Reuben Kapur

  • 4635 Citations
  • 36 h-Index
1991 …2020

Research output per year

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Publications

2015

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms

Pandey, R. & Kapur, R., Jun 11 2015, In : Molecular Cancer. 14, 1, 118.

Research output: Contribution to journalReview article

10 Scopus citations
2016

LIM kinase inhibitor Pyr1 reduces the growth and metastatic load of breast cancers

Prunier, C., Josserand, V., Vollaire, J., Beerling, E., Petropoulos, C., Destaing, O., Montemagno, C., Hurbin, A., Prudent, R., De Koning, L., Kapur, R., Cohen, P. A., Albiges-Rizo, C., Coll, J. L., Van Rheenen, J., Billaud, M. & Lafanechère, L., Jun 15 2016, In : Cancer Research. 76, 12, p. 3541-3552 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J. & Kapur, R., Dec 1 2016, In : Current Stem Cell Reports. 2, 4, p. 368-378 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R. J., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sepsis induces hematopoietic stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88

Zhang, H., Rodriguez, S., Wang, L., Wang, S., Serezani, H., Kapur, R., Cardoso, A. A. & Carlesso, N., Jun 14 2016, In : Stem Cell Reports. 6, 6, p. 940-956 17 p.

Research output: Contribution to journalArticle

32 Scopus citations

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Oct 1 2016, In : Leukemia. 30, 10, p. 2094-2097 4 p.

Research output: Contribution to journalLetter

9 Scopus citations

Targeting LIM kinases in taxane resistant tumors

Prunier, C., Kapur, R. & Lafanechère, L., Aug 1 2016, In : Oncotarget. 7, 32, p. 50816-50817 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations
2017

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells

Metts, J., Bradley, H. L., Wang, Z., Shah, N. P., Kapur, R., Arbiser, J. L. & Bunting, K. D., Dec 1 2017, In : Scientific reports. 7, 1, 4447.

Research output: Contribution to journalArticle

4 Scopus citations

LIM kinases: Cofilin and beyond

Prunier, C., Prudent, R., Kapur, R., Sadoul, K. & Lafanechère, L., Jan 1 2017, In : Oncotarget. 8, 25, p. 41749-41763 15 p.

Research output: Contribution to journalReview article

27 Scopus citations

P190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

Hinge, A., Xu, J., Javier, J., Mose, E., Kumar, S., Kapur, R., Srour, E. F., Malik, P., Aronow, B. J. & Filippi, M. D., Feb 8 2017, In : Nature communications. 8, 14382.

Research output: Contribution to journalArticle

11 Scopus citations

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice

Chen, S., Gao, R., Kobayashi, M., Yu, H., Yao, C., Kapur, R., Yoder, M. C. & Liu, Y., Jan 1 2017, In : Experimental Hematology. 45, p. 74-84 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H. S., Yoder, M. C., Kapur, R., Mulloy, J. C., Zhang, Z. Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of mTORC1–S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia

Ghosh, J. & Kapur, R., Jun 2017, In : Experimental Hematology. 50, p. 13-21 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Role of SHP2 in hematopoiesis and leukemogenesis

Pandey, R., Saxena, M. & Kapur, R., Jul 1 2017, In : Current opinion in hematology. 24, 4, p. 307-313 7 p.

Research output: Contribution to journalReview article

14 Scopus citations

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Ramadan, A., Griesenauer, B., Adom, D., Kapur, R., Hanenberg, H., Liu, C., Kaplan, M. H. & Paczesny, S., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3577-3596 20 p.

Research output: Contribution to journalArticle

22 Scopus citations
2018

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Prudent, R., Demoncheaux, N., Diemer, H., Collin-Faure, V., Kapur, R., Paublant, F., Lafanechère, L., Cianférani, S. & Rabilloud, T., Dec 2018, In : PloS one. 13, 12, e0208979.

Research output: Contribution to journalArticle

4 Scopus citations

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

Chen, S., Gao, R., Yao, C., Kobayashi, M., Liu, S. Z., Yoder, M. C., Broxmeyer, H., Kapur, R., Boswell, H. S., Mayo, L. D. & Liu, Y., Mar 1 2018, In : Leukemia. 32, 3, p. 850-854 5 p.

Research output: Contribution to journalLetter

10 Scopus citations

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., Sandusky, G., Mohseni, M., Williams, A., Henao-Mejia, J. & Kapur, R., Dec 6 2018, In : Cell Stem Cell. 23, 6, p. 833-849.e5

Research output: Contribution to journalArticle

40 Scopus citations

Kinase inhibitors in clinical practice: An expanding world

Pandey, R. & Kapur, R., Feb 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 522-524 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI Insight. 3, 4

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M. C., Filippi, M. D., Broxmeyer, H. E. & Kapur, R., Dec 1 2018, In : Nature communications. 9, 1, 3518.

Research output: Contribution to journalArticle

6 Scopus citations

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. J. & Kapur, R., 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation

Kurkewich, J. L., Boucher, A., Klopfenstein, N., Baskar, R., Kapur, R. & Dahl, R., Mar 2018, In : Experimental Hematology. 59, p. 14-29 16 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M. H., Waisman, A., Rad, R., Schotta, G., Huehn, J. & 2 others, Kallies, A. & Korn, T., Feb 12 2019, In : Cell Reports. 26, 7, p. 1854-1868.e5

Research output: Contribution to journalArticle

18 Scopus citations

DNA damage on the DOCK in FLT3-ITD-driven acute myeloid leukemia

Pandey, R. & Kapur, R., 2019, In : Haematologica. 104, 12, p. 2330-2332 3 p.

Research output: Contribution to journalEditorial

Open Access

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H. S., Sandusky, G. E., Mayo, L. D., Kapur, R. & Liu, Y., Jun 1 2019, In : Leukemia. 33, 6, p. 1535-1539 5 p.

Research output: Contribution to journalLetter

5 Scopus citations

Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion

Jiang, J., Srivastava, S., Seim, G., Pavlova, N. N., King, B., Zou, L., Zhang, C., Zhong, M., Feng, H., Kapur, R., Wek, R. C., Fan, J. & Zhang, J., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18674-18684 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations

Pandey, R., Ramdas, B., Wan, C., Sandusky, G., Mohseni, M., Zhang, C. & Kapur, R., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5468-5473 6 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2020

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2020, In : Nature communications. 11, 1, 3856.

Research output: Contribution to journalComment/debate

Open Access

Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia

Burns, S. S. & Kapur, R., Aug 11 2020, In : Stem Cell Reports. 15, 2, p. 279-291 13 p.

Research output: Contribution to journalReview article

Open Access

Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation

Ramdas, B., Mali, R. S., Palam, L. R., Pandey, R., Cai, Z., Pasupuleti, S. K., Burns, S. S. & Kapur, R., Jul 14 2020, In : Stem Cell Reports. 15, 1, p. 95-109 15 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Putative Mechanisms Underlying Cardiovascular Disease Associated with Clonal Hematopoiesis of Indeterminate Potential

Burns, S. S. & Kapur, R., Aug 11 2020, In : Stem Cell Reports. 15, 2, p. 292-306 15 p.

Research output: Contribution to journalReview article

Open Access

Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Cai, Z., Aguilera, F., Ramdas, B., Daulatabad, S. V., Srivastava, R., Kotzin, J. J., Carroll, M., Wertheim, G., Williams, A., Janga, S. C., Zhang, C., Henao-Mejia, J. & Kapur, R., Jun 23 2020, In : Cell Reports. 31, 12, 107816.

Research output: Contribution to journalArticle

Open Access