Ruben Vidal

  • 3537 Citations
  • 32 h-Index
1992 …2020

Research output per year

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Publications

2020

Novel tau filament fold in corticobasal degeneration

Zhang, W., Tarutani, A., Newell, K. L., Murzin, A. G., Matsubara, T., Falcon, B., Vidal, R., Garringer, H. J., Shi, Y., Ikeuchi, T., Murayama, S., Ghetti, B., Hasegawa, M., Goedert, M. & Scheres, S. H. W., Apr 9 2020, In : Nature. 580, 7802, p. 283-287 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2019

Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration

Muhoberac, B. B. & Vidal, R., Dec 11 2019, In : Frontiers in Neuroscience. 13, 1195.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Falcon, B., Zivanov, J., Zhang, W., Murzin, A. G., Garringer, H. J., Vidal, R., Crowther, R. A., Newell, K. L., Ghetti, B., Goedert, M. & Scheres, S. H. W., Apr 18 2019, In : Nature. 568, 7752, p. 420-423 4 p.

Research output: Contribution to journalLetter

80 Scopus citations

Sub-3 Å apoferritin structure determined with full range of phase shifts using a single position of volta phase plate

Li, K., Sun, C., Klose, T., Irimia-Dominguez, J., Vago, F. S., Vidal, R. & Jiang, W., May 1 2019, In : Journal of Structural Biology. 206, 2, p. 225-232 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

You, Y., Perkins, A., Cisternas, P., Muñoz, B., Taylor, X., You, Y., Garringer, H. J., Oblak, A. L., Atwood, B. K., Vidal, R. & Lasagna-Reeves, C. A., Feb 26 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis

Pappolla, M. A., Matsubara, E., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., Zagorski, M. & Sambamurti, K., Jan 1 2018, In : Current Alzheimer Research. 15, 7, p. 637-642 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Falcon, B., Zhang, W., Murzin, A. G., Murshudov, G., Garringer, H. J., Vidal, R., Crowther, R. A., Ghetti, B., Scheres, S. H. W. & Goedert, M., Sep 6 2018, In : Nature. 561, 7721, p. 137-140 4 p.

Research output: Contribution to journalLetter

140 Scopus citations

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A. G., Vidal, R., Garringer, H. J., Ghetti, B., Scheres, S. H. W. & Goedert, M., Nov 1 2018, In : Acta Neuropathologica. 136, 5, p. 699-708 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2017

Amyloid and intracellular accumulation of BRI2

Garringer, H., Sammeta, N., Oblak, A., Ghetti, B. & Vidal, R., Apr 1 2017, In : Neurobiology of Aging. 52, p. 90-97 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 1 2016, In : PLoS One. 11, 8, e0161341.

Research output: Contribution to journalArticle

11 Scopus citations
2015

A human monoclonal IgG that binds Aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo

Levites, Y., O’Nuallain, B., Puligedda, R. D., Ondrejcak, T., Adekar, S. P., Chen, C., Cruz, P. E., Rosario, A. M., Macy, S., Mably, A. J., Walsh, D. M., Vidal, R., Solomon, A., Brown, D., Rowan, M. J., Golde, T. E. & Dessain, S. K., Apr 22 2015, In : Journal of Neuroscience. 35, 16, p. 6265-6276 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H. J., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R. J., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PloS one. 10, 1, e0117435.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

Marcora, M. S., Fernández-Gamba, A. C., Avendaño, L. A., Rotondaro, C., Podhajcer, O. L., Vidal, R., Morelli, L., Ceriani, M. F. & Castaño, E. M., Jan 9 2014, In : Molecular Neurodegeneration. 9, 1, 5.

Research output: Contribution to journalArticle

11 Scopus citations

A novel ferritin light chain mutation in neuroferritinopathy with an atypical presentation

Nishida, K., Garringer, H. J., Futamura, N., Funakawa, I., Jinnai, K., Vidal, R. & Takao, M., Jul 15 2014, In : Journal of the Neurological Sciences. 342, 1-2, p. 173-177 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Other neurodegenerative conditions I

Vidal, R. & Ghetti, B., Jan 1 2014, Neuropathology of Neurodegenerative Diseases: A Practical Guide. Cambridge University Press, p. 249-258 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Other neurodegenerative conditions II

Vidal, R. & Ghetti, B., Jan 1 2014, Neuropathology of Neurodegenerative Diseases: A Practical Guide. Cambridge University Press, p. 259-262 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Other neurogenerative conditions III

Vidal, R. & Ghetti, B., Jan 1 2014, Neuropathology of Neurodegenerative Diseases: A Practical Guide. Cambridge University Press, p. 263-267 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2013

Abnormal iron homeostasis and neurodegeneration

Muhoberac, B. B. & Vidal, R., Sep 11 2013, In : Frontiers in Aging Neuroscience. 5, JUL, article 32.

Research output: Contribution to journalReview article

31 Scopus citations

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

Garringer, H. J., Murrell, J., Sammeta, N., Gnezda, A., Ghetti, B. & Vidal, R., Feb 13 2013, In : PloS one. 8, 2, e56426.

Research output: Contribution to journalArticle

15 Scopus citations

Neurodegeneración causada por mutaciones en el gen de la cadena liviana de ferritina

Translated title of the contribution: Neurodegeneration caused by mutations in the ferritin light chain geneVidal, R., Mar 1 2013, In : Acta Bioquimica Clinica Latinoamericana. 47, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

2012

A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B. & Vidal, R., May 1 2012, In : Free Radical Biology and Medicine. 52, 9, p. 1692-1697 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Generation of a novel murine model of Aβ deposition based on the expression of human wild-type amyloid precursor protein gene

Vidal, R. & Ghetti, B., Sep 1 2012, In : Prion. 6, 4, p. 346-349 4 p.

Research output: Contribution to journalReview article

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice

Vidal, R., Sammeta, N., Garringer, H. J., Sambamurti, K., Miravalle, L., Lamb, B. T. & Ghetti, B., Jul 1 2012, In : FASEB Journal. 26, 7, p. 2899-2910 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Characterization of amyloid deposits in neurodegenerative diseases

Vidal, R. & Ghetti, B., Oct 24 2011, Neurodegeneration: Methods and Protocols. Manfredi, G. & Kawamata, H. (eds.). p. 241-258 18 p. (Methods in Molecular Biology; vol. 793).

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Hereditary Ferritinopathies

Vidal, R., Delisle, M. B., Rascol, O. & Ghetti, B., Sep 21 2011, Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. Wiley-Blackwell, p. 461-466 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M. R., Robling, A. G., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H. J., Vidal, R., Chan, R. J., Goodwin, C. B., Hui, S. L., Peacock, M. & White, K. E., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. E1146-E1155

Research output: Contribution to journalArticle

205 Scopus citations
18 Scopus citations
2010

Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy

Barbeito, A. G., Levade, T., Delisle, M. B., Ghetti, B. & Vidal, R., Nov 12 2010, In : Molecular Neurodegeneration. 5, 1, 50.

Research output: Contribution to journalArticle

19 Scopus citations

Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy

Deng, X., Vidal, R. & Englander, E. W., Jul 1 2010, In : Neuroscience Letters. 479, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis

Tamayev, R., Giliberto, L., Li, W., D'Abramo, C., Arancio, O., Vidal, R. & D'Adamio, L., Nov 3 2010, In : Journal of Neuroscience. 30, 44, p. 14915-14924 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Modeling familial British and Danish dementia

Garringer, H. J., Murrell, J., D'Adamio, L., Ghetti, B. & Vidal, R., Mar 1 2010, In : Brain Structure and Function. 214, 2-3, p. 235-244 10 p.

Research output: Contribution to journalReview article

24 Scopus citations
37 Scopus citations
2009

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene

Barbeito, A. G., Garringer, H. J., Baraibar, M. A., Gao, X., Arredondo, M., Núñez, M. T., Smith, M. A., Ghetti, B. & Vidal, R., May 1 2009, In : Journal of Neurochemistry. 109, 4, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2

Vidal, R., Barbeito, A. G., Miravalle, L. & Ghetti, B., Jan 1 2009, In : Brain Pathology. 19, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Clinical phenotype and neuroimaging findings in a French family with hereditary ferritinopathy (FTL498-499InsTC)

Ory-Magne, F., Brefel-Courbon, C., Payoux, P., Debruxelles, S., Sibon, I., Goizet, C., Labauge, P., Menegon, P., Uro-Coste, E., Ghetti, B., Delisle, M. B., Vidal, R. & Rascol, O., Aug 15 2009, In : Movement Disorders. 24, 11, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease

Xiao, X., Miravalle, L., Yuan, J., McGeehan, J., Dong, Z., Wyza, R., MacLennan, G. T., Golichowski, A. M., Kneale, G., King, N., Kong, Q., Spina, S., Vidal, R., Ghetti, B., Roos, K., Gambetti, P. & Zou, W. Q., May 2009, In : American Journal of Pathology. 174, 5, p. 1602-1608 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Generation and initial characterization of FDD knock in mice

Giliberto, L., Matsuda, S., Vidal, R. & D'Adamio, L., Nov 18 2009, In : PloS one. 4, 11, e7900.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice

Vidal, R., Miravalle, L., Gao, X., Barbeito, A. G., Baraibar, M. A., Hekmatyar, S. K., Widel, M., Bansal, N., Delisle, M. B. & Ghetti, B., Jan 2 2008, In : Journal of Neuroscience. 28, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

Maarouf, C. L., Daugs, I. D., Spina, S., Vidal, R., Kokjohn, T. A., Patton, R. L., Kalback, W. M., Luehrs, D. C., Walker, D. G., Castaño, E. M., Beach, T. G., Ghetti, B. & Roher, A. E., Dec 22 2008, In : Molecular Neurodegeneration. 3, 1, 20.

Research output: Contribution to journalArticle

31 Scopus citations

Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B. & Vidal, R., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31679-31689 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Presenilin-1 280Glu→ala mutation alters C-terminal APP processing yielding longer Aβ peptides: Implications for Alzheimer's disease

Van Vickle, G. D., Esh, C. L., Kokjohn, T. A., Patton, R. L., Kalback, W. M., Luehrs, D. C., Beach, T. G., Newel, A. J., Lopera, F., Ghetti, B., Vidal, R., Castaño, E. M. & Roher, A. E., Mar 1 2008, In : Molecular Medicine. 14, 3-4, p. 184-194 11 p.

Research output: Contribution to journalReview article

21 Scopus citations
2007

Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation

Spina, S., Murrell, J. R., Huey, E. D., Wassermann, E. M., Pietrini, P., Baraibar, M. A., Barbeito, A. G., Troncoso, J. C., Vidal, R., Ghetti, B. & Grafman, J., Mar 2007, In : Neurology. 68, 11, p. 820-827 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
2005

Amino-terminally truncated Aβ peptide species are the main component of cotton wool plaques

Miravalle, L., Calero, M., Takao, M., Roher, A. E., Ghetti, B. & Vidal, R., Aug 16 2005, In : Biochemistry. 44, 32, p. 10810-10821 12 p.

Research output: Contribution to journalArticle

113 Scopus citations

A mutation in myotilin causes spheroid body myopathy

Foroud, T., Pankratz, N., Batchman, A. P., Pauciulo, M. W., Vidal, R., Miravalle, L., Goebel, H. H., Cushman, L. J., Azzarelli, B., Horak, H., Farlow, M. & Nichols, W. C., Dec 1 2005, In : Neurology. 65, 12, p. 1936-1940 5 p.

Research output: Contribution to journalArticle

62 Scopus citations
2004

Axonal transport of British and Danish amyloid peptides via secretory vesicles.

Choi, S. I., Vidal, R., Frangione, B. & Levy, E., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 373-375 3 p.

Research output: Contribution to journalArticle

36 Scopus citations

Early-onset dementia with Lewy bodies

Takao, M., Ghetti, B., Yoshida, H., Piccardo, P., Narain, Y., Murrell, J. R., Vidal, R., Glazier, B. S., Jakes, R., Tsutsui, M., Spillantini, M. G., Crowther, R. A., Goedert, M. & Koto, A., Apr 2004, In : Brain Pathology. 14, 2, p. 137-147 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Immunolocalization of the Oligodendrocyte Transcription Factor 1 (Olig1) in Brain Tumors

Azzarelli, B., Miravalle, L. & Vidal, R., Feb 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Intracellular Ferritin Accumulation in Neural and Extraneural Tissue Characterizes A Neurodegenerative Disease Associated with A Mutation in the Ferritin Light Polypeptide Gene

Vidal, R., Ghetti, B., Takao, M., Brefel-Courbon, C., Uro-Coste, E., Glazier, B. S., Siani, V., Benson, M. D., Calvas, P., Miravalle, L., Rascol, O. & Delisle, M. B., Apr 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 4, p. 363-380 18 p.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Neurodegeneration caused by proteins with an aberrant carboxyl-terminus

Vidal, R., Delisle, M. B. & Ghetti, B., Aug 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 8, p. 787-800 14 p.

Research output: Contribution to journalReview article

Open Access
30 Scopus citations