatidylinositol-3-kinase, and SHIP Are essential for mast cell growth and maturation

Ma, P., Vemula, S., Munugalavadla, V., Chen, J., Sims, E., Borneo, J., Kondo, T., Ramdas, B., Mali, R. S., Li, S., Hashino, E., Takemoto, C. & Kapur, R., Oct 1 2011, In : Molecular and cellular biology. 31, 19, p. 4052-4062 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Lee, Y. N., Brandal, S., Noel, P., Wentzel, E., Mendell, J. T., McDevitt, M. A., Kapur, R., Carter, M., Metcalfe, D. D. & Takemoto, C. M., Mar 31 2011, In : Blood. 117, 13, p. 3629-3640 12 p.

Research output: Contribution to journalArticle

46 Scopus citations
27 Scopus citations

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F. C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Class i A pi3kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes

Krishnan, S., Mali, R. S., Koehler, K. R., Vemula, S., Chatterjee, A., Ghosh, J., Ramdas, B., Ma, P., Hashino, E. & Kapur, R., Jan 4 2012, In : PLoS ONE. 7, 1, e28979.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

89 Scopus citations

Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J. S., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

P85β regulatory subunit of class I A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Krishnan, S., Mali, R. S., Ramdas, B., Sims, E., Ma, P., Ghosh, J., Munugalavadla, V., Hanneman, P., Beane, J. D. & Kapur, R., Apr 19 2012, In : Blood. 119, 17, p. 3951-3961 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R. R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease

Ma, P., Mali, R. S., Martin, H., Ramdas, B., Sims, E. & Kapur, R., Jul 2012, In : Leukemia. 26, 7, p. 1499-1506 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R. J., Zhang, Z. Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L. F., Zhang, Z. Y., Feng, G. S., Hartmann, K., Roers, A. & Craig, A. W. B., Jul 1 2012, In : Molecular and cellular biology. 32, 14, p. 2653-2663 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis

Traina, F., Visconte, V., Jankowska, A. M., Makishima, H., O'Keefe, C. L., Elson, P., Han, Y., Hsieh, F. H., Sekeres, M. A., Mali, R. S., Kalaycio, M., Lichtin, A. E., Advani, A. S., Duong, H. K., Copelan, E., Kapur, R., Olalla Saad, S. T., Maciejewski, J. P. & Tiu, R. V., Aug 15 2012, In : PloS one. 7, 8, e43090.

Research output: Contribution to journalArticle

65 Scopus citations

Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms

Mali, R. S. & Kapur, R., Sep 2012, In : Oncotarget. 3, 9, p. 909-910 2 p.

Research output: Contribution to journalEditorial

Open Access
5 Scopus citations

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., Jan 1 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalEditorial

Open Access
2 Scopus citations

The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells

Ruschmann, J., Antignano, F., Lam, V., Snyder, K., Kim, C., Essak, M., Zhang, A., Lin, A. H. A., Mali, R. S., Kapur, R. & Krystal, G., Apr 15 2012, In : Journal of Immunology. 188, 8, p. 3839-3850 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 1 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journalArticle

94 Scopus citations

Heterozygous inactivation of the NF1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B., Li, F., Sarchet, K. N., DiStasi, M. R., Conway, S. J., Kapur, R. & Ingram, D. A., Mar 1 2013, In : Human molecular genetics. 22, 5, p. 977-988 12 p., dds502.

Research output: Contribution to journalArticle

11 Scopus citations

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

Martin, H., Mali, R. S., Ma, P., Chatterjee, A., Ramdas, B., Sims, E., Munugalavadla, V., Ghosh, J., Mattingly, R. R., Visconte, V., Tiu, R. V., Vlaar, C. P., Dharmawardhane, S. & Kapur, R., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4449-4463 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z. Y., Kapur, R. & Chan, R. J., Feb 1 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development

Mali, R. S. & Kapur, R., Jan 1 2013, In : Cell Cycle. 12, 1, p. 7-8 2 p.

Research output: Contribution to journalEditorial

2014

Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development

Kobayashi, M., Shelley, W. C., Seo, W., Vemula, S., Lin, Y., Liu, Y., Kapur, R., Taniuchi, I. & Yoshimoto, M., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12151-12156 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Global microRNA expression is essential for murine mast cell development invivo

Oh, S. Y., Brandal, S., Kapur, R., Zhu, Z. & Takemoto, C. M., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 919-923.e1

Research output: Contribution to journalArticle

8 Scopus citations

Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the rho-associated kinase via the Cxcl12/Cxcr4 signaling axis

Onish, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 7 2014, In : Journal of Biological Chemistry. 289, 45, p. 31053-31065 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

108 Scopus citations

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Sharma, N., Everingham, S., Zeng, L. F., Zhang, Z. Y., Kapur, R. & Craig, A. W. B., 2014, In : Oncotarget. 5, 15, p. 6130-6141 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R. J., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal

Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L., Yoder, M. C., Kapur, R., Zhang, Z. Y. & Liu, Y., Jul 2014, In : STEM CELLS. 32, 7, p. 1956-1967 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ras-mek-erk signaling regulates Nf1 heterozygous neointima formation

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B. D., Kapur, R. & Ingram, D. A., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS ONE. 9, 3, e90758.

Research output: Contribution to journalArticle

22 Scopus citations

Role of Rho kinases in abnormal and normal hematopoiesis

Mali, R. S., Kapur, S. & Kapur, R., Jul 2014, In : Current opinion in hematology. 21, 4, p. 271-275 5 p.

Research output: Contribution to journalReview article

7 Scopus citations

SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis

Sharma, N., Everingham, S., Ramdas, B., Kapur, R. & Craig, A. W. B., May 15 2014, In : Journal of Immunology. 192, 10, p. 4859-4866 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D. & Zhang, Z. Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

58 Scopus citations

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

Kumar, S., Xu, J., Kumar, R. S., Lakshmikanthan, S., Kapur, R., Kofron, M., Chrzanowska-Wodnicka, M. & Filippi, M. D., 2014, In : Journal of Experimental Medicine. 211, 9, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

36 Scopus citations
2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis

Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M. C., Wek, R. C., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : STEM CELLS. 33, 3, p. 925-938 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H. E., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

130 Scopus citations

Erratum: Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of rho-associated kinase via the Cxcl12/Cxcr4 signaling axis (Journal of Biological Chemistry)

Onishi, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28356 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mastocytosis- a mutated KIT receptor induced myeloproliferative disorder

Chatterjee, A., Ghosh, J. & Kapur, R., 2015, In : Oncotarget. 6, 21, p. 18250-18264 15 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation

Bessler, W. K., Kim, G., Hudson, F. Z., Mund, J. A., Mali, R., Menon, K., Kapur, R., Clapp, D. W., Ingram, D. A. & Stansfield, B. K., Aug 17 2015, In : Human molecular genetics. 25, 6, p. 1129-1139 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Zhang, J., Ramadan, A. M., Griesenauer, B., Li, W., Turner, M. J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B. R., Tawara, I. & Paczesny, S., Oct 7 2015, In : Science translational medicine. 7, 308, 308ra160.

Research output: Contribution to journalArticle

72 Scopus citations