Reuben Kapur

Article

Analysis of an evolutionarily-conserved function-associated molecule (FAM) on murine natural killer (NK) cells

Acevedo, A., Kapur, R. & Harris, D. T., Jan 1 1991, In : Developmental and Comparative Immunology. 15, SUPPL. 1, p. S106

Research output: Contribution to journal › Article

An evolutionary conserved target cell antigen along with MHC class I molecules influences susceptibility to murine NK cell lysis

Kapur, R., Evans, D. L. & Harris, D. T., Jan 1 1995, In : Developmental and Comparative Immunology. 19, 4, p. 347-355 9 p.

Research output: Contribution to journal › Article

A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin

Kapur, R. & Zhang, L., Jan 12 2001, In : Journal of Biological Chemistry. 276, 2, p. 1099-1106 8 p.

Research output: Contribution to journal › Article

59 Scopus citations

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Prudent, R., Demoncheaux, N., Diemer, H., Collin-Faure, V., Kapur, R., Paublant, F., Lafanechère, L., Cianférani, S. & Rabilloud, T., Dec 2018, In : PloS one. 13, 12, e0208979.

Research output: Contribution to journal › Article

4 Scopus citations

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype

Chandra, S., Kapur, R., Chuzhanova, N., Summey, V., Prentice, D., Barker, J., Cooper, D. N. & Williams, D. A., Nov 15 2003, In : Blood. 102, 10, p. 3548-3555 8 p.

Research output: Contribution to journal › Article

3 Scopus citations

A species-conserved NK cell antigen receptor is a novel vimentin-like molecule

Harris, D. T., Kapur, R., Frye, C., Acevedo, A., Camenisch, T., Jaso-Friedmann, L. & Evans, D. L., Jan 1 1992, In : Developmental and Comparative Immunology. 16, 5, p. 395-403 9 p.

Research output: Contribution to journal › Article

18 Scopus citations

Balanced interactions between Lyn, the p85α Regulatory Subunit of Class I _A phosphatidylinositol-3-kinase, and SHIP Are essential for mast cell growth and maturation

Ma, P., Vemula, S., Munugalavadla, V., Chen, J., Sims, E., Borneo, J., Kondo, T., Ramdas, B., Mali, R. S., Li, S., Hashino, E., Takemoto, C. & Kapur, R., Oct 1 2011, In : Molecular and cellular biology. 31, 19, p. 4052-4062 11 p.

Research output: Contribution to journal › Article

15 Scopus citations

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M. H., Waisman, A., Rad, R., Schotta, G., Huehn, J. & 2 others, Kallies, A. & Korn, T., Feb 12 2019, In : Cell Reports. 26, 7, p. 1854-1868.e5

Research output: Contribution to journal › Article

18 Scopus citations

Bmi1 promotes erythroid development through regulating ribosome biogenesis

Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M. C., Wek, R. C., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : STEM CELLS. 33, 3, p. 925-938 14 p.

Research output: Contribution to journal › Article

12 Scopus citations

c-Kit-Mediated Overlapping and Unique Functional and Biochemical Outcomes via Diverse Signaling Pathways

Hong, L., Munugalavadla, V. & Kapur, R., Feb 1 2004, In : Molecular and cellular biology. 24, 3, p. 1401-1410 10 p.

Research output: Contribution to journal › Article

51 Scopus citations

Class i _A pi3kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes

Krishnan, S., Mali, R. S., Koehler, K. R., Vemula, S., Chatterjee, A., Ghosh, J., Ramdas, B., Ma, P., Hashino, E. & Kapur, R., Jan 4 2012, In : PLoS ONE. 7, 1, e28979.

Research output: Contribution to journal › Article

6 Scopus citations

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journal › Article

1 Scopus citations

Cross-talk between α₄β₁/α₅β₁ and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways

Kapur, R., Cooper, R., Zhang, L. & Williams, D. A., Apr 1 2001, In : Blood. 97, 7, p. 1975-1981 7 p.

Research output: Contribution to journal › Article

75 Scopus citations

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Li, B., Jia, N., Kapur, R. & Chun, K. T., Jun 1 2006, In : Blood. 107, 11, p. 4291-4299 9 p.

Research output: Contribution to journal › Article

67 Scopus citations

Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells

Orschell, C. M., Borneo, J., Munugalavadla, V., Ma, P., Sims, E., Ramdas, B., Yoder, M. C. & Kapur, R., May 2008, In : Experimental Hematology. 36, 5, p. 655-666 12 p.

Research output: Contribution to journal › Article

11 Scopus citations

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

Roberts, A. W., Chaekyun, K., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., Atkinson, S. J., Dinauer, M. C. & Williams, D. A., Feb 1999, In : Immunity. 10, 2, p. 183-196 14 p.

Research output: Contribution to journal › Article

Open Access

454 Scopus citations

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 1 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journal › Article

94 Scopus citations

Distinct roles of stress-activated protein kinases in fanconi anemia type C deficient hematopoiesis

Saadatzadeh, M. R., Bijangi-Vishehsaraei, K., Kapur, R. & Haneline, L. S., Mar 19 2009, In : Blood. 113, 12, p. 2655-2660 6 p.

Research output: Contribution to journal › Article

16 Scopus citations

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journal › Article

7 Scopus citations

Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation

Ramdas, B., Mali, R. S., Palam, L. R., Pandey, R., Cai, Z., Pasupuleti, S. K., Burns, S. S. & Kapur, R., Jul 14 2020, In : Stem Cell Reports. 15, 1, p. 95-109 15 p.

Research output: Contribution to journal › Article

Open Access

1 Scopus citations

Enhanced TNF-α-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Werne, A., McKenzie, K. A. W., Kapur, R., Ichijo, H. & Haneline, L. S., Dec 15 2005, In : Blood. 106, 13, p. 4124-4130 7 p.

Research output: Contribution to journal › Article

32 Scopus citations

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H. E., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journal › Article

130 Scopus citations

Erratum: Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of rho-associated kinase via the Cxcl12/Cxcr4 signaling axis (Journal of Biological Chemistry)

Onishi, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28356 1 p.

Research output: Contribution to journal › Article

3 Scopus citations

Essential role for focal adhesion kinase in regulating stress hematopoiesis

Vemula, S., Ramdas, B., Hanneman, P., Martin, J., Beggs, H. E. & Kapur, R., Nov 18 2010, In : Blood. 116, 20, p. 4103-4115 13 p.

Research output: Contribution to journal › Article

27 Scopus citations

Evolutionary Conservation of a Human Function‐Associated Molecule on Murine Natural Killer Cells: Expression and Function

KAPUR, R., EVANS, D. L. & HARRIS, D. T., Jul 1994, In : Scandinavian Journal of Immunology. 40, 1, p. 50-56 7 p.

Research output: Contribution to journal › Article

4 Scopus citations

Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit: Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor

Tan, B. L., Hong, L., Munugalavadla, V. & Kapur, R., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11686-11695 10 p.

Research output: Contribution to journal › Article

25 Scopus citations

Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development

Kobayashi, M., Shelley, W. C., Seo, W., Vemula, S., Lin, Y., Liu, Y., Kapur, R., Taniuchi, I. & Yoshimoto, M., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12151-12156 6 p.

Research output: Contribution to journal › Article

42 Scopus citations

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F-C., White, H., Wenning, M. J., Orazi, A., Yoder, M. C., Kapur, R. & Ingram, D. A., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journal › Article

27 Scopus citations

Genetically modified hematopoietic stem cells expressing o⁶methylguanine dna methyltransferase via a retrovirus vector protect the lymphoid and stem cell compartments in long-term engrafted animals treated with nitrosourea

Maze, R., Kapur, R. & Williams, D. A., Jan 1 1996, In : Journal of Investigative Medicine. 44, 3, p. 318a

Research output: Contribution to journal › Article

1 Scopus citations

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Lasater, E. A., Li, F., Bessler, W. K., Estes, M. L., Vemula, S., Hingtgen, C. M., Dinauer, M. C., Kapur, R., Conway, S. J. & Ingram, D. A., Mar 1 2010, In : Journal of Clinical Investigation. 120, 3, p. 859-870 12 p.

Research output: Contribution to journal › Article

51 Scopus citations

Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis

Munugalavadla, V., Sims, E. C., Borneo, J., Chan, R. J. & Kapur, R., Sep 1 2007, In : Blood. 110, 5, p. 1612-1620 9 p.

Research output: Contribution to journal › Article

29 Scopus citations

Genetic evidence for convergence of c-Kit- and α₄ integrin-mediated signals on class I_A PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

Tan, B. L., Yazicioglu, M. N., Ingram, D., McCarthy, J., Borneo, J., Williams, D. A. & Kapur, R., Jun 15 2003, In : Blood. 101, 12, p. 4725-4732 8 p.

Research output: Contribution to journal › Article

60 Scopus citations

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journal › Article

8 Scopus citations

Genetic reduction of class I_a PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L. S., White, H., Yang, F-C., Chen, S., Orschell, C., Kapur, R. & Ingram, D. A., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journal › Article

25 Scopus citations

Global microRNA expression is essential for murine mast cell development invivo

Oh, S. Y., Brandal, S., Kapur, R., Zhu, Z. & Takemoto, C. M., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 919-923.e1

Research output: Contribution to journal › Article

8 Scopus citations

Heterozygous inactivation of the NF1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B., Li, F., Sarchet, K. N., DiStasi, M. R., Conway, S. J., Kapur, R. & Ingram, D. A., Mar 1 2013, In : Human molecular genetics. 22, 5, p. 977-988 12 p., dds502.

Research output: Contribution to journal › Article

11 Scopus citations

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Chan, R. J., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.

Research output: Contribution to journal › Article

121 Scopus citations

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journal › Article

89 Scopus citations

IL-4-stimulated NF-κB activity is required for Stat6 DNA binding

Thieu, V. T., Nguyen, E. T., McCarthy, B. P., Bruns, H. A., Kapur, R., Chang, C. H. & Kaplan, M. H., Aug 1 2007, In : Journal of Leukocyte Biology. 82, 2, p. 370-379 10 p.

Research output: Contribution to journal › Article

22 Scopus citations

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells

Metts, J., Bradley, H. L., Wang, Z., Shah, N. P., Kapur, R., Arbiser, J. L. & Bunting, K. D., Dec 1 2017, In : Scientific reports. 7, 1, 4447.

Research output: Contribution to journal › Article

4 Scopus citations

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., Sandusky, G., Mohseni, M., Williams, A., Henao-Mejia, J. & Kapur, R., Dec 6 2018, In : Cell Stem Cell. 23, 6, p. 833-849.e5

Research output: Contribution to journal › Article

40 Scopus citations

Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J. S., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.

Research output: Contribution to journal › Article

57 Scopus citations

Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the rho-associated kinase via the Cxcl12/Cxcr4 signaling axis

Onish, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 7 2014, In : Journal of Biological Chemistry. 289, 45, p. 31053-31065 13 p.

Research output: Contribution to journal › Article

7 Scopus citations

Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells

Samayawardhena, L. A., Kapur, R. & Craig, A. W. B., May 1 2007, In : Blood. 109, 9, p. 3679-3686 8 p.

Research output: Contribution to journal › Article

56 Scopus citations

KIT associated intracellular tyrosines play an essential role in EpoR co-signaling

Hong, L., Ramdas, B., Chen, J., Harris, C., Wojchowski, D. M. & Kapur, R., Aug 2008, In : Cellular Signalling. 20, 8, p. 1513-1520 8 p.

Research output: Contribution to journal › Article

9 Scopus citations

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Lee, Y. N., Brandal, S., Noel, P., Wentzel, E., Mendell, J. T., McDevitt, M. A., Kapur, R., Carter, M., Metcalfe, D. D. & Takemoto, C. M., Mar 31 2011, In : Blood. 117, 13, p. 3629-3640 12 p.

Research output: Contribution to journal › Article

46 Scopus citations

K-Ras is essential for normal fetal liver erythropoiesis

Khalaf, W. F., White, H., Wenning, M. J., Orazi, A., Kapur, R. & Ingram, D. A., May 1 2005, In : Blood. 105, 9, p. 3538-3541 4 p.

Research output: Contribution to journal › Article

21 Scopus citations

LIM kinase inhibitor Pyr1 reduces the growth and metastatic load of breast cancers

Prunier, C., Josserand, V., Vollaire, J., Beerling, E., Petropoulos, C., Destaing, O., Montemagno, C., Hurbin, A., Prudent, R., De Koning, L., Kapur, R., Cohen, P. A., Albiges-Rizo, C., Coll, J. L., Van Rheenen, J., Billaud, M. & Lafanechère, L., Jun 15 2016, In : Cancer Research. 76, 12, p. 3541-3552 12 p.

Research output: Contribution to journal › Article

17 Scopus citations

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway

Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI Insight. 3, 4

Research output: Contribution to journal › Article

Open Access

3 Scopus citations

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E. A., Goebl, M. G., Yang, F-C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. W. & Harrington, M. A., Feb 1 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journal › Article

4 Scopus citations