Roberto Pili

  • 11513 Citations
  • 53 h-Index
1987 …2020

Research output per year

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Publications

Article

Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: Therapy with sequential 1-β -D-arabinofuranosylcytosine, mitoxantrone, and bevacizumab

Karp, J. E., Gojo, I., Pili, R., Gocke, C. D., Greer, J., Guo, C., Qian, D., Morris, L., Tidwell, M., Chen, H. & Zwiebel, J., Jun 1 2004, In : Clinical Cancer Research. 10, 11, p. 3577-3585 9 p.

Research output: Contribution to journalArticle

152 Scopus citations

Tasquinimod: A novel angiogenesis inhibitor-development in prostate cancer

George, S. & Pili, R., Apr 1 2013, In : Current oncology reports. 15, 2, p. 65-68 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine models

Shen, L., Sundstedt, A., Ciesielski, M., Miles, K. M., Celander, M., Adelaiye, R., Orillion, A., Ciamporcero, E., Ramakrishnan, S., Ellis, L., Fenstermaker, R., Abrams, S. I., Eriksson, H., Leanderson, T., Olsson, A. & Pili, R., Feb 2015, In : Cancer Immunology Research. 3, 2, p. 136-148 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Tasquinimod targets suppressive myeloid cells in the tumor microenvironment

Shen, L. & Pili, R., Jan 1 2019, In : OncoImmunology. 8, 10, e1072672.

Research output: Contribution to journalArticle

1 Scopus citations

The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma

Keizman, D., Ish-Shalom, M., Huang, P., Eisenberger, M. A., Pili, R., Hammers, H. & Carducci, M. A., Jan 2012, In : European Journal of Cancer. 48, 2, p. 202-208 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

The combination of low skeletal muscle mass and high tumor interleukin-6 associates with decreased survival in clear cell renal cell carcinoma

Kays, J. K., Koniaris, L. G., Cooper, C. A., Pili, R., Jiang, G., Liu, Y. & Zimmers, T. A., Jun 2020, In : Cancers. 12, 6, p. 1-11 11 p., 1605.

Research output: Contribution to journalArticle

Open Access

The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584

Qian, D. Z., Wang, X., Kachhap, S. K., Kato, Y., Wei, Y., Zhang, L., Atadja, P. & Pili, R., Sep 15 2004, In : Cancer Research. 64, 18, p. 6626-6634 9 p.

Research output: Contribution to journalArticle

195 Scopus citations

The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin

Kachhap, S. K., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., DeMarzo, A. M. & Carducci, M. A., Sep 5 2007, In : PloS one. 2, 9, e844.

Research output: Contribution to journalArticle

79 Scopus citations

Therapeutic targeting of sunitinib-induced AR phosphorylation in renal cell carcinoma

Adelaiye-Ogala, R., Damayanti, N. P., Orillion, A. R., Arisa, S., Chintala, S., Titus, M. A., Kao, C. & Pili, R., Jun 1 2018, In : Cancer Research. 78, 11, p. 2886-2896 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Therapeutic targeting of TFE3/IRS-1/PI3K/mTOR axis in translocation renal cell carcinoma

Damayanti, N. P., Budka, J. A., Khella, H. W. Z., Ferris, M. W., Ku, S. Y., Kauffman, E., Wood, A. C., Ahmed, K., Chintala, V. N., Adelaiye-Ogala, R., Elbanna, M., Orillion, A., Chintala, S., Kao, C., Marston Linehan, W., Yousef, G. M., Hollenhorst, P. C. & Pili, R., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5977-5989 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

The Relationship of Vascular Endothelial Growth Factor and Coagulation Factor (Fibrin and Fibrinogen) Expression in Clear Cell Renal Cell Carcinoma

Verheul, H. M. W., van Erp, K., Homs, M. Y. V., Yoon, G. S., van Der Groep, P., Rogers, C., Hansel, D. E., Netto, G. J. & Pili, R., Mar 1 2010, In : Urology. 75, 3, p. 608-614 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

The α-Glucosidase I Inhibitor Castanospermine Alters Endothelial Cell Glycosylation, Prevents Angiogenesis, and Inhibits Tumor Growth

Pili, R., Chang, J., Partis, R. A., Mueller, R. A., Chrest, F. J. & Passaniti, A., Jul 1 1995, In : Cancer Research. 55, 13, p. 2920-2926 7 p.

Research output: Contribution to journalArticle

183 Scopus citations

Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

Kirk, J. S., Schaarschuch, K., Dalimov, Z., Lasorsa, E., Ku, S. Y., Ramakrishnan, S., Hu, Q., Azabdaftari, G., Wang, J., Pili, R. & Ellis, L., 2015, In : Oncotarget. 6, 5, p. 3136-3146 11 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Unclassified Renal Cell Carcinoma With Significant Response to Nivolumab

Adra, N., Cheng, L. & Pili, R., Jun 2017, In : Clinical Genitourinary Cancer. 15, 3, p. e517-e519

Research output: Contribution to journalArticle

4 Scopus citations

Understanding avoidance, refusal, and abandonment of chemotherapy before and after cystectomy for bladder cancer

Rehman, S., Crane, A., Din, R., Raza, S. J., Shi, Y., Wilding, G., Levine, E. G., George, S., Pili, R., Trump, D. L. & Guru, K. A., Dec 1 2013, In : Urology. 82, 6, p. 1370-1375 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Use of a Glycolipid Inhibitor to Ameliorate Renal Cancer in a Mouse Model

Chatterjee, S., Alsaeedi, N., Hou, J., Bandaru, V. V. R., Wu, L., Halushka, M. K., Pili, R., Ndikuyeze, G. & Haughey, N. J., May 9 2013, In : PloS one. 8, 5, e63726.

Research output: Contribution to journalArticle

14 Scopus citations

Valutazione di alterazioni latenti della coagulazione mediante il dosaggio plasmatico del complesso trombina antitrombina nelle neoplasie gastrointestinali.

Translated title of the contribution: Evaluation of latent changes in blood coagulation by the determination of plasma thrombin-antithrombin complex in gastrointestinal neoplasmsGuidi, L., Bartoloni, C., Pellicanò, P., Cappelli, A., Cursi, F., Pili, R., Tricerri, A., Patriarca, F. & Gambassi, G., Mar 31 1991, In : La Clinica terapeutica. 136, 6, p. 367-373 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Vascular disruption in combination with mTOR inhibition in renal cell carcinoma

Ellis, L., Shah, P., Hammers, H., Lehet, K., Sotomayor, P., Azabdaftari, G., Seshadri, M. & Pili, R., Feb 2012, In : Molecular cancer therapeutics. 11, 2, p. 383-392 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model

Verheul, H. M. W., Hammers, H., Van Erp, K., Wei, Y., Sanni, T., Salumbides, B., Qian, D. Z., Yancopoulos, G. D. & Pili, R., Jul 15 2007, In : Clinical Cancer Research. 13, 14, p. 4201-4208 8 p.

Research output: Contribution to journalArticle

113 Scopus citations

VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo

Muhlhauser, J., Merrill, M. J., Pili, R., Maeda, H., Bacic, M., Bewig, B., Passaniti, A., Edwards, N. A., Crystal, R. G. & Capogrossi, M. C., 1995, In : Circulation research. 77, 6, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

146 Scopus citations

VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo

Kolmakova, A., Rajesh, M., Zang, D., Pili, R. & Chatterjee, S., Jul 1 2009, In : Glycoconjugate Journal. 26, 5, p. 547-558 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma: Results of a large phase 2 study

Vaughn, D. J., Srinivas, S., Stadler, W. M., Pili, R., Petrylak, D., Sternberg, C. N., Smith, D. C., Ringuette, S., De Wit, E., Pautret, V. & George, C., Sep 15 2009, In : Cancer. 115, 18, p. 4110-4117 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago phase 2 consortium

Bradley, D., Rathkopf, D., Dunn, R., Stadler, W. M., Liu, G., Smith, D. C., Pili, R., Zwiebel, J., Scher, H. & Hussain, M., Jan 12 2009, In : Cancer. 115, 23, p. 5541-5549 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

Ciamporcero, E., Shen, H., Ramakrishnan, S., Yu Ku, S., Chintala, S., Shen, L., Adelaiye, R., Miles, K. M., Ullio, C., Pizzimenti, S., Daga, M., Azabdaftari, G., Attwood, K., Johnson, C., Zhang, J., Barrera, G. & Pili, R., Mar 24 2016, In : Oncogene. 35, 12, p. 1541-1553 13 p.

Research output: Contribution to journalArticle

50 Scopus citations
Chapter

Bisphosphonates in renal cell carcinoma: Palliation versus antitumor effects

George, S. & Pili, R., Oct 1 2011, Targeted Therapies for Renal Cell Carcinoma. Future Medicine Ltd., p. 121-125 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cancer of the Kidney

Pili, R., Kauffman, E. & Rodriguez, R., Jan 1 2014, Abeloff's Clinical Oncology: Fifth Edition. Elsevier Inc., p. 1416-1444.e5

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Can post-transcription modifiers change the course of prostate cancer?

Qian, D. Z. & Pili, R., Apr 19 2016, Prostate Cancer: Translational and Emerging Therapies. CRC Press, p. 179-194 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenetic targeting and histone deacetylase inhibition in RCC

Ramakrishnan, S. & Pili, R., Nov 1 2012, Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets. Springer US, Vol. 9781461424000. p. 193-211 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Comment/debate

Erratum: CEP-7055: A Novel, Orally Active Pan Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases with Potent Antiangiogenic Activity and Antitumor Efficacy in Preclinical Models (Cancer Research (September 15, 2003) (5978-5991))

Ruggeri, B., Singh, J., Gingrich, D., Angeles, T., Albom, M., Yang, S., Chang, H., Robinson, C., Hunter, K., Dobrzanski, P., Jones-Bolin, S., Pritchard, S., Aimone, L., Klein-Szanto, A., Herbert, J. M., Bono, F., Schaeffer, P., Casellas, P., Bourie, B., Pili, R. & 6 others, Isaacs, J., Ator, M., Hudkins, R., Vaught, J., Mallamo, J. & Dionne, C., Nov 1 2003, In : Cancer Research. 63, 21, 1 p.

Research output: Contribution to journalComment/debate

Is this a true renaissance for the treatment of prostate cancer?

Roberto, P., Dec 1 2010, In : Oncology. 24, 14

Research output: Contribution to journalComment/debate

Is this a true renaissance for the treatment of prostate cancer?

Pili, R., Dec 1 2010, In : Oncology (Williston Park, N.Y.). 24, 14, p. 1327-1328 2 p.

Research output: Contribution to journalComment/debate

Editorial

Genomic profiling of collecting duct renal carcinoma

Chintala, S. & Pili, R., 2016, In : Aging. 8, 10, p. 2260-2261 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Is HIF-1α a valid therapeutic target?

Pili, R. & Donehower, R. C., Apr 2 2003, In : Journal of the National Cancer Institute. 95, 7, p. 498-499 2 p.

Research output: Contribution to journalEditorial

Open Access
20 Scopus citations

Provenge: Combating prostate cancer with a vengeance?

Schwaab, T. & Pili, R., Aug 1 2011, In : Expert Review of Vaccines. 10, 8, p. 1113-1114 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations
Letter

Modulation of chemotherapeutic efficacy by vascular disrupting agents: Optimizing the sequence and schedule

Wang, E. S., Pili, R. & Seshadri, M., Mar 1 2012, In : Journal of Clinical Oncology. 30, 7, p. 760-761 2 p.

Research output: Contribution to journalLetter

15 Scopus citations
Review article

Ageing, Disability, and Spinal Cord Injury: Some Issues of Analysis

Pili, R., Gaviano, L., Pili, L. & Petretto, D. R., Jan 1 2018, In : Current Gerontology and Geriatrics Research. 2018, 4017858.

Research output: Contribution to journalReview article

3 Scopus citations

Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Böck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A. M. & 66 others, Cleaver, O., Coukos, G., Davis, G. E., De Palma, M., Dimberg, A., Dings, R. P. M., Djonov, V., Dudley, A. C., Dufton, N. P., Fendt, S. M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R. J., Harris, A. L., Hughes, C. C. W., Hultgren, N. W., Iruela-Arispe, M. L., Irving, M., Jain, R. K., Kalluri, R., Kalucka, J., Kerbel, R. S., Kitajewski, J., Klaassen, I., Kleinmann, H. K., Koolwijk, P., Kuczynski, E., Kwak, B. R., Marien, K., Melero-Martin, J. M., Munn, L. L., Nicosia, R. F., Noel, A., Nurro, J., Olsson, A. K., Petrova, T. V., Pietras, K., Pili, R., Pollard, J. W., Post, M. J., Quax, P. H. A., Rabinovich, G. A., Raica, M., Randi, A. M., Ribatti, D., Ruegg, C., Schlingemann, R. O., Schulte-Merker, S., Smith, L. E. H., Song, J. W., Stacker, S. A., Stalin, J., Stratman, A. N., Van de Velde, M., van Hinsbergh, V. W. M., Vermeulen, P. B., Waltenberger, J., Weinstein, B. M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M. C. & Griffioen, A. W., Aug 1 2018, In : Angiogenesis. 21, 3, p. 425-532 108 p.

Research output: Contribution to journalReview article

130 Scopus citations

Epigenetic dysregulation in advanced kidney cancer: Opportunities for therapeutic interventions

Goldsamt, A., Damayanti, N. P., De Nigris, F. & Pili, R., Sep 1 2020, In : Cancer Journal (United States). 26, 5, p. 399-406 8 p.

Research output: Contribution to journalReview article

Histone deacetylase inhibitors: Advancing therapeutic strategies in hematological and solid malignancies

Ellis, L. & Pili, R., 2010, In : Pharmaceuticals. 3, 8, p. 2441-2469 29 p.

Research output: Contribution to journalReview article

58 Scopus citations

Histone deacetylase inhibitors and epigenetic modifications as a novel strategy in renal cell carcinoma

Ramakrishnan, S. & Pili, R., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 333-340 8 p.

Research output: Contribution to journalReview article

17 Scopus citations

Histone deacetylase inhibitors as immunomodulators in cancer therapeutics

Shen, L., Orillion, A. & Pili, R., Mar 2016, In : Epigenomics. 8, 3, p. 415-428 14 p.

Research output: Contribution to journalReview article

37 Scopus citations

Kidney cancer

Motzer, R. J., Agarwal, N., Beard, C., Bhayani, S., Bolger, G. B., Carducci, M. A., Chang, S. S., Choueiri, T. K., Hancock, S. L., Hudes, G. R., Jonasch, E., Josephson, D., Kuzel, T. M., Levine, E. G., Lin, D. W., Margolin, K. A., Michaelson, M. D., Olencki, T., Pili, R., Ratliff, T. W. & 7 others, Redman, B. G., Robertson, C. N., Ryan, C. J., Sheinfeld, J., Spiess, P. E., Wang, J. & Wilder, R. B., Sep 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 9, p. 960-977 18 p.

Research output: Contribution to journalReview article

Open Access
67 Scopus citations

Kidney cancer: Clinical practice guidelines

Motzer, R. J., Carducci, M. A., Fishman, M., Hancock, S. L., Hauke, R. J., Hudes, G. R., Kantoff, P., Kuzel, T. M., Lange, P. H., Levine, E. G., Logothetis, C., Margolin, K. A., Pili, R., Pohar, K. S., Redman, B. G., Richey, S., Robertson, C. N., Samlowski, W. E., Sheinfeld, J. & Urban, D. A., Jan 1 2005, In : JNCCN Journal of the National Comprehensive Cancer Network. 3, 1, p. 84-93 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Kidney cancer

Motzer, R. J., Agarwal, N., Beard, C., Bolger, G. B., Boston, B., Carducci, M. A., Choueiri, T. K., Figlin, R. A., Fishman, M., Hancock, S. L., Hudes, G. R., Jonasch, E., Kessinger, A., Kuzel, T. M., Lange, P. H., Levine, E. G., Margolin, K. A., Michaelson, M. D., Olencki, T., Pili, R. & 5 others, Redman, B. G., Robertson, C. N., Schwartz, L. H., Sheinfeld, J. & Wang, J., Jun 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 6, p. 618-630 13 p.

Research output: Contribution to journalReview article

Open Access
149 Scopus citations

Kidney cancer, version 2.2014

Motzer, R. J., Jonasch, E., Agarwal, N., Beard, C., Bhayani, S., Bolger, G. B., Chang, S. S., Choueiri, T. K., Derweesh, I. H., Gupta, S., Hancock, S. L., Kim, J. J., Kuzel, T. M., Lam, E. T., Lau, C., Levine, E. G., Lin, D. W., Margolin, K. A., Michaelson, M. D., Olencki, T. & 12 others, Pili, R., Plimack, E. R., Rampersaud, E. N., Redman, B. G., Ryan, C. J., Sheinfeld, J., Sircar, K., Somer, B., Wang, J., Wilder, R. B., Dwyer, M. A. & Kumar, R., Feb 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 2, p. 175-182 8 p.

Research output: Contribution to journalReview article

Open Access
44 Scopus citations

Kidney cancer, version 3.2015: Featured updates to the NCCN guidelines

Motzer, R. J., Jonasch, E., Agarwal, N., Beard, C., Bhayani, S., Bolger, G. B., Chang, S. S., Choueiri, T. K., Costello, B. A., Derweesh, I. H., Gupta, S., Hancock, S. L., Kim, J. J., Kuzel, T. M., Lam, E. T., Lau, C., Levine, E. G., Lin, D. W., Michaelson, M. D., Olencki, T. & 12 others, Pili, R., Plimack, E. R., Rampersaud, E. N., Redman, B. G., Ryan, C. J., Sheinfeld, J., Shuch, B., Sircar, K., Somer, B., Wilder, R. B., Dwyer, M. & Kumar, R., Feb 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 2, p. 151-159 9 p.

Research output: Contribution to journalReview article

Open Access
167 Scopus citations

Mechanisms of action of tasquinimod on the tumour microenvironment

Raymond, E., Dalgleish, A., Damber, J. E., Smith, M. & Pili, R., Jan 2014, In : Cancer Chemotherapy and Pharmacology. 73, 1, p. 1-8 8 p.

Research output: Contribution to journalReview article

34 Scopus citations

Posttranscription regulation of prostate cancer growth

Shen, L. & Pili, R., Jan 1 2008, In : Cancer Journal. 14, 1, p. 46-53 8 p.

Research output: Contribution to journalReview article

11 Scopus citations

Pre-clinical models of renal carcinoma and their utility in drug development

Salumbides, B. C., Lehet, K. M., Ndikuyeze, G. & Pili, R., Dec 1 2009, In : Current Protocols in Pharmacology. SUPPL.47, p. 14.13.1-14.13.19

Research output: Contribution to journalReview article

3 Scopus citations

Role of immunotherapy for renal cell cancer in 2011

George, S., Pili, R., Carducci, M. A. & Kim, J. J., Sep 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 9, p. 1011-1018 8 p.

Research output: Contribution to journalReview article

23 Scopus citations