Robert Stratford Jr.

  • 1133 Citations
  • 21 h-Index
1980 …2019

Research output per year

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Publications

  • 1133 Citations
  • 21 h-Index
  • 48 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Short survey
Article

Activities of the semisynthetic glycopeptide LY191145 against vancomycin- resistant enterococci and other gram-positive bacteria

Nicas, T. I., Mullen, D. L., Flokowitsch, J. E., Preston, D. A., Snyder, N. J., Stratford, R. E. & Cooper, R. D. G., Jan 1 1995, In : Antimicrobial Agents and Chemotherapy. 39, 11, p. 2585-2587 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

Age-related changes in esterase activity in rabbit eyes

Lee, V. H. L., Stratford, R. E. & Morimoto, K. W., Jan 1983, In : International Journal of Pharmaceutics. 13, 2, p. 183-195 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Aminopeptidase activity in albino rabbit extraocular tissues relative to the small intestine

Stratford, R. E. & Lee, V. H. L., Jul 1985, In : Journal of Pharmaceutical Sciences. 74, 7, p. 731-734 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
121 Scopus citations

A novel response to propranolol: Contractile response in the isolated rabbit ear artery

Ashbrook, D. W., Purdy, R. E., Hurlbut, D. E., Rains, L. A., Reidy, J. P. & Stratford, R. E., Jan 14 1980, In : Life Sciences. 26, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism

Alt, A., Weiss, B., Ornstein, P. L., Gleason, S. D., Bleakman, D., Stratford, R. E. & Witkin, J. M., Jun 1 2007, In : Neuropharmacology. 52, 7, p. 1482-1487 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication

Stratford, R. E., Clay, M. P., Heinz, B. A., Kuhfeld, M. T., Osborne, S. J., Phillips, D. L., Sweetana, S. A., Tebbe, M. J., Vasudevan, V., Zornes, L. L. & Lindstrom, T. D., Aug 1999, In : Journal of Pharmaceutical Sciences. 88, 8, p. 747-753 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
3 Scopus citations

Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes

Bhattacharya, C., Kirby, D., Van Stipdonk, M. & Stratford, R. E., Apr 9 2019, In : European Journal of Drug Metabolism and Pharmacokinetics. 44, 2, p. 261-274 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Liu, B., Croy, C. H., Hitchcock, S. A., Allen, J. R., Rao, Z., Evans, D., Bures, M. G., McKinzie, D. L., Watt, M. L., Stuart Gregory, G., Hansen, M. M., Hoogestraat, P. J., Jamison, J. A., Okha-Mokube, F. M., Stratford Jr., R., Turner, W., Bymaster, F. & Felder, C. C., Oct 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 19, p. 4158-4163 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response

Folgering, J. H., Choi, M., Schlumbohm, C., van Gaalen, M. M. & Stratford, R. E., Apr 1 2019, In : Journal of Neuroscience Methods. 317, p. 71-81 11 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
8 Scopus citations

Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine

van Gaalen, M. M., Schlumbohm, C., Folgering, J. H., Adhikari, S., Bhattacharya, C., Steinbach, D. & Stratford, R. E., Apr 2019, In : Journal of Pharmacology and Experimental Therapeutics. 369, 1, p. 107-120 14 p.

Research output: Contribution to journalArticle

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

Bueno, A. B., Collado, I., De Dios, A., Domínguez, C., Martín, J. A., Martín, L. M., Martínez-Grau, M. A., Montero, C., Pedregal, C., Catlow, J., Coffey, D. S., Clay, M. P., Dantzig, A. H., Lindstrom, T., Monn, J. A., Jiang, H., Schoepp, D. D., Stratford, R. E., Tabas, L. B., Tizzano, J. P. & 2 others, Wright, R. A. & Herin, M. F., Aug 11 2005, In : Journal of Medicinal Chemistry. 48, 16, p. 5305-5320 16 p.

Research output: Contribution to journalArticle

48 Scopus citations

Disposition of topically applied sodium cromoglycate in the albino rabbit eye

LEE, VINCENT. H. L., SWARBRICK, JAMES., STRATFORD, ROBERT. E. & MORIMOTO, KIM. W., Jul 1983, In : Journal of Pharmacy and Pharmacology. 35, 7, p. 445-450 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Drug conjugates—an emerging approach to treat breast cancer

Hasan, M., Leak, R. K., Stratford Jr., R., Zlotos, D. P. & Witt-Enderby, P. A., Jul 1 2018, In : Pharmacology Research and Perspectives. 6, 4, e00417.

Research output: Contribution to journalArticle

7 Scopus citations

Effects of reserpinization, surgical denervation and in vitro chemical denervation with 6-hydroxydopamine on the contractile response of isolated rabbit ear artery to propranolol

Purdy, R. E., Ashbrook, D. W., Hurlbut, D. E., Reidy, J. P., Stratford, R. E. & Watanabe, M. Y., Jan 1 1981, In : Journal of Vascular Research. 18, 4-5, p. 153-160 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of topically applied liposomes on disposition of epinephrine and inulin in the albino rabbit eye

Stratford, R. E., Yang, D. C., Redell, M. A. & Lee, V. H. L., Feb 1983, In : International Journal of Pharmaceutics. 13, 3, p. 263-272 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability

Lee, V. H. L., Morimoto, K. W. & Stratford, R. E., Jan 1 1982, In : Biopharmaceutics & Drug Disposition. 3, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Ethyl (3s,4aR,6S,8aR)-6-(4-ethoxycar-bonylimidazol-1-ylmethyl) decahydroiso-quinoline-3-carboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine

Filla, S. A., Winter, M. A., Johnson, K. W., Bleakman, D., Bell, M. G., Bleisch, T. J., Castaño, A. M., Clemens-Smith, A., Del Prado, M., Dieckman, D. K., Dominguez, E., Escribano, A., Ho, K. H., Hudziak, K. J., Katofiasc, M. A., Martinez-Perez, J. A., Mateo, A., Mathes, B. M., Mattiuz, E. L., Ogden, A. M. L. & 4 others, Phebus, L. A., Stack, D. R., Stratford, R. E. & Ornstein, P. L., Sep 26 2002, In : Journal of Medicinal Chemistry. 45, 20, p. 4383-4386 4 p.

Research output: Contribution to journalArticle

44 Scopus citations
28 Scopus citations
17 Scopus citations

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Martinez-Perez, J. A., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Arnold, B. M., Bell, M. G., Bleisch, T. J., Castaño, A. M., Del Prado, M., Dominguez, E., Escribano, A. M., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Mateo, A., Mathes, B. M., Mattiuz, E. L., Ogden, A. M. L. & 6 others, Simmons, R. M. A., Stack, D. R., Stratford, R. E., Winter, M. A., Wu, Z. & Ornstein, P. L., Dec 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 23, p. 6459-6462 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Martinez-Perez, J. A., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Clawson, D. K., Arnold, B. M., Bell, M. G., Bleisch, T. J., Castaño, A. M., Del Prado, M., Dominguez, E., Escribano, A. M., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Mateo, A., Mathes, B. M., Mattiuz, E. L. & 7 others, Ogden, A. M. L., Simmons, R. M. A., Stack, D. R., Stratford, R. E., Winter, M. A., Wu, Z. & Ornstein, P. L., Dec 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 23, p. 6463-6466 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions

Chimezie, C., Ewing, A., Schexnayder, C., Bratton, M., Glotser, E., Skripnikova, E., Sá, P., Boué, S. & Stratford Jr., R., Feb 1 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 972-981 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Glyceollin transport, metabolism, and effects on P-glycoprotein function in Caco-2 cells

Chimezie, C., Ewing, A. C., Quadri, S. S., Cole, R. B., Boué, S. M., Omari, C. F., Bratton, M., Glotser, E., Skripnikova, E., Townley, I. & Stratford, R. E., Apr 1 2014, In : Journal of Medicinal Food. 17, 4, p. 462-471 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
6 Scopus citations
8 Scopus citations
77 Scopus citations

Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison with Cephalexin

Hu, M., Zheng, L., Chen, J., Liu, L., Zhu, Y., Dantzig, A. H. & Stratford, R. E., Aug 1995, In : Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12, 8, p. 1120-1125 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Metabolic and Permeation Barriers to the Ocular Absorption of Topically Applied Enkephalins in Albino Rabbits

Lee, V. H. L., Carson, L. W., Kashi, S. D. & Stratford, R. E., Jan 1 1986, In : Journal of Ocular Pharmacology. 2, 4, p. 345-352 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats

Kielbasa, W., Kalvass, J. C. & Stratford, R., Jan 1 2009, In : Drug Metabolism and Disposition. 37, 1, p. 137-142 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain

Cremers, T. I. F. H., Flik, G., Hofland, C. & Stratford, R. E., Oct 1 2012, In : Drug Metabolism and Disposition. 40, 10, p. 1909-1916 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Ocular aminopeptidase activity and distribution in the albino rabbit

Stratford, R. E. & Lee, V. H. L., Jan 1 1985, In : Current Eye Research. 4, 9, p. 995-1000 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Ocular distribution of liposome-encapsulated epinephrine and inulin in the albino rabbit

Stratford, R. E., Yang, D. C., Redell, M. A. & Lee, V. H. L., Jan 1 1982, In : Current Eye Research. 2, 6, p. 377-386 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Peptide transporter function and prolidase activities in caco-2 cells: A lack of coordinated expression

Hu, M., Zheng, L., Chen, J., Liu, L., Li, Y., Dantzig, A. H. & Stratford, R. E., Jan 1 1995, In : Journal of Drug Targeting. 3, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pharmacokinetics in rats of a long-acting human parathyroid hormone-collagen binding domain peptide construct

Stratford, R., Vu, C., Sakon, J., Katikaneni, R., Gensure, R. & Ponnapakkam, T., Jan 1 2014, In : Journal of Pharmaceutical Sciences. 103, 2, p. 768-775 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacological, mechanistic, and pharmacokinetic assessment of novel_ melatonin-tamoxifen drug conjugates as breast cancer drugs

Hasan, M., Marzouk, M. A., Adhikari, S., Wright, T. D., Miller, B. P., Matossian, M. D., Elliott, S., Wright, M., Alzoubi, M., Collins-Burow, B. M., Burow, M. E., Holzgrabe, U., Zlotos, D. P., Stratford, R. E. & Witt-Enderby, P. A., Jan 1 2019, In : Molecular pharmacology. 96, 2, p. 272-296 25 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

Weiss, B., Alt, A., Ogden, A. M., Gates, M., Dieckman, D. K., Clemens-Smith, A., Ho, K. H., Jarvie, K., Rizkalla, G., Wright, R. A., Calligaro, D. O., Schoepp, D., Mattiuz, E. L., Stratford, R. E., Johnson, B., Salhoff, C., Katofiasc, M., Phebus, L. A., Schenck, K., Cohen, M. & 4 others, Filla, S. A., Ornstein, P. L., Johnson, K. W. & Bleakman, D., Jul 21 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 2, p. 772-781 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

Li, C. H., Stratford, R. E., Velez de Mendizabal, N., Cremers, T. I. F. H., Pollock, B. G., Mulsant, B. H., Remington, G. & Bies, R. R., Aug 20 2014, In : Journal of Translational Medicine. 12, 1, 203.

Research output: Contribution to journalArticle

9 Scopus citations

Regional-dependent intestinal absorption and meal effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs

Li, C., Fleisher, D., Li, L., Schwier, J. R., Sweetana, S. A., Vasudevan, V., Zornes, L. L., Pao, L. H., Zhou, S. Y. & Stratford, R. E., Jan 1 2001, In : Journal of Pharmaceutical Sciences. 90, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Screening and identification of glyceollins and their metabolites by electrospray ionization tandem mass spectrometry with precursor ion scanning

Quadri, S. S., Stratford, R. E., Boué, S. M. & Cole, R. B., Feb 5 2013, In : Analytical Chemistry. 85, 3, p. 1727-1733 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Selective cannabinoid receptor type 2 (CB2) agonists: Optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain

Hollinshead, S. P., Tidwell, M. W., Palmer, J., Guidetti, R., Sanderson, A., Johnson, M. P., Chambers, M. G., Oskins, J., Stratford, R. & Astles, P. C., Jul 25 2013, In : Journal of Medicinal Chemistry. 56, 14, p. 5722-5733 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Systemic absorption of ocularly administered enkephalinamide and inulin in the albino rabbit: Extent, pathways, and vehicle effects

Stratford, R. E., Carson, L. W., Dodda‐Kashi, S. & Lee, V. H. L., Oct 1988, In : Journal of Pharmaceutical Sciences. 77, 10, p. 838-842 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Ekins, S., Durst, G. L., Stratford, R. E., Thorner, D. A., Lewis, R., Loncharich, R. J. & Wikel, J. H., Dec 1 2001, In : Journal of Chemical Information and Computer Sciences. 41, 6, p. 1578-1586 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain

Dominguez, E., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Arnold, B. M., Bell, M. G., Bleisch, T. J., Buckmaster, J. L., Castano, A. M., Del Prado, M., Escribano, A., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Martinez-Perez, J. A., Mateo, A., Mathes, B. M., Mattiuz, E. L. & 7 others, Ogden, A. M. L., Simmons, R. M. A., Stack, D. R., Stratford, R. E., Winter, M. A., Wu, Z. & Ornsteint, P. L., Jun 30 2005, In : Journal of Medicinal Chemistry. 48, 13, p. 4200-4203 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
7 Scopus citations
Chapter

Microdialysis to Assess Free Drug Concentration in Brain

Kielbasa, W. & Stratford Jr., R., Jan 2 2015, Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs. wiley, p. 351-364 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Comment/debate

Erratum: Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria (Antimicrobial Agents and Chemotherapy 39:1 (2585))

Nicas, T. I., Mullen, D. L., Flokowitsch, J. E., Preston, D. A., Snyder, N. J., Stratford, R. E. & Cooper, R. D. G., May 14 1996, In : Antimicrobial Agents and Chemotherapy. 40, 5, 1 p.

Research output: Contribution to journalComment/debate