Roberto Pili

  • 11262 Citations
  • 52 h-Index
1987 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

2007

Antitumor effect of the histone deacetylase inhibitor LAQ824 in combination with 13-cis-retinoic acid in human malignant melanoma

Kato, Y., Salumbides, B. C., Wang, X. F., Qian, D. Z., Williams, S., Wei, Y., Sanni, T. B., Atadja, P. & Pili, R., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 70-81 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phase II Study of Imatinib Mesylate in Patients with Prostate Cancer with Evidence of Biochemical Relapse After Definitive Radical Retropubic Prostatectomy or Radiotherapy

Bajaj, G. K., Zhang, Z., Garrett-Mayer, E., Drew, R., Sinibaldi, V., Pili, R., Denmeade, S. R., Carducci, M. A., Eisenberger, M. A. & DeWeese, T. L., Mar 1 2007, In : Urology. 69, 3, p. 526-531 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Platelets take up the monoclonal antibody bevacizumab

Verheul, H. M. W., Lolkema, M. P. J., Qian, D. Z., Hilkes, Y. H. A., Liapi, E., Akkerman, J. W. N., Pili, R. & Voest, E. E., Sep 15 2007, In : Clinical Cancer Research. 13, 18, p. 5341-5347 7 p.

Research output: Contribution to journalArticle

83 Scopus citations

Preclinical and clinical studies with the multi-kinase inhibitor CEP-701 as treatment for prostate cancer demonstrate the inadequacy of PSA response as a primary endpoint

Collins, C., Carducci, M. A., Eisenberger, M. A., Isaacs, J. T., Partin, A. W., Pili, R., Sinibaldi, V. J., Walczak, J. S. & Denmeade, S. R., Sep 2007, In : Cancer Biology and Therapy. 6, 9, p. 1356-1363 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Sequence-dependent antitumor effects of differentiation agents in combination with cell cycle-dependent cytotoxic drugs

Verheul, H. M. W., Qian, D. Z., Carducci, M. A. & Pili, R., Aug 1 2007, In : Cancer Chemotherapy and Pharmacology. 60, 3, p. 329-339 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma

Kato, Y., Yoshimura, K., Shin, T., Verheul, H., Hammers, H., Sanni, T. B., Salumbides, B. C., Van Erp, K., Schulick, R. & Pili, R., Aug 1 2007, In : Clinical Cancer Research. 13, 15, p. 4538-4546 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin

Kachhap, S. K., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., DeMarzo, A. M. & Carducci, M. A., Sep 5 2007, In : PloS one. 2, 9, e844.

Research output: Contribution to journalArticle

78 Scopus citations

Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model

Verheul, H. M. W., Hammers, H., Van Erp, K., Wei, Y., Sanni, T., Salumbides, B., Qian, D. Z., Yancopoulos, G. D. & Pili, R., Jul 15 2007, In : Clinical Cancer Research. 13, 14, p. 4201-4208 8 p.

Research output: Contribution to journalArticle

112 Scopus citations
2006

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α

Qian, D. Z., Kachhap, S. K., Collis, S. J., Verheul, H. M. W., Carducci, M. A., Atadja, P. & Pili, R., Sep 1 2006, In : Cancer Research. 66, 17, p. 8814-8821 8 p.

Research output: Contribution to journalArticle

239 Scopus citations

Identification of ABR-215050 as lead second generation quinoline-3- carboxamide anti-angiogenic agent for the treatment of prostate cancer

Isaacs, J. T., Pili, R., Qian, D. Z., Dalrymple, S. L., Garrison, J. B., Kyprianou, N., Björk, A., Olsson, A. & Leanderson, T., Dec 1 2006, In : Prostate. 66, 16, p. 1768-1778 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target

Chong, C. R., Qian, D. Z., Pan, F., Wei, Y., Pili, R., Sullivan, D. J. & Liu, J. O., May 4 2006, In : Journal of Medicinal Chemistry. 49, 9, p. 2677-2680 4 p.

Research output: Contribution to journalArticle

78 Scopus citations

Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer

Carducci, M. A., Musib, L., Kies, M. S., Pili, R., Truong, M., Brahmer, J. R., Cole, P., Sullivan, R., Riddle, J., Schmidt, J., Enas, N., Sinha, V., Thornton, D. E. & Herbst, R. S., Sep 1 2006, In : Journal of Clinical Oncology. 24, 25, p. 4092-4099 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Phase II evaluation of docetaxel plus exisulind in patients with androgen independent prostate carcinoma

Sinibaldi, V. J., Elza-Brown, K., Schmidt, J., Eisenberger, M. A., Rosenbaum, E., Denmeade, S. R., Pili, R., Walczak, J., Baker, S. D., Zahurak, M. & Carducci, M. A., Aug 1 2006, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 29, 4, p. 395-398 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Targeting tumor angiogenesis with histone deacetylase inhibitors: The hydroxamic acid derivative LBH589

Qian, D. Z., Kato, Y., Shabbeer, S., Wei, Y., Verheul, H. M. W., Salumbides, B., Sanni, T., Atadja, P. & Pili, R., Jan 15 2006, In : Clinical Cancer Research. 12, 2, p. 634-642 9 p.

Research output: Contribution to journalArticle

224 Scopus citations
2005

A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation

Lin, K. S., Luu, A., Baidoo, K. E., Hashemzadeh-Gargari, H., Chen, M. K., Brenneman, K., Pili, R., Pomper, M., Carducci, M. A. & Wagner, H. N., Jan 1 2005, In : Bioconjugate Chemistry. 16, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

Heath, E. I., Gaskins, M., Pitot, H. C., Pili, R., Tan, W., Marschke, R., Liu, G., Hillman, D., Sarkar, F., Sheng, S., Erlichman, C. & Ivy, P., Sep 2005, In : Clinical Prostate Cancer. 4, 2, p. 138-141 4 p.

Research output: Contribution to journalArticle

48 Scopus citations

Epigenetic modulation of retinoic acid receptor β2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma

Wang, X. F., Qian, D. Z., Ren, M., Kato, Y., Wei, Y., Zhang, L., Fansler, Z., Clark, D., Nakanishi, O. & Pili, R., May 1 2005, In : Clinical Cancer Research. 11, 9, p. 3535-3542 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

In vivo imaging of retinoic acid receptor β2 transcriptional activation by the histone deacetylase inhibitor MS-275 in retinoid-resistant prostate cancer cells

Qian, D. Z., Ren, M., Wei, Y., Wang, X., Van De Geijn, F., Rasmussen, C., Nakanishi, O., Sacchi, N. & Pili, R., Jun 15 2005, In : Prostate. 64, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Kidney cancer: Clinical practice guidelines

Motzer, R. J., Carducci, M. A., Fishman, M., Hancock, S. L., Hauke, R. J., Hudes, G. R., Kantoff, P., Kuzel, T. M., Lange, P. H., Levine, E. G., Logothetis, C., Margolin, K. A., Pili, R., Pohar, K. S., Redman, B. G., Richey, S., Robertson, C. N., Samlowski, W. E., Sheinfeld, J. & Urban, D. A., Jan 1 2005, In : JNCCN Journal of the National Comprehensive Cancer Network. 3, 1, p. 84-93 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Marimastat in the treatment of patients with biochemically relapsed prostate cancer: A prospective randomized, double-blind, phase I/II trial

Rosenbaum, E., Zahurak, M., Sinibaldi, V., Carducci, M. A., Pili, R., Laufer, M., DeWeese, T. L. & Eisenberger, M. A., Jun 15 2005, In : Clinical Cancer Research. 11, 12, p. 4437-4443 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Modeling the cost of management options for stage I nonseminomatous germ cell tumors: A decision tree analysis

Link, R. E., Allaf, M. E., Pili, R. & Kavoussi, L. R., Dec 1 2005, In : Journal of Clinical Oncology. 23, 24, p. 5762-5773 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2004

A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier

Lin, K. S., Luu, A., Baidoo, K. E., Hashemzadeh-Gargari, H., Chen, M. K., Pili, R., Pomper, M., Carducci, M. & Wagner, H. N., Nov 1 2004, In : Bioconjugate Chemistry. 15, 6, p. 1416-1423 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

A Phase II Trial of Temozolomide and IFN-α in Patients with Advanced Renal Cell Carcinoma

Sunkara, U., Walczak, J. R., Summerson, L., Rogers, T., Eisenberger, M., Denmeade, S., Pili, R., Huff, C. A., Sinibaldi, V. & Carducci, M. A., Jan 1 2004, In : Journal of Interferon and Cytokine Research. 24, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: Therapy with sequential 1-β -D-arabinofuranosylcytosine, mitoxantrone, and bevacizumab

Karp, J. E., Gojo, I., Pili, R., Gocke, C. D., Greer, J., Guo, C., Qian, D., Morris, L., Tidwell, M., Chen, H. & Zwiebel, J., Jun 1 2004, In : Clinical Cancer Research. 10, 11, p. 3577-3585 9 p.

Research output: Contribution to journalArticle

152 Scopus citations

The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584

Qian, D. Z., Wang, X., Kachhap, S. K., Kato, Y., Wei, Y., Zhang, L., Atadja, P. & Pili, R., Sep 15 2004, In : Cancer Research. 64, 18, p. 6626-6634 9 p.

Research output: Contribution to journalArticle

195 Scopus citations
2003

CEP-7055: A novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models

Ruggeri, B., Singh, J., Gingrich, D., Angeles, T., Albom, M., Chang, H., Robinson, C., Hunter, K., Dobrzanski, P., Jones-Bolin, S., Aimone, L., Klein-Szanto, A., Herbert, J. M., Bono, F., Schaeffer, P., Casellas, P., Bourie, B., Pili, R., Isaacs, J., Ator, M. & 4 others, Hudkins, R., Vaught, J., Mallamo, J. & Dionne, C., Sep 15 2003, In : Cancer Research. 63, 18, p. 5978-5991 14 p.

Research output: Contribution to journalArticle

110 Scopus citations

Erratum: CEP-7055: A Novel, Orally Active Pan Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases with Potent Antiangiogenic Activity and Antitumor Efficacy in Preclinical Models (Cancer Research (September 15, 2003) (5978-5991))

Ruggeri, B., Singh, J., Gingrich, D., Angeles, T., Albom, M., Yang, S., Chang, H., Robinson, C., Hunter, K., Dobrzanski, P., Jones-Bolin, S., Pritchard, S., Aimone, L., Klein-Szanto, A., Herbert, J. M., Bono, F., Schaeffer, P., Casellas, P., Bourie, B., Pili, R. & 6 others, Isaacs, J., Ator, M., Hudkins, R., Vaught, J., Mallamo, J. & Dionne, C., Nov 1 2003, In : Cancer Research. 63, 21, 1 p.

Research output: Contribution to journalComment/debate

Is HIF-1α a valid therapeutic target?

Pili, R. & Donehower, R. C., Apr 2 2003, In : Journal of the National Cancer Institute. 95, 7, p. 498-499 2 p.

Research output: Contribution to journalEditorial

Open Access
20 Scopus citations
2002

Endogenous reactivation of the RARβ2 tumor suppressor gene epigenetically silenced in breast cancer

Sirchia, S. M., Ren, M., Pili, R., Sironi, E., Somenzi, G., Ghidoni, R., Toma, S., Nicolò, G. & Sacchi, N., May 1 2002, In : Cancer Research. 62, 9, p. 2455-2461 7 p.

Research output: Contribution to journalArticle

145 Scopus citations

Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1

Volpert, O. V., Pili, R., Sikder, H. A., Nelius, T., Zaichuk, T., Morris, C., Shiflett, C. B., Devlin, M. K., Conant, K. & Alani, R. M., Dec 2002, In : Cancer Cell. 2, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

158 Scopus citations
2001

Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis

Pili, R., Kruszewski, M. P., Hager, B. W., Lantz, J. & Carducci, M. A., Feb 15 2001, In : Cancer Research. 61, 4, p. 1477-1485 9 p.

Research output: Contribution to journalArticle

114 Scopus citations

Modified synthesis and antiangiogenic activity of Linomide

Khan, S. R., Mhaka, A., Pili, R. & Isaacs, J. T., Feb 26 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 4, p. 451-452 2 p.

Research output: Contribution to journalArticle

16 Scopus citations
1997

Adenovirus-mediated gene transfer of fibroblast growth factor-1: Angiogenesis and tumorigenicity in nude mice

Pili, R., Chang, J., Muhlhauser, J., Crystal, R. G., Capogrossi, M. C. & Passaniti, A., Oct 29 1997, In : International Journal of Cancer. 73, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
1995

Adenovirus‐mediated gene transfer of wild‐type p53 results in melanoma cell apoptosis in vitro and in vivo

Cirielli, C., Riccioni, T., Yang, C., Pili, R., Gloe, T., Chang, J., Inyaku, K., Passaniti, A. & Capogrossi, M. C., Nov 27 1995, In : International Journal of Cancer. 63, 5, p. 673-679 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

In Vivo Angiogenesis Induced by Recombinant Adenovirus Vectors Coding Either for Secreted or Nonsecreted Forms of Acidic Fibroblast Growth Factor

Mühlhauser, J., Pili, R., Merrill, M. J., Maeda, H., Passaniti, A., Crystal, R. G. & Capogrossi, M. C., Nov 1 1995, In : Human gene therapy. 6, 11, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

The α-Glucosidase I Inhibitor Castanospermine Alters Endothelial Cell Glycosylation, Prevents Angiogenesis, and Inhibits Tumor Growth

Pili, R., Chang, J., Partis, R. A., Mueller, R. A., Chrest, F. J. & Passaniti, A., Jul 1 1995, In : Cancer Research. 55, 13, p. 2920-2926 7 p.

Research output: Contribution to journalArticle

178 Scopus citations

VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo

Muhlhauser, J., Merrill, M. J., Pili, R., Maeda, H., Bacic, M., Bewig, B., Passaniti, A., Edwards, N. A., Crystal, R. G. & Capogrossi, M. C., 1995, In : Circulation research. 77, 6, p. 1077-1086 10 p.

Research output: Contribution to journalArticle

146 Scopus citations
1994

A functional ryanodine-sensitive intracellular Ca2+ store is present in vascular endothelial cells

Ziegelstein, R. C., Spurgeon, H. A., Pili, R., Passaniti, A., Cheng, L., Corda, S., Lakatta, E. G. & Capogrossi, M. C., Jan 1 1994, In : Circulation research. 74, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Altered angiogenesis underlying age-dependent changes in tumor growth

Pili, R., Guo, Y., Chang, J., Nakanishi, H., Martin, G. R. & Passaniti, A., Sep 7 1994, In : Journal of the National Cancer Institute. 86, 17, p. 1303-1314 12 p.

Research output: Contribution to journalArticle

110 Scopus citations

Initial contact and subsequent adhesion of human neutrophils or monocytes to human aortic endothelial cells releases an endothelial intracellular calcium store

Ziegelstein, R. C., Corda, S., Pili, R., Passaniti, A., Lefer, D., Zweier, J. L., Fraticelli, A. & Capogrossi, M. C., Oct 1994, In : Circulation. 90, 4 I, p. 1899-1907 9 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations
22 Scopus citations
1993

Endothelial cell Ca2+ increases upon tumor cell contact and modulates cell-cell adhesion

Pili, R., Corda, S., Passaniti, A., Ziegelstein, R. C., Heldman, A. W. & Capogrossi, M. C., Jan 1 1993, In : Journal of Clinical Investigation. 92, 6, p. 3017-3022 6 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Endothelial cell Ca2+ is increased by melanoma cell adhesion

Pili, R., Ziegelstein, R. C., Passaniti, A. & Capogrossi, M. C., Dec 1 1993, In : Clinical Chemistry and Enzymology Communications. 6, 1-2, p. 79-83 5 p.

Research output: Contribution to journalArticle

Psychological status, life and social conditions: A study in a population of institutionalized elderly people

Bartoloni, C., Guidi, L., di Giovanni, A. L., Antico, L., Cursi, F., Pili, R., Tricerri, A., Janiri, L., Mannelli, P., Pariante, C., Menini, E., Carbonin, P. & Gambassi, G., May 1993, In : International Journal of Geriatric Psychiatry. 8, 5, p. 419-426 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
1992

Latent coagulation disorders evaluated by the assay of plasma thrombin-antithrombin III complexes in a large series of 'solid tumours'

Bartoloni, C., Guidi, L., Tricerri, A., Patriarca, F., Pili, R., Cursi, F., Canetta, M., Cappelli, A., Vangeli, M., Salvati, F. & Gambassi, G., 1992, In : Oncology (Switzerland). 49, 6, p. 426-430 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Methods in laboratory investigation: A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor

Passaniti, A., Taylor, R. M., Pili, R., Guo, Y., Long, P. V., Haney, J. A., Pauly, R. R., Grant, D. S. & Martin, G. R., Jan 1 1992, In : Laboratory Investigation. 67, 4, p. 519-528 10 p.

Research output: Contribution to journalArticle

735 Scopus citations
1991

Immune parameters in a populatio of institutionalized elderly subjects: influence of depressive disorders and endocrinological correlations

Bartoloni, C., Guidi, L., Frasca, D., Antico, L., Pili, R., Cursi, F., Di Giovanni, A., Rumi, C., Menini, E., Carbonin, P., Doria, G. & Gambassi, G., Sep 1991, In : Mechanisms of Ageing and Development. 60, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Impairment of lymphocyte activities in depressed aged subjects

Guidi, L., Bartoloni, C., Frasca, D., Antico, L., Pili, R., Cursi, F., Tempesta, E., Rumi, C., Menini, E., Carbonin, P., Doria, G. & Gambassi, G., Sep 1991, In : Mechanisms of Ageing and Development. 60, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Psychological status and immunological parameters of institutionalized aged.

Bartoloni, C., Guidi, L., Antico, L., Pariante, C. M., Di Giovanni, A., Pili, R., Cursi, F., Tricerri, A., Tempesta, E. & Frasca, D., Jan 1 1991, In : Panminerva medica. 33, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Valutazione di alterazioni latenti della coagulazione mediante il dosaggio plasmatico del complesso trombina antitrombina nelle neoplasie gastrointestinali.

Translated title of the contribution: Evaluation of latent changes in blood coagulation by the determination of plasma thrombin-antithrombin complex in gastrointestinal neoplasmsGuidi, L., Bartoloni, C., Pellicanò, P., Cappelli, A., Cursi, F., Pili, R., Tricerri, A., Patriarca, F. & Gambassi, G., Mar 31 1991, In : La Clinica terapeutica. 136, 6, p. 367-373 7 p.

Research output: Contribution to journalArticle

3 Scopus citations