Ruben Vidal

  • 3319 Citations
  • 32 h-Index
1992 …2019
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Publications 1992 2019

  • 3319 Citations
  • 32 h-Index
  • 77 Article
  • 5 Chapter
  • 3 Letter
2019
38 Citations (Scopus)

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Falcon, B., Zivanov, J., Zhang, W., Murzin, A. G., Garringer, H., Vidal, R., Crowther, R. A., Newell, K. L., Ghetti, B., Goedert, M. & Scheres, S. H. W., Jan 1 2019, In : Nature.

Research output: Contribution to journalLetter

Alzheimer Disease
Tauopathies
Brain
Chronic Traumatic Encephalopathy
Pick Disease of the Brain
1 Citation (Scopus)

Sub-3 Å apoferritin structure determined with full range of phase shifts using a single position of volta phase plate

Li, K., Sun, C., Klose, T., Irimia-Dominguez, J., Vago, F. S., Vidal, R. & Jiang, W., Jan 1 2019, In : Journal of Structural Biology.

Research output: Contribution to journalArticle

Apoferritins
Equipment and Supplies
Datasets
Proteins
2018
8 Citations (Scopus)

Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis

Pappolla, M. A., Matsubara, E., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., Zagorski, M. & Sambamurti, K., Jan 1 2018, In : Current Alzheimer Research. 15, 7, p. 637-642 6 p.

Research output: Contribution to journalArticle

Lymphatic System
Amyloidosis
Melatonin
Transgenic Mice
Brain
93 Citations (Scopus)

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Falcon, B., Zhang, W., Murzin, A. G., Murshudov, G., Garringer, H., Vidal, R., Crowther, R. A., Ghetti, B., Scheres, S. H. W. & Goedert, M., Sep 6 2018, In : Nature. 561, 7721, p. 137-140 4 p.

Research output: Contribution to journalLetter

Pick Disease of the Brain
tau Proteins
Alzheimer Disease
Protein Isoforms
Cryoelectron Microscopy
25 Citations (Scopus)

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A. G., Vidal, R., Garringer, H., Ghetti, B., Scheres, S. H. W. & Goedert, M., Jan 1 2018, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Alzheimer Disease
Gold
Electron Microscopy
Coloring Agents
Frontal Lobe
2017
3 Citations (Scopus)

Amyloid and intracellular accumulation of BRI2

Garringer, H., Sammeta, N., Oblak, A., Ghetti, B. & Vidal, R., Apr 1 2017, In : Neurobiology of Aging. 52, p. 90-97 8 p.

Research output: Contribution to journalArticle

Amyloid
Neurites
Alzheimer Disease
Neurofibrillary Tangles
Proteins
2016
10 Citations (Scopus)

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 1 2016, In : PLoS One. 11, 8, e0161341.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Chelation Therapy
iron overload
Iron Overload
chelation
2015
10 Citations (Scopus)

A human monoclonal IgG that binds Aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo

Levites, Y., O’Nuallain, B., Puligedda, R. D., Ondrejcak, T., Adekar, S. P., Chen, C., Cruz, P. E., Rosario, A. M., Macy, S., Mably, A. J., Walsh, D. M., Vidal, R., Solomon, A., Brown, D., Rowan, M. J., Golde, T. E. & Dessain, S. K., Apr 22 2015, In : Journal of Neuroscience. 35, 16, p. 6265-6276 12 p.

Research output: Contribution to journalArticle

Amyloid
Immunoglobulin G
Alzheimer Disease
Antibodies
Epitopes
17 Citations (Scopus)

Systemic and cerebral iron homeostasis in ferritin knock-out Mice

Li, W., Garringer, H., Goodwin, C. B., Richine, B., Acton, A., VanDuyn, N., Muhoberac, B. B., Irimia-Dominguez, J., Chan, R., Peacock, M., Nass, R., Ghetti, B. & Vidal, R., Jan 28 2015, In : PLoS One. 10, 1, e0117435.

Research output: Contribution to journalArticle

ferritin
Ferritins
Knockout Mice
homeostasis
Homeostasis
2014
11 Citations (Scopus)

Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

Marcora, M. S., Fernández-Gamba, A. C., Avendaño, L. A., Rotondaro, C., Podhajcer, O. L., Vidal, R., Morelli, L., Ceriani, M. F. & Castaño, E. M., Jan 9 2014, In : Molecular Neurodegeneration. 9, 1, 5.

Research output: Contribution to journalArticle

Amyloid
Drosophila
Peptides
Familial Danish dementia
Familial British Dementia
11 Citations (Scopus)

A novel ferritin light chain mutation in neuroferritinopathy with an atypical presentation

Nishida, K., Garringer, H., Futamura, N., Funakawa, I., Jinnai, K., Vidal, R. & Takao, M., Jul 15 2014, In : Journal of the Neurological Sciences. 342, 1-2, p. 173-177 5 p.

Research output: Contribution to journalArticle

Apoferritins
Ferritins
Mutation
Cerebrospinal Fluid
Dysarthria
26 Citations (Scopus)

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

Transgenic Mice
Lymph Nodes
Brain
Alzheimer Disease
Lymphoid Tissue

Other neurodegenerative conditions I

Vidal, R. & Ghetti, B., Jan 1 2014, Neuropathology of Neurodegenerative Diseases: A Practical Guide. Cambridge University Press, p. 249-258 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cerebral Amyloid Angiopathy
Amyloid
Peptides
Familial Cerebral Amyloid Angiopathy
Brain

Other neurodegenerative conditions II

Vidal, R. & Ghetti, B., Jan 1 2014, Neuropathology of Neurodegenerative Diseases: A Practical Guide. Cambridge University Press, p. 259-262 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inclusion Bodies
Mutation
Neurons
Seizures
Central Nervous System

Other neurogenerative conditions III

Vidal, R. & Ghetti, B., Jan 1 2014, Neuropathology of Neurodegenerative Diseases: A Practical Guide. Cambridge University Press, p. 263-267 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Apoferritins
Ferritins
Inclusion Bodies
Iron
Peptides
2013
27 Citations (Scopus)

Abnormal iron homeostasis and neurodegeneration

Muhoberac, B. B. & Vidal, R., 2013, In : Frontiers in Aging Neuroscience. 5, JUL, article 32.

Research output: Contribution to journalArticle

Ferritins
Homeostasis
Iron
Apoferritins
Inclusion Bodies
15 Citations (Scopus)

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

Garringer, H., Murrell, J., Sammeta, N., Gnezda, A., Ghetti, B. & Vidal, R., Feb 13 2013, In : PLoS One. 8, 2, e56426.

Research output: Contribution to journalArticle

Synaptophysin
Phosphorylation
dementia
Transgenic Mice
phosphorylation

Neurodegeneración causada por mutaciones en el gen de la cadena liviana de ferritina

Translated title of the contribution: Neurodegeneration caused by mutations in the ferritin light chain geneVidal, R., Mar 2013, In : Acta Bioquimica Clinica Latinoamericana. 47, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

Apoferritins
Ferritins
Iron
Genes
Inclusion Bodies
2012
29 Citations (Scopus)

A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B. & Vidal, R., May 1 2012, In : Free Radical Biology and Medicine. 52, 9, p. 1692-1697 6 p.

Research output: Contribution to journalArticle

Apoferritins
Ferritins
Iron
Inclusion Bodies
Peptides
Amyloid beta-Protein Precursor
Genes
Alzheimer Disease
Amyloid
Mutation
11 Citations (Scopus)

The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice

Vidal, R., Sammeta, N., Garringer, H., Sambamurti, K., Miravalle, L., Lamb, B. & Ghetti, B., Jul 2012, In : FASEB Journal. 26, 7, p. 2899-2910 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Pathology
Amyloid
Transgenic Mice
Mutation
2011
10 Citations (Scopus)

Characterization of amyloid deposits in neurodegenerative diseases

Vidal, R. & Ghetti, B., 2011, Methods in Molecular Biology. Vol. 793. p. 241-258 18 p. (Methods in Molecular Biology; vol. 793).

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid Plaques
Amyloid
Neurodegenerative Diseases
Birefringence
Amyloidogenic Proteins
5 Citations (Scopus)

Hereditary Ferritinopathies

Vidal, R., Delisle, M. B., Rascol, O. & Ghetti, B., Sep 21 2011, Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders: Second Edition. Wiley-Blackwell, p. 461-466 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ferritins
Apoferritins
Putamen
Inclusion Bodies
Iron
186 Citations (Scopus)

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M., Robling, A., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H., Vidal, R., Chan, R., Goodwin, C. B., Hui, S., Peacock, M. & White, K., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46

Research output: Contribution to journalArticle

Iron
Phenotype
Diet
fibroblast growth factor 23
Autosomal Dominant Hypophosphatemic Rickets
17 Citations (Scopus)
Ferritins
Iron
Light
Inclusion Bodies
Peptides
2010
18 Citations (Scopus)

Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy

Barbeito, A. G., Levade, T., Delisle, M. B., Ghetti, B. & Vidal, R., 2010, In : Molecular Neurodegeneration. 5, 1, 50.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Iron
Fibroblasts
Ferritins
Peptides
33 Citations (Scopus)

Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy

Deng, X., Vidal, R. & Englander, E. W., Jul 2010, In : Neuroscience Letters. 479, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

Apoferritins
DNA Damage
Mitochondria
Iron
Brain
30 Citations (Scopus)

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis

Tamayev, R., Giliberto, L., Li, W., D'Abramo, C., Arancio, O., Vidal, R. & D'Adamio, L., Nov 3 2010, In : Journal of Neuroscience. 30, 44, p. 14915-14924 10 p.

Research output: Contribution to journalArticle

Memory Disorders
Amyloidosis
Mutation
Tauopathies
Dementia
23 Citations (Scopus)

Modeling familial British and Danish dementia

Garringer, H., Murrell, J., D'Adamio, L., Ghetti, B. & Vidal, R., Mar 2010, In : Brain Structure and Function. 214, 2-3, p. 235-244 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloid
Transgenic Mice
Animal Models
Gene Knockout Techniques
36 Citations (Scopus)

Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration

Baraibar, M. A., Muhoberac, B. B., Garringer, H., Hurley, T. & Vidal, R., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1950-1956 7 p.

Research output: Contribution to journalArticle

Ferritins
Iron
Apoferritins
Peptides
Inclusion Bodies
2009
53 Citations (Scopus)

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene

Barbeito, A. G., Garringer, H., Baraibar, M. A., Gao, X., Arredondo, M., Núñez, M. T., Smith, M. A., Ghetti, B. & Vidal, R., May 2009, In : Journal of Neurochemistry. 109, 4, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Apoferritins
Ferritins
Metabolism
Oxidative Stress
36 Citations (Scopus)

Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2

Vidal, R., Barbeito, A. G., Miravalle, L. & Ghetti, B., Jan 2009, In : Brain Pathology. 19, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloid
Transgenic Mice
Grooming
Cerebellar Ataxia
20 Citations (Scopus)

Clinical phenotype and neuroimaging findings in a French family with hereditary ferritinopathy (FTL498-499InsTC)

Ory-Magne, F., Brefel-Courbon, C., Payoux, P., Debruxelles, S., Sibon, I., Goizet, C., Labauge, P., Menegon, P., Uro-Coste, E., Ghetti, B., Delisle, M. B., Vidal, R. & Rascol, O., Aug 15 2009, In : Movement Disorders. 24, 11, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

Neuroimaging
Iron
Fluorodeoxyglucose F18
Dyskinesias
Tremor
14 Citations (Scopus)

Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease

Xiao, X., Miravalle, L., Yuan, J., McGeehan, J., Dong, Z., Wyza, R., MacLennan, G. T., Golichowski, A. M., Kneale, G., King, N., Kong, Q., Spina, S., Vidal, R., Ghetti, B., Roos, K., Gambetti, P. & Zou, W. Q., May 2009, In : American Journal of Pathology. 174, 5, p. 1602-1608 7 p.

Research output: Contribution to journalArticle

Creutzfeldt-Jakob Syndrome
Prions
Prion Diseases
Amniotic Fluid
Placenta
23 Citations (Scopus)

Generation and initial characterization of FDD knock in mice

Giliberto, L., Matsuda, S., Vidal, R. & D'Adamio, L., Nov 18 2009, In : PLoS One. 4, 11, e7900.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
amyloid
Amyloid
Abrus
mice
2008
78 Citations (Scopus)

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice

Vidal, R., Miravalle, L., Gao, X., Barbeito, A. G., Baraibar, M. A., Hekmatyar, S. K., Widel, M., Bansal, N., Delisle, M. B. & Ghetti, B., Jan 2 2008, In : Journal of Neuroscience. 28, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Apoferritins
Iron Overload
Transgenic Mice
Inclusion Bodies
Ferritins
31 Citations (Scopus)

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

Maarouf, C. L., Daugs, I. D., Spina, S., Vidal, R., Kokjohn, T. A., Patton, R. L., Kalback, W. M., Luehrs, D. C., Walker, D. G., Castaño, E. M., Beach, T. G., Ghetti, B. & Roher, A. E., 2008, In : Molecular Neurodegeneration. 3, 1, 20.

Research output: Contribution to journalArticle

Presenilins
Dementia
Mutation
Amyloid Precursor Protein Secretases
Alzheimer Disease
39 Citations (Scopus)

Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B. & Vidal, R., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31679-31689 11 p.

Research output: Contribution to journalArticle

Ferritins
Apoferritins
Agglomeration
Iron
Light
21 Citations (Scopus)

Presenilin-1 280Glu→ala mutation alters C-terminal APP processing yielding longer Aβ peptides: Implications for Alzheimer's disease

Van Vickle, G. D., Esh, C. L., Kokjohn, T. A., Patton, R. L., Kalback, W. M., Luehrs, D. C., Beach, T. G., Newel, A. J., Lopera, F., Ghetti, B., Vidal, R., Castaño, E. M. & Roher, A. E., Mar 2008, In : Molecular Medicine. 14, 3-4, p. 184-194 11 p.

Research output: Contribution to journalArticle

Presenilins
Presenilin-1
Amyloid beta-Protein Precursor
Alzheimer Disease
Amyloid
2007
62 Citations (Scopus)

Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation

Spina, S., Murrell, J. R., Huey, E. D., Wassermann, E. M., Pietrini, P., Baraibar, M. A., Barbeito, A. G., Troncoso, J. C., Vidal, R., Ghetti, B. & Grafman, J., Mar 2007, In : Neurology. 68, 11, p. 820-827 8 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Frontotemporal Lobar Degeneration
Intranuclear Inclusion Bodies
Ubiquitin
Atrophy
2005
112 Citations (Scopus)

Amino-terminally truncated Aβ peptide species are the main component of cotton wool plaques

Miravalle, L., Calero, M., Takao, M., Roher, A. E., Ghetti, B. & Vidal, R., Aug 16 2005, In : Biochemistry. 44, 32, p. 10810-10821 12 p.

Research output: Contribution to journalArticle

Wool
Cotton
Peptides
Presenilin-1
Microdissection
61 Citations (Scopus)

A mutation in myotilin causes spheroid body myopathy

Foroud, T., Pankratz, N., Batchman, A. P., Pauciulo, M. W., Vidal, R., Miravalle, L., Goebel, H. H., Cushman, L. J., Azzarelli, B., Horak, H., Farlow, M. & Nichols, W. C., Dec 2005, In : Neurology. 65, 12, p. 1936-1940 5 p.

Research output: Contribution to journalArticle

Mutation
Genes
Lod Score
Biopsy
Muscles
2004
36 Citations (Scopus)

Axonal transport of British and Danish amyloid peptides via secretory vesicles.

Choi, S. I., Vidal, R., Frangione, B. & Levy, E., 2004, In : FASEB Journal. 18, 2, p. 373-375 3 p.

Research output: Contribution to journalArticle

Axonal Transport
Secretory Vesicles
Amyloid
Abrus
Peptides
20 Citations (Scopus)

Early-onset dementia with Lewy bodies

Takao, M., Ghetti, B., Yoshida, H., Piccardo, P., Narain, Y., Murrell, J. R., Vidal, R., Glazier, B. S., Jakes, R., Tsutsui, M., Spillantini, M. G., Crowther, R. A., Goedert, M. & Koto, A., Apr 2004, In : Brain Pathology. 14, 2, p. 137-147 11 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Lewy Bodies
Neurites
Cerebral Cortex
28 Citations (Scopus)

Immunolocalization of the Oligodendrocyte Transcription Factor 1 (Olig1) in Brain Tumors

Azzarelli, B., Miravalle, L. & Vidal, R., Feb 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Oligodendroglia
Oligodendroglioma
Brain Neoplasms
Transcription Factors
Neuroepithelial Neoplasms
123 Citations (Scopus)

Intracellular Ferritin Accumulation in Neural and Extraneural Tissue Characterizes A Neurodegenerative Disease Associated with A Mutation in the Ferritin Light Polypeptide Gene

Vidal, R., Ghetti, B., Takao, M., Brefel-Courbon, C., Uro-Coste, E., Glazier, B. S., Siani, V., Benson, M., Calvas, P., Miravalle, L., Rascol, O. & Delisle, M. B., Apr 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 4, p. 363-380 18 p.

Research output: Contribution to journalArticle

Ferritins
Neurodegenerative Diseases
Light
Peptides
Mutation
30 Citations (Scopus)

Neurodegeneration caused by proteins with an aberrant carboxyl-terminus

Vidal, R., Delisle, M. B. & Ghetti, B., Aug 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 8, p. 787-800 14 p.

Research output: Contribution to journalArticle

Ferritins
Nervous System Heredodegenerative Disorders
Molecular Biology
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 13
24 Citations (Scopus)

The Human Amyloid-β Precursor Protein770 Mutation V717F Generates Peptides Longer Than Amyloid-β-(40-42) and Flocculent Amyloid Aggregates

Roher, A. E., Kokjohn, T. A., Esh, C., Weiss, N., Childress, J., Kalback, W., Luehrs, D. C., Lopez, J., Brune, D., Kuo, Y. M., Farlow, M., Murrell, J., Vidal, R. & Ghetti, B., Feb 13 2004, In : Journal of Biological Chemistry. 279, 7, p. 5829-5836 8 p.

Research output: Contribution to journalArticle

Amyloid
Amyloid beta-Protein Precursor
Alzheimer Disease
Peptides
Mutation
2003
32 Citations (Scopus)

Hereditary ferritinopathy

Vidal, R., Delisle, M. B., Rascol, O. & Ghetti, B., Mar 15 2003, In : Journal of the Neurological Sciences. 207, 1-2, p. 110-111 2 p.

Research output: Contribution to journalArticle

Nervous System Heredodegenerative Disorders
Ferritins
Neuroferritinopathy
2002
92 Citations (Scopus)

Familial Danish dementia: A novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-Beta

Holton, J. L., Lashley, T., Ghiso, J., Braendgaard, H., Vidal, R., Guerin, C. J., Gibb, G., Hanger, D. P., Rostagno, A., Anderton, B. H., Strand, C., Ayling, H., Plant, G., Frangione, B., Bojsen-Møller, M. & Revesz, T., 2002, In : Journal of Neuropathology and Experimental Neurology. 61, 3, p. 254-267 14 p.

Research output: Contribution to journalArticle

Amyloid
Blood Vessels
Central Nervous System
Cerebral Amyloid Angiopathy
Pathology