Ruben Vidal

  • 3606 Citations
  • 32 h-Index
1992 …2020

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A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

Taylor, X., Cisternas, P., You, Y., You, Y., Xiang, S., Marambio, Y., Zhang, J., Vidal, R. & Lasagna-Reeves, C. A., Jul 25 2020, In : Journal of Neuroinflammation. 17, 1, 223.

Research output: Contribution to journalArticle

Open Access

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene

Barbeito, A. G., Garringer, H. J., Baraibar, M. A., Gao, X., Arredondo, M., Núñez, M. T., Smith, M. A., Ghetti, B. & Vidal, R., May 1 2009, In : Journal of Neurochemistry. 109, 4, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Abnormal iron metabolism in fibroblasts from a patient with the neurodegenerative disease hereditary ferritinopathy

Barbeito, A. G., Levade, T., Delisle, M. B., Ghetti, B. & Vidal, R., Nov 12 2010, In : Molecular Neurodegeneration. 5, 1, 50.

Research output: Contribution to journalArticle

19 Scopus citations

Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy

Deng, X., Vidal, R. & Englander, E. W., Jul 1 2010, In : Neuroscience Letters. 479, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

Vidal, R., Révész, T., Rostagno, A., Kim, E., Holton, J. L., Bek, T., Bojsen-Møller, M., Braendgaard, H., Plant, G., Ghiso, J. & Frangione, B., Apr 25 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 9, p. 4920-4925 6 p.

Research output: Contribution to journalArticle

231 Scopus citations

A human monoclonal IgG that binds Aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo

Levites, Y., O’Nuallain, B., Puligedda, R. D., Ondrejcak, T., Adekar, S. P., Chen, C., Cruz, P. E., Rosario, A. M., Macy, S., Mably, A. J., Walsh, D. M., Vidal, R., Solomon, A., Brown, D., Rowan, M. J., Golde, T. E. & Dessain, S. K., Apr 22 2015, In : Journal of Neuroscience. 35, 16, p. 6265-6276 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant

Vidal, R., Ghiso, J., Wisniewski, T. & Frangione, B., Sep 9 1996, In : FEBS Letters. 393, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Amino-terminal identity of co-existent amyloid and non-amyloid immunoglobulin K light chain deposits. A human disease to study alterations of protein conformation

Kaplan, B., Vidal, R., Kumar, A., Ghiso, J., Frangione, B. & Gallo, G., Jan 1 1997, In : Clinical and Experimental Immunology. 110, 3, p. 472-478 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Amino-terminally truncated Aβ peptide species are the main component of cotton wool plaques

Miravalle, L., Calero, M., Takao, M., Roher, A. E., Ghetti, B. & Vidal, R., Aug 16 2005, In : Biochemistry. 44, 32, p. 10810-10821 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B. & Vidal, R., May 1 2012, In : Free Radical Biology and Medicine. 52, 9, p. 1692-1697 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

A mutation in myotilin causes spheroid body myopathy

Foroud, T., Pankratz, N., Batchman, A. P., Pauciulo, M. W., Vidal, R., Miravalle, L., Goebel, H. H., Cushman, L. J., Azzarelli, B., Horak, H., Farlow, M. & Nichols, W. C., Dec 2005, In : Neurology. 65, 12, p. 1936-1940 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

Amyloid and intracellular accumulation of BRI2

Garringer, H., Sammeta, N., Oblak, A., Ghetti, B. & Vidal, R., Apr 1 2017, In : Neurobiology of Aging. 52, p. 90-97 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis

Teng, M. H., Yin, J. Y., Vidal, R., Ghiso, J., Kumar, A., Rabenou, R., Shah, A., Jacobson, D. R., Tagoe, C., Gallo, G. & Buxbaum, J., 2001, In : Laboratory Investigation. 81, 3, p. 385-396 12 p.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations

Amyloidogenesis in Familial British dementia is associated with a genetics defect on chromosome 13

Ghiso, J., Vidal, R., Rostagno, A., Miravalle, L., Holton, J. L., Mead, S., Révész, T., Plant, G. & Frangione, B., 2000, In : Annals of the New York Academy of Sciences. 920, p. 84-92 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Amyloidoma of the cns: II. immunohistochemical and biochemical study

Vidal, R. G., Ghiso, J., Gallo, G., Cohen, M., Gambetti, P. L. & Frangione, B., Oct 1992, In : Neurology. 42, 10, p. 2024-2028 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia

Marcora, M. S., Fernández-Gamba, A. C., Avendaño, L. A., Rotondaro, C., Podhajcer, O. L., Vidal, R., Morelli, L., Ceriani, M. F. & Castaño, E. M., Jan 9 2014, In : Molecular Neurodegeneration. 9, 1, 5.

Research output: Contribution to journalArticle

12 Scopus citations

A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia

Ghiso, J., Vidal, R., Rostagno, A., Mead, S., Révész, T., Plant, G. & Frangione, B., 2000, In : Annals of the New York Academy of Sciences. 903, p. 129-137 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

A novel ferritin light chain mutation in neuroferritinopathy with an atypical presentation

Nishida, K., Garringer, H. J., Futamura, N., Funakawa, I., Jinnai, K., Vidal, R. & Takao, M., Jul 15 2014, In : Journal of the Neurological Sciences. 342, 1-2, p. 173-177 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Apolipoprotein E and amyloidogenesis

Frangione, B., Castaño, E. M., Wisniewski, T., Ghiso, J., Prelli, F. & Vidal, R., Dec 1 1996, In : CIBA Foundation Symposia. 199, p. 132-145 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Axonal transport of British and Danish amyloid peptides via secretory vesicles.

Choi, S. I., Vidal, R., Frangione, B. & Levy, E., Feb 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 2, p. 373-375 3 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2

Vidal, R., Barbeito, A. G., Miravalle, L. & Ghetti, B., Jan 1 2009, In : Brain Pathology. 19, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Clinical phenotype and neuroimaging findings in a French family with hereditary ferritinopathy (FTL498-499InsTC)

Ory-Magne, F., Brefel-Courbon, C., Payoux, P., Debruxelles, S., Sibon, I., Goizet, C., Labauge, P., Menegon, P., Uro-Coste, E., Ghetti, B., Delisle, M. B., Vidal, R. & Rascol, O., Aug 15 2009, In : Movement Disorders. 24, 11, p. 1676-1683 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation

Spina, S., Murrell, J. R., Huey, E. D., Wassermann, E. M., Pietrini, P., Baraibar, M. A., Barbeito, A. G., Troncoso, J. C., Vidal, R., Ghetti, B. & Grafman, J., Mar 2007, In : Neurology. 68, 11, p. 820-827 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Complete primary sequences of two λ immunoglobulin light chains in myelomas with nonamyloid (Randall-type) light chain deposition disease

Decourt, C., Touchard, G., Preud'homme, J. L., Vidal, R., Beaufils, H., Diemert, M. C. & Cogné, M., Jul 1998, In : American Journal of Pathology. 153, 1, p. 313-318 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Early-onset dementia with Lewy bodies

Takao, M., Ghetti, B., Yoshida, H., Piccardo, P., Narain, Y., Murrell, J. R., Vidal, R., Glazier, B. S., Jakes, R., Tsutsui, M., Spillantini, M. G., Crowther, R. A., Goedert, M. & Koto, A., Apr 2004, In : Brain Pathology. 14, 2, p. 137-147 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of systemic iron overload and a chelation therapy in a mouse model of the neurodegenerative disease hereditary ferritinopathy

Garringer, H. J., Irimia, J. M., Li, W., Goodwin, C. B., Richine, B., Acton, A., Chan, R. J., Peacock, M., Muhoberac, B. B., Ghetti, B. & Vidal, R., Aug 2016, In : PloS one. 11, 8, e0161341.

Research output: Contribution to journalArticle

11 Scopus citations

Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues

Jiménez-Huete, A., Lievens, P. M. J., Vidal, R., Piccardo, P., Ghetti, B., Tagliavini, F., Frangione, B. & Prelli, F., Nov 1998, In : American Journal of Pathology. 153, 5, p. 1561-1572 12 p.

Research output: Contribution to journalArticle

146 Scopus citations

Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease

Ghiso, J., Wisniewski, T., Vidal, R., Rostagno, A. & Frangione, B., Jan 1 1992, In : Biochemical Journal. 282, 2, p. 517-522 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice

Vidal, R., Miravalle, L., Gao, X., Barbeito, A. G., Baraibar, M. A., Hekmatyar, S. K., Widel, M., Bansal, N., Delisle, M. B. & Ghetti, B., Jan 2 2008, In : Journal of Neuroscience. 28, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Failure to detect the presence of prions in the uterine and gestational tissues from a gravida with Creutzfeldt-Jakob disease

Xiao, X., Miravalle, L., Yuan, J., McGeehan, J., Dong, Z., Wyza, R., MacLennan, G. T., Golichowski, A. M., Kneale, G., King, N., Kong, Q., Spina, S., Vidal, R., Ghetti, B., Roos, K., Gambetti, P. & Zou, W. Q., May 2009, In : American Journal of Pathology. 174, 5, p. 1602-1608 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Familial cerebral amyloid angiopathies and dementia

Frangione, B., Vidal, R., Rostagno, A. & Ghiso, J., Jul 6 2000, In : Alzheimer disease and associated disorders. 14, SUPPL. 1, p. S25-S30

Research output: Contribution to journalArticle

12 Scopus citations

Familial cerebral amyloid angiopathy related to stroke and dementia

Frangione, B., Révész, T., Vidal, R., Holton, J., Lashley, T., Houlden, H., Wood, N., Rostagno, A., Plant, G. & Ghiso, J., Oct 3 2001, In : Amyloid. 8, SUPPL. 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Familial Danish dementia: A novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-Beta

Holton, J. L., Lashley, T., Ghiso, J., Braendgaard, H., Vidal, R., Guerin, C. J., Gibb, G., Hanger, D. P., Rostagno, A., Anderton, B. H., Strand, C., Ayling, H., Plant, G., Frangione, B., Bojsen-Møller, M. & Revesz, T., Jan 1 2002, In : Journal of Neuropathology and Experimental Neurology. 61, 3, p. 254-267 14 p.

Research output: Contribution to journalArticle

Open Access
93 Scopus citations

Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin- fibronectin complexes

Rostagno, A., Vidal, R., Kumar, A., Chuba, J., Niederman, G., Gold, L., Frangione, B., Ghiso, J. & Gallo, G., Nov 1996, In : American Journal of Kidney Diseases. 28, 5, p. 676-684 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Generation and initial characterization of FDD knock in mice

Giliberto, L., Matsuda, S., Vidal, R. & D'Adamio, L., Nov 18 2009, In : PloS one. 4, 11, e7900.

Research output: Contribution to journalArticle

23 Scopus citations

Hereditary ferritinopathy

Vidal, R., Delisle, M. B., Rascol, O. & Ghetti, B., Mar 15 2003, In : Journal of the Neurological Sciences. 207, 1-2, p. 110-111 2 p.

Research output: Contribution to journalArticle

32 Scopus citations

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

Maarouf, C. L., Daugs, I. D., Spina, S., Vidal, R., Kokjohn, T. A., Patton, R. L., Kalback, W. M., Luehrs, D. C., Walker, D. G., Castaño, E. M., Beach, T. G., Ghetti, B. & Roher, A. E., 2008, In : Molecular Neurodegeneration. 3, 1, 20.

Research output: Contribution to journalArticle

31 Scopus citations

IgG1-κ biclonal gammopathy associated with multiple myeloma suggests a regulatory mechanism

Pizzolato, M., Bragantini, G., Bresciani, P., Pavlovsky, S., Chuba, J., Vidal, R., Rostagno, A. & Ghiso, J., Aug 5 1998, In : British journal of haematology. 102, 2, p. 503-508 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat

Kaplan, B., Vidal, R., Kumar, A., Ghiso, J. & Gallo, G., Jan 1 1999, In : American journal of clinical pathology. 112, 3, p. 403-407 5 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Immunolocalization of the Oligodendrocyte Transcription Factor 1 (Olig1) in Brain Tumors

Azzarelli, B., Miravalle, L. & Vidal, R., Feb 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele

Askanas, V., Engel, W. K., Alvarez, R. B., Frangione, B., Ghiso, J. & Vidal, R., Apr 19 2000, In : Annals of Neurology. 47, 4, p. 544-549 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

Garringer, H. J., Murrell, J., Sammeta, N., Gnezda, A., Ghetti, B. & Vidal, R., Feb 13 2013, In : PloS one. 8, 2, e56426.

Research output: Contribution to journalArticle

15 Scopus citations

Intracellular Ferritin Accumulation in Neural and Extraneural Tissue Characterizes A Neurodegenerative Disease Associated with A Mutation in the Ferritin Light Polypeptide Gene

Vidal, R., Ghetti, B., Takao, M., Brefel-Courbon, C., Uro-Coste, E., Glazier, B. S., Siani, V., Benson, M. D., Calvas, P., Miravalle, L., Rascol, O. & Delisle, M. B., Apr 2004, In : Journal of Neuropathology and Experimental Neurology. 63, 4, p. 363-380 18 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Farrow, E. G., Yu, X., Summers, L. J., Davis, S. I., Fleet, J. C., Allen, M. R., Robling, A. G., Stayrook, K. R., Jideonwo, V., Magers, M. J., Garringer, H. J., Vidal, R., Chan, R. J., Goodwin, C. B., Hui, S. L., Peacock, M. & White, K. E., Nov 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 46, p. E1146-E1155

Research output: Contribution to journalArticle

207 Scopus citations
19 Scopus citations

Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B. & Vidal, R., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31679-31689 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Kappa light chain-associated Fanconi's syndrome: Molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals

Déret, S., Denoroy, L., Lamarine, M., Vidal, R., Mougenot, B., Frangione, B., Stevens, F. J., Ronco, P. M. & Aucouturier, P., Jan 1 1999, In : Protein Engineering. 12, 4, p. 363-369 7 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Light chain cardiomyopathy: Structural analysis of the light chain tissue deposits

Gallo, G., Goñi, F., Boctor, F., Vidal, R., Kumar, A., Stevens, F. J., Frangione, B. & Ghiso, J., May 1 1996, In : American Journal of Pathology. 148, 5, p. 1397-1406 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

Tokuda, T., Calero, M., Matsubara, E., Vidal, R., Kumar, A., Permanne, B., Zlokovic, B., Smith, J. D., Ladu, M. J., Rostagno, A., Frangione, B. & Ghiso, J., Jun 1 2000, In : Biochemical Journal. 348, 2, p. 359-365 7 p.

Research output: Contribution to journalArticle

184 Scopus citations