Reuben Kapur

  • 4635 Citations
  • 36 h-Index
1991 …2020

Research output per year

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Publications

KIT associated intracellular tyrosines play an essential role in EpoR co-signaling

Hong, L., Ramdas, B., Chen, J., Harris, C., Wojchowski, D. M. & Kapur, R., Aug 2008, In : Cellular Signalling. 20, 8, p. 1513-1520 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Lee, Y. N., Brandal, S., Noel, P., Wentzel, E., Mendell, J. T., McDevitt, M. A., Kapur, R., Carter, M., Metcalfe, D. D. & Takemoto, C. M., Mar 31 2011, In : Blood. 117, 13, p. 3629-3640 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

K-Ras is essential for normal fetal liver erythropoiesis

Khalaf, W. F., White, H., Wenning, M. J., Orazi, A., Kapur, R. & Ingram, D. A., May 1 2005, In : Blood. 105, 9, p. 3538-3541 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

LIM kinase inhibitor Pyr1 reduces the growth and metastatic load of breast cancers

Prunier, C., Josserand, V., Vollaire, J., Beerling, E., Petropoulos, C., Destaing, O., Montemagno, C., Hurbin, A., Prudent, R., De Koning, L., Kapur, R., Cohen, P. A., Albiges-Rizo, C., Coll, J. L., Van Rheenen, J., Billaud, M. & Lafanechère, L., Jun 15 2016, In : Cancer Research. 76, 12, p. 3541-3552 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

LIM kinases: Cofilin and beyond

Prunier, C., Prudent, R., Kapur, R., Sadoul, K. & Lafanechère, L., Jan 1 2017, In : Oncotarget. 8, 25, p. 41749-41763 15 p.

Research output: Contribution to journalReview article

27 Scopus citations

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI Insight. 3, 4

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 1 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Hiatt, K., Ingram, D. A., Huddleston, H., Spandau, D. F., Kapur, R. & Clapp, D. W., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F. C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mastocytosis- a mutated KIT receptor induced myeloproliferative disorder

Chatterjee, A., Ghosh, J. & Kapur, R., 2015, In : Oncotarget. 6, 21, p. 18250-18264 15 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H. S., Sandusky, G. E., Mayo, L. D., Kapur, R. & Liu, Y., Jun 1 2019, In : Leukemia. 33, 6, p. 1535-1539 5 p.

Research output: Contribution to journalLetter

5 Scopus citations
27 Scopus citations

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F. C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

154 Scopus citations

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F. C., Oct 1 2006, In : Human molecular genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation

Bessler, W. K., Kim, G., Hudson, F. Z., Mund, J. A., Mali, R., Menon, K., Kapur, R., Clapp, D. W., Ingram, D. A. & Stansfield, B. K., Aug 17 2015, In : Human molecular genetics. 25, 6, p. 1129-1139 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

108 Scopus citations

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Sharma, N., Everingham, S., Zeng, L. F., Zhang, Z. Y., Kapur, R. & Craig, A. W. B., 2014, In : Oncotarget. 5, 15, p. 6130-6141 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Overexpression of human stem cell factor impairs melanocyte, mast cell, and thymocyte development: A role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation

Kapur, R., Everett, E. T., Uffman, J., McAndrews-Hill, M., Cooper, R., Ryder, J., Vik, T. & Williams, D. A., Oct 15 1997, In : Blood. 90, 8, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

P190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

Hinge, A., Xu, J., Javier, J., Mose, E., Kumar, S., Kapur, R., Srour, E. F., Malik, P., Aronow, B. J. & Filippi, M. D., Feb 8 2017, In : Nature communications. 8, 14382.

Research output: Contribution to journalArticle

11 Scopus citations

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M. C., Filippi, M. D., Broxmeyer, H. E. & Kapur, R., Dec 1 2018, In : Nature communications. 9, 1, 3518.

Research output: Contribution to journalArticle

6 Scopus citations

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F. C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration

Munugalavadla, V., Borneo, J., Ingram, D. A. & Kapur, R., Jul 1 2005, In : Blood. 106, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

P85β regulatory subunit of class I A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Krishnan, S., Mali, R. S., Ramdas, B., Sims, E., Ma, P., Ghosh, J., Munugalavadla, V., Hanneman, P., Beane, J. D. & Kapur, R., Apr 19 2012, In : Blood. 119, 17, p. 3951-3961 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

Martin, H., Mali, R. S., Ma, P., Chatterjee, A., Ramdas, B., Sims, E., Munugalavadla, V., Ghosh, J., Mattingly, R. R., Visconte, V., Tiu, R. V., Vlaar, C. P., Dharmawardhane, S. & Kapur, R., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4449-4463 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice

Chen, S., Gao, R., Kobayashi, M., Yu, H., Yao, C., Kapur, R., Yoder, M. C. & Liu, Y., Jan 1 2017, In : Experimental Hematology. 45, p. 74-84 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H. S., Yoder, M. C., Kapur, R., Mulloy, J. C., Zhang, Z. Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R. J., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal

Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L., Yoder, M. C., Kapur, R., Zhang, Z. Y. & Liu, Y., Jul 2014, In : STEM CELLS. 32, 7, p. 1956-1967 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion

Jiang, J., Srivastava, S., Seim, G., Pavlova, N. N., King, B., Zou, L., Zhang, C., Zhong, M., Feng, H., Kapur, R., Wek, R. C., Fan, J. & Zhang, J., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18674-18684 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Putative Mechanisms Underlying Cardiovascular Disease Associated with Clonal Hematopoiesis of Indeterminate Potential

Burns, S. S. & Kapur, R., Aug 11 2020, In : Stem Cell Reports. 15, 2, p. 292-306 15 p.

Research output: Contribution to journalReview article

Open Access

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F. C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., Jan 1 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Open Access
139 Scopus citations

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8322-8331 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins (Journal of Immunology (2007) 179 (8322-8331))

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Mar 1 2008, In : Journal of Immunology. 180, 5, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. J. & Kapur, R., 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Ras-mek-erk signaling regulates Nf1 heterozygous neointima formation

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B. D., Kapur, R. & Ingram, D. A., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J. & Kapur, R., Dec 1 2016, In : Current Stem Cell Reports. 2, 4, p. 368-378 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

Regulation of Th2 cytokine expression in NKT cells: Unconventional use of Stat6, GATA-3, and NFAT2

Wang, Z. Y., Kusam, S., Munugalavadla, V., Kapur, R., Brutkiewicz, R. R. & Dent, A. L., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 880-888 9 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R. R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Repression of c-Kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation

Munugalavadla, V., Dore, L. C., Tan, B. L., Hong, L., Vishnu, M., Weiss, M. J. & Kapur, R., Aug 1 2005, In : Molecular and cellular biology. 25, 15, p. 6747-6759 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R. J., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
33 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS ONE. 9, 3, e90758.

Research output: Contribution to journalArticle

22 Scopus citations

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

86 Scopus citations