Reuben Kapur

  • 4678 Citations
  • 37 h-Index
1991 …2020

Research output per year

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Publications

Article

Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Hiatt, K., Ingram, D. A., Huddleston, H., Spandau, D. F., Kapur, R. & Clapp, D. W., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D. A., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F. C., Wade Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mastocytosis- a mutated KIT receptor induced myeloproliferative disorder

Chatterjee, A., Ghosh, J. & Kapur, R., 2015, In : Oncotarget. 6, 21, p. 18250-18264 15 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
27 Scopus citations

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F. C., Ingram, D. A., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D. W., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

155 Scopus citations

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T. D., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. C. & Yang, F. C., Oct 1 2006, In : Human molecular genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Nf1+/- monocytes/macrophages induce neointima formation via CCR2 activation

Bessler, W. K., Kim, G., Hudson, F. Z., Mund, J. A., Mali, R., Menon, K., Kapur, R., Clapp, D. W., Ingram, D. A. & Stansfield, B. K., Aug 17 2015, In : Human molecular genetics. 25, 6, p. 1129-1139 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

108 Scopus citations

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

Sharma, N., Everingham, S., Zeng, L. F., Zhang, Z. Y., Kapur, R. & Craig, A. W. B., 2014, In : Oncotarget. 5, 15, p. 6130-6141 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Overexpression of human stem cell factor impairs melanocyte, mast cell, and thymocyte development: A role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation

Kapur, R., Everett, E. T., Uffman, J., McAndrews-Hill, M., Cooper, R., Ryder, J., Vik, T. & Williams, D. A., Oct 15 1997, In : Blood. 90, 8, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

P190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

Hinge, A., Xu, J., Javier, J., Mose, E., Kumar, S., Kapur, R., Srour, E. F., Malik, P., Aronow, B. J. & Filippi, M. D., Feb 8 2017, In : Nature communications. 8, 14382.

Research output: Contribution to journalArticle

11 Scopus citations

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M. C., Filippi, M. D., Broxmeyer, H. E. & Kapur, R., Dec 1 2018, In : Nature communications. 9, 1, 3518.

Research output: Contribution to journalArticle

6 Scopus citations

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F. C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration

Munugalavadla, V., Borneo, J., Ingram, D. A. & Kapur, R., Jul 1 2005, In : Blood. 106, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

P85β regulatory subunit of class I A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Krishnan, S., Mali, R. S., Ramdas, B., Sims, E., Ma, P., Ghosh, J., Munugalavadla, V., Hanneman, P., Beane, J. D. & Kapur, R., Apr 19 2012, In : Blood. 119, 17, p. 3951-3961 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

Martin, H., Mali, R. S., Ma, P., Chatterjee, A., Ramdas, B., Sims, E., Munugalavadla, V., Ghosh, J., Mattingly, R. R., Visconte, V., Tiu, R. V., Vlaar, C. P., Dharmawardhane, S. & Kapur, R., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4449-4463 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Pharmacological inhibition of AKT activity in human CD34+ cells enhances their ability to engraft immunodeficient mice

Chen, S., Gao, R., Kobayashi, M., Yu, H., Yao, C., Kapur, R., Yoder, M. C. & Liu, Y., Jan 1 2017, In : Experimental Hematology. 45, p. 74-84 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacologic inhibition of PI3K p110d in mutant Shp2E76Kexpressing mice

Deng, L., Virts, E. L., Kapur, R. & Chan, R. J., Oct 17 2017, In : Oncotarget. 8, 49, p. 84776-84781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Goodwin, C. B., Li, X. J., Mali, R. S., Chan, G., Kang, M., Liu, Z., Vanhaesebroeck, B., Neel, B. G., Loh, M. L., Lannutti, B. J., Kapur, R. & Chan, R. J., May 1 2014, In : Blood. 123, 18, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal

Kobayashi, M., Bai, Y., Dong, Y., Yu, H., Chen, S., Gao, R., Zhang, L., Yoder, M. C., Kapur, R., Zhang, Z. Y. & Liu, Y., Jul 2014, In : STEM CELLS. 32, 7, p. 1956-1967 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion

Jiang, J., Srivastava, S., Seim, G., Pavlova, N. N., King, B., Zou, L., Zhang, C., Zhong, M., Feng, H., Kapur, R., Wek, R. C., Fan, J. & Zhang, J., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18674-18684 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F. C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., Jan 1 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Open Access
140 Scopus citations

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8322-8331 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Rapid development of myeloproliferative neoplasm in mice with PTPN11D61Y mutation and haploinsufficient for Dnmt3a

Deng, L., Richine, B. M., Virts, E. L., Jideonwo-Auman, V. N., Chan, R. J. & Kapur, R., 2018, In : Oncotarget. 9, 5, p. 6055-6061 7 p.

Research output: Contribution to journalArticle

Ras-mek-erk signaling regulates Nf1 heterozygous neointima formation

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B. D., Kapur, R. & Ingram, D. A., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

36 Scopus citations

Regulation of Th2 cytokine expression in NKT cells: Unconventional use of Stat6, GATA-3, and NFAT2

Wang, Z. Y., Kusam, S., Munugalavadla, V., Kapur, R., Brutkiewicz, R. R. & Dent, A. L., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 880-888 9 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R. R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Repression of c-Kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation

Munugalavadla, V., Dore, L. C., Tan, B. L., Hong, L., Vishnu, M., Weiss, M. J. & Kapur, R., Aug 2005, In : Molecular and cellular biology. 25, 15, p. 6747-6759 13 p.

Research output: Contribution to journalArticle

87 Scopus citations

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R. J., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
33 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS ONE. 9, 3, e90758.

Research output: Contribution to journalArticle

22 Scopus citations

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

86 Scopus citations

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease

Ma, P., Mali, R. S., Martin, H., Ramdas, B., Sims, E. & Kapur, R., Jul 2012, In : Leukemia. 26, 7, p. 1499-1506 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia

Cai, Z., Zhang, C., Kotzin, J. J., Williams, A., Henao-Mejia, J. & Kapur, R., Jul 2020, In : Blood Advances. 4, 14, p. 3246-3251 6 p.

Research output: Contribution to journalArticle

Open Access

Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor

Kapur, R., Chandra, S., Cooper, R., McCarthy, J. & Williams, D. A., Aug 15 2002, In : Blood. 100, 4, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R. J., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R. J., Zhang, Z. Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. J. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sepsis induces hematopoietic stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88

Zhang, H., Rodriguez, S., Wang, L., Wang, S., Serezani, H., Kapur, R., Cardoso, A. A. & Carlesso, N., Jun 14 2016, In : Stem Cell Reports. 6, 6, p. 940-956 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L. F., Zhang, Z. Y., Feng, G. S., Hartmann, K., Roers, A. & Craig, A. W. B., Jul 2012, In : Molecular and cellular biology. 32, 14, p. 2653-2663 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis

Sharma, N., Everingham, S., Ramdas, B., Kapur, R. & Craig, A. W. B., May 15 2014, In : Journal of Immunology. 192, 10, p. 4859-4866 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor kinase: Genetic evidence for a differential role in erythropoiesis

Kapur, R., Majumdar, M., Xiao, X., McAndrews-Hill, M., Schindler, K. & Williams, D. A., Feb 1 1998, In : Blood. 91, 3, p. 879-889 11 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis

Traina, F., Visconte, V., Jankowska, A. M., Makishima, H., O'Keefe, C. L., Elson, P., Han, Y., Hsieh, F. H., Sekeres, M. A., Mali, R. S., Kalaycio, M., Lichtin, A. E., Advani, A. S., Duong, H. K., Copelan, E., Kapur, R., Olalla Saad, S. T., Maciejewski, J. P. & Tiu, R. V., Aug 15 2012, In : PloS one. 7, 8, e43090.

Research output: Contribution to journalArticle

65 Scopus citations