Ronald Wek

  • 11501 Citations
  • 54 h-Index
1980 …2021
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Eukaryotic Initiation Factor-2 Medicine & Life Sciences
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Amino Acids Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Proteins Medicine & Life Sciences
Endoplasmic Reticulum Stress Medicine & Life Sciences

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NIH Grants 1993 2021

Opportunistic Infections
Toxoplasma
Acquired Immunodeficiency Syndrome
HIV
Guanabenz
Physiological Stress
Phosphotransferases
Eukaryotic Initiation Factor-2
Protein Kinases
Phosphorylation
Guanabenz
Toxoplasmosis
Phosphoric Monoester Hydrolases
Toxoplasma
Infection
Toxoplasma
Cysts
Parasites
Infection
Phosphorylation
Eukaryotic Initiation Factor-2
phosphotransferases (kinases)
Phosphotransferases
protein synthesis
Phosphorylation

Publications 1980 2018

  • 11501 Citations
  • 54 h-Index
  • 134 Article
  • 1 Chapter
  • 1 Review article
1 Citation (Scopus)

Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Augusto, L., Martynowicz, J., Staschke, K. A., Wek, R. & Sullivan, W., Nov 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Toxoplasma
Parasites
Phosphotransferases
Endoplasmic Reticulum Stress
6 Citations (Scopus)

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

Ogbechi, J., Hall, B. S., Sbarrato, T., Taunton, J., Willis, A. E., Wek, R. & Simmonds, R. E., Mar 1 2018, In : Cell Death and Disease. 9, 3, 397.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Activating Transcription Factor 4
Mycobacterium ulcerans
Buruli Ulcer
14 Citations (Scopus)
Eukaryotic Initiation Factor-2
Phosphorylation
Phosphotransferases
Open Reading Frames
Genes
4 Citations (Scopus)

Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Nikonorova, I. A., Mirek, E. T., Signore, C. C., Goudie, M. P., Wek, R. & Anthony, T. G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 14, p. 5005-5015 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Liver
Amino Acids
Asparaginase
Activating Transcription Factor 4

Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes

Collier, A. E., Spandau, D. & Wek, R., Jan 1 2018, In : Molecular Biology of the Cell. 29, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

Keratinocytes
DNA Repair
Messenger RNA
Protein Biosynthesis
Cytoprotection