Ronald Wek

  • 13018 Citations
  • 56 h-Index
1980 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

2020

The transcription factor Sp1 modulates RNA polymerase III gene transcription by controlling BRF1 and GTF3C2 expression in human cells

Peng, F., Zhou, Y., Wang, J., Guo, B., Wei, Y., Deng, H., Wu, Z., Zhang, C., Shi, K., Li, Y., Wang, X., Shore, P., Zhao, S., Deng, W. & Wek, R. C., Apr 3 2020, In : Journal of Biological Chemistry. 295, 14, p. 4617-4630 14 p.

Research output: Contribution to journalArticle

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

Augusto, L., Martynowicz, J., Amin, P. H., Alakhras, N. S., Kaplan, M. H., Wek, R. C. & Sullivan, W. J., Aug 2020, In : mBio. 11, 4, p. 1-13 13 p., e00915-20.

Research output: Contribution to journalArticle

Open Access
2019

Adapting to cell stress from inside and out

Staschke, K. A. & Wek, R. C., Jul 1 2019, In : Nature Cell Biology. 21, 7, p. 799-800 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Guanabenz reverses a key behavioral change caused by latent toxoplasmosis in mice by reducing neuroinflammation

Martynowicz, J., Augusto, L., Wek, R. C., Boehm, S. L. & Sullivan, W. J., Mar 1 2019, In : mBio. 10, 2, e00381-19.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality

Shao, Y., Wichern, E., Childress, P. J., Adaway, M., Misra, J., Klunk, A., Burr, D. B., Wek, R. C., Mosley, A. L., Liu, Y., Robling, A. G., Brustovetsky, N., Hamilton, J., Jacobs, K., Vashishth, D., Stayrook, K. R., Allen, M. R., Wallace, J. M. & Bidwell, J. P., May 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 5, p. E749-E772

Research output: Contribution to journalArticle

2 Scopus citations

Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion

Jiang, J., Srivastava, S., Seim, G., Pavlova, N. N., King, B., Zou, L., Zhang, C., Zhong, M., Feng, H., Kapur, R., Wek, R. C., Fan, J. & Zhang, J., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18674-18684 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of arginine transport by GCN2 eiF2 kinase is important for replication of the intracellular parasite toxoplasma gondii

Augusto, L., Amin, P. H., Wek, R. C. & Sullivan, W. J., Jun 2019, In : PLoS pathogens. 15, 6, e1007746.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii

Holmes, M. J., Shah, P., Wek, R. C. & Sullivan, W. J., May 1 2019, In : mSphere. 4, 3, e00292-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii

Augusto, L., Martynowicz, J., Staschke, K. A., Wek, R. & Sullivan, W., Nov 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11

Research output: Contribution to journalArticle

3 Scopus citations

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

Ogbechi, J., Hall, B. S., Sbarrato, T., Taunton, J., Willis, A. E., Wek, R. C. & Simmonds, R. E., Mar 1 2018, In : Cell Death and Disease. 9, 3, 397.

Research output: Contribution to journalArticle

15 Scopus citations
73 Scopus citations

Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Nikonorova, I. A., Mirek, E. T., Signore, C. C., Goudie, M. P., Wek, R. C. & Anthony, T. G., Apr 6 2018, In : Journal of Biological Chemistry. 293, 14, p. 5005-5015 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2 Scopus citations
2017

Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis

Karam, J. A., Parikh, R. Y., Nayak, D., Rosenkranz, D., Gangaraju, V. K. & Wek, R. C., Apr 14 2017, In : Journal of Biological Chemistry. 292, 15, p. 6039-6046 8 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Dietary methionine restriction regulates liver protein synthesis and gene expression independently of eukaryotic initiation factor 2 phosphorylation in mice

Pettit, A. P., Jonsson, W. O., Bargoud, A. R., Mirek, E. T., Peelor, F. F., Wang, Y., Gettys, T. W., Kimball, S. R., Miller, B. F., Hamilton, K. L., Wek, R. C. & Anthony, T. G., Jun 1 2017, In : Journal of Nutrition. 147, 6, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
8 Scopus citations

Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2

Collier, A. E., Wek, R. C. & Spandau, D. F., Sep 2017, In : Journal of Investigative Dermatology. 137, 9, p. 1924-1934 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Improving combination osteoporosis therapy in a preclinical model of heightened osteoanabolism

Shao, Y., Hernandez-Buquer, S., Childress, P., Stayrook, K. R., Alvarez, M. B., Davis, H., Plotkin, L. I., He, Y., Condon, K. W., Burr, D. B., Warden, S. J., Robling, A. G., Yang, F-C., Wek, R. C., Allen, M. R. & Bidwell, J. P., Sep 1 2017, In : Endocrinology. 158, 9, p. 2722-2740 19 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency

Zhang, M., Gallego-Delgado, J., Fernandez-Arias, C., Waters, N. C., Rodriguez, A., Tsuji, M., Wek, R. C., Nussenzweig, V. & Sullivan, W. J., Dec 13 2017, In : Cell Host and Microbe. 22, 6, p. 766-776.e4

Research output: Contribution to journalArticle

33 Scopus citations

Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice

Nikonorova, I. A., Al-Baghdadi, R. J. T., Mirek, E. T., Wang, Y., Goudie, M. P., Wetstein, B. B., Dixon, J. L., Hine, C., Mitchell, J. R., Adams, C. M., Wek, X. R. C. & Anthony, T. G., 2017, In : Journal of Biological Chemistry. 292, 16, p. 6786-6798 13 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase

Al-Baghdadi, R. J. T., Nikonorova, I. A., Mirek, E. T., Wang, Y., Park, J., Belden, W. J., Wek, R. C. & Anthony, T. G., Dec 1 2017, In : Scientific reports. 7, 1, 1272.

Research output: Contribution to journalArticle

4 Scopus citations

Transcriptional fidelities of human mitochondrial POLRMT, yeast mitochondrial Rpo41, and phage T7 single-subunit RNA polymerases

Sultana, S., Solotchi, M., Ramachandran, A., Patel, S. S. & Wek, R. C., Nov 3 2017, In : Journal of Biological Chemistry. 292, 44, p. 18145-18160 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Translational Control in the Latency of Apicomplexan Parasites

Holmes, M. J., Augusto, L. D. S., Zhang, M., Wek, R. C. & Sullivan, W. J., Dec 2017, In : Trends in Parasitology. 33, 12, p. 947-960 14 p.

Research output: Contribution to journalReview article

18 Scopus citations
2016

ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis

Srivastava, R. K., Li, C., Ahmad, A., Abrams, O., Gorbatyuk, M. S., Harrod, K. S., Wek, R. C., Afaq, F. & Athar, M., Nov 1 2016, In : Archives of Biochemistry and Biophysics. 609, p. 39-50 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Elongation stall directs gene-specific translation in the integrated stress response

Young, S. K., Palam, L. R., Wu, C., Sachs, M. S. & Wek, R. C., Mar 18 2016, In : Journal of Biological Chemistry. 291, 12, p. 6546-6558 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Evolution of eIF2α kinases: Adapting translational control to diverse stresses

Rothenburg, S., Georgiadis, M. M. & Wek, R. C., Jan 1 2016, Evolution of the Protein Synthesis Machinery and Its Regulation. Springer International Publishing, p. 235-260 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice

Phillipson-Weiner, L., Mirek, E. T., Wang, Y., McAuliffe, W. G., Wek, R. C. & Anthony, T. G., Jun 1 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 310, 11, p. G1061-G1070

Research output: Contribution to journalArticle

11 Scopus citations

Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential

Kwon, J. J., Willy, J. A., Quirin, K. A., Wek, R. C., Korc, M., Yin, X. M. & Kota, J., Jan 1 2016, In : Oncotarget. 7, 44, p. 71635-71650 16 p.

Research output: Contribution to journalArticle

29 Scopus citations
8 Scopus citations

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

Fusakio, M. E., Willy, J. A., Wang, Y., Mirek, E. T., Baghdadi, R. J. T. A., Adams, C. M., Anthony, T. G. & Wek, R. C., May 1 2016, In : Molecular Biology of the Cell. 27, 9, p. 1536-1551 16 p.

Research output: Contribution to journalArticle

62 Scopus citations

Translation regulation of the glutamyl-prolyl-tRNA synthetase gene EPRS through bypass of upstream open reading frames with noncanonical initiation codons

Young, S. K., Baird, T. D. & Wek, R. C., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10824-10835 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Upstream open reading frames differentially regulate genespecific translation in the integrated stress response

Young, S. K. & Wek, R. C., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 16927-16935 9 p.

Research output: Contribution to journalReview article

104 Scopus citations
2015

Bmi1 promotes erythroid development through regulating ribosome biogenesis

Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S. K., Soltis, A., Yu, M., Vemula, S., Fraenkel, E., Cantor, A., Antipin, Y., Xu, Y., Yoder, M. C., Wek, R. C., Ellis, S. R., Kapur, R., Zhu, X. & Liu, Y., Mar 1 2015, In : STEM CELLS. 33, 3, p. 925-938 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis

Willy, J. A., Young, S. K., Stevens, J. L., Masuoka, H. C. & Wek, R. C., Jun 15 2015, In : Molecular Biology of the Cell. 26, 12, p. 2190-2204 15 p.

Research output: Contribution to journalArticle

60 Scopus citations

GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment

Wilson, G. J., Lennox, B. A., She, P., Mirek, E. T., Al Baghdadi, R. J. T., Fusakio, M. E., Dixon, J. L., Henderson, G. C., Wek, R. C. & Anthony, T. G., 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 4, p. E283-E293

Research output: Contribution to journalArticle

29 Scopus citations

Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis

Benmerzouga, I., Checkley, L. A., Ferdig, M. T., Arrizabalaga, G., Wek, R. C. & Sullivan, W. J., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6939-6945 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Ribosome reinitiation directs gene-specific translation and regulates the integrated stress response

Young, S. K., Willy, J. A., Wu, C., Sachs, M. S. & Wek, R., Nov 20 2015, In : Journal of Biological Chemistry. 290, 47, p. 28257-28271 15 p.

Research output: Contribution to journalArticle

29 Scopus citations
9 Scopus citations
2014

Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals

He, H., Singh, I., Wek, S. A., Dey, S., Baird, T. D., Wek, R. C. & Georgiadis, M. M., Jan 1 2014, In : Journal of Biological Chemistry. 289, 21, p. 15023-15034 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

Cambiaghi, T. D., Pereira, C. M., Shanmugam, R., Bolech, M., Wek, R. C., Sattlegger, E. & Castilho, B. A., Jan 10 2014, In : Biochemical and Biophysical Research Communications. 443, 2, p. 592-597 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, C., Wek, R. C. & Sullivan, W. J., Feb 1 2014, In : International Journal for Parasitology. 44, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

Baird, T. D., Palam, L. R., Fusakio, M. E., Willy, J. A., Davis, C. M., McClintick, J. N., Anthony, T. G. & Wek, R. C., May 15 2014, In : Molecular Biology of the Cell. 25, 10, p. 1666-1675 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2013

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

Teske, B. F., Fusakio, M. E., Zhou, D., Shan, J., McClintick, J. N., Kilberg, M. S. & Wek, R. C., Aug 1 2013, In : Molecular Biology of the Cell. 24, 15, p. 2477-2490 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice

She, P., Bunpo, P., Cundiff, J. K., Wek, R. C., Harris, R. A. & Anthony, T. G., Oct 25 2013, In : Journal of Biological Chemistry. 288, 43, p. 31250-31260 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
23 Scopus citations
23 Scopus citations

The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment

Wilson, G. J., Bunpo, P., Cundiff, J. K., Wek, R. C. & Anthony, T. G., Nov 1 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 9, p. E1124-E1133

Research output: Contribution to journalArticle

30 Scopus citations

The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control

Joyce, B. R., Tampaki, Z., Kim, K., Wek, R. C. & Sullivan, W. J., Jul 2013, In : Eukaryotic Cell. 12, 7, p. 979-989 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Trinh, M. A., Kaphzan, H., Wek, R. C., Pierre, P., Cavener, D. R. & Klann, E., Jun 28 2012, In : Cell Reports. 1, 6, p. 676-688 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism

Baird, T. D. & Wek, R. C., May 1 2012, In : Advances in Nutrition. 3, 3, p. 307-321 15 p.

Research output: Contribution to journalReview article

237 Scopus citations