Reuben Kapur

  • 4275 Citations
  • 35 h-Index
1991 …2019
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Publications 1991 2019

  • 4275 Citations
  • 35 h-Index
  • 125 Article
  • 3 Review article
  • 2 Letter
  • 1 Editorial
2014
32 Citations (Scopus)

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

Kumar, S., Xu, J., Kumar, R. S., Lakshmikanthan, S., Kapur, R., Kofron, M., Chrzanowska-Wodnicka, M. & Filippi, M. D., 2014, In : Journal of Experimental Medicine. 211, 9, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

Transendothelial and Transepithelial Migration
Monomeric GTP-Binding Proteins
Chemotaxis
Neutrophils
Phosphatidylinositol 3-Kinases
2013
76 Citations (Scopus)

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actin Depolymerizing Factors
Actomyosin
Stress Fibers
Phosphorylation
11 Citations (Scopus)

Heterozygous inactivation of the NF1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway

Stansfield, B. K., Bessler, W. K., Mali, R., Mund, J. A., Downing, B., Li, F., Sarchet, K. N., DiStasi, M. R., Conway, S., Kapur, R. & Ingram, D., Mar 2013, In : Human Molecular Genetics. 22, 5, p. 977-988 12 p., dds502.

Research output: Contribution to journalArticle

Neurofibromatosis 1 Genes
Neointima
Neurofibromatosis 1
Myeloid Cells
Neurofibromin 1
27 Citations (Scopus)

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

Martin, H., Mali, R. S., Ma, P., Chatterjee, A., Ramdas, B., Sims, E., Munugalavadla, V., Ghosh, J., Mattingly, R. R., Visconte, V., Tiu, R. V., Vlaar, C. P., Dharmawardhane, S. & Kapur, R., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4449-4463 15 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
GTP Phosphohydrolases
Growth
Neoplasms
Oncogenes
21 Citations (Scopus)

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G., Boswell, H., Zhang, Z-Y., Kapur, R. & Chan, R., Feb 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Acute Myeloid Leukemia
Bone Marrow
Vascular Endothelial Growth Factor Receptor-1
Receptor Protein-Tyrosine Kinases

Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development

Mali, R. S. & Kapur, R., Jan 1 2013, In : Cell Cycle. 12, 1, p. 7-8 2 p.

Research output: Contribution to journalArticle

Mast Cells
2012
6 Citations (Scopus)

Class i A pi3kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes

Krishnan, S., Mali, R. S., Koehler, K. R., Vemula, S., Chatterjee, A., Ghosh, J., Ramdas, B., Ma, P., Hashino, E. & Kapur, R., Jan 4 2012, In : PLoS One. 7, 1, e28979.

Research output: Contribution to journalArticle

Stem Cell Factor
mast cells
Mast Cells
Genes
Cells
7 Citations (Scopus)

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms

Hu, P., Carlesso, N., Xu, M., Liu, Y., Nebreda, A. R., Takemoto, C. & Kapur, R., Jun 8 2012, In : Journal of Biological Chemistry. 287, 24, p. 20258-20269 12 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Chemotaxis
Mast Cells
Cell Differentiation
Microphthalmia-Associated Transcription Factor
80 Citations (Scopus)

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Aurora Kinase A
Polyploidy
Megakaryocytes
Small Interfering RNA
54 Citations (Scopus)

Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Myeloid Cells
Immunosuppression
Carcinogenesis
Inflammation
9 Citations (Scopus)

P38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals

Hu, P., Nebreda, A. R., Liu, Y., Carlesso, N., Kaplan, M. & Kapur, R., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33215-33226 12 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Antigen Receptor
T-Lymphocytes
Interleukin-4
Ovalbumin
10 Citations (Scopus)

P85β regulatory subunit of class I A PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

Krishnan, S., Mali, R. S., Ramdas, B., Sims, E., Ma, P., Ghosh, J., Munugalavadla, V., Hanneman, P., Beane, J. D. & Kapur, R., Apr 19 2012, In : Blood. 119, 17, p. 3951-3961 11 p.

Research output: Contribution to journalArticle

Cell growth
Phosphatidylinositol 3-Kinases
Mast Cells
Growth
Microphthalmia-Associated Transcription Factor
21 Citations (Scopus)

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Antigen Presentation
Lim Kinases
Actin Cytoskeleton
Natural Killer T-Cells
24 Citations (Scopus)

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

Erythropoiesis
Survival
Stem cells
rho-Associated Kinases
Enhanced recovery
9 Citations (Scopus)

Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease

Ma, P., Mali, R. S., Martin, H., Ramdas, B., Sims, E. & Kapur, R., Jul 2012, In : Leukemia. 26, 7, p. 1499-1506 8 p.

Research output: Contribution to journalArticle

Tyrosine
Systemic Mastocytosis
Mutation
Gastrointestinal Stromal Tumors
Extracellular Signal-Regulated MAP Kinases
38 Citations (Scopus)

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R., Zhang, Z-Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Bearings (structural)
Systemic Mastocytosis
Phosphatidylinositol 3-Kinases
Oncogenes
16 Citations (Scopus)

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L. F., Zhang, Z-Y., Feng, G. S., Hartmann, K., Roers, A. & Craig, A. W. B., Jul 2012, In : Molecular and Cellular Biology. 32, 14, p. 2653-2663 11 p.

Research output: Contribution to journalArticle

Connective Tissue Cells
src Homology Domains
Phosphoric Monoester Hydrolases
Mast Cells
Cell Survival
60 Citations (Scopus)

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis

Traina, F., Visconte, V., Jankowska, A. M., Makishima, H., O'Keefe, C. L., Elson, P., Han, Y., Hsieh, F. H., Sekeres, M. A., Mali, R. S., Kalaycio, M., Lichtin, A. E., Advani, A. S., Duong, H. K., Copelan, E., Kapur, R., Olalla Saad, S. T., Maciejewski, J. P. & Tiu, R. V., Aug 15 2012, In : PLoS One. 7, 8, e43090.

Research output: Contribution to journalArticle

Systemic Mastocytosis
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Nucleotides
5 Citations (Scopus)

Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms

Mali, R. S. & Kapur, R., Sep 2012, In : Oncotarget. 3, 9, p. 909-910 2 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Myeloproliferative Disorders
rho-Associated Kinases
Isoenzymes
Leukemia
2 Citations (Scopus)

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalArticle

Non-Receptor Type 11 Protein Tyrosine Phosphatase
Myeloproliferative Disorders
Enzyme Inhibitors
Neoplasms
13 Citations (Scopus)

The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells

Ruschmann, J., Antignano, F., Lam, V., Snyder, K., Kim, C., Essak, M., Zhang, A., Lin, A. H. A., Mali, R. S., Kapur, R. & Krystal, G., Apr 15 2012, In : Journal of Immunology. 188, 8, p. 3839-3850 12 p.

Research output: Contribution to journalArticle

Connective Tissue Cells
Mast Cells
Immunoglobulin E
Mucous Membrane
Cytokines
2011
14 Citations (Scopus)

Balanced interactions between Lyn, the p85α Regulatory Subunit of Class I A phosphatidylinositol-3-kinase, and SHIP Are essential for mast cell growth and maturation

Ma, P., Vemula, S., Munugalavadla, V., Chen, J., Sims, E., Borneo, J., Kondo, T., Ramdas, B., Mali, R. S., Li, S., Hashino, E., Takemoto, C. & Kapur, R., Oct 2011, In : Molecular and Cellular Biology. 31, 19, p. 4052-4062 11 p.

Research output: Contribution to journalArticle

Class I Phosphatidylinositol 3-Kinases
Mast Cells
Bone Marrow
Phosphatidylinositol 3-Kinase
Growth
43 Citations (Scopus)

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

Lee, Y. N., Brandal, S., Noel, P., Wentzel, E., Mendell, J. T., McDevitt, M. A., Kapur, R., Carter, M., Metcalfe, D. D. & Takemoto, C. M., Mar 31 2011, In : Blood. 117, 13, p. 3629-3640 12 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Cell proliferation
MicroRNAs
Mast Cells
Cell Proliferation
25 Citations (Scopus)
Sterol Esterase
Myeloid Cells
T-Lymphocytes
Myelopoiesis
Thymus Gland
16 Citations (Scopus)

P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway

Wu, X., Chen, S., Orlando, S. A., Yuan, J., Kim, E. T., Munugalavadla, V., Mali, R. S., Kapur, R. & Yang, F. C., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13512-13521 10 p.

Research output: Contribution to journalArticle

Osteoblasts
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Phosphotransferases
Cell growth
54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. & Kapur, R., Sep 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia
15 Citations (Scopus)

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Phosphatidylinositol 3-Kinases
Mast Cells
Chemical activation
Tissue
2010
26 Citations (Scopus)

Essential role for focal adhesion kinase in regulating stress hematopoiesis

Vemula, S., Ramdas, B., Hanneman, P., Martin, J., Beggs, H. E. & Kapur, R., Nov 18 2010, In : Blood. 116, 20, p. 4103-4115 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Hematopoiesis
Myeloid Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Bone
47 Citations (Scopus)

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Lasater, E. A., Li, F., Bessler, W. K., Estes, M. L., Vemula, S., Hingtgen, C. M., Dinauer, M. C., Kapur, R., Conway, S. & Ingram, D., Mar 1 2010, In : Journal of Clinical Investigation. 120, 3, p. 859-870 12 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibromatosis 1
Blood Vessels
Inflammation
Neointima
4 Citations (Scopus)

Loss of SIMPL compromises TNF-α-dependent survival of hematopoietic progenitors

Benson, E., Goebl, M., Yang, F. C., Kapur, R., McClintick, J., Sanghani, S., Clapp, D. & Harrington, M., Feb 2010, In : Experimental Hematology. 38, 2, p. 71-81 11 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Hematopoietic Stem Cells
Hematopoiesis
Gene Expression
Small Interfering RNA
80 Citations (Scopus)

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Macrophages
Cell Movement
Chemical activation
Glycogen Synthase Kinase 3
2009
16 Citations (Scopus)

Distinct roles of stress-activated protein kinases in fanconi anemia type C deficient hematopoiesis

Saadatzadeh, M. R., Bijangi-Vishehsaraei, K., Kapur, R. & Haneline, L., Mar 19 2009, In : Blood. 113, 12, p. 2655-2660 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
JNK Mitogen-Activated Protein Kinases
Hematopoiesis
Heat-Shock Proteins
Protein Kinases
2008
10 Citations (Scopus)

Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells

Orschell, C., Borneo, J., Munugalavadla, V., Ma, P., Sims, E., Ramdas, B., Yoder, M. & Kapur, R., May 2008, In : Experimental Hematology. 36, 5, p. 655-666 12 p.

Research output: Contribution to journalArticle

src-Family Kinases
Hematopoietic Stem Cells
Bone Marrow Cells
Stem Cells
Phosphotransferases

Erratum: Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1 (Human Molecular Genetics (2008) vol. 17(7) (936-948) 10.1093/hmg/ddm366)

Yan, J., Chen, S., Zhang, Y., Li, X., Li, Y., Wu, X., Yuan, J., Robling, A., Kapur, R., Chan, R. & Yang, F. C., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1876 1 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Medical Genetics
Osteoclasts
Molecular Biology
8 Citations (Scopus)

KIT associated intracellular tyrosines play an essential role in EpoR co-signaling

Hong, L., Ramdas, B., Chen, J., Harris, C., Wojchowski, D. M. & Kapur, R., Aug 2008, In : Cellular Signalling. 20, 8, p. 1513-1520 8 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
Tyrosine
Binding Sites
src-Family Kinases
1 Citation (Scopus)

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins (Journal of Immunology (2007) 179 (8322-8331))

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M., Dinauer, M. C., Durden, D. L. & Quilliam, L., Mar 1 2008, In : Journal of Immunology. 180, 5, p. 3612 1 p.

Research output: Contribution to journalArticle

rap1 GTP-Binding Proteins
Myeloid Cells
Allergy and Immunology
11 Citations (Scopus)

Requirement for p85α regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT

Munugalavadla, V., Sims, E. C., Chan, R., Lenz, S. D. & Kapur, R., Mar 2008, In : Experimental Hematology. 36, 3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Myeloproliferative Disorders
Bone Marrow Cells
Biochemical Phenomena
Transplantation
28 Citations (Scopus)

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A., Yang, F. C. & Kapur, R., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Osteoclasts
Gene Expression
Integrins
Cathepsin K
2007
28 Citations (Scopus)
Systemic Mastocytosis
GTP Phosphohydrolases
Acute Myeloid Leukemia
Phosphotransferases
Hematopoietic Stem Cells
19 Citations (Scopus)

IL-4-stimulated NF-κB activity is required for Stat6 DNA binding

Thieu, V. T., Nguyen, E. T., McCarthy, B. P., Bruns, H. A., Kapur, R., Chang, C. H. & Kaplan, M., Aug 1 2007, In : Journal of Leukocyte Biology. 82, 2, p. 370-379 10 p.

Research output: Contribution to journalArticle

Interleukin-4
DNA
B-Lymphocytes
Gene Expression
TNF Receptor-Associated Factor 3
55 Citations (Scopus)

Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells

Samayawardhena, L. A., Kapur, R. & Craig, A. W. B., May 1 2007, In : Blood. 109, 9, p. 3679-3686 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Chemotaxis
Mast Cells
Integrins
Phosphotransferases
77 Citations (Scopus)

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M., Dinauer, M. C., Durden, D. L. & Quilliam, L., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8322-8331 10 p.

Research output: Contribution to journalArticle

rap1 GTP-Binding Proteins
Myeloid Cells
Chemotaxis
Superoxides
Neutrophils
10 Citations (Scopus)

Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors

Borneo, J., Munugalavadla, V., Sims, E. C., Vemula, S., Orschell, C., Yoder, M. & Kapur, R., Jul 2007, In : Experimental Hematology. 35, 7, p. 1026-1037 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Mobilization
Intrinsic Factor
src-Family Kinases
Granulocyte Colony-Stimulating Factor
Stem Cells
397 Citations (Scopus)

Stat3 and Stat4 direct development of IL-17-secreting Th cells

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O'Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S. & Kaplan, M., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4901-4907 7 p.

Research output: Contribution to journalArticle

Interleukin-17
Interleukin-23
Interleukin-6
T-Lymphocytes
Interleukin-18
2006
61 Citations (Scopus)

Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis

Li, B., Jia, N., Kapur, R. & Chun, K., Jun 1 2006, In : Blood. 107, 11, p. 4291-4299 9 p.

Research output: Contribution to journalArticle

Erythropoiesis
Cell proliferation
Ubiquitin
Cell Differentiation
Erythroblasts
24 Citations (Scopus)

Genetic reduction of class Ia PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

Haneline, L., White, H., Yang, F. C., Chen, S., Orschell, C., Kapur, R. & Ingram, D., Feb 15 2006, In : Blood. 107, 4, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Fetal Movement
Hematopoiesis
Hematopoietic Stem Cells
Stem cells
63 Citations (Scopus)

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Wu, X., Estwick, S. A., Chen, S., Yu, M., Ming, W., Nebesio, T., Li, Y., Yuan, J., Kapur, R., Ingram, D., Yoder, M. & Yang, F. C., Oct 1 2006, In : Human Molecular Genetics. 15, 19, p. 2837-2845 9 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Osteoblasts
Mesenchymal Stromal Cells
Stem Cells
Fibroblasts
50 Citations (Scopus)

Regulation of Th2 cytokine expression in NKT cells: Unconventional use of Stat6, GATA-3, and NFAT2

Wang, Z. Y., Kusam, S., Munugalavadla, V., Kapur, R., Brutkiewicz, R. & Dent, A., Jan 15 2006, In : Journal of Immunology. 176, 2, p. 880-888 9 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Cytokines
Interleukin-4
T-Lymphocytes
Interleukin-13
120 Citations (Scopus)

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Kapur, R., Belladonna, M. L., Kansas, G. S. & Kaplan, M., Sep 1 2006, In : Blood. 108, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

Interleukin-17
Interleukin-23
Phenotype
Th1 Cells
Cytokines
2005
31 Citations (Scopus)

Enhanced TNF-α-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Werne, A., McKenzie, K. A. W., Kapur, R., Ichijo, H. & Haneline, L., Dec 15 2005, In : Blood. 106, 13, p. 4124-4130 7 p.

Research output: Contribution to journalArticle

MAP Kinase Kinase Kinase 5
Fanconi Anemia
Fibroblasts
Tumor Necrosis Factor-alpha
Apoptosis