Reuben Kapur

  • 4678 Citations
  • 37 h-Index
1991 …2020

Research output per year

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Publications

Article

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Ramadan, A., Griesenauer, B., Adom, D., Kapur, R., Hanenberg, H., Liu, C., Kaplan, M. H. & Paczesny, S., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3577-3596 20 p.

Research output: Contribution to journalArticle

23 Scopus citations

Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors

Borneo, J., Munugalavadla, V., Sims, E. C., Vemula, S., Orschell, C. M., Yoder, M. & Kapur, R., Jul 1 2007, In : Experimental Hematology. 35, 7, p. 1026-1037 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Zhang, J., Ramadan, A. M., Griesenauer, B., Li, W., Turner, M. J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B. R., Tawara, I. & Paczesny, S., Oct 7 2015, In : Science translational medicine. 7, 308, 308ra160.

Research output: Contribution to journalArticle

72 Scopus citations

Stat3 and Stat4 direct development of IL-17-secreting Th cells

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O'Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S. & Kaplan, M. H., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4901-4907 7 p.

Research output: Contribution to journalArticle

Open Access
411 Scopus citations

Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Cai, Z., Aguilera, F., Ramdas, B., Daulatabad, S. V., Srivastava, R., Kotzin, J. J., Carroll, M., Wertheim, G., Williams, A., Janga, S. C., Zhang, C., Henao-Mejia, J. & Kapur, R., Jun 23 2020, In : Cell Reports. 31, 12, 107816.

Research output: Contribution to journalArticle

Open Access

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Kapur, R., Belladonna, M. L., Kansas, G. S. & Kaplan, M. H., Sep 1 2006, In : Blood. 108, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation

Kurkewich, J. L., Boucher, A., Klopfenstein, N., Baskar, R., Kapur, R. & Dahl, R., Mar 2018, In : Experimental Hematology. 59, p. 14-29 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F. C. & Kapur, R., Dec 2008, In : Molecular and cellular biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
48 Scopus citations

The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(117H) mice

Kapur, R., Cooper, R., Xiao, X., Weiss, M. J., Donovan, P. & Williams, D. A., Sep 15 1999, In : Blood. 94, 6, p. 1915-1925 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z. Y., Kapur, R. & Chan, R. J., Feb 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D. & Zhang, Z. Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

59 Scopus citations

The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells

Ruschmann, J., Antignano, F., Lam, V., Snyder, K., Kim, C., Essak, M., Zhang, A., Lin, A. H. A., Mali, R. S., Kapur, R. & Krystal, G., Apr 15 2012, In : Journal of Immunology. 188, 8, p. 3839-3850 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

Kumar, S., Xu, J., Kumar, R. S., Lakshmikanthan, S., Kapur, R., Kofron, M., Chrzanowska-Wodnicka, M. & Filippi, M. D., 2014, In : Journal of Experimental Medicine. 211, 9, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

37 Scopus citations

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R. J., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M. C., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations

Majumdar, M. K., Everett, E. T., Xiao, X., Cooper, R., Langley, K., Kapur, R., Vik, T. & Williams, D. A., Apr 15 1996, In : Blood. 87, 8, p. 3203-3211 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
Comment/debate

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2020, In : Nature communications. 11, 1, 3856.

Research output: Contribution to journalComment/debate

Open Access

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A. G., Kapur, R., Chan, R. J. & Yang, F. C., Jun 15 2008, In : Human molecular genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalComment/debate

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins (Journal of Immunology (2007) 179 (8322-8331))

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Mar 1 2008, In : Journal of Immunology. 180, 5, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
Editorial

DNA damage on the DOCK in FLT3-ITD-driven acute myeloid leukemia

Pandey, R. & Kapur, R., 2019, In : Haematologica. 104, 12, p. 2330-2332 3 p.

Research output: Contribution to journalEditorial

Open Access

Kinase inhibitors in clinical practice: An expanding world

Pandey, R. & Kapur, R., Feb 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 522-524 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Targeting LIM kinases in taxane resistant tumors

Prunier, C., Kapur, R. & Lafanechère, L., Aug 1 2016, In : Oncotarget. 7, 32, p. 50816-50817 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms

Mali, R. S. & Kapur, R., Sep 2012, In : Oncotarget. 3, 9, p. 909-910 2 p.

Research output: Contribution to journalEditorial

Open Access
5 Scopus citations

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., Jan 1 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalEditorial

Open Access
2 Scopus citations

Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development

Mali, R. S. & Kapur, R., Jan 1 2013, In : Cell Cycle. 12, 1, p. 7-8 2 p.

Research output: Contribution to journalEditorial

Letter

Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

Chen, S., Gao, R., Yao, C., Kobayashi, M., Liu, S. Z., Yoder, M. C., Broxmeyer, H., Kapur, R., Boswell, H. S., Mayo, L. D. & Liu, Y., Mar 1 2018, In : Leukemia. 32, 3, p. 850-854 5 p.

Research output: Contribution to journalLetter

10 Scopus citations

Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development

Nabinger, S. C., Chen, S., Gao, R., Yao, C., Kobayashi, M., Vemula, S., Fahey, A. C., Wang, C., Daniels, C., Boswell, H. S., Sandusky, G. E., Mayo, L. D., Kapur, R. & Liu, Y., Jun 1 2019, In : Leukemia. 33, 6, p. 1535-1539 5 p.

Research output: Contribution to journalLetter

5 Scopus citations

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

Kobayashi, M., Chen, S., Bai, Y., Yao, C., Gao, R., Sun, X. J., Mu, C., Twiggs, T. A., Yu, Z. H., Boswell, H. S., Yoder, M. C., Kapur, R., Mulloy, J. C., Zhang, Z. Y. & Liu, Y., Jun 1 2017, In : Leukemia. 31, 6, p. 1453-1457 5 p.

Research output: Contribution to journalLetter

4 Scopus citations

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Oct 1 2016, In : Leukemia. 30, 10, p. 2094-2097 4 p.

Research output: Contribution to journalLetter

9 Scopus citations
Review article

Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia

Burns, S. S. & Kapur, R., Aug 11 2020, In : Stem Cell Reports. 15, 2, p. 279-291 13 p.

Research output: Contribution to journalReview article

Open Access

LIM kinases: Cofilin and beyond

Prunier, C., Prudent, R., Kapur, R., Sadoul, K. & Lafanechère, L., Jan 1 2017, In : Oncotarget. 8, 25, p. 41749-41763 15 p.

Research output: Contribution to journalReview article

28 Scopus citations

Putative Mechanisms Underlying Cardiovascular Disease Associated with Clonal Hematopoiesis of Indeterminate Potential

Burns, S. S. & Kapur, R., Aug 11 2020, In : Stem Cell Reports. 15, 2, p. 292-306 15 p.

Research output: Contribution to journalReview article

Open Access

Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway

Ghosh, J. & Kapur, R., Dec 1 2016, In : Current Stem Cell Reports. 2, 4, p. 368-378 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

Role of c-Kit and erythropoietin receptor in erythropoiesis

Munugalavadla, V. & Kapur, R., Apr 2005, In : Critical Reviews in Oncology/Hematology. 54, 1, p. 63-75 13 p.

Research output: Contribution to journalReview article

93 Scopus citations

Role of mTORC1–S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia

Ghosh, J. & Kapur, R., Jun 2017, In : Experimental Hematology. 50, p. 13-21 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Role of Rho kinases in abnormal and normal hematopoiesis

Mali, R. S., Kapur, S. & Kapur, R., Jul 2014, In : Current opinion in hematology. 21, 4, p. 271-275 5 p.

Research output: Contribution to journalReview article

7 Scopus citations

Role of SHP2 in hematopoiesis and leukemogenesis

Pandey, R., Saxena, M. & Kapur, R., Jul 1 2017, In : Current opinion in hematology. 24, 4, p. 307-313 7 p.

Research output: Contribution to journalReview article

14 Scopus citations

SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations

Pandey, R., Ramdas, B., Wan, C., Sandusky, G., Mohseni, M., Zhang, C. & Kapur, R., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5468-5473 6 p.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms

Pandey, R. & Kapur, R., Jun 11 2015, In : Molecular Cancer. 14, 1, 118.

Research output: Contribution to journalReview article

10 Scopus citations