Roberto Pili

  • 11262 Citations
  • 52 h-Index
1987 …2020

Research output per year

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Publications

YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

Ciamporcero, E., Shen, H., Ramakrishnan, S., Yu Ku, S., Chintala, S., Shen, L., Adelaiye, R., Miles, K. M., Ullio, C., Pizzimenti, S., Daga, M., Azabdaftari, G., Attwood, K., Johnson, C., Zhang, J., Barrera, G. & Pili, R., Mar 24 2016, In : Oncogene. 35, 12, p. 1541-1553 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago phase 2 consortium

Bradley, D., Rathkopf, D., Dunn, R., Stadler, W. M., Liu, G., Smith, D. C., Pili, R., Zwiebel, J., Scher, H. & Hussain, M., Jan 12 2009, In : Cancer. 115, 23, p. 5541-5549 9 p.

Research output: Contribution to journalArticle

90 Scopus citations

Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma: Results of a large phase 2 study

Vaughn, D. J., Srinivas, S., Stadler, W. M., Pili, R., Petrylak, D., Sternberg, C. N., Smith, D. C., Ringuette, S., De Wit, E., Pautret, V. & George, C., Sep 15 2009, In : Cancer. 115, 18, p. 4110-4117 8 p.

Research output: Contribution to journalArticle

102 Scopus citations

VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo

Kolmakova, A., Rajesh, M., Zang, D., Pili, R. & Chatterjee, S., Jul 1 2009, In : Glycoconjugate Journal. 26, 5, p. 547-558 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo

Muhlhauser, J., Merrill, M. J., Pili, R., Maeda, H., Bacic, M., Bewig, B., Passaniti, A., Edwards, N. A., Crystal, R. G. & Capogrossi, M. C., 1995, In : Circulation research. 77, 6, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

146 Scopus citations

Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model

Verheul, H. M. W., Hammers, H., Van Erp, K., Wei, Y., Sanni, T., Salumbides, B., Qian, D. Z., Yancopoulos, G. D. & Pili, R., Jul 15 2007, In : Clinical Cancer Research. 13, 14, p. 4201-4208 8 p.

Research output: Contribution to journalArticle

112 Scopus citations

Vascular disruption in combination with mTOR inhibition in renal cell carcinoma

Ellis, L., Shah, P., Hammers, H., Lehet, K., Sotomayor, P., Azabdaftari, G., Seshadri, M. & Pili, R., Feb 2012, In : Molecular cancer therapeutics. 11, 2, p. 383-392 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Valutazione di alterazioni latenti della coagulazione mediante il dosaggio plasmatico del complesso trombina antitrombina nelle neoplasie gastrointestinali.

Translated title of the contribution: Evaluation of latent changes in blood coagulation by the determination of plasma thrombin-antithrombin complex in gastrointestinal neoplasmsGuidi, L., Bartoloni, C., Pellicanò, P., Cappelli, A., Cursi, F., Pili, R., Tricerri, A., Patriarca, F. & Gambassi, G., Mar 31 1991, In : La Clinica terapeutica. 136, 6, p. 367-373 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Use of a Glycolipid Inhibitor to Ameliorate Renal Cancer in a Mouse Model

Chatterjee, S., Alsaeedi, N., Hou, J., Bandaru, V. V. R., Wu, L., Halushka, M. K., Pili, R., Ndikuyeze, G. & Haughey, N. J., May 9 2013, In : PLoS ONE. 8, 5, e63726.

Research output: Contribution to journalArticle

13 Scopus citations

Update on novel agents in renal cell carcinoma

Tamaskar, I. & Pili, R., Dec 1 2009, In : Expert Review of Anticancer Therapy. 9, 12, p. 1817-1827 11 p.

Research output: Contribution to journalReview article

18 Scopus citations

Understanding avoidance, refusal, and abandonment of chemotherapy before and after cystectomy for bladder cancer

Rehman, S., Crane, A., Din, R., Raza, S. J., Shi, Y., Wilding, G., Levine, E. G., George, S., Pili, R., Trump, D. L. & Guru, K. A., Dec 1 2013, In : Urology. 82, 6, p. 1370-1375 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Unclassified Renal Cell Carcinoma With Significant Response to Nivolumab

Adra, N., Cheng, L. & Pili, R., Jun 2017, In : Clinical Genitourinary Cancer. 15, 3, p. e517-e519

Research output: Contribution to journalArticle

4 Scopus citations

Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

Kirk, J. S., Schaarschuch, K., Dalimov, Z., Lasorsa, E., Ku, S. Y., Ramakrishnan, S., Hu, Q., Azabdaftari, G., Wang, J., Pili, R. & Ellis, L., 2015, In : Oncotarget. 6, 5, p. 3136-3146 11 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

The α-Glucosidase I Inhibitor Castanospermine Alters Endothelial Cell Glycosylation, Prevents Angiogenesis, and Inhibits Tumor Growth

Pili, R., Chang, J., Partis, R. A., Mueller, R. A., Chrest, F. J. & Passaniti, A., Jul 1 1995, In : Cancer Research. 55, 13, p. 2920-2926 7 p.

Research output: Contribution to journalArticle

178 Scopus citations

The Relationship of Vascular Endothelial Growth Factor and Coagulation Factor (Fibrin and Fibrinogen) Expression in Clear Cell Renal Cell Carcinoma

Verheul, H. M. W., van Erp, K., Homs, M. Y. V., Yoon, G. S., van Der Groep, P., Rogers, C., Hansel, D. E., Netto, G. J. & Pili, R., Mar 1 2010, In : Urology. 75, 3, p. 608-614 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Therapeutic targeting of TFE3/IRS-1/PI3K/mTOR axis in translocation renal cell carcinoma

Damayanti, N. P., Budka, J. A., Khella, H. W. Z., Ferris, M. W., Ku, S. Y., Kauffman, E., Wood, A. C., Ahmed, K., Chintala, V. N., Adelaiye-Ogala, R., Elbanna, M., Orillion, A., Chintala, S., Kao, C., Marston Linehan, W., Yousef, G. M., Hollenhorst, P. C. & Pili, R., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5977-5989 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Therapeutic targeting of sunitinib-induced AR phosphorylation in renal cell carcinoma

Adelaiye-Ogala, R., Damayanti, N. P., Orillion, A. R., Arisa, S., Chintala, S., Titus, M. A., Kao, C. & Pili, R., Jun 1 2018, In : Cancer Research. 78, 11, p. 2886-2896 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin

Kachhap, S. K., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., DeMarzo, A. M. & Carducci, M. A., Sep 5 2007, In : PloS one. 2, 9, e844.

Research output: Contribution to journalArticle

78 Scopus citations

The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584

Qian, D. Z., Wang, X., Kachhap, S. K., Kato, Y., Wei, Y., Zhang, L., Atadja, P. & Pili, R., Sep 15 2004, In : Cancer Research. 64, 18, p. 6626-6634 9 p.

Research output: Contribution to journalArticle

195 Scopus citations

The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma

Keizman, D., Ish-Shalom, M., Huang, P., Eisenberger, M. A., Pili, R., Hammers, H. & Carducci, M. A., Jan 1 2012, In : European Journal of Cancer. 48, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

138 Scopus citations

Testicular cancer, version 2.2015: Clinical pactice guidelines in oncology

Motzer, R. J., Jonasch, E., Agarwal, N., Beard, C., Bhayani, S., Bolger, G. B., Chang, S. S., Choueiri, T. K., Costello, B. A., Derweesh, I. H., Gupta, S., Hancock, S. L., Kim, J. J., Kuzel, T. M., Lam, E. T., Lau, C., Levine, E. G., Lin, D. W., Michaelson, M. D., Olencki, T. & 12 others, Pili, R., Plimack, E. R., Rampersaud, E. N., Redman, B. G., Ryan, C. J., Sheinfeld, J., Shuch, B., Sircar, K., Somer, B., Wilder, R. B., Dwyer, M. & Kumar, R., Jun 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 6, p. 772-799 28 p.

Research output: Contribution to journalReview article

Open Access
68 Scopus citations

Testicular cancer

Motzer, R. J., Agarwal, N., Beard, C., Bolger, G. B., Boston, B., Carducci, M. A., Choueiri, T. K., Figlin, R. A., Fishman, M., Hancock, S. L., Hudes, G. R., Jonasch, E., Kessinger, A., Kuzel, T. M., Lange, P. H., Levine, E. G., Margolin, K. A., Michaelson, M. D., Olencki, T., Pili, R. & 5 others, Redman, B. G., Robertson, C. N., Schwartz, L. H., Sheinfeld, J. & Wang, J., Jun 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 6, p. 672-693 22 p.

Research output: Contribution to journalReview article

Open Access
82 Scopus citations

Testicular cancer

Motzer, R. J., Agarwal, N., Beard, C., Bhayani, S., Bolger, G. B., Buyyounouski, M. K., Carducci, M. A., Chang, S. S., Choueiri, T. K., Gupta, S., Hancock, S. L., Hudes, G. R., Jonasch, E., Kuzel, T. M., Lau, C., Levine, E. G., Lin, D. W., Margolin, K. A., Michaelson, M. D., Olencki, T. & 8 others, Pili, R., Ratliff, T. W., Redman, B. G., Robertson, C. N., Ryan, C. J., Sheinfeld, J., Wang, J. & Wilder, R. B., Apr 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 4, p. 502-535 34 p.

Research output: Contribution to journalReview article

Open Access
52 Scopus citations

Tasquinimod targets suppressive myeloid cells in the tumor microenvironment

Shen, L. & Pili, R., Jan 1 2019, In : OncoImmunology. 8, 10, e1072672.

Research output: Contribution to journalArticle

Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models

Shen, L., Sundstedt, A., Ciesielski, M., Miles, K. M., Celander, M., Adelaiye, R., Orillion, A., Ciamporcero, E., Ramakrishnan, S., Ellis, L., Fenstermaker, R., Abrams, S. I., Eriksson, H., Leanderson, T., Olsson, A. & Pili, R., Feb 2015, In : Cancer Immunology Research. 3, 2, p. 136-148 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Tasquinimod: A novel angiogenesis inhibitor-development in prostate cancer

George, S. & Pili, R., Apr 1 2013, In : Current oncology reports. 15, 2, p. 65-68 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: Therapy with sequential 1-β -D-arabinofuranosylcytosine, mitoxantrone, and bevacizumab

Karp, J. E., Gojo, I., Pili, R., Gocke, C. D., Greer, J., Guo, C., Qian, D., Morris, L., Tidwell, M., Chen, H. & Zwiebel, J., Jun 1 2004, In : Clinical Cancer Research. 10, 11, p. 3577-3585 9 p.

Research output: Contribution to journalArticle

152 Scopus citations

Targeting tumor angiogenesis with histone deacetylase inhibitors

Ellis, L., Hammers, H. & Pili, R., Aug 8 2009, In : Cancer Letters. 280, 2, p. 145-153 9 p.

Research output: Contribution to journalShort survey

172 Scopus citations

Targeting tumor angiogenesis with histone deacetylase inhibitors: The hydroxamic acid derivative LBH589

Qian, D. Z., Kato, Y., Shabbeer, S., Wei, Y., Verheul, H. M. W., Salumbides, B., Sanni, T., Atadja, P. & Pili, R., Jan 15 2006, In : Clinical Cancer Research. 12, 2, p. 634-642 9 p.

Research output: Contribution to journalArticle

224 Scopus citations

Targeting the programmed cell death-1 pathway in genitourinary tumors: Current progress and future perspectives

Mann, S. A., Lopez-Beltran, A., Massari, F., Pili, R., Fiorentino, M., Koch, M. O., Kaimakliotis, H. Z., Wang, L., Scarpelli, M., Ciccarese, C., Moch, H., Montironi, R. & Cheng, L., Jan 1 2017, In : Current drug metabolism. 18, 8, p. 700-711 12 p.

Research output: Contribution to journalReview article

17 Scopus citations

TAp73 expression and P1 promoter methylation, a potential marker for chemoresponsiveness to cisplatin therapy and survival in muscle-invasive bladder cancer (MIBC)

Bunch, B., Krishnan, N., Greenspan, R. D., Ramakrishnan, S., Attwood, K., Yan, L., Qi, Q., Wang, D., Morrison, C., Omilian, A., Bshara, W., Pili, R., Trump, D. L., Johnson, C. & Woloszynska, A., Sep 2 2019, In : Cell Cycle. 18, 17, p. 2055-2066 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma

Kato, Y., Yoshimura, K., Shin, T., Verheul, H., Hammers, H., Sanni, T. B., Salumbides, B. C., Van Erp, K., Schulick, R. & Pili, R., Aug 1 2007, In : Clinical Cancer Research. 13, 15, p. 4538-4546 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Symptoms, supportive care needs, and function in cancer patients: How are they related?

Snyder, C. F., Garrett-Mayer, E., Brahmer, J. R., Carducci, M. A., Pili, R., Stearns, V., Wolff, A. C., Dy, S. M. & Wu, A. W., Jun 1 2008, In : Quality of Life Research. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Sunitinib dose escalation overcomes transient resistance in clear cell renal cell carcinoma and is associated with epigenetic modifications

Adelaiye, R., Ciamporcero, E., Miles, K. M., Sotomayor, P., Bard, J., Tsompana, M., Conroy, D., Shen, L., Ramakrishnan, S., Ku, S. Y., Orillion, A., Prey, J., Fetterly, G., Buck, M., Chintala, S., Bjarnasone, G. A. & Pili, R., Feb 1 2015, In : Molecular cancer therapeutics. 14, 2, p. 513-522 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Structural variation and fusion detection using targeted sequencing data from circulating cell free DNA

Gawroński, A. R., Lin, Y. Y., McConeghy, B., Lebihan, S., Asghari, H., Koçkan, C., Orabi, B., Adra, N., Pili, R., Collins, C. C., Sahinalp, S. C. & Hach, F., Apr 23 2019, In : Nucleic acids research. 47, 7, e38.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs

Verheul, H. M. W., Qian, D. Z., Carducci, M. A. & Pili, R., Aug 1 2007, In : Cancer Chemotherapy and Pharmacology. 60, 3, p. 329-339 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Separation and dual detection of prostate cancer cells and protein biomarkers using a microchip device

Huang, W., Chang, C. L., Brault, N. D., Gur, O., Wang, Z., Jalal, S. I., Low, P. S., Ratliff, T. L., Pili, R. & Savran, C. A., Feb 7 2017, In : Lab on a Chip. 17, 3, p. 415-428 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Selenomethionine and methyl selenocysteine: Multiple-dose pharmacokinetics in selenium-replete men

Marshall, J. R., Burk, R. F., Ondracek, R. P., Hill, K. E., Perloff, M., Davis, W., Pili, R., George, S. & Bergan, R., Jan 1 2017, In : Oncotarget. 8, 16, p. 26312-26322 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Role of immunotherapy for renal cell cancer in 2011

George, S., Pili, R., Carducci, M. A. & Kim, J. J., Sep 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 9, p. 1011-1018 8 p.

Research output: Contribution to journalReview article

22 Scopus citations

Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: Evidence from a xenograft study

Hammers, H. J., Verheul, H. M., Salumbides, B., Sharma, R., Rudek, M., Jaspers, J., Shah, P., Ellis, L., Shen, L., Paesante, S., Dykema, K., Furge, K., Teh, B. T., Netto, G. & Pili, R., Jun 2010, In : Molecular cancer therapeutics. 9, 6, p. 1525-1535 11 p.

Research output: Contribution to journalArticle

129 Scopus citations

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

Lamming, D. W., Cummings, N. E., Rastelli, A. L., Gao, F., Cava, E., Bertozzi, B., Spelta, F., Pili, R. & Fontana, L., 2015, In : Oncotarget. 6, 31, p. 31233-31240 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Resistance to angiogenesis inhibitors in renal cell carcinoma

Tamaskar, I., Dhillon, J. & Pili, R., Feb 1 2011, In : Clinical Advances in Hematology and Oncology. 9, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Reproducibility of tumor blood flow quantification with15O-water PET

Lodge, M. A., Jacene, H. A., Pili, R. & Wahl, R. L., Oct 1 2008, In : Journal of Nuclear Medicine. 49, 10, p. 1620-1627 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
22 Scopus citations

Recent investigations of histone deacetylase inhibitors in renal cell carcinoma

Pili, R., Jun 9 2009, In : Clinical Advances in Hematology and Oncology. 7, 4, p. 252-254 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Real-Time Multiplex Kinase Phosphorylation Sensors in Living Cells

Damayanti, N. P., Buno, K., Cui, Y., Voytik-Harbin, S. L., Pili, R., Freeman, J. & Irudayaraj, J. M. K., Aug 25 2017, In : ACS Sensors. 2, 8, p. 1225-1230 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Weiss, A., Ding, X., van Beijnum, J. R., Wong, I., Wong, T. J., Berndsen, R. H., Dormond, O., Dallinga, M., Shen, L., Schlingemann, R. O., Pili, R., Ho, C. M., Dyson, P. J., van den Bergh, H., Griffioen, A. W. & Nowak-Sliwinska, P., Jul 20 2015, In : Angiogenesis. 18, 3, p. 233-244 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Randomized, double-blind, placebo-controlled phase III study of tasquinimod in men with metastatic castration-resistant prostate cancer

Sternberg, C., Armstrong, A., Pili, R., Ng, S., Huddart, R., Agarwal, N., Khvorostenko, D., Lyulko, O., Brize, A., Vogelzang, N., Delva, R., Harza, M., Thanos, A., James, N., Werbrouck, P., Bögemann, M., Hutson, T., Milecki, P., Chowdhury, S., Gallardo, E. & 6 others, Schwartsmann, G., Pouget, J. C., Baton, F., Nederman, T., Tuvesson, H. & Carducci, M., Aug 1 2016, In : Journal of Clinical Oncology. 34, 22, p. 2636-2643 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Psychological status of institutionalized aged: Influences on immune parameters and endocrinological correlates

Bartoloni, C., Guidi, L., Antico, L., Pili, R., Cursi, F., Carbonin, P., Gambassi, G., Rumi, C., Di Giovanni, A., Menichella, G., Menini, E., Doria, D. F. G. & Doria, G., Jan 1 1990, In : International Journal of Neuroscience. 51, 3-4, p. 279-281 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Psychological status and immunological parameters of institutionalized aged.

Bartoloni, C., Guidi, L., Antico, L., Pariante, C. M., Di Giovanni, A., Pili, R., Cursi, F., Tricerri, A., Tempesta, E. & Frasca, D., Jan 1 1991, In : Panminerva medica. 33, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

4 Scopus citations