Roberto Pili

  • 11262 Citations
  • 52 h-Index
1987 …2020

Research output per year

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Publications

Article

Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model

Affronti, H. C., Long, M. D., Rosario, S. R., Gillard, B. M., Karasik, E., Boerlin, C. S., Pellerite, A. J., Foster, B. A., Attwood, K., Pili, R., Wilton, J. H., Campbell, M. J. & Smiraglia, D. J., Jan 1 2017, In : Oncotarget. 8, 61, p. 103758-103774 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer

Fontana, L., Adelaiye, R. M., Rastelli, A. L., Miles, K. M., Ciamporcero, E., Longo, V. D., Nguyen, H., Vessella, R. & Pili, R., Dec 2013, In : Oncotarget. 4, 12, p. 2451-2461 11 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

Dietary protein restriction reprograms tumor-associated macrophages and enhances immunotherapy

Orillion, A., Damayanti, N. P., Shen, L., Adelaiye-Ogala, R., Affronti, H., Elbanna, M., Chintala, S., Ciesielski, M., Fontana, L., Kao, C., Elzey, B. D., Ratliff, T. L., Nelson, D. E., Smiraglia, D., Abrams, S. I. & Pili, R., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6383-6395 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K. A., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., Dang, C. V., Liu, J. O. & Semenza, G. L., Dec 16 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 50, p. 19579-19586 8 p.

Research output: Contribution to journalArticle

417 Scopus citations

Dll4 blockade potentiates the anti-tumor Effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts

Miles, K. M., Seshadri, M., Ciamporcero, E., Adelaiye, R., Gillard, B., Sotomayor, P., Attwood, K., Shen, L., Conroy, D., Kuhnert, F., Lalani, A. S., Thurston, G. & Pili, R., Nov 13 2014, In : PLoS ONE. 9, 11, e112371.

Research output: Contribution to journalArticle

29 Scopus citations

Dual inhibition of angiopoietin-Tie2 and MET alters the tumor microenvironment and prolongs survival in a metastatic model of renal cell carcinoma

Elbanna, M., Orillion, A. R., Damayanti, N. P., Adelaiye-Ogala, R., Shen, L., Miles, K. M., Chintala, S., Ciamporcero, E., Ramakrishnan, S., Ku, S. Y., Rex, K., Caenepeel, S., Coxon, A. & Pili, R., Jan 1 2020, In : Molecular cancer therapeutics. 19, 1, p. 147-156 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer

Tolcher, A. W., Chi, K. N., Shore, N. D., Pili, R., Molina, A., Acharya, M., Kheoh, T., Jiao, J. J., Gonzalez, M., Trinh, A., Pankras, C. & Tran, N., Aug 1 2012, In : Cancer Chemotherapy and Pharmacology. 70, 2, p. 305-313 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Endogenous reactivation of the RARβ2 tumor suppressor gene epigenetically silenced in breast cancer

Sirchia, S. M., Ren, M., Pili, R., Sironi, E., Somenzi, G., Ghidoni, R., Toma, S., Nicolò, G. & Sacchi, N., May 1 2002, In : Cancer Research. 62, 9, p. 2455-2461 7 p.

Research output: Contribution to journalArticle

145 Scopus citations

Endothelial cell Ca2+ increases upon tumor cell contact and modulates cell-cell adhesion

Pili, R., Corda, S., Passaniti, A., Ziegelstein, R. C., Heldman, A. W. & Capogrossi, M. C., Jan 1 1993, In : Journal of Clinical Investigation. 92, 6, p. 3017-3022 6 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Endothelial cell Ca2+ is increased by melanoma cell adhesion

Pili, R., Ziegelstein, R. C., Passaniti, A. & Capogrossi, M. C., Dec 1 1993, In : Clinical Chemistry and Enzymology Communications. 6, 1-2, p. 79-83 5 p.

Research output: Contribution to journalArticle

Entinostat neutralizes myeloid-derived suppressor cells and enhances the antitumor effect of PD-1 inhibition in murine models of lung and renal cell carcinoma

Orillion, A., Hashimoto, A., Damayanti, N., Shen, L., Adelaiye-Ogala, R., Arisa, S., Chintala, S., Ordentlich, P., Kao, C., Elzey, B., Gabrilovich, D. & Pili, R., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5187-5201 15 p.

Research output: Contribution to journalArticle

88 Scopus citations

Epigenetic modulation of retinoic acid receptor β2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma

Wang, X. F., Qian, D. Z., Ren, M., Kato, Y., Wei, Y., Zhang, L., Fansler, Z., Clark, D., Nakanishi, O. & Pili, R., May 1 2005, In : Clinical Cancer Research. 11, 9, p. 3535-3542 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming

Adelaiye-Ogala, R., Budka, J., Damayanti, N. P., Arrington, J., Ferris, M., Hsu, C. C., Chintala, S., Orillion, A., Miles, K. M., Shen, L., Elbanna, M., Ciamporcero, E., Arisa, S., Pettazzoni, P., Draetta, G. F., Seshadri, M., Hancock, B., Radovich, M., Kota, J., Buck, M. & 9 others, Keilhack, H., McCarthy, B. P., Persohn, S. A., Territo, P. R., Zang, Y., Irudayaraj, J., Tao, W. A., Hollenhorst, P. & Pili, R., Dec 1 2017, In : Cancer Research. 77, 23, p. 6651-6666 16 p.

Research output: Contribution to journalArticle

18 Scopus citations

Generation of a C57BL/6 MYC-Driven Mouse Model and Cell Line of Prostate Cancer

Ellis, L., Ku, S. Y., Li, Q., Azabdaftari, G., Seliski, J., Olson, B., Netherby, C. S., Tang, D. G., Abrams, S. I., Goodrich, D. W. & Pili, R., Sep 15 2016, In : Prostate. 76, 13, p. 1192-1202 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Generation of a syngeneic orthotopic transplant model of prostate cancer metastasis

Ellis, L., Lehet, K., Ku, S. Y., Azabdaftari, G. & Pili, R., Jan 1 2014, In : Oncoscience. 1, 10, p. 609-613 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts

Wei, L., Chintala, S., Ciamporcero, E., Ramakrishnan, S., Elbanna, M., Wang, J., Hu, Q., Glenn, S. T., Murakami, M., Liu, L., Gomez, E. C., Sun, Y., Conroy, J., Miles, K. M., Malathi, K., Ramaiah, S., Anbarasu, A., Woloszynska-Read, A., Johnson, C. S., Conroy, J. & 3 others, Liu, S., Morrison, C. D. & Pili, R., 2016, In : Oncotarget. 7, 47, p. 76374-76389 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma

Ramakrishnan, S., Ku, S. Y., Ciamporcero, E., Miles, K. M., Attwood, K., Chintala, S., Shen, L., Ellis, L., Sotomayor, P., Swetzig, W., Huang, R., Conroy, D., Orillion, A., Das, G. & Pili, R., Jan 1 2016, In : BMC Cancer. 16, 1, 617.

Research output: Contribution to journalArticle

11 Scopus citations

High-dose interleukin-2 therapy for metastatic renal cell carcinoma: A contemporary experience

Hanzly, M., Aboumohamed, A., Yarlagadda, N., Creighton, T., Digiorgio, L., Fredrick, A., Rao, G., Mehedint, D., George, S., Attwood, K., Kauffman, E., Narashima, D., Khushalani, N. I., Pili, R. & Schwaab, T., May 2014, In : Urology. 83, 5, p. 1129-1134 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Histone modifications: Implications in renal cell carcinoma

Ramakrishnan, S., Ellis, L. & Pili, R., Aug 2013, In : Epigenomics. 5, 4, p. 453-462 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

Volpert, O. V., Pili, R., Sikder, H. A., Nelius, T., Zaichuk, T., Morris, C., Shiflett, C. B., Devlin, M. K., Conant, K. & Alani, R. M., Dec 2002, In : Cancer Cell. 2, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

158 Scopus citations

Identification of ABR-215050 as lead second generation quinoline-3- carboxamide anti-angiogenic agent for the treatment of prostate cancer

Isaacs, J. T., Pili, R., Qian, D. Z., Dalrymple, S. L., Garrison, J. B., Kyprianou, N., Björk, A., Olsson, A. & Leanderson, T., Dec 1 2006, In : Prostate. 66, 16, p. 1768-1778 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Pili, R., Sullivan, D. J. & Liu, J. O., May 4 2006, In : Journal of Medicinal Chemistry. 49, 9, p. 2677-2680 4 p.

Research output: Contribution to journalArticle

78 Scopus citations

Immune parameters in a populatio of institutionalized elderly subjects: influence of depressive disorders and endocrinological correlations

Bartoloni, C., Guidi, L., Frasca, D., Antico, L., Pili, R., Cursi, F., Di Giovanni, A., Rumi, C., Menini, E., Carbonin, P., Doria, G. & Gambassi, G., Sep 1991, In : Mechanisms of Ageing and Development. 60, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Immunomodulation by entinostat in renal cell carcinoma patients receiving high-dose interleukin 2: A multicenter, single-arm, phase I/II trial (NCI-CTEP#7870)

Pili, R., Quinn, D. I., Hammers, H. J., Monk, P., George, S., Dorff, T. B., Olencki, T., Shen, L., Orillion, A., Lamonica, D., Fragomeni, R. S., Szabo, Z., Hutson, A., Groman, A., Perkins, S. M., Piekarz, R. & Carducci, M. A., Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7199-7208 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Impact of cytoreductive nephrectomy on eligibility for systemic treatment and effects on survival: Are surgical complications or disease related factors responsible?

O'Malley, R. L., Brewer, K. A., Hayn, M. H., Kim, H. L., Underwood, W., Pili, R. & Schwaab, T., Sep 1 2011, In : Urology. 78, 3, p. 595-600 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Impairment of lymphocyte activities in depressed aged subjects

Guidi, L., Bartoloni, C., Frasca, D., Antico, L., Pili, R., Cursi, F., Tempesta, E., Rumi, C., Menini, E., Carbonin, P., Doria, G. & Gambassi, G., Sep 1991, In : Mechanisms of Ageing and Development. 60, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

Pettazzoni, P., Pizzimenti, S., Toaldo, C., Sotomayor, P., Tagliavacca, L., Liu, S., Wang, D., Minelli, R., Ellis, L., Atadja, P., Ciamporcero, E., Dianzani, M. U., Barrera, G. & Pili, R., Jan 15 2011, In : Free Radical Biology and Medicine. 50, 2, p. 313-322 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Inhibition of Hsp90 augments docetaxel therapy in castrate resistant prostate cancer

Ku, S. Y., Lasorsa, E., Adelaiye, R., Ramakrishnan, S., Ellis, L. & Pili, R., Jul 29 2014, In : PloS one. 9, 7, e103680.

Research output: Contribution to journalArticle

7 Scopus citations

Initial contact and subsequent adhesion of human neutrophils or monocytes to human aortic endothelial cells releases an endothelial intracellular calcium store

Ziegelstein, R. C., Corda, S., Pili, R., Passaniti, A., Lefer, D., Zweier, J. L., Fraticelli, A. & Capogrossi, M. C., Oct 1994, In : Circulation. 90, 4 I, p. 1899-1907 9 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Intravenous Bevacizumab Causes Regression of Choroidal Neovascularization Secondary to Diseases Other Than Age-related Macular Degeneration

Nguyen, Q. D., Shah, S. M., Hafiz, G., Do, D. V., Haller, J. A., Pili, R., Zimmer-Galler, I. E., Janjua, K., Symons, R. C. A. & Campochiaro, P. A., Feb 2008, In : American Journal of Ophthalmology. 145, 2, p. 257-266.e2

Research output: Contribution to journalArticle

29 Scopus citations

In Vivo Angiogenesis Induced by Recombinant Adenovirus Vectors Coding Either for Secreted or Nonsecreted Forms of Acidic Fibroblast Growth Factor

Mühlhauser, J., Pili, R., Merrill, M. J., Maeda, H., Passaniti, A., Crystal, R. G. & Capogrossi, M. C., Nov 1 1995, In : Human gene therapy. 6, 11, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

In vivo imaging of retinoic acid receptor β2 transcriptional activation by the histone deacetylase inhibitor MS-275 in retinoid-resistant prostate cancer cells

Qian, D. Z., Ren, M., Wei, Y., Wang, X., Van De Geijn, F., Rasmussen, C., Nakanishi, O., Sacchi, N. & Pili, R., Jun 15 2005, In : Prostate. 64, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'

Bartoloni, C., Guidi, L., Tricerri, A., Patriarca, F., Pili, R., Cursi, F., Canetta, M., Cappelli, A., Vangeli, M., Salvati, F. & Gambassi, G., 1992, In : Oncology (Switzerland). 49, 6, p. 426-430 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lenalidomide in nonmetastatic biochemically relapsed prostate cancer: Results of a phase I/II double-blinded, randomized study

Keizman, D., Zahurak, M., Sinibaldi, V., Carducci, M., Denmeade, S., Drake, C., Pili, R., Antonarakis, E. S., Hudock, S. & Eisenberger, M., Nov 1 2010, In : Clinical Cancer Research. 16, 21, p. 5269-5276 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer

Armstrong, A. J., Häggman, M., Stadler, W. M., Gingrich, J. R., Assikis, V., Polikoff, J., Damber, J. E., Belkoff, L., Nordle, Ö., Forsberg, G., Carducci, M. A. & Pili, R., Dec 15 2013, In : Clinical Cancer Research. 19, 24, p. 6891-6901 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Low-protein diet in cancer: Ready for prime time?

Pili, R. & Fontana, L., Jul 1 2018, In : Nature Reviews Endocrinology. 14, 7, p. 384-386 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lysosomal sequestration of sunitinib: A novel mechanism of drug resistance

Gotink, K. J., Broxterman, H. J., Labots, M., De Haas, R. R., Dekker, H., Honeywell, R. J., Rudek, M. A., Beerepoot, L. V., Musters, R. J., Jansen, G., Griffioen, A. W., Assaraf, Y. G., Pili, R., Peters, G. J. & Verheul, H. M. W., Dec 1 2011, In : Clinical Cancer Research. 17, 23, p. 7337-7346 10 p.

Research output: Contribution to journalArticle

172 Scopus citations

Major response to cyclophosphamide and prednisone in recurrent castration-resistant prostate cancer

Batty, N., Yarlagadda, N. & Pili, R., Aug 1 2013, In : JNCCN Journal of the National Comprehensive Cancer Network. 11, 8, p. 911-915 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Marimastat in the treatment of patients with biochemically relapsed prostate cancer: A prospective randomized, double-blind, phase I/II trial

Rosenbaum, E., Zahurak, M., Sinibaldi, V., Carducci, M. A., Pili, R., Laufer, M., DeWeese, T. L. & Eisenberger, M. A., Jun 15 2005, In : Clinical Cancer Research. 11, 12, p. 4437-4443 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Mechanism of action and clinical activity of tasquinimod in castrate-resistant prostate cancer

Gupta, N., Ustwani, O. A., Shen, L. & Pili, R., Feb 12 2014, In : OncoTargets and Therapy. 7, p. 223-234 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mental disorders in obese patients with and without metabolic syndrome

Carpiniello, B., Pinna, F., Pili, R., Velluzzi, F. & Loviselli, A., Jan 1 2011, In : International Journal of Psychiatry in Medicine. 42, 4, p. 369-375 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Methods in laboratory investigation: A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor

Passaniti, A., Taylor, R. M., Pili, R., Guo, Y., Long, P. V., Haney, J. A., Pauly, R. R., Grant, D. S. & Martin, G. R., Jan 1 1992, In : Laboratory Investigation. 67, 4, p. 519-528 10 p.

Research output: Contribution to journalArticle

735 Scopus citations

Mind the gap: Potential for rebounds during antiangiogenic treatment breaks

Ebos, J. M. L. & Pili, R., Jul 15 2012, In : Clinical Cancer Research. 18, 14, p. 3719-3721 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modeling spontaneous metastatic renal cell carcinoma (mRCC) in mice following nephrectomy

Tracz, A., Mastri, M., Lee, C. R., Pili, R. & Ebos, J. M. L., Apr 29 2014, In : Journal of Visualized Experiments. 86, e51485.

Research output: Contribution to journalArticle

9 Scopus citations

Modeling the cost of management options for stage I nonseminomatous germ cell tumors: A decision tree analysis

Link, R. E., Allaf, M. E., Pili, R. & Kavoussi, L. R., Dec 1 2005, In : Journal of Clinical Oncology. 23, 24, p. 5762-5773 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Modified synthesis and antiangiogenic activity of Linomide

Khan, S. R., Mhaka, A., Pili, R. & Isaacs, J. T., Feb 26 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 4, p. 451-452 2 p.

Research output: Contribution to journalArticle

16 Scopus citations

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer

Kalmuk, J., Folaron, M., Buchinger, J., Pili, R. & Seshadri, M., 2015, In : Oncotarget. 6, 27, p. 24376-24392 17 p.

Research output: Contribution to journalArticle

6 Scopus citations

Muscadine grape skin extract (MPX) in men with biochemically recurrent prostate cancer: A randomized, multicenter, placebo-controlled clinical trial

Paller, C. J., Zhou, X. C., Heath, E. I., Taplin, M. E., Mayer, T., Stein, M. N., Bubley, G. J., Pili, R., Hudson, T., Kakarla, R., Abbas, M. M., Anders, N. M., Dowling, D., King, S., Bruns, A. B., Wagner, W. D., Drake, C. G., Antonarakis, E. S., Eisenberger, M. A., Denmeade, S. R. & 3 others, Rudek, M. A., Rosner, G. L. & Carducci, M. A., Jan 15 2018, In : Clinical Cancer Research. 24, 2, p. 306-315 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells

Minelli, R., Cavalli, R., Ellis, L., Pettazzoni, P., Trotta, F., Ciamporcero, E., Barrera, G., Fantozzi, R., Dianzani, C. & Pili, R., Nov 20 2012, In : European Journal of Pharmaceutical Sciences. 47, 4, p. 686-694 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

NCCN task force report: Optimizing treatment of advanced renal cell carcinoma with molecular targeted therapy

Hudes, G. R., Carducci, M. A., Choueiri, T. K., Esper, P., Jonasch, E., Kumar, R., Margolin, K. A., Michaelson, M. D., Motzer, R. J., Pili, R., Roethke, S. & Srinivas, S., Mar 24 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, SUPPL. 1, p. S1-S29

Research output: Contribution to journalArticle

43 Scopus citations