Roberto Pili

  • 11420 Citations
  • 53 h-Index
1987 …2020

Research output per year

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Publications

2007

Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs

Verheul, H. M. W., Qian, D. Z., Carducci, M. A. & Pili, R., Aug 1 2007, In : Cancer Chemotherapy and Pharmacology. 60, 3, p. 329-339 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma

Kato, Y., Yoshimura, K., Shin, T., Verheul, H., Hammers, H., Sanni, T. B., Salumbides, B. C., Van Erp, K., Schulick, R. & Pili, R., Aug 1 2007, In : Clinical Cancer Research. 13, 15, p. 4538-4546 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin

Kachhap, S. K., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., DeMarzo, A. M. & Carducci, M. A., Sep 5 2007, In : PloS one. 2, 9, e844.

Research output: Contribution to journalArticle

79 Scopus citations

Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model

Verheul, H. M. W., Hammers, H., Van Erp, K., Wei, Y., Sanni, T., Salumbides, B., Qian, D. Z., Yancopoulos, G. D. & Pili, R., Jul 15 2007, In : Clinical Cancer Research. 13, 14, p. 4201-4208 8 p.

Research output: Contribution to journalArticle

112 Scopus citations
2008

A Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

Heath, E. I., Hillman, D. W., Vaishampayan, U., Sheng, S., Sarkar, F., Harper, F., Gaskins, M., Pitot, H. C., Tan, W., Ivy, S. P., Pili, R., Carducci, M. A., Erlichman, C. & Liu, G., Dec 1 2008, In : Clinical Cancer Research. 14, 23, p. 7940-7946 7 p.

Research output: Contribution to journalArticle

137 Scopus citations

Combination strategy targeting the hypoxia inducible factor-1 α with mammalian target of rapamycin and histone deacetylase inhibitors

Verheul, H. M. W., Salumbides, B., Van Erp, K., Hammers, H., Qian, D. Z., Sanni, T., Atadja, P. & Pili, R., Jun 1 2008, In : Clinical Cancer Research. 14, 11, p. 3589-3597 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K. A., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., Dang, C. V., Liu, J. O. & Semenza, G. L., Dec 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 50, p. 19579-19586 8 p.

Research output: Contribution to journalArticle

418 Scopus citations

Intravenous Bevacizumab Causes Regression of Choroidal Neovascularization Secondary to Diseases Other Than Age-related Macular Degeneration

Nguyen, Q. D., Shah, S. M., Hafiz, G., Do, D. V., Haller, J. A., Pili, R., Zimmer-Galler, I. E., Janjua, K., Symons, R. C. A. & Campochiaro, P. A., Feb 2008, In : American Journal of Ophthalmology. 145, 2, p. 257-266.e2

Research output: Contribution to journalArticle

29 Scopus citations

Phase II trial of docetaxel with rapid androgen cycling for progressive noncastrate prostate cancer

Rathkopf, D., Carducci, M. A., Morris, M. J., Slovin, S. F., Eisenberger, M. A., Pili, R., Denmeade, S. R., Kelsen, M., Curley, T., Halter, M., Collins, C., Fleisher, M., Heller, G., Baker, S. D. & Scher, H. I., 2008, In : Journal of Clinical Oncology. 26, 18, p. 2959-2965 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors

Siu, L. L., Pili, R., Duran, I., Messersmith, W. A., Chen, E. X., Sullivan, R., MacLean, M., King, S., Brown, S., Reid, G. K., Li, Z., Kalita, A. M., Laille, E. J., Besterman, J. M., Martell, R. E. & Carducci, M. A., Sep 15 2008, In : Journal of Clinical Oncology. 26, 12, p. 1940-1947 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

Population pharmacokinetic-pharmacodynamic model of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acidin cancer patients

Li, J., Jameson, M. B., Baguley, B. C., Pili, R. & Baker, S. D., Apr 1 2008, In : Clinical Cancer Research. 14, 7, p. 2102-2110 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Posttranscription regulation of prostate cancer growth

Shen, L. & Pili, R., Jan 1 2008, In : Cancer Journal. 14, 1, p. 46-53 8 p.

Research output: Contribution to journalReview article

11 Scopus citations

Reproducibility of tumor blood flow quantification with15O-water PET

Lodge, M. A., Jacene, H. A., Pili, R. & Wahl, R. L., Oct 1 2008, In : Journal of Nuclear Medicine. 49, 10, p. 1620-1627 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Symptoms, supportive care needs, and function in cancer patients: How are they related?

Snyder, C. F., Garrett-Mayer, E., Brahmer, J. R., Carducci, M. A., Pili, R., Stearns, V., Wolff, A. C., Dy, S. M. & Wu, A. W., Jun 2008, In : Quality of Life Research. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Concordance of cancer patients' function, symptoms, and supportive care needs

Snyder, C. F., Garrett-Mayer, E., Blackford, A. L., Brahmer, J. R., Carducci, M. A., Pili, R., Stearns, V., Wolff, A. C., Dy, S. M. & Wu, A. W., Oct 1 2009, In : Quality of Life Research. 18, 8, p. 991-998 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Kidney cancer

Motzer, R. J., Agarwal, N., Beard, C., Bolger, G. B., Boston, B., Carducci, M. A., Choueiri, T. K., Figlin, R. A., Fishman, M., Hancock, S. L., Hudes, G. R., Jonasch, E., Kessinger, A., Kuzel, T. M., Lange, P. H., Levine, E. G., Margolin, K. A., Michaelson, M. D., Olencki, T., Pili, R. & 5 others, Redman, B. G., Robertson, C. N., Schwartz, L. H., Sheinfeld, J. & Wang, J., Jun 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 6, p. 618-630 13 p.

Research output: Contribution to journalReview article

Open Access
149 Scopus citations

Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma

Motzer, R. J., Hutson, T. E., Tomczak, P., Michaelson, M. D., Bukowski, R. M., Oudard, S., Negrier, S., Szczylik, C., Pili, R., Bjarnason, G. A., Garcia-del-Muro, X., Sosman, J. A., Solska, E., Wilding, G., Thompson, J. A., Kim, S. T., Chen, I., Huang, X. & Figlin, R. A., Aug 1 2009, In : Journal of Clinical Oncology. 27, 22, p. 3584-3590 7 p.

Research output: Contribution to journalArticle

1708 Scopus citations

Pre-clinical models of renal carcinoma and their utility in drug development

Salumbides, B. C., Lehet, K. M., Ndikuyeze, G. & Pili, R., Dec 1 2009, In : Current Protocols in Pharmacology. SUPPL.47, p. 14.13.1-14.13.19

Research output: Contribution to journalReview article

3 Scopus citations

Recent investigations of histone deacetylase inhibitors in renal cell carcinoma

Pili, R., Jun 9 2009, In : Clinical Advances in Hematology and Oncology. 7, 4, p. 252-254 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Targeting tumor angiogenesis with histone deacetylase inhibitors

Ellis, L., Hammers, H. & Pili, R., Aug 8 2009, In : Cancer Letters. 280, 2, p. 145-153 9 p.

Research output: Contribution to journalReview article

176 Scopus citations

Testicular cancer

Motzer, R. J., Agarwal, N., Beard, C., Bolger, G. B., Boston, B., Carducci, M. A., Choueiri, T. K., Figlin, R. A., Fishman, M., Hancock, S. L., Hudes, G. R., Jonasch, E., Kessinger, A., Kuzel, T. M., Lange, P. H., Levine, E. G., Margolin, K. A., Michaelson, M. D., Olencki, T., Pili, R. & 5 others, Redman, B. G., Robertson, C. N., Schwartz, L. H., Sheinfeld, J. & Wang, J., Jun 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 6, p. 672-693 22 p.

Research output: Contribution to journalReview article

Open Access
81 Scopus citations

Update on novel agents in renal cell carcinoma

Tamaskar, I. & Pili, R., Dec 1 2009, In : Expert Review of Anticancer Therapy. 9, 12, p. 1817-1827 11 p.

Research output: Contribution to journalReview article

18 Scopus citations

VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo

Kolmakova, A., Rajesh, M., Zang, D., Pili, R. & Chatterjee, S., Jul 1 2009, In : Glycoconjugate Journal. 26, 5, p. 547-558 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma: Results of a large phase 2 study

Vaughn, D. J., Srinivas, S., Stadler, W. M., Pili, R., Petrylak, D., Sternberg, C. N., Smith, D. C., Ringuette, S., De Wit, E., Pautret, V. & George, C., Sep 15 2009, In : Cancer. 115, 18, p. 4110-4117 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago phase 2 consortium

Bradley, D., Rathkopf, D., Dunn, R., Stadler, W. M., Liu, G., Smith, D. C., Pili, R., Zwiebel, J., Scher, H. & Hussain, M., Jan 12 2009, In : Cancer. 115, 23, p. 5541-5549 9 p.

Research output: Contribution to journalArticle

91 Scopus citations
2010

Histone deacetylase inhibitors: Advancing therapeutic strategies in hematological and solid malignancies

Ellis, L. & Pili, R., 2010, In : Pharmaceuticals. 3, 8, p. 2441-2469 29 p.

Research output: Contribution to journalReview article

58 Scopus citations

Is this a true renaissance for the treatment of prostate cancer?

Roberto, P., Dec 1 2010, In : Oncology. 24, 14

Research output: Contribution to journalComment/debate

Is this a true renaissance for the treatment of prostate cancer?

Pili, R., Dec 1 2010, In : Oncology (Williston Park, N.Y.). 24, 14, p. 1327-1328 2 p.

Research output: Contribution to journalComment/debate

Lenalidomide in nonmetastatic biochemically relapsed prostate cancer: Results of a phase I/II double-blinded, randomized study

Keizman, D., Zahurak, M., Sinibaldi, V., Carducci, M., Denmeade, S., Drake, C., Pili, R., Antonarakis, E. S., Hudock, S. & Eisenberger, M., Nov 1 2010, In : Clinical Cancer Research. 16, 21, p. 5269-5276 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Needs assessments can identify scores on HRQOL questionnaires that represent problems for patients: An illustration with the Supportive Care Needs Survey and the QLQ-C30

Snyder, C. F., Blackford, A. L., Brahmer, J. R., Carducci, M. A., Pili, R., Stearns, V., Wolff, A. C., Dy, S. M. & Wu, A. W., Aug 1 2010, In : Quality of Life Research. 19, 6, p. 837-845 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

Koskimaki, J. E., Karagiannis, E. D., Tang, B. C., Hammers, H., Watkins, D. N., Pili, R. & Popel, A. S., Feb 1 2010, In : BMC Cancer. 10, 29.

Research output: Contribution to journalArticle

33 Scopus citations

Phase II study on the addition of ASA404 (vadimezan; 5,6- dimethylxanthenone-4-acetic acid) to docetaxel in CRMPC

Pili, R., Rosenthal, M. A., Mainwaring, P. N., Van Hazel, G., Srinivas, S., Dreicer, R., Goel, S., Leach, J., Wong, S. & Clingan, P., May 15 2010, In : Clinical Cancer Research. 16, 10, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: Evidence from a xenograft study

Hammers, H. J., Verheul, H. M., Salumbides, B., Sharma, R., Rudek, M., Jaspers, J., Shah, P., Ellis, L., Shen, L., Paesante, S., Dykema, K., Furge, K., Teh, B. T., Netto, G. & Pili, R., Jun 2010, In : Molecular cancer therapeutics. 9, 6, p. 1525-1535 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

The Relationship of Vascular Endothelial Growth Factor and Coagulation Factor (Fibrin and Fibrinogen) Expression in Clear Cell Renal Cell Carcinoma

Verheul, H. M. W., van Erp, K., Homs, M. Y. V., Yoon, G. S., van Der Groep, P., Rogers, C., Hansel, D. E., Netto, G. J. & Pili, R., Mar 1 2010, In : Urology. 75, 3, p. 608-614 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination

Keizman, D., Huang, P., Eisenberger, M. A., Pili, R., Kim, J. J., Antonarakis, E. S., Hammers, H. & Carducci, M. A., Sep 1 2011, In : European Journal of Cancer. 47, 13, p. 1955-1961 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal ® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC)

Harrison, M. R., Hahn, N. M., Pili, R., Oh, W. K., Hammers, H., Sweeney, C., Kim, K. M., Perlman, S., Arnott, J., Sidor, C., Wilding, G. & Liu, G., Dec 1 2011, In : Investigational New Drugs. 29, 6, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

A Phase I study of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors potentially responsive to mitoxantrone

Resta, L. P., Pili, R., Eisenberger, M. A., Spitz, A., King, S., Porter, J., Franke, A., Boinpally, R., Carducci, M. A. & Sweeney, C. J., Feb 2011, In : Cancer Chemotherapy and Pharmacology. 67, 2, p. 431-438 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bisphosphonates in renal cell carcinoma: Palliation versus antitumor effects

George, S. & Pili, R., Oct 1 2011, Targeted Therapies for Renal Cell Carcinoma. Future Medicine Ltd., p. 121-125 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Concurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in MicroRNA expression

Ellis, L., Lehet, K., Ramakrishnan, S., Adelaiye, R., Miles, K. M., Wang, D., Liu, S., Atadja, P., Carducci, M. A. & Pili, R., Nov 7 2011, In : PloS one. 6, 11, e27178.

Research output: Contribution to journalArticle

14 Scopus citations

Impact of cytoreductive nephrectomy on eligibility for systemic treatment and effects on survival: Are surgical complications or disease related factors responsible?

O'Malley, R. L., Brewer, K. A., Hayn, M. H., Kim, H. L., Underwood, W., Pili, R. & Schwaab, T., Sep 1 2011, In : Urology. 78, 3, p. 595-600 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

Pettazzoni, P., Pizzimenti, S., Toaldo, C., Sotomayor, P., Tagliavacca, L., Liu, S., Wang, D., Minelli, R., Ellis, L., Atadja, P., Ciamporcero, E., Dianzani, M. U., Barrera, G. & Pili, R., Jan 15 2011, In : Free Radical Biology and Medicine. 50, 2, p. 313-322 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Kidney cancer

Motzer, R. J., Agarwal, N., Beard, C., Bhayani, S., Bolger, G. B., Carducci, M. A., Chang, S. S., Choueiri, T. K., Hancock, S. L., Hudes, G. R., Jonasch, E., Josephson, D., Kuzel, T. M., Levine, E. G., Lin, D. W., Margolin, K. A., Michaelson, M. D., Olencki, T., Pili, R., Ratliff, T. W. & 7 others, Redman, B. G., Robertson, C. N., Ryan, C. J., Sheinfeld, J., Spiess, P. E., Wang, J. & Wilder, R. B., Sep 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 9, p. 960-977 18 p.

Research output: Contribution to journalReview article

Open Access
67 Scopus citations

Lysosomal sequestration of sunitinib: A novel mechanism of drug resistance

Gotink, K. J., Broxterman, H. J., Labots, M., De Haas, R. R., Dekker, H., Honeywell, R. J., Rudek, M. A., Beerepoot, L. V., Musters, R. J., Jansen, G., Griffioen, A. W., Assaraf, Y. G., Pili, R., Peters, G. J. & Verheul, H. M. W., Dec 1 2011, In : Clinical Cancer Research. 17, 23, p. 7337-7346 10 p.

Research output: Contribution to journalArticle

175 Scopus citations

Mental disorders in obese patients with and without metabolic syndrome

Carpiniello, B., Pinna, F., Pili, R., Velluzzi, F. & Loviselli, A., Jan 1 2011, In : International Journal of Psychiatry in Medicine. 42, 4, p. 369-375 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

NCCN task force report: Optimizing treatment of advanced renal cell carcinoma with molecular targeted therapy

Hudes, G. R., Carducci, M. A., Choueiri, T. K., Esper, P., Jonasch, E., Kumar, R., Margolin, K. A., Michaelson, M. D., Motzer, R. J., Pili, R., Roethke, S. & Srinivas, S., Mar 24 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, SUPPL. 1, p. S1-S29

Research output: Contribution to journalArticle

43 Scopus citations

Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells

Pettazzoni, P., Ciamporcero, E., Medana, C., Pizzimenti, S., Dal Bello, F., Minero, V. G., Toaldo, C., Minelli, R., Uchida, K., Dianzani, M. U., Pili, R. & Barrera, G., Oct 15 2011, In : Free Radical Biology and Medicine. 51, 8, p. 1610-1618 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancer

Pili, R., Hag̈gman, M., Stadler, W. M., Gingrich, J. R., Assikis, V. J., Bjor̈k, A., Nordle, O., Forsberg, G., Carducci, M. A. & Armstrong, A. J., Oct 20 2011, In : Journal of Clinical Oncology. 29, 30, p. 4022-4028 7 p.

Research output: Contribution to journalArticle

155 Scopus citations

Provenge: Combating prostate cancer with a vengeance?

Schwaab, T. & Pili, R., Aug 1 2011, In : Expert Review of Vaccines. 10, 8, p. 1113-1114 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Resistance to angiogenesis inhibitors in renal cell carcinoma

Tamaskar, I., Dhillon, J. & Pili, R., Feb 1 2011, In : Clinical Advances in Hematology and Oncology. 9, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Role of immunotherapy for renal cell cancer in 2011

George, S., Pili, R., Carducci, M. A. & Kim, J. J., Sep 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 9, p. 1011-1018 8 p.

Research output: Contribution to journalReview article

23 Scopus citations