Ronald Wek

  • 11101 Citations
  • 51 h-Index
1980 …2021
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  • 7 Similar Profiles
Eukaryotic Initiation Factor-2 Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Amino Acids Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences
eIF-2 Kinase Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Proteins Medicine & Life Sciences

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NIH Grants 1993 2021

Opportunistic Infections
Toxoplasma
Acquired Immunodeficiency Syndrome
HIV
Guanabenz

HISRS-DOMAIN AND REGULATING GCN2 PROTEIN KINASE

Wek, R.

National Institutes of Health

4/1/934/30/20

Project: Research projectResearch Project

Physiological Stress
Phosphotransferases
Eukaryotic Initiation Factor-2
Protein Kinases
Phosphorylation
Guanabenz
Toxoplasmosis
Phosphoric Monoester Hydrolases
Toxoplasma
Infection

Translational control and latent Toxoplasma infection

Wek, R. & Sullivan, W.

National Institutes of Health

6/15/095/31/12

Project: Research projectExploratory/Developmental Grants

Toxoplasma
Cysts
Parasites
Infection
Phosphorylation

Translational Control by elF-2 Kinase during ER Stress

Wek, R.

National Institutes of Health

8/1/017/31/10

Project: Research projectResearch Project

Eukaryotic Initiation Factor-2
phosphotransferases (kinases)
Phosphotransferases
protein synthesis
Phosphorylation

Publications 1980 2018

  • 11101 Citations
  • 51 h-Index
  • 134 Article
  • 1 Chapter
  • 1 Review article

Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Augusto, L., Martynowicz, J., Staschke, K. A., Wek, R. & Sullivan, W., Nov 1 2018, In : Antimicrobial agents and chemotherapy. 62, 11

Research output: Contribution to journalArticle

Toxoplasma
Parasites
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Toxoplasmosis
3 Citations

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

Ogbechi, J., Hall, B. S., Sbarrato, T., Taunton, J., Willis, A. E., Wek, R. & Simmonds, R. E., Mar 1 2018, In : Cell Death and Disease. 9, 3, 397.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Activating Transcription Factor 4
Mycobacterium ulcerans
Buruli Ulcer
4 Citations
Phosphorylation
Phosphotransferases
Open Reading Frames
Genes
Eukaryotic Initiation Factor-2
1 Citations

Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Nikonorova, I. A., Mirek, E. T., Signore, C. C., Goudie, M. P., Wek, R. & Anthony, T. G., Jan 1 2018, In : Journal of Biological Chemistry. 293, 14, p. 5005-5015 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Liver
Amino acids
Amino Acids
Asparaginase

Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes

Collier, A. E., Spandau, D. & Wek, R., Jan 1 2018, In : Molecular Biology of the Cell. 29, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

Keratinocytes
DNA Repair
Messenger RNA
Protein Biosynthesis
Cytoprotection