Robert Stratford Jr.

  • 1120 Citations
  • 21 h-Index
1980 …2019

Research output per year

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Publications

  • 1120 Citations
  • 21 h-Index
  • 48 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Short survey
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Article
2019

Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes

Bhattacharya, C., Kirby, D., Van Stipdonk, M. & Stratford, R. E., Apr 9 2019, In : European Journal of Drug Metabolism and Pharmacokinetics. 44, 2, p. 261-274 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response

Folgering, J. H., Choi, M., Schlumbohm, C., van Gaalen, M. M. & Stratford, R. E., Apr 1 2019, In : Journal of Neuroscience Methods. 317, p. 71-81 11 p.

Research output: Contribution to journalArticle

Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine

van Gaalen, M. M., Schlumbohm, C., Folgering, J. H., Adhikari, S., Bhattacharya, C., Steinbach, D. & Stratford, R. E., Apr 2019, In : Journal of Pharmacology and Experimental Therapeutics. 369, 1, p. 107-120 14 p.

Research output: Contribution to journalArticle

Pharmacological, mechanistic, and pharmacokinetic assessment of novel_ melatonin-tamoxifen drug conjugates as breast cancer drugs

Hasan, M., Marzouk, M. A., Adhikari, S., Wright, T. D., Miller, B. P., Matossian, M. D., Elliott, S., Wright, M., Alzoubi, M., Collins-Burow, B. M., Burow, M. E., Holzgrabe, U., Zlotos, D. P., Stratford, R. E. & Witt-Enderby, P. A., Jan 1 2019, In : Molecular pharmacology. 96, 2, p. 272-296 25 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018
2 Scopus citations

Drug conjugates—an emerging approach to treat breast cancer

Hasan, M., Leak, R. K., Stratford Jr., R., Zlotos, D. P. & Witt-Enderby, P. A., Jul 1 2018, In : Pharmacology Research and Perspectives. 6, 4, e00417.

Research output: Contribution to journalArticle

5 Scopus citations
2016
8 Scopus citations
8 Scopus citations
2015

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Liu, B., Croy, C. H., Hitchcock, S. A., Allen, J. R., Rao, Z., Evans, D., Bures, M. G., McKinzie, D. L., Watt, M. L., Stuart Gregory, G., Hansen, M. M., Hoogestraat, P. J., Jamison, J. A., Okha-Mokube, F. M., Stratford Jr., R., Turner, W., Bymaster, F. & Felder, C. C., Oct 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 19, p. 4158-4163 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
16 Scopus citations
2014

Glyceollin transport, metabolism, and effects on P-glycoprotein function in Caco-2 cells

Chimezie, C., Ewing, A. C., Quadri, S. S., Cole, R. B., Boué, S. M., Omari, C. F., Bratton, M., Glotser, E., Skripnikova, E., Townley, I. & Stratford, R. E., Apr 1 2014, In : Journal of Medicinal Food. 17, 4, p. 462-471 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
6 Scopus citations

Pharmacokinetics in rats of a long-acting human parathyroid hormone-collagen binding domain peptide construct

Stratford, R., Vu, C., Sakon, J., Katikaneni, R., Gensure, R. & Ponnapakkam, T., Jan 1 2014, In : Journal of Pharmaceutical Sciences. 103, 2, p. 768-775 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Martinez-Perez, J. A., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Clawson, D. K., Arnold, B. M., Bell, M. G., Bleisch, T. J., Castaño, A. M., Del Prado, M., Dominguez, E., Escribano, A. M., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Mateo, A., Mathes, B. M., Mattiuz, E. L. & 7 others, Ogden, A. M. L., Simmons, R. M. A., Stack, D. R., Stratford, R. E., Winter, M. A., Wu, Z. & Ornstein, P. L., Dec 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 23, p. 6463-6466 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Screening and identification of glyceollins and their metabolites by electrospray ionization tandem mass spectrometry with precursor ion scanning

Quadri, S. S., Stratford, R. E., Boué, S. M. & Cole, R. B., Feb 5 2013, In : Analytical Chemistry. 85, 3, p. 1727-1733 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Selective cannabinoid receptor type 2 (CB2) agonists: Optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain

Hollinshead, S. P., Tidwell, M. W., Palmer, J., Guidetti, R., Sanderson, A., Johnson, M. P., Chambers, M. G., Oskins, J., Stratford, R. & Astles, P. C., Jul 25 2013, In : Journal of Medicinal Chemistry. 56, 14, p. 5722-5733 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain

Cremers, T. I. F. H., Flik, G., Hofland, C. & Stratford, R. E., Oct 1 2012, In : Drug Metabolism and Disposition. 40, 10, p. 1909-1916 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats

Kielbasa, W., Kalvass, J. C. & Stratford, R., Jan 1 2009, In : Drug Metabolism and Disposition. 37, 1, p. 137-142 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
2007

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism

Alt, A., Weiss, B., Ornstein, P. L., Gleason, S. D., Bleakman, D., Stratford, R. E. & Witkin, J. M., Jun 1 2007, In : Neuropharmacology. 52, 7, p. 1482-1487 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

Weiss, B., Alt, A., Ogden, A. M., Gates, M., Dieckman, D. K., Clemens-Smith, A., Ho, K. H., Jarvie, K., Rizkalla, G., Wright, R. A., Calligaro, D. O., Schoepp, D., Mattiuz, E. L., Stratford, R. E., Johnson, B., Salhoff, C., Katofiasc, M., Phebus, L. A., Schenck, K., Cohen, M. & 4 others, Filla, S. A., Ornstein, P. L., Johnson, K. W. & Bleakman, D., Jul 21 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 2, p. 772-781 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
2005

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

Bueno, A. B., Collado, I., De Dios, A., Domínguez, C., Martín, J. A., Martín, L. M., Martínez-Grau, M. A., Montero, C., Pedregal, C., Catlow, J., Coffey, D. S., Clay, M. P., Dantzig, A. H., Lindstrom, T., Monn, J. A., Jiang, H., Schoepp, D. D., Stratford, R. E., Tabas, L. B., Tizzano, J. P. & 2 others, Wright, R. A. & Herin, M. F., Aug 11 2005, In : Journal of Medicinal Chemistry. 48, 16, p. 5305-5320 16 p.

Research output: Contribution to journalArticle

48 Scopus citations

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain

Dominguez, E., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Arnold, B. M., Bell, M. G., Bleisch, T. J., Buckmaster, J. L., Castano, A. M., Del Prado, M., Escribano, A., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Martinez-Perez, J. A., Mateo, A., Mathes, B. M., Mattiuz, E. L. & 7 others, Ogden, A. M. L., Simmons, R. M. A., Stack, D. R., Stratford, R. E., Winter, M. A., Wu, Z. & Ornsteint, P. L., Jun 30 2005, In : Journal of Medicinal Chemistry. 48, 13, p. 4200-4203 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
2001

Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Ekins, S., Durst, G. L., Stratford, R. E., Thorner, D. A., Lewis, R., Loncharich, R. J. & Wikel, J. H., Dec 1 2001, In : Journal of Chemical Information and Computer Sciences. 41, 6, p. 1578-1586 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
1999

Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication

Stratford, R. E., Clay, M. P., Heinz, B. A., Kuhfeld, M. T., Osborne, S. J., Phillips, D. L., Sweetana, S. A., Tebbe, M. J., Vasudevan, V., Zornes, L. L. & Lindstrom, T. D., Aug 1999, In : Journal of Pharmaceutical Sciences. 88, 8, p. 747-753 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
1997
18 Scopus citations
1996
8 Scopus citations
1995

Activities of the semisynthetic glycopeptide LY191145 against vancomycin- resistant enterococci and other gram-positive bacteria

Nicas, T. I., Mullen, D. L., Flokowitsch, J. E., Preston, D. A., Snyder, N. J., Stratford, R. E. & Cooper, R. D. G., Jan 1 1995, In : Antimicrobial Agents and Chemotherapy. 39, 11, p. 2585-2587 3 p.

Research output: Contribution to journalArticle

45 Scopus citations
48 Scopus citations
9 Scopus citations
1986
121 Scopus citations

Metabolic and Permeation Barriers to the Ocular Absorption of Topically Applied Enkephalins in Albino Rabbits

Lee, V. H. L., Carson, L. W., Kashi, S. D. & Stratford, R. E., Jan 1 1986, In : Journal of Ocular Pharmacology. 2, 4, p. 345-352 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
1985

Aminopeptidase activity in albino rabbit extraocular tissues relative to the small intestine

Stratford, R. E. & Lee, V. H. L., Jul 1985, In : Journal of Pharmaceutical Sciences. 74, 7, p. 731-734 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
1983

Age-related changes in esterase activity in rabbit eyes

Lee, V. H. L., Stratford, R. E. & Morimoto, K. W., Jan 1983, In : International Journal of Pharmaceutics. 13, 2, p. 183-195 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Disposition of topically applied sodium cromoglycate in the albino rabbit eye

LEE, VINCENT. H. L., SWARBRICK, JAMES., STRATFORD, ROBERT. E. & MORIMOTO, KIM. W., Jul 1983, In : Journal of Pharmacy and Pharmacology. 35, 7, p. 445-450 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effects of topically applied liposomes on disposition of epinephrine and inulin in the albino rabbit eye

Stratford, R. E., Yang, D. C., Redell, M. A. & Lee, V. H. L., Feb 1983, In : International Journal of Pharmaceutics. 13, 3, p. 263-272 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
1982

Ocular distribution of liposome-encapsulated epinephrine and inulin in the albino rabbit

Stratford, R. E., Yang, D. C., Redell, M. A. & Lee, V. H. L., Jan 1 1982, In : Current Eye Research. 2, 6, p. 377-386 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
1981

Effects of reserpinization, surgical denervation and in vitro chemical denervation with 6-hydroxydopamine on the contractile response of isolated rabbit ear artery to propranolol

Purdy, R. E., Ashbrook, D. W., Hurlbut, D. E., Reidy, J. P., Stratford, R. E. & Watanabe, M. Y., Jan 1 1981, In : Journal of Vascular Research. 18, 4-5, p. 153-160 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
1980

A novel response to propranolol: Contractile response in the isolated rabbit ear artery

Ashbrook, D. W., Purdy, R. E., Hurlbut, D. E., Rains, L. A., Reidy, J. P. & Stratford, R. E., Jan 14 1980, In : Life Sciences. 26, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

15 Scopus citations