Romil Saxena

  • 5904 Citations
  • 36 h-Index
1990 …2019
If you made any changes in Pure, your changes will be visible here soon.

Publications 1990 2019

  • 5904 Citations
  • 36 h-Index
  • 126 Article
  • 18 Chapter
  • 2 Book
  • 2 Foreword/postscript
Filter
Article
2019

Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2−/− mouse model of primary sclerosing cholangitis (PSC)

Zhou, T., Kyritsi, K., Wu, N., Francis, H., Yang, Z., Chen, L., O'Brien, A., Kennedy, L., Ceci, L., Meadows, V., Kusumanchi, P., Wu, C., Baiocchi, L., Skill, N. J., Saxena, R., Sybenga, A., Xie, L., Liangpunsakul, S., Meng, F., Alpini, G. & 1 others, Glaser, S., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Sclerosing Cholangitis
Vimentin
Phenotype
Liver
Morpholinos
7 Citations (Scopus)
Metformin
Fatty Liver
Fibrosis
Hepatocellular Carcinoma
Transplants

Metabolomic Characterization of Human Model of Liver Rejection Identifies Aberrancies Linked to Cyclooxygenase (COX) and Nitric Oxide Synthase (NOS)

Skill, N., Elliott, C. M., Ceballos, B., Saxena, R., Pepin, R., Bettcher, L., Ellensberg, M., Raftery, D., Maluccio, M., Ekser, B., Mangus, R. & Kubal, C. A., Jun 11 2019, In : Annals of transplantation. 24, p. 341-349 9 p.

Research output: Contribution to journalArticle

Metabolomics
Prostaglandin-Endoperoxide Synthases
Nitric Oxide Synthase
Liver
Biopsy
2 Citations (Scopus)

Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis

Kyritsi, K., Chen, L., O'Brien, A., Francis, H., Hein, T. W., Venter, J., Wu, N., Ceci, L., Zhou, T., Zawieja, D., Gashev, A. A., Meng, F., Invernizzi, P., Fabris, L., Wu, C., Skill, N. J., Saxena, R., Liangpunsakul, S., Alpini, G. & Glaser, S. S., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Serotonin Receptors
Cholestasis
Monoamine Oxidase
Liver Cirrhosis

Non-obese histologically confirmed NASH patients with abnormal liver biochemistry have more advanced fibrosis

Wang, Q., You, H., Ou, X., Zhao, X., Sun, Y., Wang, M., Wang, P., Wang, Y., Duan, W., Wang, X., Wu, S., Kong, Y., Saxena, R., Gouw, A. S. H. & Jia, J., Jan 1 2019, (Accepted/In press) In : Hepatology International.

Research output: Contribution to journalArticle

Fatty Liver
Biochemistry
Fibrosis
Liver
Alleles

Sestrin 3 Protects Against Diet-Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction

Huang, M., Kim, H. G., Zhong, X., Dong, C., Zhang, B., Fang, Z., Zhang, Y., Lu, X., Saxena, R., Liu, Y., Zhang, C., Liangpunsakul, S. & Dong, X. C., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Transforming Growth Factors
Signal Transduction
Diet
Liver
Transgenic Mice
9 Citations (Scopus)
Vitamin E
Fibrosis
Transplants
Survival
Liver
2018
44 Citations (Scopus)

cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Brunt, E., Aishima, S., Clavien, P. A., Fowler, K., Goodman, Z., Gores, G., Gouw, A., Kagen, A., Klimstra, D., Komuta, M., Kondo, F., Miksad, R., Nakano, M., Nakanuma, Y., Ng, I., Paradis, V., Nyun Park, Y., Quaglia, A., Roncalli, M., Roskams, T. & 15 others, Sakamoto, M., Saxena, R., Sempoux, C., Sirlin, C., Stueck, A., Thung, S., Tsui, W. M. S., Wang, X. W., Wee, A., Yano, H., Yeh, M., Zen, Y., Zucman-Rossi, J., Zucman-Rossi, J. & Zucman-Rossi, J., Jul 1 2018, In : Hepatology. 68, 1, p. 113-126 14 p.

Research output: Contribution to journalArticle

Terminology
Carcinoma
Cholangiocarcinoma
Liver
Gastroenterology
4 Citations (Scopus)

Clinicopathological features of He Shou Wu-induced liver injury: This ancient anti-aging therapy is not liver-friendly

Wang, Y., Wang, L., Saxena, R., Wee, A., Yang, R., Tian, Q., Zhang, J., Zhao, X. & Jia, J., Jan 1 2018, (Accepted/In press) In : Liver International.

Research output: Contribution to journalArticle

Liver
Wounds and Injuries
Therapeutics
Thumb
Hepatitis
1 Citation (Scopus)

Drug-Induced Liver Injury—Perspectives from Pathology

Chopra, S. & Saxena, R., Jun 1 2018, In : Current Pharmacology Reports. 4, 3, p. 182-192 11 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Pathology
Liver
Pharmaceutical Preparations
Liver Diseases
3 Citations (Scopus)

Lower expression of tumor microRNA-26a is associated with higher recurrence in patients with hepatocellular carcinoma undergoing surgical treatment

Jones, K. R., Nabinger, S. C., Lee, S., Sahu, S. S., Althouse, S., Saxena, R., Johnson, M. S., Chalasani, N., Gawrieh, S. & Kota, J., Jan 1 2018, (Accepted/In press) In : Journal of Surgical Oncology.

Research output: Contribution to journalArticle

MicroRNAs
Hepatocellular Carcinoma
Recurrence
Neoplasms
Liver Diseases
8 Citations (Scopus)

Primate fetal hepatic responses to maternal obesity: Epigenetic signalling pathways and lipid accumulation

Puppala, S., Li, C., Glenn, J. P., Saxena, R., Gawrieh, S., Quinn, A., Palarczyk, J., Dick, E. J., Nathanielsz, P. W. & Cox, L. A., Jan 1 2018, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Epigenomics
Primates
Obesity
Mothers
Lipids
2017
1 Citation (Scopus)

Differential diagnosis of epithelioid and clear cell tumors in the liver

Mann, S. A. & Saxena, R., 2017, (Accepted/In press) In : Seminars in Diagnostic Pathology.

Research output: Contribution to journalArticle

Epithelioid Cells
Differential Diagnosis
Liver
Hepatocellular Carcinoma
Neoplasms
9 Citations (Scopus)

Hepatoblastoma

Sharma, D., Subbarao, G. & Saxena, R., 2017, (Accepted/In press) In : Seminars in Diagnostic Pathology.

Research output: Contribution to journalArticle

Hepatoblastoma
Neoplasms
Drug Therapy
Liver
alpha-Fetoproteins

Introduction

Saxena, R., 2017, (Accepted/In press) In : Seminars in Diagnostic Pathology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Primary mesenchymal liver tumors of childhood

Saeed, O. & Saxena, R., 2017, (Accepted/In press) In : Seminars in Diagnostic Pathology.

Research output: Contribution to journalArticle

Hamartoma
Liver
Neoplasms
Newborn Infant
Hemangioendothelioma
15 Citations (Scopus)

Role of Stereotactic Body Radiation Therapy Before Orthotopic Liver Transplantation: Retrospective Evaluation of Pathologic Response and Outcomes

Mannina, E. M., Cardenes, H. R., Lasley, F. D., Goodman, B., Zook, J., Althouse, S., Cox, J. A., Saxena, R., Tector, J. & Maluccio, M., Apr 1 2017, In : International Journal of Radiation Oncology Biology Physics. 97, 5, p. 931-938 8 p.

Research output: Contribution to journalArticle

transplantation
liver
Liver Transplantation
radiation therapy
Radiotherapy
2 Citations (Scopus)

Variant differentiation patterns in primary liver carcinoma

Sempoux, C., Paradis, V. & Saxena, R., Mar 1 2017, In : Seminars in Diagnostic Pathology. 34, 2, p. 176-182 7 p.

Research output: Contribution to journalArticle

Stem Cells
Carcinoma
Liver
Cholangiocarcinoma
Terminology
2016
16 Citations (Scopus)

Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis

Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium, Dec 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 12, p. 1831-1838.e3

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Alcohol Drinking
Body Weight
Drinking
Body Mass Index
3 Citations (Scopus)

Hepatic arterial buffer response: pathologic evidence in non-cirrhotic human liver with extrahepatic portal vein thrombosis

Rush, N., Sun, H., Nakanishi, Y., Mneimneh, W., Kwo, P. Y. & Saxena, R., Feb 26 2016, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Portal Vein
Buffers
Thrombosis
Liver
Budd-Chiari Syndrome
13 Citations (Scopus)

Nodular regenerative hyperplasia after treatment with trastuzumab emtansine

Force, J., Saxena, R., Schneider, B., Storniolo, A. M., Sledge, G. W., Chalasani, N. & Vuppalanchi, R., Jan 20 2016, In : Journal of Clinical Oncology. 34, 3, p. e9-e12

Research output: Contribution to journalArticle

Maytansine
Carcinoma, Ductal, Breast
Antibodies, Monoclonal, Humanized
Portal Hypertension
Hyperplasia
21 Citations (Scopus)

Optimization of Perioperative Conditions to Prevent Ischemic Cholangiopathy in Donation After Circulatory Death Donor Liver Transplantation

Kubal, C., Mangus, R., Fridell, J., Saxena, R., Rush, N., Wingler, M., Ekser, B. & Tector, J., Apr 29 2016, (Accepted/In press) In : Transplantation.

Research output: Contribution to journalArticle

Liver Transplantation
Tissue Donors
Cold Ischemia
Warm Ischemia
Tissue Plasminogen Activator
1 Citation (Scopus)

Recurrence of Hyperoxaluria and Kidney Disease after Combined Intestine-Kidney Transplantation for Enteric Hyperoxaluria

Ekser, B., Mangus, R., Kubal, C. A., Fridell, J. A., Powelson, J. A., Nagaraju, S., Mihaylov, P., Phillips, C., Saxena, R. & Goggins, W. C., Jul 14 2016, (Accepted/In press) In : American Journal of Nephrology. p. 85-91 7 p.

Research output: Contribution to journalArticle

Hyperoxaluria
Kidney Diseases
Kidney Transplantation
Intestines
Oxalates
2015
49 Citations (Scopus)

Drug-induced liver injury

Fisher, K., Vuppalanchi, R. & Saxena, R., Jul 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 7, p. 876-887 12 p.

Research output: Contribution to journalArticle

Chemical and Drug Induced Liver Injury
Liver
National Library of Medicine (U.S.)
Biopsy
Self Medication
8 Citations (Scopus)

Evaluation of <sup>11</sup>C-Acetate and <sup>18</sup> F-FDG PET/CT in mouse multidrug resistance gene-2 deficient mouse model of hepatocellular carcinoma

Territo, P., Maluccio, M., Riley, A. A., McCarthy, B. P., Fletcher, J., Tann, M., Saxena, R. & Skill, N., May 16 2015, In : BMC Medical Imaging. 15, 1, 15.

Research output: Contribution to journalArticle

MDR Genes
Hepatocellular Carcinoma
Multiple Drug Resistance
Liver
carbon-11 acetate
13 Citations (Scopus)

Liver injury and fibrosis induced by dietary challenge in the ossabaw miniature swine

Liang, T., Alloosh, M., Bell, L. N., Fullenkamp, A., Saxena, R., Van Alstine, W., Bybee, P., Werling, K., Sturek, M., Chalasani, N. & Masuoka, H., May 15 2015, In : PLoS One. 10, 5, 0124173.

Research output: Contribution to journalArticle

Miniature Swine
miniature swine
Nutrition
fibrosis
Liver Cirrhosis
3 Citations (Scopus)

One hundred thirteen consecutive transgastric liver biopsies for hepatic parenchymal diseases

Nakanishi, Y., Mneimneh, W. S., Sey, M., Al-Haddad, M., DeWitt, J. & Saxena, R., Jun 29 2015, In : American Journal of Surgical Pathology. 39, 7, p. 968-976 9 p.

Research output: Contribution to journalArticle

Biopsy
Liver
Needles
Liver Diseases
Endosonography
37 Citations (Scopus)

Pathophysiological role of microRNA-29 in pancreatic cancer stroma

Kwon, J. J., Nabinger, S. C., Vega, Z., Sahu, S. S., Alluri, R. K., Abdul-Sater, Z., Yu, Z., Gore, J., Nalepa, G., Saxena, R., Korc, M. & Kota, J., Jun 22 2015, In : Scientific Reports. 5, 11450.

Research output: Contribution to journalArticle

MicroRNAs
Pancreatic Neoplasms
Adenocarcinoma
Pancreatic Stellate Cells
Neoplasms
6 Citations (Scopus)

Pathophysiology and diseases of the proximal pathways of the biliary system

Nakanishi, Y. & Saxena, R., Jul 1 2015, In : Archives of Pathology and Laboratory Medicine. 139, 7, p. 858-866 9 p.

Research output: Contribution to journalArticle

Biliary Tract
Bile Ducts
Chemical and Drug Induced Liver Injury
Sclerosing Cholangitis
Biliary Liver Cirrhosis
19 Citations (Scopus)

Prospective monitoring of donor-specific anti-HLA antibodies after intestine/multivisceral transplantation: Significance of De novo antibodies

Kubal, C., Mangus, R., Saxena, R., Lobashevsky, A., Higgins, N., Fridell, J. & Tector, A. J., Aug 1 2015, In : Transplantation. 99, 8, p. e49-e56

Research output: Contribution to journalArticle

Intestines
Anti-Idiotypic Antibodies
Transplantation
Tissue Donors
Antibodies
2014
2 Citations (Scopus)

A de novo unclassified malignant spindle cell neoplasm of liver allograft

Clevenger, J. A., Saxena, R. & Idrees, M., Feb 2014, In : Archives of Pathology and Laboratory Medicine. 138, 2, p. 274-277 4 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Allografts
Liver
Neoplasms
Human Herpesvirus 8
15 Citations (Scopus)

Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction

Kubal, C. A., Mangus, R., Saxena, R., Lobashevsky, A., Higgins, N., Agarwal, A., Fridell, J. A. & Tector, A. J., Jan 15 2014, In : Transplantation. 97, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

Liver Transplantation
Antibodies
Tissue Donors
Graft Survival
Incidence
4 Citations (Scopus)

HIV-1 coinfection profoundly alters intrahepatic chemokine but not inflammatory cytokine profiles in HCV-infected subjects

Hu, S., Ghabril, M., Amet, T., Hu, N., Byrd, D., Yang, K., Vuppalanchi, R., Saxena, R., Desai, M., Lan, J., Johnson, R., Gupta, S., Chalasani, N. & Yu, A., Feb 6 2014, In : PLoS One. 9, 2, e86964.

Research output: Contribution to journalArticle

Hepatitis C virus
chemokines
Human immunodeficiency virus 1
Coinfection
mixed infection

Newborn with an underrecognized triad: Skin lesion, abdominal distention, and hypothyroidism

Sun, J., Karmazyn, B., Lin, J., Faught, P. R., Fan, R. & Saxena, R., Feb 2014, In : Journal of Pediatrics. 164, 2, p. 419-420 2 p.

Research output: Contribution to journalArticle

Intra-Abdominal Hypertension
X Ray Computed Tomography
Fatal Outcome
Hemangioma
Liver Neoplasms
29 Citations (Scopus)

Serum hepcidin levels are associated with obesity but not liver disease

Vuppalanchi, R., Troutt, J. S., Konrad, R. J., Ghabril, M., Saxena, R., Bell, L. N., Kowdley, K. V. & Chalasani, N., 2014, In : Obesity. 22, 3, p. 836-841 6 p.

Research output: Contribution to journalArticle

Hepcidins
Liver Diseases
Obesity
Serum
Liver
6 Citations (Scopus)

Utility of pre-procurement bedside liver biopsy in the deceased extended-criteria liver donor

Mangus, R., Borup, T. C., Popa, S., Saxena, R., Cummings, O. & Tector, A. J., Dec 1 2014, In : Clinical Transplantation. 28, 12, p. 1358-1364 7 p.

Research output: Contribution to journalArticle

Tissue Donors
Biopsy
Liver
Tissue and Organ Procurement
Graft Survival
2013
1 Citation (Scopus)

Autoimmune Hepatitis

Cole, C. D. & Saxena, R., Jun 2013, In : Surgical Pathology Clinics. 6, 2, p. 259-276 18 p.

Research output: Contribution to journalArticle

Autoimmune Hepatitis
Disease Management
Transaminases
Autoantibodies
Hepatitis
16 Citations (Scopus)

The usefulness of diffusion-weighted imaging in the characterization of liver lesions in patients with cirrhosis

Sandrasegaran, K., Tahir, B., Patel, A., Ramaswamy, R., Bertrand, K., Akisik, M. & Saxena, R., Jul 2013, In : Clinical Radiology. 68, 7, p. 708-715 8 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Fibrosis
Liver
Patents
Histology
2011
13 Citations (Scopus)

Alcohol Induces Liver Neoplasia in a Novel Alcohol-Preferring Rat Model

Yip-Schneider, M., Doyle, C. J., Mckillop, I. H., Wentz, S. C., Brandon-Warner, E., Matos, J. M., Sandrasegaran, K., Saxena, R., Hennig, M. E., Wu, H., Waters, J. A., Klein, P. J., Froehlich, J. & Schmidt, C., Dec 2011, In : Alcoholism: Clinical and Experimental Research. 35, 12, p. 2216-2225 10 p.

Research output: Contribution to journalArticle

Liver
Rats
Alcohols
Water
Neoplasms
10 Citations (Scopus)

Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules

Ahn, M., Witting, S. R., Ruiz, R., Saxena, R. & Morral, N., Dec 1 2011, In : Human Gene Therapy. 22, 12, p. 1483-1497 15 p.

Research output: Contribution to journalArticle

Small Interfering RNA
RNA Interference
Karyopherins
Gene Knockdown Techniques
Technology
4 Citations (Scopus)

Diffusion-weighted MRI of the transplanted liver

Sandrasegaran, K., Ramaswamy, R., Ghosh, S., Tahir, B., Akisik, M., Saxena, R. & Kwo, P., Sep 2011, In : Clinical Radiology. 66, 9, p. 820-825 6 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Liver
Liver Transplantation
Biopsy
Magnetic Resonance Imaging
7 Citations (Scopus)

Does the hepatocellular phase of gadobenate dimeglumine help to differentiate hepatocellular carcinoma in cirrhotic patients according to histological grade?

Tahir, B., Sandrasegaran, K., Ramaswamy, R., Bertrand, K., Mhapsekar, R., Akisik, M. & Saxena, R., Sep 2011, In : Clinical Radiology. 66, 9, p. 845-852 8 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Logistic Models
ROC Curve
gadobenic acid
Magnetic Resonance Imaging
13 Citations (Scopus)

Effect of different obesogenic diets on pancreatic histology in Ossabaw miniature swine

Fullenkamp, A. M., Bell, L. N., Robbins, R. D., Lee, L., Saxena, R., Alloosh, M., Klaunig, J. E., Mirmira, R., Sturek, M. & Chalasani, N., Apr 2011, In : Pancreas. 40, 3, p. 438-443 6 p.

Research output: Contribution to journalArticle

Miniature Swine
Atherogenic Diet
Histology
Swine
Diet
17 Citations (Scopus)

Hepatic lipid peroxidation and cytochrome P-450 2E1 in pediatric nonalcoholic fatty liver disease and its subtypes

Bell, L. N., Molleston, J., Morton, M. J., Klipsch, A., Saxena, R., Vuppalanchi, R. & Chalasani, N., Oct 2011, In : Journal of Clinical Gastroenterology. 45, 9, p. 800-807 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Lipid Peroxidation
Pediatrics
Liver
Biopsy
14 Citations (Scopus)

Oxidative stress in chronic liver disease: Relationship between peripheral and hepatic measurements

Vuppalanchi, R., Juluri, R., Bell, L. N., Ghabril, M., Kamendulis, L., Klaunig, J. E., Saxena, R., Agarwal, D., Johnson, M. S. & Chalasani, N., Oct 2011, In : American Journal of the Medical Sciences. 342, 4, p. 314-317 4 p.

Research output: Contribution to journalArticle

Liver Diseases
Oxidative Stress
Chronic Disease
Malondialdehyde
Liver

Preface

Saxena, R., 2011, In : Unknown Journal.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Utility of formalin-fixed, paraffin-embedded liver biopsy specimens for global proteomic analysis in nonalcoholic steatohepatitis

Bell, L. N., Saxena, R., Mattar, S. G., You, J., Wang, M. & Chalasani, N., Aug 2011, In : Proteomics - Clinical Applications. 5, 7-8, p. 397-404 8 p.

Research output: Contribution to journalArticle

Biopsy
Liver
Paraffin
Proteomics
Formaldehyde
2010
76 Citations (Scopus)

Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma

Wu, J. M., Xu, Y., Skill, N., Sheng, H., Zhao, Z., Yu, M., Saxena, R. & Maluccio, M., Mar 31 2010, In : Molecular Cancer. 9, 71.

Research output: Contribution to journalArticle

NF-kappa B
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Hepatocytes
Inflammation
5 Citations (Scopus)

Clonality and TP53 mutation analysis of focal nodular hyperplasia of the liver

Zheng, S., Cummings, O., Saxena, R., Zhang, S., Wang, M., Williamson, S. R., Cheng, M., Lopez-Beltran, A., Montironi, R., Hodges, K. B. & Cheng, L., Jul 2010, In : American Journal of Clinical Pathology. 134, 1, p. 65-70 6 p.

Research output: Contribution to journalArticle

Focal Nodular Hyperplasia
Mutation
Liver
X Chromosome Inactivation
Laser Capture Microdissection