Robert Bies

  • 2575 Citations
  • 27 h-Index
20012019
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Publications 2001 2019

2019

Circadian patterns of hallucinatory experiences in patients with schizophrenia: Potentials for chrono-pharmacology

Koizumi, T., Suzuki, T., Pillai, N. S., Bies, R., Takeuchi, H., Yoshimura, K., Mimura, M. & Uchida, H., Oct 1 2019, In : Journal of Psychiatric Research. 117, p. 1-6 6 p.

Research output: Contribution to journalArticle

Hallucinations
Schizophrenia
Pharmacology
Dopamine D2 Receptors
olanzapine

Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593–606, Sep/Oct 2018, DOI: 10.1002/pst.1873

ASA Special Interest Group on Statistics and Pharmacometrics/ASA Special Interest Group on Statistics and Pharmacometrics (SIG SxP), Jan 1 2019, In : Pharmaceutical Statistics.

Research output: Contribution to journalLetter

Pharmaceuticals
Curriculum
Drugs
Statistics
Pharmaceutical Preparations

Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search

Pillai, N., Schwartz, S. L., Ho, T., Dokoumetzidis, A., Bies, R. & Freedman, I., Jan 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics.

Research output: Contribution to journalArticle

Open Access
Nonlinear Dynamics
Hydrocortisone
Pharmacology
Least-Squares Analysis
Research
1 Citation (Scopus)

Estimation of Solid Tumor Doubling Times from Progression-Free Survival Plots Using a Novel Statistical Approach

Kay, K., Dolcy, K., Bies, R. & Shah, D. K., Mar 1 2019, In : AAPS Journal. 21, 2, 27.

Research output: Contribution to journalArticle

Disease-Free Survival
Neoplasms
Growth
Hepatocellular Carcinoma
Stomach Neoplasms
1 Citation (Scopus)

Model-guided antipsychotic dose reduction in schizophrenia: A pilot, single-blind randomized controlled trial

Ozawa, C., Bies, R. R., Pillai, N., Suzuki, T., Mimura, M. & Uchida, H., Jul 1 2019, In : Journal of Clinical Psychopharmacology. 39, 4, p. 329-335 7 p.

Research output: Contribution to journalArticle

Antipsychotic Agents
Schizophrenia
olanzapine
Randomized Controlled Trials
Maintenance

Panos Macheras: a pioneering scientist in pharmaceutical science

Endrenyi, L. & Bies, R., Jan 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics.

Research output: Contribution to journalArticle

tetrazepam
Biopharmaceutics
Pharmacokinetics
Pharmaceutical Preparations

Prediction of Nephropathy in Type 2 Diabetes: An Analysis of the ACCORD Trial Applying Machine Learning Techniques

Rodriguez-Romero, V., Bergstrom, R. F., Decker, B., Lahu, G., Vakilynejad, M. & Bies, R., Jan 1 2019, In : Clinical and translational science.

Research output: Contribution to journalArticle

Open Access
Diabetic Nephropathies
Medical problems
Glomerular Filtration Rate
Type 2 Diabetes Mellitus
Learning systems

Preface to Special Issue for Panos Macheras

Bies, R., Jan 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics.

Research output: Contribution to journalArticle

Open Access
tetrazepam
2018
2 Citations (Scopus)

Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: Estimating tumor antigenicity in a model of immunotherapy

Pillai, N., Craig, M., Dokoumetzidis, A., Schwartz, S. L., Bies, R. & Freedman, I., Jan 1 2018, (Accepted/In press) In : Progress in Biophysics and Molecular Biology.

Research output: Contribution to journalArticle

Immunotherapy
Pharmacology
Neoplasms
Nonlinear Dynamics
Least-Squares Analysis

Mathematical modeling of intracrine androgen metabolism in prostate cancer: Methodological aspects

Cook, S. F., Fiandalo, M. V., Watt, D. S., Wu, Y., Mohler, J. L. & Bies, R., Oct 1 2018, In : Prostate. 78, 14, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

Androgens
Androsterone
Prostatic Neoplasms
Castration
Enzymes

Pharmacokinetics and pharmacodynamics of ropinirole in patients with prolactinomas

Liu, S., Hu, C., Peters, J., Tsang, A., Cremers, S., Bies, R. & Page-Wilson, G., Jan 1 2018, (Accepted/In press) In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Prolactinoma
Pharmacokinetics
Prolactin
Dopamine Agonists
Ergolines
4 Citations (Scopus)

Physiologically-based pharmacokinetic model of vaginally administered dapivirine ring and film formulations

Kay, K., Shah, D. K., Rohan, L. & Bies, R., Sep 1 2018, In : British Journal of Clinical Pharmacology. 84, 9, p. 1950-1969 20 p.

Research output: Contribution to journalArticle

Pharmacokinetics
HIV
Pharmaceutical Preparations
Space Simulation
Anti-Infective Agents

The clinical utility of pharmacometric models

Kumar, S. S., Biltaji, E., Bies, R. & Sherwin, C. M., Jan 1 2018, (Accepted/In press) In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

2017
10 Citations (Scopus)

Population pharmacokinetic modeling to estimate the contributions of genetic and nongenetic factors to efavirenz disposition

Robarge, J. D., Metzger, I. F., Lu, J., Thong, N., Skaar, T., Desta, Z. & Bies, R., Jan 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, e01813-16.

Research output: Contribution to journalArticle

efavirenz
Pharmacokinetics
Population
Fats
Body Mass Index
2016
5 Citations (Scopus)

A population pharmacokinetic model for R- and S-citalopram and desmethylcitalopram in Alzheimer’s disease patients with agitation

Akil, A., Bies, R., Pollock, B. G., Avramopoulos, D., Devanand, D. P., Mintzer, J. E., Porsteinsson, A. P., Schneider, L. S., Weintraub, D., Yesavage, J., Shade, D. M. & Lyketsos, C. G., Feb 1 2016, In : Journal of Pharmacokinetics and Pharmacodynamics. 43, 1, p. 99-109 11 p.

Research output: Contribution to journalArticle

Citalopram
Alzheimer Disease
Pharmacokinetics
Population
desmethylcitalopram
10 Citations (Scopus)

A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer

Sawyer, M. B., Pituskin, E., Damaraju, S., Bies, R., Vos, L. J., Prado, C. M. M., Kuzma, M., Scarfe, A. G., Clemons, M., Tonkin, K., Au, H. J., Koski, S., Joy, A. A., Smylie, M., King, K., Carandang, D., Damaraju, V. L., Hanson, J., Cass, C. E. & Mackey, J. R., Apr 1 2016, In : Clinical Breast Cancer. 16, 2, p. 139-144e3

Research output: Contribution to journalArticle

Glucuronosyltransferase
Epirubicin
Uridine
Homozygote
Breast Neoplasms
2 Citations (Scopus)

Big Data: Challenges and opportunities for clinical pharmacology

Flockhart, D., Bies, R., Gastonguay, M. R. & Schwartz, S. L., 2016, (Accepted/In press) In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Pharmaceutical Databases
Clinical Pharmacology
8 Citations (Scopus)

Comparative Effects of CT Imaging Measurement on RECIST End Points and Tumor Growth Kinetics Modeling

Li, C., Bies, R., Wang, Y., Sharma, M., Karovic, S., Werk, L., Edelman, M., Miller, A., Vokes, E., Oto, A., Ratain, M., Schwartz, L. & Maitland, M., Feb 1 2016, In : Clinical and Translational Science. 9, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Growth kinetics
Tumor Burden
Tumors
Imaging techniques
Growth
5 Citations (Scopus)

Disease Progression Modeling: Key Concepts and Recent Developments

Cook, S. F. & Bies, R., Oct 1 2016, In : Current Pharmacology Reports. 2, 5, p. 221-230 10 p.

Research output: Contribution to journalReview article

Disease Progression
Pharmaceutical Preparations
Cost-Benefit Analysis
Alzheimer Disease
Biomarkers
16 Citations (Scopus)

Dopamine D2/3 Receptor Occupancy Following Dose Reduction Is Predictable with Minimal Plasma Antipsychotic Concentrations: An Open-Label Clinical Trial

Nakajima, S., Uchida, H., Bies, R., Caravaggio, F., Suzuki, T., Plitman, E., Mar, W., Gerretsen, P., Pollock, B. G., Mulsant, B. H., Mamo, D. C. & Graff-Guerrero, A., Jan 1 2016, In : Schizophrenia Bulletin. 42, 1, p. 212-219 8 p.

Research output: Contribution to journalArticle

olanzapine
Dopamine D2 Receptors
Risperidone
Antipsychotic Agents
Clinical Trials
3 Citations (Scopus)

Increasing versus maintaining the dose of olanzapine or risperidone in schizophrenia patients who did not respond to a modest dosage: A double-blind randomized controlled trial

Sakurai, H., Suzuki, T., Bies, R., Pollock, B. G., Mimura, M., Kapur, S. & Uchida, H., Oct 1 2016, In : Journal of Clinical Psychiatry. 77, 10, p. 1381-1390 10 p.

Research output: Contribution to journalArticle

olanzapine
Risperidone
Antipsychotic Agents
Schizophrenia
Randomized Controlled Trials
13 Citations (Scopus)

Organised crime against the academic peer review system

Cohen, A., Pattanaik, S., Kumar, P., Bies, R., De Boer, A., Ferro, A., Gilchrist, A., Isbister, G. K., Ross, S. & Webb, A. J., Jun 1 2016, In : British Journal of Clinical Pharmacology. 81, 6, p. 1012-1017 6 p.

Research output: Contribution to journalArticle

Peer Review
Crime
2 Citations (Scopus)

Quantifying intraindividual variations in plasma clozapine levels: A population pharmacokinetic approach

Lee, J., Bies, R., Takeuchi, H., Fervaha, G., Bhaloo, A., Powell, V. & Remington, G., May 1 2016, In : Journal of Clinical Psychiatry. 77, 5, p. 681-687 7 p.

Research output: Contribution to journalArticle

norclozapine
Clozapine
Pharmacokinetics
Population
Smoking
8 Citations (Scopus)

R- and S-citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation

Ho, T., Pollock, B. G., Mulsant, B. H., Schantz, O., Devanand, D. P., Mintzer, J. E., Porsteinsson, A. P., Schneider, L. S., Weintraub, D., Yesavage, J., Drye, L. T., Munro, C. A., Shade, D. M., Lyketsos, C. & Bies, R., 2016, In : British Journal of Clinical Pharmacology. p. 784-792 9 p.

Research output: Contribution to journalArticle

Citalopram
Area Under Curve
Dementia
Alzheimer Disease
Therapeutics
5 Citations (Scopus)

SSRI-antipsychotic combination in psychotic depression: Sertraline pharmacokinetics in the presence of olanzapine, a brief report from the STOP-PD study

Davies, S. J. C., Mulsant, B. H., Flint, A. J., Meyers, B. S., Rothschild, A. J., Whyte, E. M., Kirshner, M. M., Sorisio, D., Pollock, B. G. & Bies, R., May 1 2016, In : Human Psychopharmacology. 31, 3, p. 252-255 4 p.

Research output: Contribution to journalArticle

olanzapine
Sertraline
Antipsychotic Agents
Pharmacokinetics
Population
2015
4 Citations (Scopus)

A population PK model for citalopram and its major metabolite, N-desmethyl citalopram, in rats

Velez de Mendizabal, N., Jackson, K., Eastwood, B., Swanson, S., Bender, D. M., Lowe, S. & Bies, R., Sep 22 2015, In : Journal of Pharmacokinetics and Pharmacodynamics. 42, 6, p. 721-733 13 p.

Research output: Contribution to journalArticle

Citalopram
Population
Oral Administration
Wistar Rats
Pharmacokinetics
19 Citations (Scopus)

Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation

Akil, A., Zhang, Q., Mumaw, C. L., Raiker, N., Yu, J., Velez de Mendizabal, N., Haneline, L., Robertson, K., Skiles, J., Diaz-Ricart, M., Carreras, E., Renbarger, J., Hanash, S., Bies, R. & Paczesny, S., Oct 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 10, p. 1739-1745 7 p.

Research output: Contribution to journalArticle

Hepatic Veno-Occlusive Disease
Cell Transplantation
Biomarkers
Vascular Cell Adhesion Molecule-1
Hyaluronic Acid
6 Citations (Scopus)

Challenging the need for sustained blockade of dopamine D<inf>2</inf> receptor estimated from antipsychotic plasma levels in the maintenance treatment of schizophrenia: A single-blind, randomized, controlled study

Tsuboi, T., Suzuki, T., Bies, R., Remington, G., Pollock, B. G., Mimura, M. & Uchida, H., May 1 2015, In : Schizophrenia Research. 164, 1-3, p. 149-154 6 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Antipsychotic Agents
Schizophrenia
olanzapine
Single-Blind Method
2 Citations (Scopus)

Clinical trial simulation to evaluate population pharmacokinetics and food effect: Capturing abiraterone and nilotinib exposures

Li, C. H., Sherer, E. A., Lewis, L. D. & Bies, R., May 1 2015, In : Journal of Clinical Pharmacology. 55, 5, p. 556-562 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Clinical Trials
Food
Population
4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
6 Citations (Scopus)

Clozapine and anemia: A 2-year follow-up study

Lee, J., Bies, R., Bhaloo, A., Powell, V. & Remington, G., Dec 1 2015, In : Journal of Clinical Psychiatry. 76, 12, p. 1642-1647 6 p.

Research output: Contribution to journalArticle

Clozapine
varespladib methyl
Anemia
Smoking
Hemoglobins
Dopamine D2 Receptors
Antipsychotic Agents
Schizophrenia
Pharmaceutical Preparations
corrigendum
Psychopharmacology
Dopamine D2 Receptors
Schizophrenia
13 Citations (Scopus)

Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment

Yang, Q. J., Jerath, A., Bies, R., Wąsowicz, M. & Pang, K. S., Jul 1 2015, In : Biopharmaceutics and Drug Disposition. 36, 5, p. 294-307 14 p.

Research output: Contribution to journalArticle

Patient Simulation
Tranexamic Acid
Thoracic Surgery
Pharmacokinetics
Cardiopulmonary Bypass
1 Citation (Scopus)
Aircraft
Mathematics
Theoretical Models
Pharmacokinetics
5 Citations (Scopus)

Predicting Plasma Olanzapine Concentration Following a Change in Dosage: A Population Pharmacokinetic Study

Tsuboi, T., Bies, R., Suzuki, T., Takeuchi, H., Nakajima, S., Graff-Guerrero, A., Mamo, D. C., Caravaggio, F., Plitman, E., Mimura, M., Pollock, B. G. & Uchida, H., Oct 27 2015, In : Pharmacopsychiatry. 48, 7, p. 286-291 6 p.

Research output: Contribution to journalArticle

olanzapine
Pharmacokinetics
Population
Antipsychotic Agents
Schizophrenia
17 Citations (Scopus)

The Effect of Clozapine on Hematological Indices: A 1-Year Follow-Up Study

Lee, J., Takeuchi, H., Fervaha, G., Powell, V., Bhaloo, A., Bies, R. & Remington, G., Oct 12 2015, In : Journal of Clinical Psychopharmacology. 35, 5, p. 510-516 7 p.

Research output: Contribution to journalArticle

Clozapine
Agranulocytosis
Neutrophils
Leukocytes
Blood Platelets
4 Citations (Scopus)

The Impact of Sertraline Co-Administration on the Pharmacokinetics of Olanzapine: A Population Pharmacokinetic Analysis of the STOP-PD

Davies, S. J. C., Mulsant, B. H., Flint, A. J., Meyers, B. S., Rothschild, A. J., Whyte, E. M., Kirshner, M. M., Sorisio, D., Pollock, B. G. & Bies, R., May 14 2015, In : Clinical Pharmacokinetics. 54, 11, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

olanzapine
Sertraline
Pharmacokinetics
Depression
Drug Therapy
2014
9 Citations (Scopus)

Dose reduction of risperidone and olanzapine and estimated dopamine D<inf>2</inf> receptor occupancy in stable patients with schizophrenia: Findings from an open-label, randomized, controlled study

Takeuchi, H., Suzuki, T., Bies, R., Remington, G., Watanabe, K., Mimura, M. & Uchida, H., Nov 1 2014, In : Journal of Clinical Psychiatry. 75, 11, p. 1209-1214 6 p.

Research output: Contribution to journalArticle

olanzapine
Risperidone
Dopamine D2 Receptors
Antipsychotic Agents
Schizophrenia

Erratum: Predicting relapsing-remitting dynamics in multiple sclerosis using discrete distribution models: A population approach

De Mendizabal, N. V., Hutmacher, M. M., Troconiz, I. F., Goñi, J., Villoslada, P., Bagnato, F. & Bies, R., Jan 6 2014, In : PLoS One. 9, 1, 407.

Research output: Contribution to journalArticle

sclerosis
Multiple Sclerosis
Population
8 Citations (Scopus)

Impact of once- versus twice-daily perphenazine dosing on clinical outcomes: An analysis of the CATIE data

Takeuchi, H., Fervaha, G., Uchida, H., Suzuki, T., Bies, R., Gronte, D. & Remington, G., 2014, In : Journal of Clinical Psychiatry. 75, 5, p. 506-511 6 p.

Research output: Contribution to journalArticle

Perphenazine
Antipsychotic Agents
Clinical Trials
Schizophrenia
Half-Life
15 Citations (Scopus)

Modelling the sitagliptin effect on dipeptidyl peptidase-4 activity in adults with haematological malignancies after umbilical cord blood haematopoietic cell transplantation

Vélez De Mendizábal, N., Strother, R. M., Farag, S., Broxmeyer, H., Messina-Graham, S., Chitnis, S. D. & Bies, R., Mar 2014, In : Clinical Pharmacokinetics. 53, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

Dipeptidyl Peptidase 4
Cell Transplantation
Hematologic Neoplasms
Fetal Blood
Blood Cells
11 Citations (Scopus)

Nicotine and Cotinine Exposure from Electronic Cigarettes: A Population Approach

Vélez de Mendizábal, N., Jones, D. R., Jahn, A., Bies, R. & Brown, J. W., Dec 12 2014, In : Clinical Pharmacokinetics. 54, 6, p. 615-626 12 p.

Research output: Contribution to journalArticle

Cotinine
Nicotine
Pharmacokinetics
Population
Carbon Monoxide
6 Citations (Scopus)

Optimal sampling of antipsychotic medicines: A pharmacometric approach for clinical practice

Perera, V., Bies, R., Mo, G., Dolton, M. J., Carr, V. J., McLachlan, A. J., Day, R. O., Polasek, T. M. & Forrest, A., Apr 29 2014, In : British Journal of Clinical Pharmacology. 78, 4, p. 800-814 15 p.

Research output: Contribution to journalArticle

Antipsychotic Agents
Pharmacokinetics
olanzapine
Perphenazine
Risperidone
1 Citation (Scopus)

Predicted impact of various clinical practice strategies on cardiovascular risk for the treatment of hypertension: a clinical trial simulation study

Jin, Y., Bies, R., Gastonguay, M. R., Wang, Y., Stockbridge, N., Gobburu, J. & Madabushi, R., Nov 9 2014, In : Journal of Pharmacokinetics and Pharmacodynamics. 41, 6, p. 693-704 12 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Clinical Trials
Hypertension
Therapeutics
Morbidity

Predicting dopamine D2 receptor occupancy following antipsychotic dose reduction: a pilot PET study.

Uchida, H., Bies, R. R., Suzuki, T., Graff-Guerrero, A., Pollock, B. G., Mulsant, B. H. & Mamo, D. C., 2014, In : Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. 34, 2, p. 55-56 2 p.

Research output: Contribution to journalArticle

Risperidone
Dopamine D2 Receptors
Positron-Emission Tomography
Antipsychotic Agents
Schizophrenia

Predicting dopamine D2 receptor occupancy following antipsychotic dose reduction: A pilot PET study

Uchida, H., Bies, R., Suzuki, T., Graff-Guerrero, A., Pollock, B. G., Mulsant, B. H. & Mamo, D. C., 2014, In : Japanese Journal of Neuropsychopharmacology. 34, 2, p. 55-56 2 p.

Research output: Contribution to journalArticle

Antipsychotic Agents
Dopamine
9 Citations (Scopus)

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

Li, C. H., Stratford Jr., R., Velez de Mendizabal, N., Cremers, T. I. F. H., Pollock, B. G., Mulsant, B. H., Remington, G. & Bies, R., Aug 20 2014, In : Journal of Translational Medicine. 12, 1, 203.

Research output: Contribution to journalArticle

norclozapine
Pharmacokinetics
Clozapine
Rats
Brain
18 Citations (Scopus)

Tardive dyskinesia in relation to estimated dopamine D2 receptor occupancy in patients with schizophrenia: Analysis of the CATIE data

Yoshida, K., Bies, R., Suzuki, T., Remington, G., Pollock, B. G., Mizuno, Y., Mimura, M. & Uchida, H., 2014, In : Schizophrenia Research. 153, 1-3, p. 184-188 5 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Antipsychotic Agents
Schizophrenia
Clinical Trials
Dyskinesias
2013
9 Citations (Scopus)

Bayesian model of Hamilton Depression Rating Score (HDRS) with memantine augmentation in bipolar depression

Stevens, J., Bies, R., Shekhar, A. & Anand, A., Mar 2013, In : British Journal of Clinical Pharmacology. 75, 3, p. 791-798 8 p.

Research output: Contribution to journalArticle

Memantine
Bipolar Disorder
Confidence Intervals
Depression
Placebos