Reuben Kapur

  • 4275 Citations
  • 35 h-Index
1991 …2019
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Publications 1991 2019

  • 4275 Citations
  • 35 h-Index
  • 125 Article
  • 3 Review article
  • 2 Letter
  • 1 Editorial
2005
117 Citations (Scopus)

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

Chan, R., Leedy, M. B., Munugalavadla, V., Voorhorst, C. S., Li, Y., Yu, M. & Kapur, R., May 1 2005, In : Blood. 105, 9, p. 3737-3742 6 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
Hypersensitivity
Mutation
Juvenile Myelomonocytic Leukemia
Macrophages
19 Citations (Scopus)

K-Ras is essential for normal fetal liver erythropoiesis

Khalaf, W. F., White, H., Wenning, M. J., Orazi, A., Kapur, R. & Ingram, D., May 1 2005, In : Blood. 105, 9, p. 3538-3541 4 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Erythropoiesis
Liver
Protein Isoforms
Erythroid Cells
50 Citations (Scopus)

p85α subunit of class IA PI-3 kinase is crucial for macrophage growth and migration

Munugalavadla, V., Borneo, J., Ingram, D. & Kapur, R., Jul 1 2005, In : Blood. 106, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Macrophages
Growth
Bone
Cells
85 Citations (Scopus)

Repression of c-Kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation

Munugalavadla, V., Dore, L. C., Tan, B. L., Hong, L., Vishnu, M., Weiss, M. J. & Kapur, R., Aug 2005, In : Molecular and Cellular Biology. 25, 15, p. 6747-6759 13 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Cell Proliferation
Erythropoietin
Activator Appliances
G1 Phase Cell Cycle Checkpoints
90 Citations (Scopus)

Role of c-Kit and erythropoietin receptor in erythropoiesis

Munugalavadla, V. & Kapur, R., Apr 2005, In : Critical Reviews in Oncology/Hematology. 54, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-kit
Erythropoietin Receptors
Erythropoiesis
Erythropoietin
Stem Cell Factor
2004
50 Citations (Scopus)

c-Kit-Mediated Overlapping and Unique Functional and Biochemical Outcomes via Diverse Signaling Pathways

Hong, L., Munugalavadla, V. & Kapur, R., Feb 2004, In : Molecular and Cellular Biology. 24, 3, p. 1401-1410 10 p.

Research output: Contribution to journalArticle

Binding Sites
Phosphatidylinositol 3-Kinase
Proto-Oncogene Proteins c-kit
MAP Kinase Kinase 4
src-Family Kinases
19 Citations (Scopus)

Loss of the Nf1 Tumor Suppressor Gene Decreases Fas Antigen Expression in Myeloid Cells

Hiatt, K., Ingram, D., Huddleston, H., Spandau, D., Kapur, R. & Clapp, D., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1471-1479 9 p.

Research output: Contribution to journalArticle

CD95 Antigens
Myeloid Cells
Tumor Suppressor Genes
Mast Cells
Stem Cell Factor
2003
3 Citations (Scopus)

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype

Chandra, S., Kapur, R., Chuzhanova, N., Summey, V., Prentice, D., Barker, J., Cooper, D. N. & Williams, D. A., Nov 15 2003, In : Blood. 102, 10, p. 3548-3555 8 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Steel
Exons
Genes
Phenotype
25 Citations (Scopus)
Erythropoietin Receptors
src-Family Kinases
Chemical activation
Phosphatidylinositol 3-Kinase
Stem Cell Factor
27 Citations (Scopus)

Functional p85α gene is required for normal murine fetal erythropoiesis

Huddleston, H., Tan, B., Yang, F. C., White, H., Wenning, M. J., Orazi, A., Yoder, M., Kapur, R. & Ingram, D., Jul 1 2003, In : Blood. 102, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Erythropoiesis
Phosphotransferases
Genes
Liver
60 Citations (Scopus)

Genetic evidence for convergence of c-Kit- and α4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

Tan, B. L., Yazicioglu, M. N., Ingram, D., McCarthy, J., Borneo, J., Williams, D. A. & Kapur, R., Jun 15 2003, In : Blood. 101, 12, p. 4725-4732 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Mast Cells
Integrins
151 Citations (Scopus)

Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for NF1+/- mast cells

Yang, F. C., Ingram, D., Chen, S., Hingtgen, C. M., Ratner, N., Monk, K. R., Clegg, T., White, H., Mead, L., Wenning, M. J., Williams, D. A., Kapur, R., Atkinson, S. J. & Clapp, D., Dec 2003, In : Journal of Clinical Investigation. 112, 12, p. 1851-1861 11 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibromatosis 1
Schwann Cells
Neurofibroma
Mast Cells
17 Citations (Scopus)

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Thrombopoietin
Yolk Sac
Erythropoiesis
Cell growth
Growth
2002
32 Citations (Scopus)

Lymphoproliferative defects in mice lacking the expression of neurofibromin: Functional and biochemical consequences of Nf1 deficiency in T-cell development and function

Ingram, D., Zhang, L., McCarthy, J., Wenning, M. J., Fisher, L., Yang, F. C., Clapp, D. & Kapur, R., Nov 15 2002, In : Blood. 100, 10, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

Neurofibromin 1
T-cells
T-Lymphocytes
Defects
ras GTPase-Activating Proteins
40 Citations (Scopus)

Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor

Kapur, R., Chandra, S., Cooper, R., McCarthy, J. & Williams, D. A., Aug 15 2002, In : Blood. 100, 4, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Extracellular Signal-Regulated MAP Kinases
p38 Mitogen-Activated Protein Kinases
Protein Isoforms
Membranes
45 Citations (Scopus)
Platelet Activating Factor
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor Receptor
Cell Proliferation
2001
57 Citations (Scopus)
Proto-Oncogene Proteins c-kit
Erythropoietin Receptors
Stem Cell Factor
Erythropoietin
Cells
72 Citations (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinases
Cell Survival
Chemical activation
Cells
2000
137 Citations (Scopus)

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Yang, F. C., Kapur, R., King, A. J., Tao, W., Kim, C., Borneo, J., Breese, R., Marshall, M., Dinauer, M. C. & Williams, D. A., 2000, In : Immunity. 12, 5, p. 557-568 12 p.

Research output: Contribution to journalArticle

Mast Cells
Actins
Intercellular Signaling Peptides and Proteins
rac1 GTP-Binding Protein
1999
446 Citations (Scopus)

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

Roberts, A. W., Chaekyun, K., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., Atkinson, S. J., Dinauer, M. C. & Williams, D. A., Feb 1999, In : Immunity. 10, 2, p. 183-196 14 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Neutrophils
Exudates and Transudates
rac GTP-Binding Proteins
L-Selectin
21 Citations (Scopus)

The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(117H) mice

Kapur, R., Cooper, R., Xiao, X., Weiss, M. J., Donovan, P. & Williams, D. A., Sep 15 1999, In : Blood. 94, 6, p. 1915-1925 11 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Steel
Amino Acids
Defects
Membranes
1998
66 Citations (Scopus)

Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor kinase: Genetic evidence for a differential role in erythropoiesis

Kapur, R., Majumdar, M., Xiao, X., McAndrews-Hill, M., Schindler, K. & Williams, D. A., Feb 1 1998, In : Blood. 91, 3, p. 879-889 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-kit
Stem Cell Factor
Erythropoiesis
Phosphotransferases
Membranes
1997
12 Citations (Scopus)

Overexpression of human stem cell factor impairs melanocyte, mast cell, and thymocyte development: A role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation

Kapur, R., Everett, E. T., Uffman, J., McAndrews-Hill, M., Cooper, R., Ryder, J., Vik, T. & Williams, D. A., Oct 15 1997, In : Blood. 90, 8, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Melanocytes
Receptor Protein-Tyrosine Kinases
Thymocytes
Mitogen-Activated Protein Kinases
33 Citations (Scopus)
Carmustine
Methyltransferases
Stem Cells
Complementary DNA
DNA
Erythropoietin Receptors
Stem Cell Factor
Erythropoiesis
Membranes
Protein Isoforms
1996
1 Citation (Scopus)
Lymphoid Progenitor Cells
Methyltransferases
Retroviridae
Hematopoietic Stem Cells
Stem cells
9 Citations (Scopus)

Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations

Majumdar, M. K., Everett, E. T., Xiao, X., Cooper, R., Langley, K., Kapur, R., Vik, T. & Williams, D. A., Apr 15 1996, In : Blood. 87, 8, p. 3203-3211 9 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Transgenic Mice
Forehead
Cells
Dental Caries
1995
Natural Killer Cells
Antigens
Monoclonal Antibodies
Histocompatibility Antigens Class I
Lymphokine-Activated Killer Cells
1994
4 Citations (Scopus)

Evolutionary Conservation of a Human Function‐Associated Molecule on Murine Natural Killer Cells: Expression and Function

Kapur, R., EVANS, D. L. & HARRIS, D. T., Jan 1 1994, In : Scandinavian Journal of Immunology. 40, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Monoclonal Antibodies
Wool
Lymphokines
Nylons
1992
18 Citations (Scopus)

A species-conserved NK cell antigen receptor is a novel vimentin-like molecule

Harris, D. T., Kapur, R., Frye, C., Acevedo, A., Camenisch, T., Jaso-Friedmann, L. & Evans, D. L., 1992, In : Developmental and Comparative Immunology. 16, 5, p. 395-403 9 p.

Research output: Contribution to journalArticle

Natural Killer Cell Receptors
Antigen Receptors
Vimentin
Natural Killer Cells
Signal Transduction
1991

Analysis of an evolutionarily-conserved function-associated molecule (FAM) on murine natural killer (NK) cells

Acevedo, A., Kapur, R. & Harris, D. T., 1991, In : Developmental and Comparative Immunology. 15, SUPPL. 1

Research output: Contribution to journalArticle

Natural Killer Cells