Robert Stearman

  • 3449 Citations
  • 26 h-Index
1981 …2019

Research output per year

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Publications

  • 3449 Citations
  • 26 h-Index
  • 45 Article
  • 1 Letter
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Article

A macrophage gene expression signature defines a field effect in the lung tumor microenvironment

Stearman, R. S., Dwyer-Nield, L., Grady, M. C., Malkinson, A. M. & Geraci, M., Jan 1 2008, In : Cancer Research. 68, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model

Stearman, R. S., Dwyer-Nield, L., Zerbe, L., Blaine, S. A., Chan, Z., Bunn, P. A., Johnson, G. L., Hirsch, F. R., Merrick, D. T., Franklin, W. A., Baron, A. E., Keith, R. L., Nemenoff, R. A., Malkinson, A. M. & Geraci, M., Dec 2005, In : American Journal of Pathology. 167, 6, p. 1763-1775 13 p.

Research output: Contribution to journalArticle

205 Scopus citations

An Engineered Intersubunit Disulfide Enhances the Stability and DNA Binding of the N-Terminal Domain of λ Repressor

Sauer, R. T., Hehir, K., Stearman, R. S., Weiss, M. A., Jeitler-Nilsson, A., Suchanek, E. G. & Pabo, C. O., Oct 1986, In : Biochemistry. 25, 20, p. 5992-5998 7 p.

Research output: Contribution to journalArticle

131 Scopus citations

An IRP-like protein from Plasmodium falciparum binds to a mammalian iron-responsive element

Loyevsky, M., LaVaute, T., Allerson, C. R., Stearman, R., Kassim, O. O., Cooperman, S., Gordeuk, V. R. & Rouault, T. A., Oct 15 2001, In : Blood. 98, 8, p. 2555-2562 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Antitumorigenic effects of peroxisome proliferator-activated receptor-γ in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-κB

Bren-Mattison, Y., Meyer, A. M., Van Putten, V., Li, H., Kuhn, K., Stearman, R., Weiser-Evans, M., Winn, R. A., Heasley, L. E. & Nemenoff, R. A., Mar 2008, In : Molecular pharmacology. 73, 3, p. 709-717 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

A permease-oxidase complex involved in high-affinity iron uptake in yeast

Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D. & Dancis, A., Mar 15 1996, In : Science. 271, 5255, p. 1552-1557 6 p.

Research output: Contribution to journalArticle

534 Scopus citations

Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions

Nakachi, I., Rice, J. L., Coldren, C. D., Edwards, M. G., Stearman, R. S., Glidewell, S. C., Varella-Garcia, M., Franklin, W. A., Keith, R. L., Lewis, M. T., Gao, B., Merrick, D. T., Miller, Y. E. & Geraci, M. W., Feb 2014, In : Cancer Prevention Research. 7, 2, p. 256-265 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Blood transcriptional biomarkers for active tuberculosis among patients in the United States: A case-control study with systematic cross-classifier evaluation

Walter, N. D., Miller, M. A., Vasquez, J., Weiner, M., Chapman, A., Engle, M., Higgins, M., Quinones, A. M., Rosselli, V., Canono, E., Yoon, C., Cattamanchi, A., Lucian Davis, J., Phang, T., Stearman, R. S., Datta, G., Garcia, B. J., Daley, C. L., Strong, M., Kechris, K. & 3 others, Fingerlin, T. E., Reves, R. & Geraci, M., Feb 2016, In : Journal of clinical microbiology. 54, 2, p. 274-282 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Carbonic anhydrase inhibition ameliorates inflammation and experimental pulmonary hypertension

Hudalla, H., Michael, Z., Christodoulou, N., Willis, G. R., Fernandez-Gonzalez, A., Filatava, E. J., Dieffenbach, P., Fredenburgh, L. E., Stearman, R. S., Geraci, M., Kourembanas, S. & Christou, H., Oct 1 2019, In : American journal of respiratory cell and molecular biology. 61, 4, p. 512-524 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation

Zaffiri, L., Shah, R. J., Stearman, R. S., Rothhaar, K., Emtiazjoo, A. M., Yoshimoto, M., Fisher, A. J., Mickler, E. A., Gartenhaus, M. D., Cohort, L. T. O. G., Diamond, J. M., Geraci, M., Christie, J. D. & Wilkes, D., Oct 2019, In : Transplant Immunology. 56, 101224.

Research output: Contribution to journalArticle

1 Scopus citations

Combining Thermostable Mutations Increases the Stability of λ Repressor

Stearman, R. S., Frankel, A. D., Freire, E., Liu, B. & Pabo, C. O., Sep 1 1988, In : Biochemistry. 27, 19, p. 7571-7574 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

Development of a native plasmid as a cloning vector in clavibacter xyli subsp. Cynodontis

Taylor, J., Stearman, R. S. & Uratani, B. B., May 1993, In : Plasmid. 29, 3, p. 241-244 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fibroblast growth factor signaling mediates pulmonary endothelial glycocalyx reconstitution

Yang, Y., Haeger, S. M., Suflita, M. A., Zhang, F., Dailey, K. L., Colbert, J. F., Ford, J. A., Picon, M. A., Stearman, R., Lin, L., Liu, X., Han, X., Linhardt, R. J. & Schmidt, E. P., Jun 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 6, p. 727-737 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Functional prostacyclin synthase promoter polymorphisms impact in pulmonary arterial hypertension

Stearman, R. S., Cornelius, A. R., Lu, X., Conklin, D. S., Del Rosario, M. J., Lowe, A. M., Elos, M. T., Fettig, L. M., Wong, R. E., Hara, N., Cogan, J. D., Phillips, J. A., Taylor, M. R., Graham, B. B., Tuder, R. M., Loyd, J. E. & Geraci, M. W., May 1 2014, In : American journal of respiratory and critical care medicine. 189, 9, p. 1110-1120 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines

Stearman, R. S., Grady, M. C., Nana-Sinkam, P., Varella-Garcia, M. & Geraci, M., Mar 2007, In : Molecular Cancer Research. 5, 3, p. 295-308 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hands-on Workshops as An Effective Means of Learning Advanced Technologies Including Genomics, Proteomics and Bioinformatics

Reisdorph, N., Stearman, R., Kechris, K., Phang, T. L., Reisdorph, R., Prenni, J., Erle, D. J., Coldren, C., Schey, K., Nesvizhskii, A. & Geraci, M., Dec 1 2013, In : Genomics, Proteomics and Bioinformatics. 11, 6, p. 368-377 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension

Nozik-Grayck, E., Woods, C., Stearman, R. S., Venkataraman, S., Ferguson, B. S., Swain, K., Bowler, R. P., Geraci, M., Ihida-Stansbury, K., Stenmark, K. R., McKinsey, T. A. & Domann, F. E., Jul 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L124-L134

Research output: Contribution to journalArticle

21 Scopus citations

Induction of hepatic synthesis of serum amyloid A protein and actin

Morrow, J. F., Stearman, R. S., Peltzman, C. G. & Potter, D. A., 1981, In : Proceedings of the National Academy of Sciences of the United States of America. 78, 8 I, p. 4718-4722 5 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

Iron overload in urban Africans in the 1990s

Gangaidzo, I. T., Moyo, V. M., Saungweme, T., Khumalo, H., Charakupa, R. M., Gomo, Z. A. R., Loyevsky, M., Stearman, R., La Vaute, T., Enquist, E. G., Rouault, T. A. & Gordeuk, V. R., 1999, In : Gut. 45, 2, p. 278-283 6 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast

Yamaguchi-Iwai, Y., Stearman, R., Dancis, A. & Klausner, R. D., Jul 1 1996, In : EMBO Journal. 15, 13, p. 3377-3384 8 p.

Research output: Contribution to journalArticle

275 Scopus citations

Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension

Maloney, J. P., Stearman, R. S., Bull, T. M., Calabrese, D. W., Tripp-Addison, M. L., Wick, M. J., Broeckel, U., Robbins, I. M., Wheeler, L. A., Cogan, J. D. & Loyd, J. E., Mar 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 6, p. L541-L554

Research output: Contribution to journalArticle

28 Scopus citations

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase

Brower, C. S., Sato, S., Tomomori-Sato, C., Kamura, T., Pause, A., Stearman, R., Klausner, R. D., Malik, S., Lane, W. S., Sorokina, I., Roeder, R. G., Conaway, J. W. & Conaway, R. C., Aug 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 16, p. 10353-10358 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor

Vasselli, J. R., Shih, J. H., Iyengar, S. R., Maranchie, J., Riss, J., Worrell, R., Torres-Cabala, C., Tabios, R., Mariotti, A., Stearman, R., Merino, M., Walther, M. M., Simon, R., Klausner, R. D. & Linehan, W. M., Jun 10 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 12, p. 6958-6963 6 p.

Research output: Contribution to journalArticle

143 Scopus citations

Prostacyclin in endotoxemia-induced acute kidney injury: Cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice

Wang, W., Zolty, E., Falk, S., Summer, S., Stearman, R., Geraci, M. & Schrier, R., Oct 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1131-F1136

Research output: Contribution to journalArticle

20 Scopus citations

Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator-activated receptor γ

Nemenoff, R., Meyer, A. M., Hudish, T. M., Mozer, A. B., Snee, A., Narumiya, S., Stearman, R. S., Winn, R. A., Weiser-Evans, M., Geraci, M. & Keith, R. L., Oct 1 2008, In : Cancer Prevention Research. 1, 5, p. 349-356 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke

Nana-Sinkam, S. P., Jong, D. L., Sotto-Santiago, S., Stearman, R. S., Keith, R. L., Choudhury, Q., Cool, C., Parr, J., Moore, M. D., Bull, T. M., Voelkel, N. F. & Geraci, M., Apr 1 2007, In : American journal of respiratory and critical care medicine. 175, 7, p. 676-685 10 p.

Research output: Contribution to journalArticle

105 Scopus citations

Prostacyclin synthase in smoking-related lung disease

Nana-Sinkam, S. P., Jong, D. L., Stearman, R., Sakao, S., Sotto-Santiago, S., Voelkel, N. F. & Geraci, M., Aug 31 2006, In : Proceedings of the American Thoracic Society. 3, 6, 1 p.

Research output: Contribution to journalArticle

7 Scopus citations

Prostacyclin synthese promoter regulation and familial pulmonary arterial hypertension

Nana-Sinkam, P., Oyer, R. J., Stearman, R. S., Sotto-Santiago, S., Moore, M. D., Bull, T. M., Grady, M. C., Choudhery, Q., Nemenoff, R. A., Lane, K., Loyd, J. E. & Geraci, M., Dec 2005, In : Chest. 128, 6 SUPPL., p. 612S

Research output: Contribution to journalArticle

4 Scopus citations

Protein-Protein Interactions in DNA Recognition: 1H-NMR Studies of Lambda cI Repressors Genetically Altered by Site-Directed Mutagenesis

Weiss, M. A., Stearman, R., Jeitler-Nilsson, A., Karplus, M. & Sauer, R. T., 1986, In : Biophysical journal. 49, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines

Nakachi, I., Helfrich, B. A., Spillman, M. A., Mickler, E. A., Olson, C. J., Rice, J. L., Coldren, C. D., Heasley, L. E., Geraci, M. & Stearman, R. S., Dec 1 2016, In : Clinical and translational science. 9, 6, p. 293-301 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Reductive iron uptake by Candida albicans: Role of copper, iron and the TUP1 regulator

Knight, S. A. B., Lesuisse, E., Stearman, R., Klausner, R. D. & Dancis, A., Jan 1 2002, In : Microbiology. 148, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Regulation of Synthesis of Amyloid A‐Related Protein

Stearman, R. S., Lowell, C. A., Pearson, W. R. & Morrow, J. F., Jun 1982, In : Annals of the New York Academy of Sciences. 389, 1, p. 106-115 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae

Carmel-Harel, O., Stearman, R., Gasch, A. P., Botstein, D., Brown, P. O. & Storz, G., Feb 27 2001, In : Molecular Microbiology. 39, 3, p. 595-605 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

Stability of the δ-endotoxin gene from Bacillus thuringiensis subsp. kurstaki in a recombinant strain of Clavibacter xyli subsp. cynodontis

Turner, J. T., Lampel, J. S., Stearman, R. S., Sundin, G. W., Gunyuzlu, P. & Anderson, J. J., Jan 1 1991, In : Applied and environmental microbiology. 57, 12, p. 3522-3528 7 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Structure of the murine serum amyloid A gene family. Gene Conversion

Lowell, C. A., Potter, D. A., Stearman, R. S. & Morrow, J. F., Dec 1 1986, In : Journal of Biological Chemistry. 261, 18, p. 8442-8452 11 p.

Research output: Contribution to journalArticle

133 Scopus citations
78 Scopus citations

Systems analysis of the human pulmonary arterial hypertension lung transcriptome

Stearman, R. S., Bui, Q. M., Speyer, G., Handen, A., Cornelius, A. R., Graham, B. B., Kim, S., Mickler, E. A., Tuder, R. M., Chan, S. Y. & Geraci, M. W., Jun 2019, In : American journal of respiratory cell and molecular biology. 60, 6, p. 637-649 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake

Yuan, D. S., Stearman, R., Dancis, A., Dunn, T., Beeler, T. & Klausner, R. D., Mar 28 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 7, p. 2632-2636 5 p.

Research output: Contribution to journalArticle

367 Scopus citations

The sequence and structure of a new serum amyloid a gene

Stearman, R. S., Lowell, C. A., Peltzman, C. G. & Morrow, J. F., Jan 26 1986, In : Nucleic acids research. 14, 2, p. 797-809 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

Koochekpour, S., Jeffers, M., Wang, P. H., Gong, C., Taylor, G. A., Roessler, L. M., Stearman, R., Vasselli, J. R., Stetler-Stevenson, W. G., Kaelin, W. G., Linehan, W. M., Klausner, R. D., Gnarra, J. R. & Vande Woude, G. F., Sep 1999, In : Molecular and cellular biology. 19, 9, p. 5902-5912 11 p.

Research output: Contribution to journalArticle

Open Access
175 Scopus citations

Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome

Glidewell, S. C., Miyamoto, S. D., Grossfeld, P. D., Clouthier, D. E., Coldren, C. D., Stearman, R. S. & Geraci, M. W., Dec 1 2015, In : Clinical and translational science. 8, 6, p. 682-689 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transcriptional regulation of serum amyloid A gene expression

Lowell, C. A., Stearman, R. S. & Morrow, J. F., Dec 1 1986, In : Journal of Biological Chemistry. 261, 18, p. 8453-8461 9 p.

Research output: Contribution to journalArticle

133 Scopus citations

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

Stephen, L., Neumann, M., Stearman, R., Stauber, R., Pause, A., Pavlakis, G. N. & Klausner, R. D., Feb 1 1999, In : Molecular and cellular biology. 19, 2, p. 1486-1497 12 p.

Research output: Contribution to journalArticle

110 Scopus citations

VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells

Bindra, R. S., Stearman, R., Vasselli, J. R., Linehan, W. M. & Klausner, R. D., Jun 1 2002, In : Cancer Research. 62, 11, p. 3014-3019 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

YIpDCE1 - An integrating plasmid for dual constitutive expression in yeast

Stearman, R., Dancis, A. & Klausner, R. D., Jun 8 1998, In : Gene. 212, 2, p. 197-202 6 p.

Research output: Contribution to journalArticle

17 Scopus citations