Reuben Kapur

  • 4635 Citations
  • 36 h-Index
1991 …2020

Research output per year

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Publications

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of c-Kit and erythropoietin receptor in erythropoiesis

Munugalavadla, V. & Kapur, R., Apr 2005, In : Critical Reviews in Oncology/Hematology. 54, 1, p. 63-75 13 p.

Research output: Contribution to journalReview article

93 Scopus citations

Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease

Ma, P., Mali, R. S., Martin, H., Ramdas, B., Sims, E. & Kapur, R., Jul 2012, In : Leukemia. 26, 7, p. 1499-1506 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of mTORC1–S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia

Ghosh, J. & Kapur, R., Jun 2017, In : Experimental Hematology. 50, p. 13-21 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor

Kapur, R., Chandra, S., Cooper, R., McCarthy, J. & Williams, D. A., Aug 15 2002, In : Blood. 100, 4, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Role of p85α in neutrophil extra-and intracellular reactive oxygen species generation

Li, X. J., Deng, L., Brandt, S. L., Goodwin, C. B., Ma, P., Yang, Z., Mali, R. S., Liu, Z., Kapur, R., Henrique Serezani, C. & Chan, R. J., Apr 26 2016, In : Oncotarget. 7, 17, p. 23096-23105 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of Rho kinases in abnormal and normal hematopoiesis

Mali, R. S., Kapur, S. & Kapur, R., Jul 2014, In : Current opinion in hematology. 21, 4, p. 271-275 5 p.

Research output: Contribution to journalReview article

7 Scopus citations

Role of SHP2 in hematopoiesis and leukemogenesis

Pandey, R., Saxena, M. & Kapur, R., Jul 1 2017, In : Current opinion in hematology. 24, 4, p. 307-313 7 p.

Research output: Contribution to journalReview article

14 Scopus citations

Role of SHP2 phosphatase in KIT-induced transformation: Identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R. J., Zhang, Z. Y. & Kapur, R., Sep 27 2012, In : Blood. 120, 13, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Ghosh, J., Kobayashi, M., Ramdas, B., Chatterjee, A., Ma, P., Mali, R. S., Carlesso, N., Liu, Y., Plas, D. R., Chan, R. & Kapur, R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2621-2625 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sepsis induces hematopoietic stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88

Zhang, H., Rodriguez, S., Wang, L., Wang, S., Serezani, H., Kapur, R., Cardoso, A. A. & Carlesso, N., Jun 14 2016, In : Stem Cell Reports. 6, 6, p. 940-956 17 p.

Research output: Contribution to journalArticle

32 Scopus citations

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

Sharma, N., Kumar, V., Everingham, S., Mali, R. S., Kapur, R., Zeng, L. F., Zhang, Z. Y., Feng, G. S., Hartmann, K., Roers, A. & Craig, A. W. B., Jul 1 2012, In : Molecular and cellular biology. 32, 14, p. 2653-2663 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations

Pandey, R., Ramdas, B., Wan, C., Sandusky, G., Mohseni, M., Zhang, C. & Kapur, R., Dec 2 2019, In : Journal of Clinical Investigation. 129, 12, p. 5468-5473 6 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis

Sharma, N., Everingham, S., Ramdas, B., Kapur, R. & Craig, A. W. B., May 15 2014, In : Journal of Immunology. 192, 10, p. 4859-4866 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor kinase: Genetic evidence for a differential role in erythropoiesis

Kapur, R., Majumdar, M., Xiao, X., McAndrews-Hill, M., Schindler, K. & Williams, D. A., Feb 1 1998, In : Blood. 91, 3, p. 879-889 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis

Traina, F., Visconte, V., Jankowska, A. M., Makishima, H., O'Keefe, C. L., Elson, P., Han, Y., Hsieh, F. H., Sekeres, M. A., Mali, R. S., Kalaycio, M., Lichtin, A. E., Advani, A. S., Duong, H. K., Copelan, E., Kapur, R., Olalla Saad, S. T., Maciejewski, J. P. & Tiu, R. V., Aug 15 2012, In : PloS one. 7, 8, e43090.

Research output: Contribution to journalArticle

65 Scopus citations

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Ramadan, A., Griesenauer, B., Adom, D., Kapur, R., Hanenberg, H., Liu, C., Kaplan, M. H. & Paczesny, S., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3577-3596 20 p.

Research output: Contribution to journalArticle

22 Scopus citations

Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors

Borneo, J., Munugalavadla, V., Sims, E. C., Vemula, S., Orschell, C. M., Yoder, M. & Kapur, R., Jul 1 2007, In : Experimental Hematology. 35, 7, p. 1026-1037 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Zhang, J., Ramadan, A. M., Griesenauer, B., Li, W., Turner, M. J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B. R., Tawara, I. & Paczesny, S., Oct 7 2015, In : Science translational medicine. 7, 308, 308ra160.

Research output: Contribution to journalArticle

72 Scopus citations

Stat3 and Stat4 direct development of IL-17-secreting Th cells

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O'Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S. & Kaplan, M. H., Apr 15 2007, In : Journal of Immunology. 178, 8, p. 4901-4907 7 p.

Research output: Contribution to journalArticle

Open Access
409 Scopus citations

Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

Richine, B. M., Virts, E. L., Bowling, J. D., Ramdas, B., Mali, R., Naoye, R., Liu, Z., Zhang, Z. Y., Boswell, H. S., Kapur, R. & Chan, R. J., Oct 1 2016, In : Leukemia. 30, 10, p. 2094-2097 4 p.

Research output: Contribution to journalLetter

9 Scopus citations

Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Cai, Z., Aguilera, F., Ramdas, B., Daulatabad, S. V., Srivastava, R., Kotzin, J. J., Carroll, M., Wertheim, G., Williams, A., Janga, S. C., Zhang, C., Henao-Mejia, J. & Kapur, R., Jun 23 2020, In : Cell Reports. 31, 12, 107816.

Research output: Contribution to journalArticle

Open Access

Targeting LIM kinases in taxane resistant tumors

Prunier, C., Kapur, R. & Lafanechère, L., Aug 1 2016, In : Oncotarget. 7, 32, p. 50816-50817 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms

Pandey, R. & Kapur, R., Jun 11 2015, In : Molecular Cancer. 14, 1, 118.

Research output: Contribution to journalReview article

10 Scopus citations

Targeting Rho associated kinases in leukemia and myeloproliferative neoplasms

Mali, R. S. & Kapur, R., Sep 2012, In : Oncotarget. 3, 9, p. 909-910 2 p.

Research output: Contribution to journalEditorial

Open Access
5 Scopus citations

Targeting SHP2 phosphatase in Myeloproliferative neoplasms

Mali, R. S., Chan, R. & Kapur, R., Jan 1 2012, In : Oncotarget. 3, 10, p. 1049-1051 3 p.

Research output: Contribution to journalEditorial

Open Access
2 Scopus citations

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

Mathur, A. N., Chang, H. C., Zisoulis, D. G., Kapur, R., Belladonna, M. L., Kansas, G. S. & Kaplan, M. H., Sep 1 2006, In : Blood. 108, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation

Kurkewich, J. L., Boucher, A., Klopfenstein, N., Baskar, R., Kapur, R. & Dahl, R., Mar 2018, In : Experimental Hematology. 59, p. 14-29 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

The p85α subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

Munugalavadla, V., Vemula, S., Sims, E. C., Krishnan, S., Chen, S., Yan, J., Li, H., Niziolek, P. J., Takemoto, C., Robling, A. G., Yang, F. C. & Kapur, R., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7182-7198 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. & Kapur, R., Sep 29 2011, In : Blood. 118, 13, p. 3459-3469 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
48 Scopus citations

The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(117H) mice

Kapur, R., Cooper, R., Xiao, X., Weiss, M. J., Donovan, P. & Williams, D. A., Sep 15 1999, In : Blood. 94, 6, p. 1915-1925 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z. Y., Kapur, R. & Chan, R. J., Feb 1 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Therapeutic potential of targeting the oncogenic SHP2 phosphatase

Zeng, L. F., Zhang, R. Y., Yu, Z. H., Li, S., Wu, L., Gunawan, A. M., Lane, B. S., Mali, R. S., Li, X., Chan, R. J., Kapur, R., Wells, C. D. & Zhang, Z. Y., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6594-6609 16 p.

Research output: Contribution to journalArticle

58 Scopus citations

The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells

Ruschmann, J., Antignano, F., Lam, V., Snyder, K., Kim, C., Essak, M., Zhang, A., Lin, A. H. A., Mali, R. S., Kapur, R. & Krystal, G., Apr 15 2012, In : Journal of Immunology. 188, 8, p. 3839-3850 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

Kumar, S., Xu, J., Kumar, R. S., Lakshmikanthan, S., Kapur, R., Kofron, M., Chrzanowska-Wodnicka, M. & Filippi, M. D., 2014, In : Journal of Experimental Medicine. 211, 9, p. 1741-1758 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs

Xie, X., Chan, R. J., Johnson, S. A., Starr, M., McCarthy, J., Kapur, R. & Yoder, M. C., Feb 15 2003, In : Blood. 101, 4, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development

Mali, R. S. & Kapur, R., Jan 1 2013, In : Cell Cycle. 12, 1, p. 7-8 2 p.

Research output: Contribution to journalEditorial

Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations

Majumdar, M. K., Everett, E. T., Xiao, X., Cooper, R., Langley, K., Kapur, R., Vik, T. & Williams, D. A., Apr 15 1996, In : Blood. 87, 8, p. 3203-3211 9 p.

Research output: Contribution to journalArticle

9 Scopus citations