Research Output per year
Publications 1991 2019
- 1 - 50 out of 131 results
- Type (ascending)
Analysis of an evolutionarily-conserved function-associated molecule (FAM) on murine natural killer (NK) cells
Acevedo, A., Kapur, R. & Harris, D. T., 1991, In : Developmental and Comparative Immunology. 15, SUPPL. 1Research output: Contribution to journal › Article
An evolutionary conserved target cell antigen along with MHC class I molecules influences susceptibility to murine NK cell lysis
Kapur, R., Evans, D. L. & Harris, D. T., 1995, In : Developmental and Comparative Immunology. 19, 4, p. 347-355 9 p.Research output: Contribution to journal › Article
A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin
Kapur, R. & Zhang, L., Jan 12 2001, In : Journal of Biological Chemistry. 276, 2, p. 1099-1106 8 p.Research output: Contribution to journal › Article
A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1
Prudent, R., Demoncheaux, N., Diemer, H., Collin-Faure, V., Kapur, R., Paublant, F., Lafanechère, L., Cianférani, S. & Rabilloud, T., Dec 1 2018, In : PLoS One. 13, 12, e0208979.Research output: Contribution to journal › Article
A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype
Chandra, S., Kapur, R., Chuzhanova, N., Summey, V., Prentice, D., Barker, J., Cooper, D. N. & Williams, D. A., Nov 15 2003, In : Blood. 102, 10, p. 3548-3555 8 p.Research output: Contribution to journal › Article
A species-conserved NK cell antigen receptor is a novel vimentin-like molecule
Harris, D. T., Kapur, R., Frye, C., Acevedo, A., Camenisch, T., Jaso-Friedmann, L. & Evans, D. L., 1992, In : Developmental and Comparative Immunology. 16, 5, p. 395-403 9 p.Research output: Contribution to journal › Article
Balanced interactions between Lyn, the p85α Regulatory Subunit of Class I A phosphatidylinositol-3-kinase, and SHIP Are essential for mast cell growth and maturation
Ma, P., Vemula, S., Munugalavadla, V., Chen, J., Sims, E., Borneo, J., Kondo, T., Ramdas, B., Mali, R. S., Li, S., Hashino, E., Takemoto, C. & Kapur, R., Oct 2011, In : Molecular and Cellular Biology. 31, 19, p. 4052-4062 11 p.Research output: Contribution to journal › Article
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M., Waisman, A., Rad, R., Schotta, G., Huehn, J. & 2 others, , Feb 12 2019, In : Cell Reports. 26, 7, p. 1854-1868.e5Research output: Contribution to journal › Article
Bmi1 promotes erythroid development through regulating ribosome biogenesis
Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M., Wek, R., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : Stem Cells. 33, 3, p. 925-938 14 p.Research output: Contribution to journal › Article
c-Kit-Mediated Overlapping and Unique Functional and Biochemical Outcomes via Diverse Signaling Pathways
Hong, L., Munugalavadla, V. & Kapur, R., Feb 2004, In : Molecular and Cellular Biology. 24, 3, p. 1401-1410 10 p.Research output: Contribution to journal › Article
Class i A pi3kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes
Krishnan, S., Mali, R. S., Koehler, K. R., Vemula, S., Chatterjee, A., Ghosh, J., Ramdas, B., Ma, P., Hashino, E. & Kapur, R., Jan 4 2012, In : PLoS One. 7, 1, e28979.Research output: Contribution to journal › Article
Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML
Sayar, H., Liu, Y., Gao, R., Zaid, M. A., Cripe, L., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., Jan 1 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.Research output: Contribution to journal › Article
Cross-talk between α4β1/α5β1 and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways
Kapur, R., Cooper, R., Zhang, L. & Williams, D. A., Apr 1 2001, In : Blood. 97, 7, p. 1975-1981 7 p.Research output: Contribution to journal › Article
Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
Li, B., Jia, N., Kapur, R. & Chun, K., Jun 1 2006, In : Blood. 107, 11, p. 4291-4299 9 p.Research output: Contribution to journal › Article
Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells
Orschell, C., Borneo, J., Munugalavadla, V., Ma, P., Sims, E., Ramdas, B., Yoder, M. & Kapur, R., May 2008, In : Experimental Hematology. 36, 5, p. 655-666 12 p.Research output: Contribution to journal › Article
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
Roberts, A. W., Chaekyun, K., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., Atkinson, S. J., Dinauer, M. C. & Williams, D. A., Feb 1999, In : Immunity. 10, 2, p. 183-196 14 p.Research output: Contribution to journal › Article
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment
Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 2013, In : Cell Death and Disease. 4, 2Research output: Contribution to journal › Article
Distinct roles of stress-activated protein kinases in fanconi anemia type C deficient hematopoiesis
Saadatzadeh, M. R., Bijangi-Vishehsaraei, K., Kapur, R. & Haneline, L., Mar 19 2009, In : Blood. 113, 12, p. 2655-2660 6 p.Research output: Contribution to journal › Article
DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms
O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.Research output: Contribution to journal › Article
Enhanced TNF-α-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1
Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Werne, A., McKenzie, K. A. W., Kapur, R., Ichijo, H. & Haneline, L., Dec 15 2005, In : Blood. 106, 13, p. 4124-4130 7 p.Research output: Contribution to journal › Article
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock
Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Broustovetski, N., Srour, E., Lee, M. R., Messina-Graham, S., Haas, D., Falah, N., Kapur, R., Pelus, L., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.Research output: Contribution to journal › Article
Erratum: Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of rho-associated kinase via the Cxcl12/Cxcr4 signaling axis (Journal of Biological Chemistry)
Onishi, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28356 1 p.Research output: Contribution to journal › Article
Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)
Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Kapur, R., Chan, R. & Yang, F. C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.Research output: Contribution to journal › Article
Essential role for focal adhesion kinase in regulating stress hematopoiesis
Vemula, S., Ramdas, B., Hanneman, P., Martin, J., Beggs, H. E. & Kapur, R., Nov 18 2010, In : Blood. 116, 20, p. 4103-4115 13 p.Research output: Contribution to journal › Article
Evolutionary Conservation of a Human Function‐Associated Molecule on Murine Natural Killer Cells: Expression and Function
Kapur, R., EVANS, D. L. & HARRIS, D. T., Jan 1 1994, In : Scandinavian Journal of Immunology. 40, 1, p. 50-56 7 p.Research output: Contribution to journal › Article
Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit: Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor
Tan, B. L., Hong, L., Munugalavadla, V. & Kapur, R., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11686-11695 10 p.Research output: Contribution to journal › Article
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development
Kobayashi, M., Shelley, W. C., Seo, W., Vemula, S., Lin, Y., Liu, Y., Kapur, R., Taniuchi, I. & Yoshimoto, M., Aug 19 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 33, p. 12151-12156 6 p.Research output: Contribution to journal › Article
Functional p85α gene is required for normal murine fetal erythropoiesis
Huddleston, H., Tan, B., Yang, F. C., White, H., Wenning, M. J., Orazi, A., Yoder, M., Kapur, R. & Ingram, D., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.Research output: Contribution to journal › Article
Genetically modified hematopoietic stem cells expressing o6methylguanine dna methyltransferase via a retrovirus vector protect the lymphoid and stem cell compartments in long-term engrafted animals treated with nitrosourea
Maze, R., Kapur, R. & Williams, D. A., 1996, In : Journal of Investigative Medicine. 44, 3Research output: Contribution to journal › Article
Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans
Lasater, E. A., Li, F., Bessler, W. K., Estes, M. L., Vemula, S., Hingtgen, C. M., Dinauer, M. C., Kapur, R., Conway, S. & Ingram, D., Mar 1 2010, In : Journal of Clinical Investigation. 120, 3, p. 859-870 12 p.Research output: Contribution to journal › Article
Genetic and pharmacologic evidence implicating the p85α, but not p85β, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis
Munugalavadla, V., Sims, E. C., Borneo, J., Chan, R. & Kapur, R., Sep 1 2007, In : Blood. 110, 5, p. 1612-1620 9 p.Research output: Contribution to journal › Article
Genetic evidence for convergence of c-Kit- and α4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells
Tan, B. L., Yazicioglu, M. N., Ingram, D., McCarthy, J., Borneo, J., Williams, D. A. & Kapur, R., Jun 15 2003, In : Blood. 101, 12, p. 4725-4732 8 p.Research output: Contribution to journal › Article
Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms
Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.Research output: Contribution to journal › Article
Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo
Haneline, L., White, H., Yang, F. C., Chen, S., Orschell, C., Kapur, R. & Ingram, D., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.Research output: Contribution to journal › Article
Global microRNA expression is essential for murine mast cell development invivo
Oh, S. Y., Brandal, S., Kapur, R., Zhu, Z. & Takemoto, C. M., Oct 1 2014, In : Experimental Hematology. 42, 10, p. 919-923 5 p.Research output: Contribution to journal › Article
Heterozygous inactivation of the NF1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway
Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B., Li, F., Sarchet, K. N., DiStasi, M. R., Conway, S., Kapur, R. & Ingram, D., Mar 2013, In : Human Molecular Genetics. 22, 5, p. 977-988 12 p., dds502.Research output: Contribution to journal › Article
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor
Chan, R., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.Research output: Contribution to journal › Article
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL
Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, , Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.Research output: Contribution to journal › Article
IL-4-stimulated NF-κB activity is required for Stat6 DNA binding
Thieu, V. T., Nguyen, E. T., McCarthy, B. P., Bruns, H. A., Kapur, R., Chang, C. H. & Kaplan, M., Aug 1 2007, In : Journal of Leukocyte Biology. 82, 2, p. 370-379 10 p.Research output: Contribution to journal › Article
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells
Metts, J., Bradley, H. L., Wang, Z., Shah, N. P., Kapur, R., Arbiser, J. L. & Bunting, K. D., Dec 1 2017, In : Scientific Reports. 7, 1, 4447.Research output: Contribution to journal › Article
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M., Sandusky, G., Mohseni, M., Williams, A., Henao-Mejia, J. & Kapur, R., Jan 1 2018, (Accepted/In press) In : Cell Stem Cell.Research output: Contribution to journal › Article
Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis
Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.Research output: Contribution to journal › Article
Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the rho-associated kinase via the Cxcl12/Cxcr4 signaling axis
Onish, C., Mori-Kimachi, S., Hirade, T., Abe, M., Taketani, T., Suzumiya, J., Sugimoto, T., Yamaguchi, S., Kapur, R. & Fukuda, S., Nov 7 2014, In : Journal of Biological Chemistry. 289, 45, p. 31053-31065 13 p.Research output: Contribution to journal › Article
Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells
Samayawardhena, L. A., Kapur, R. & Craig, A. W. B., May 1 2007, In : Blood. 109, 9, p. 3679-3686 8 p.Research output: Contribution to journal › Article
Kinase inhibitors in clinical practice: An expanding world
Pandey, R. & Kapur, R., 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article
KIT associated intracellular tyrosines play an essential role in EpoR co-signaling
Hong, L., Ramdas, B., Chen, J., Harris, C., Wojchowski, D. M. & Kapur, R., Aug 2008, In : Cellular Signalling. 20, 8, p. 1513-1520 8 p.Research output: Contribution to journal › Article
KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation
Lee, Y. N., Brandal, S., Noel, P., Wentzel, E., Mendell, J. T., McDevitt, M. A., Kapur, R., Carter, M., Metcalfe, D. D. & Takemoto, C. M., Mar 31 2011, In : Blood. 117, 13, p. 3629-3640 12 p.Research output: Contribution to journal › Article
K-Ras is essential for normal fetal liver erythropoiesis
Khalaf, W. F., White, H., Wenning, M. J., Orazi, A., Kapur, R. & Ingram, D., May 1 2005, In : Blood. 105, 9, p. 3538-3541 4 p.Research output: Contribution to journal › Article
LIM kinase inhibitor Pyr1 reduces the growth and metastatic load of breast cancers
Prunier, C., Josserand, V., Vollaire, J., Beerling, E., Petropoulos, C., Destaing, O., Montemagno, C., Hurbin, A., Prudent, R., De Koning, L., Kapur, R., Cohen, P. A., Albiges-Rizo, C., Coll, J. L., Van Rheenen, J., Billaud, M. & Lafanechère, L., Jun 15 2016, In : Cancer Research. 76, 12, p. 3541-3552 12 p.Research output: Contribution to journal › Article
Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway
Palam, L. R., Mali, R. S., Ramdas, B., Srivatsan, S. N., Visconte, V., Tiu, R. V., Vanhaesebroeck, B., Roers, A., Gerbaulet, A., Xu, M., Janga, S. C., Takemoto, C. M., Paczesny, S. & Kapur, R., Feb 22 2018, In : JCI insight. 3, 4Research output: Contribution to journal › Article