Robert Stratford Jr.

  • 1111 Citations
  • 21 h-Index
1980 …2019
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Publications 1980 2019

  • 1111 Citations
  • 21 h-Index
  • 48 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2019

Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response

Folgering, J. H., Choi, M., Schlumbohm, C., van Gaalen, M. M. & Stratford Jr., R., Apr 1 2019, In : Journal of Neuroscience Methods. 317, p. 71-81 11 p.

Research output: Contribution to journalArticle

Open Access
Translational Medical Research
Amphetamine
Extracellular Fluid
Primates
Dopamine

Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine

van Gaalen, M. M., Schlumbohm, C., Folgering, J. H., Adhikari, S., Bhattacharya, C., Steinbach, D. & Stratford Jr., R., Apr 1 2019, In : The Journal of pharmacology and experimental therapeutics. 369, 1, p. 107-120 14 p.

Research output: Contribution to journalArticle

Corpus Striatum
Dextroamphetamine
Primates
Dopamine
Pharmacokinetics
1 Citation (Scopus)

Pharmacological, mechanistic, and pharmacokinetic assessment of novel_ melatonin-tamoxifen drug conjugates as breast cancer drugs

Hasan, M., Marzouk, M. A., Adhikari, S., Wright, T. D., Miller, B. P., Matossian, M. D., Elliott, S., Wright, M., Alzoubi, M., Collins-Burow, B. M., Burow, M. E., Holzgrabe, U., Zlotos, D. P., Stratford Jr., R. & Witt-Enderby, P. A., Jan 1 2019, In : Molecular Pharmacology. p. 272-296 25 p.

Research output: Contribution to journalArticle

Melatonin
Tamoxifen
Pharmacokinetics
Pharmacology
Breast Neoplasms
2018
2 Citations (Scopus)
verlukast
Caco-2 Cells
Genistein
Pharmacokinetics
Multidrug Resistance-Associated Proteins
1 Citation (Scopus)

Comparison of In Vitro Stereoselective Metabolism of Bupropion in Human, Monkey, Rat, and Mouse Liver Microsomes

Bhattacharya, C., Kirby, D., Van Stipdonk, M. & Stratford Jr., R., Jan 1 2018, (Accepted/In press) In : European Journal of Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Bupropion
Liver Microsomes
Haplorhini
Second-Generation Antidepressive Agents
Central Nervous System
3 Citations (Scopus)

Drug conjugates—an emerging approach to treat breast cancer

Hasan, M., Leak, R. K., Stratford Jr., R., Zlotos, D. P. & Witt-Enderby, P. A., Jul 1 2018, In : Pharmacology Research and Perspectives. 6, 4, e00417.

Research output: Contribution to journalArticle

Breast Neoplasms
Pharmaceutical Preparations
Nanoparticles
Immunoconjugates
Antibodies
2016
8 Citations (Scopus)
Bupropion
Extracellular Fluid
Microdialysis
Pharmacokinetics
Brain
8 Citations (Scopus)

Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions

Chimezie, C., Ewing, A., Schexnayder, C., Bratton, M., Glotser, E., Skripnikova, E., Sá, P., Boué, S. & Stratford Jr., R., Feb 1 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 972-981 10 p.

Research output: Contribution to journalArticle

Caco-2 Cells
Genistein
Prazosin
verlukast
Food-Drug Interactions
2015
3 Citations (Scopus)

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Liu, B., Croy, C. H., Hitchcock, S. A., Allen, J. R., Rao, Z., Evans, D., Bures, M. G., McKinzie, D. L., Watt, M. L., Stuart Gregory, G., Hansen, M. M., Hoogestraat, P. J., Jamison, J. A., Okha-Mokube, F. M., Stratford Jr., R., Turner, W., Bymaster, F. & Felder, C. C., Oct 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 19, p. 4158-4163 6 p.

Research output: Contribution to journalArticle

Muscarinic Agonists
N-(6-((1-((4-fluorobenzyl)(methyl)amino)ethylidene))amino)-2-hydroxy-2,3-dihydro-1H-inden-1-ylbiphenyl-4-carboxamide
Cholinergic Agents
Ligands
Acetylcholine
16 Citations (Scopus)
Genistein
Breast Neoplasms
Prazosin
verlukast
Proteins
2014
7 Citations (Scopus)

Glyceollin transport, metabolism, and effects on P-glycoprotein function in Caco-2 cells

Chimezie, C., Ewing, A. C., Quadri, S. S., Cole, R. B., Boué, S. M., Omari, C. F., Bratton, M., Glotser, E., Skripnikova, E., Townley, I. & Stratford Jr., R., Apr 1 2014, In : Journal of Medicinal Food. 17, 4, p. 462-471 10 p.

Research output: Contribution to journalArticle

Caco-2 Cells
P-Glycoprotein
Genistein
Rhodamine 123
Permeability
6 Citations (Scopus)
Electrospray ionization
Glucuronic Acid
glucuronic acid
Electrospray Ionization Mass Spectrometry
Liquid chromatography
3 Citations (Scopus)

Pharmacokinetics in rats of a long-acting human parathyroid hormone-collagen binding domain peptide construct

Stratford Jr., R., Vu, C., Sakon, J., Katikaneni, R., Gensure, R. & Ponnapakkam, T., Jan 1 2014, In : Journal of Pharmaceutical Sciences. 103, 2, p. 768-775 8 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Collagen
Pharmacokinetics
Microbial Collagenase
Anabolic Agents
9 Citations (Scopus)

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

Li, C. H., Stratford Jr., R., Velez de Mendizabal, N., Cremers, T. I. F. H., Pollock, B. G., Mulsant, B. H., Remington, G. & Bies, R., Aug 20 2014, In : Journal of Translational Medicine. 12, 1, 203.

Research output: Contribution to journalArticle

norclozapine
Pharmacokinetics
Clozapine
Rats
Brain
2013
2 Citations (Scopus)

GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models

Martinez-Perez, J. A., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Arnold, B. M., Bell, M. G., Bleisch, T. J., Castaño, A. M., Del Prado, M., Dominguez, E., Escribano, A. M., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Mateo, A., Mathes, B. M., Mattiuz, E. L., Ogden, A. M. L. & 6 others, Simmons, R. M. A., Stack, D. R., Stratford Jr., R., Winter, M. A., Wu, Z. & Ornstein, P. L., Dec 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 23, p. 6459-6462 4 p.

Research output: Contribution to journalArticle

Prodrugs
Derivatives
Pain
Benzoic Acid
Structure-Activity Relationship
7 Citations (Scopus)

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: In vitro profile and in vivo analgesic efficacy

Martinez-Perez, J. A., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Clawson, D. K., Arnold, B. M., Bell, M. G., Bleisch, T. J., Castaño, A. M., Del Prado, M., Dominguez, E., Escribano, A. M., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Mateo, A., Mathes, B. M., Mattiuz, E. L. & 7 others, Ogden, A. M. L., Simmons, R. M. A., Stack, D. R., Stratford Jr., R., Winter, M. A., Wu, Z. & Ornstein, P. L., Dec 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 23, p. 6463-6466 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Scaffolds
Analgesics
Substitution reactions
Derivatives
11 Citations (Scopus)

Screening and identification of glyceollins and their metabolites by electrospray ionization tandem mass spectrometry with precursor ion scanning

Quadri, S. S., Stratford Jr., R., Boué, S. M. & Cole, R. B., Feb 5 2013, In : Analytical Chemistry. 85, 3, p. 1727-1733 7 p.

Research output: Contribution to journalArticle

Electrospray ionization
Metabolites
Mass spectrometry
Screening
Ions
16 Citations (Scopus)

Selective cannabinoid receptor type 2 (CB2) agonists: Optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain

Hollinshead, S. P., Tidwell, M. W., Palmer, J., Guidetti, R., Sanderson, A., Johnson, M. P., Chambers, M. G., Oskins, J., Stratford Jr., R. & Astles, P. C., Jul 25 2013, In : Journal of Medicinal Chemistry. 56, 14, p. 5722-5733 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Purines
Rodentia
Cannabinoid Receptor Agonists
Pain
2012
26 Citations (Scopus)
Pharmacokinetics
Central Nervous System Agents
Brain
Pharmaceutical Preparations
Central Nervous System
15 Citations (Scopus)

Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain

Cremers, T. I. F. H., Flik, G., Hofland, C. & Stratford Jr., R., Oct 1 2012, In : Drug Metabolism and Disposition. 40, 10, p. 1909-1916 8 p.

Research output: Contribution to journalArticle

norclozapine
Clozapine
Microdialysis
Pharmacokinetics
Brain
2009
32 Citations (Scopus)

Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats

Kielbasa, W., Kalvass, J. C. & Stratford Jr., R., Jan 1 2009, In : Drug Metabolism and Disposition. 37, 1, p. 137-142 6 p.

Research output: Contribution to journalArticle

Microdialysis
Central Nervous System
Pharmacokinetics
Extracellular Fluid
Brain
2007
17 Citations (Scopus)

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism

Alt, A., Weiss, B., Ornstein, P. L., Gleason, S. D., Bleakman, D., Stratford Jr., R. & Witkin, J. M., Jun 1 2007, In : Neuropharmacology. 52, 7, p. 1482-1487 6 p.

Research output: Contribution to journalArticle

LY382884
Kainic Acid Receptors
Anti-Anxiety Agents
AMPA Receptors
Benzodiazepines
2006
51 Citations (Scopus)

Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo

Weiss, B., Alt, A., Ogden, A. M., Gates, M., Dieckman, D. K., Clemens-Smith, A., Ho, K. H., Jarvie, K., Rizkalla, G., Wright, R. A., Calligaro, D. O., Schoepp, D., Mattiuz, E. L., Stratford Jr., R., Johnson, B., Salhoff, C., Katofiasc, M., Phebus, L. A., Schenck, K., Cohen, M. & 4 others, Filla, S. A., Ornstein, P. L., Johnson, K. W. & Bleakman, D., Jul 21 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 2, p. 772-781 10 p.

Research output: Contribution to journalArticle

6-((2-carboxy-4,4-difluoro-1-pyrrolidinyl)methyl)decahydro-3-isoquinolinecarboxylic acid
Pharmacology
Migraine Disorders
Kainic Acid Receptors
Trigeminal Ganglion
2005
47 Citations (Scopus)

Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist

Bueno, A. B., Collado, I., De Dios, A., Domínguez, C., Martín, J. A., Martín, L. M., Martínez-Grau, M. A., Montero, C., Pedregal, C., Catlow, J., Coffey, D. S., Clay, M. P., Dantzig, A. H., Lindstrom, T., Monn, J. A., Jiang, H., Schoepp, D. D., Stratford Jr., R., Tabas, L. B., Tizzano, J. P. & 2 others, Wright, R. A. & Herin, M. F., Aug 11 2005, In : Journal of Medicinal Chemistry. 48, 16, p. 5305-5320 16 p.

Research output: Contribution to journalArticle

eglumetad
Excitatory Amino Acid Agonists
Metabotropic Glutamate Receptors
Dipeptides
Prodrugs
31 Citations (Scopus)

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain

Dominguez, E., Iyengar, S., Shannon, H. E., Bleakman, D., Alt, A., Arnold, B. M., Bell, M. G., Bleisch, T. J., Buckmaster, J. L., Castano, A. M., Del Prado, M., Escribano, A., Filla, S. A., Ho, K. H., Hudziak, K. J., Jones, C. K., Martinez-Perez, J. A., Mateo, A., Mathes, B. M., Mattiuz, E. L. & 7 others, Ogden, A. M. L., Simmons, R. M. A., Stack, D. R., Stratford Jr., R., Winter, M. A., Wu, Z. & Ornsteint, P. L., Jun 30 2005, In : Journal of Medicinal Chemistry. 48, 13, p. 4200-4203 4 p.

Research output: Contribution to journalArticle

Hyperalgesia
Prodrugs
Animal Models
Pain
Carrageenan
2002
44 Citations (Scopus)

Ethyl (3s,4aR,6S,8aR)-6-(4-ethoxycar-bonylimidazol-1-ylmethyl) decahydroiso-quinoline-3-carboxylic ester: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine

Filla, S. A., Winter, M. A., Johnson, K. W., Bleakman, D., Bell, M. G., Bleisch, T. J., Castaño, A. M., Clemens-Smith, A., Del Prado, M., Dieckman, D. K., Dominguez, E., Escribano, A., Ho, K. H., Hudziak, K. J., Katofiasc, M. A., Martinez-Perez, J. A., Mateo, A., Mathes, B. M., Mattiuz, E. L., Ogden, A. M. L. & 4 others, Phebus, L. A., Stack, D. R., Stratford Jr., R. & Ornstein, P. L., Sep 26 2002, In : Journal of Medicinal Chemistry. 45, 20, p. 4383-4386 4 p.

Research output: Contribution to journalArticle

Prodrugs
Migraine Disorders
Esters
Animal Models
Glutamate Receptors
2001
24 Citations (Scopus)

Regional-dependent intestinal absorption and meal effects on systemic availability of LY303366, a lipopeptide antifungal agent, in dogs

Li, C., Fleisher, D., Li, L., Schwier, J. R., Sweetana, S. A., Vasudevan, V., Zornes, L. L., Pao, L. H., Zhou, S. Y. & Stratford Jr., R., Jan 1 2001, In : Journal of Pharmaceutical Sciences. 90, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

anidulafungin
Lipopeptides
Antifungal Agents
Intestinal Absorption
Meals
44 Citations (Scopus)

Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Ekins, S., Durst, G. L., Stratford Jr., R., Thorner, D. A., Lewis, R., Loncharich, R. J. & Wikel, J. H., Dec 1 2001, In : Journal of Chemical Information and Computer Sciences. 41, 6, p. 1578-1586 9 p.

Research output: Contribution to journalArticle

permeability
Catalysts
Molecules
Hydrogen bonds
Values
1999
11 Citations (Scopus)

Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication

Stratford Jr., R., Clay, M. P., Heinz, B. A., Kuhfeld, M. T., Osborne, S. J., Phillips, D. L., Sweetana, S. A., Tebbe, M. J., Vasudevan, V., Zornes, L. L. & Lindstrom, T. D., Jan 1 1999, In : Journal of Pharmaceutical Sciences. 88, 8, p. 747-753 7 p.

Research output: Contribution to journalArticle

Rhinovirus
Solubility
Biological Availability
Permeability
Benzimidazoles
1997
17 Citations (Scopus)
Lipopeptides
Pharmacokinetics
Antifungal Agents
Assays
Plasmas
1996
8 Citations (Scopus)
Testosterone
Permeability
polycarbonate
Caco-2 Cells
Water
7 Citations (Scopus)
loracarbef
Cephalexin
Caco-2 Cells
Protons
Cell Culture Techniques
1995
45 Citations (Scopus)

Activities of the semisynthetic glycopeptide LY191145 against vancomycin- resistant enterococci and other gram-positive bacteria

Nicas, T. I., Mullen, D. L., Flokowitsch, J. E., Preston, D. A., Snyder, N. J., Stratford Jr., R. & Cooper, R. D. G., Jan 1 1995, In : Antimicrobial Agents and Chemotherapy. 39, 11, p. 2585-2587 3 p.

Research output: Contribution to journalArticle

Glycopeptides
Gram-Positive Bacteria
Teicoplanin
chloroorienticin A
Anti-Bacterial Agents
48 Citations (Scopus)

Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison with Cephalexin

Hu, M., Zheng, L., Chen, J., Liu, L., Zhu, Y., Dantzig, A. H. & Stratford Jr., R., Jan 1 1995, In : Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12, 8, p. 1120-1125 6 p.

Research output: Contribution to journalArticle

Cephalexin
Caco-2 Cells
Monolayers
loracarbef
Protons
9 Citations (Scopus)

Peptide transporter function and prolidase activities in caco-2 cells: A lack of coordinated expression

Hu, M., Zheng, L., Chen, J., Liu, L., Li, Y., Dantzig, A. H. & Stratford Jr., R., Jan 1 1995, In : Journal of Drug Targeting. 3, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

proline dipeptidase
Caco-2 Cells
Peptides
phenylalanyl-prolyl-alanine
Essential Amino Acids
1994
77 Citations (Scopus)
loracarbef
Transcytosis
Lactams
Anti-Bacterial Agents
Membranes
1988
29 Citations (Scopus)

Systemic absorption of ocularly administered enkephalinamide and inulin in the albino rabbit: Extent, pathways, and vehicle effects

Stratford Jr., R., Carson, L. W., Dodda‐Kashi, S. & Lee, V. H. L., Jan 1 1988, In : Journal of Pharmaceutical Sciences. 77, 10, p. 838-842 5 p.

Research output: Contribution to journalArticle

Inulin
Rabbits
Nasal Mucosa
Epinephrine
Polyvinyl Alcohol
1986
121 Citations (Scopus)
Aminopeptidases
Mucous Membrane
Rabbits
Peptides
Hydrolysis
35 Citations (Scopus)

Metabolic and Permeation Barriers to the Ocular Absorption of Topically Applied Enkephalins in Albino Rabbits

Lee, V. H. L., Carson, L. W., Kashi, S. D. & Stratford Jr., R., Jan 1 1986, In : Journal of Ocular Pharmacology. 2, 4, p. 345-352 8 p.

Research output: Contribution to journalArticle

Enkephalins
Rabbits
Peptides
Leucine Enkephalin
Methionine Enkephalin
1985
19 Citations (Scopus)

Aminopeptidase activity in albino rabbit extraocular tissues relative to the small intestine

Stratford Jr., R. & Lee, V. H. L., Jan 1 1985, In : Journal of Pharmaceutical Sciences. 74, 7, p. 731-734 4 p.

Research output: Contribution to journalArticle

Aminopeptidases
Small Intestine
Conjunctiva
Rabbits
Corneal Epithelium
32 Citations (Scopus)

Ocular aminopeptidase activity and distribution in the albino rabbit

Stratford Jr., R. & Lee, V. H. L., Jan 1 1985, In : Current Eye Research. 4, 9, p. 995-1000 6 p.

Research output: Contribution to journalArticle

Aminopeptidases
Conjunctiva
Ocular Physiological Phenomena
Rabbits
Corneal Stroma
1983
25 Citations (Scopus)

Age-related changes in esterase activity in rabbit eyes

Lee, V. H. L., Stratford Jr., R. & Morimoto, K. W., Jan 1 1983, In : International Journal of Pharmaceutics. 13, 2, p. 183-195 13 p.

Research output: Contribution to journalArticle

Esterases
Rabbits
Age Groups
Ciliary Body
Aqueous Humor
21 Citations (Scopus)

Disposition of topically applied sodium cromoglycate in the albino rabbit eye

LEE, VINCENT. H. L., SWARBRICK, JAMES., Stratford Jr., R. & MORIMOTO, KIM. W., Jan 1 1983, In : Journal of Pharmacy and Pharmacology. 35, 7, p. 445-450 6 p.

Research output: Contribution to journalArticle

Cromolyn Sodium
Polyvinyl Alcohol
Conjunctiva
Rabbits
Tears
40 Citations (Scopus)

Effects of topically applied liposomes on disposition of epinephrine and inulin in the albino rabbit eye

Stratford Jr., R., Yang, D. C., Redell, M. A. & Lee, V. H. L., Jan 1 1983, In : International Journal of Pharmaceutics. 13, 3, p. 263-272 10 p.

Research output: Contribution to journalArticle

Inulin
Liposomes
Epinephrine
Rabbits
Aqueous Humor
1982
48 Citations (Scopus)

Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability

Lee, V. H. L., Morimoto, K. W. & Stratford Jr., R., Jan 1 1982, In : Biopharmaceutics & Drug Disposition. 3, 4, p. 291-300 10 p.

Research output: Contribution to journalArticle

Esterases
Cornea
Biological Availability
Rabbits
Epithelium
40 Citations (Scopus)

Ocular distribution of liposome-encapsulated epinephrine and inulin in the albino rabbit

Stratford Jr., R., Yang, D. C., Redell, M. A. & Lee, V. H. L., Jan 1 1982, In : Current Eye Research. 2, 6, p. 377-386 10 p.

Research output: Contribution to journalArticle

Inulin
Liposomes
Epinephrine
Rabbits
Lacrimal Apparatus
1981
6 Citations (Scopus)

Effects of reserpinization, surgical denervation and in vitro chemical denervation with 6-hydroxydopamine on the contractile response of isolated rabbit ear artery to propranolol

Purdy, R. E., Ashbrook, D. W., Hurlbut, D. E., Reidy, J. P., Stratford Jr., R. & Watanabe, M. Y., Aug 29 1981, In : Blood Vessels. 18, 4-5, p. 153-160 8 p.

Research output: Contribution to journalArticle

Oxidopamine
Denervation
Propranolol
Ear
Arteries
1980
15 Citations (Scopus)

A novel response to propranolol: Contractile response in the isolated rabbit ear artery

Ashbrook, D. W., Purdy, R. E., Hurlbut, D. E., Rains, L. A., Reidy, J. P. & Stratford Jr., R., Jan 14 1980, In : Life Sciences. 26, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

Propranolol
Ear
Arteries
Rabbits
Tyramine