Samir Gupta

  • 2390 Citations
  • 22 h-Index
1976 …2019
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Publications 2001 2019

  • 2390 Citations
  • 22 h-Index
  • 80 Article
  • 3 Letter
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Article
2019

Depression and all-cause mortality risk in HIV-infected and HIV-uninfected US veterans: a cohort study

So-Armah, K., Gupta, S., Kundu, S., Stewart, J. C., Goulet, J. L., Butt, A. A., Sico, J. J., Marconi, V. C., Crystal, S., Rodriguez-Barradas, M. C., Budoff, M., Gibert, C. L., Chang, C. C. H., Bedimo, R. & Freiberg, M. S., Jan 1 2019, In : HIV Medicine.

Research output: Contribution to journalArticle

Veterans
Cohort Studies
HIV
Depression
HIV Infections

Endothelial Colony-Forming Cell Function Is Reduced During HIV Infection

Gupta, S., Liu, Z., Sims, E. C., Repass, M. J., Haneline, L. & Yoder, M., Mar 15 2019, In : The Journal of infectious diseases. 219, 7, p. 1076-1083 8 p.

Research output: Contribution to journalArticle

Virus Diseases
HIV
Monocytes
Fetal Blood
Flow Cytometry

GCH1 haplotypes and cardiovascular risk in HIV

Slaven, J. E., Haas, D. W., Liu, Z., Stein, J. H., Brown, T. T. & Gupta, S., Aug 1 2019, In : AIDS. 33, 10, p. 1669-1671 3 p.

Research output: Contribution to journalArticle

Haplotypes
HIV
Inflammation
Carotid Intima-Media Thickness
Dilatation

HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction Implications for Statin Treatment in HIV Patients

Chelvanambi, S., Gupta, S. K., Chen, X., Ellis, B. W., Maier, B. F., Colbert, T. M., Kuriakose, J., Zorlutuna, P., Jolicoeur, P., Obukhov, A. G. & Clauss, M., Oct 11 2019, In : Circulation research. 125, 9, p. 805-820 16 p.

Research output: Contribution to journalArticle

Open Access
Human Immunodeficiency Virus nef Gene Products
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Endothelial Cells
HIV
Therapeutics

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study

Polanka, B. M., Kundu, S., So-Armah, K. A., Freiberg, M. S., Gupta, S., Bedimo, R. J., Budoff, M. J., Butt, A. A., Chang, C. C. H., Gottlieb, S. S., Marconi, V. C., Womack, J. A. & Stewart, J. C., May 1 2019, In : Journal of acquired immune deficiency syndromes (1999). 81, 1, p. 110-117 8 p.

Research output: Contribution to journalArticle

Sleep Initiation and Maintenance Disorders
Veterans
Cohort Studies
Cardiovascular Diseases
HIV
2 Citations (Scopus)

Renal safety of tenofovir alafenamide vs. tenofovir disoproxil fumarate: A pooled analysis of 26 clinical trials

Gupta, S., Post, F. A., Arribas, J. R., Eron, J. J., Wohl, D. A., Clarke, A. E., Sax, P. E., Stellbrink, H. J., Esser, S., Pozniak, A. L., Podzamczer, D., Waters, L., Orkin, C., Rockstroh, J. K., Mudrikova, T., Negredo, E., Elion, R. A., Guo, S., Zhong, L., Carter, C. & 4 others, Martin, H., Brainard, D., Sengupta, D. & Das, M., Jul 15 2019, In : AIDS. 33, 9, p. 1455-1465 11 p.

Research output: Contribution to journalArticle

Tenofovir
Clinical Trials
Kidney
Safety
Creatinine
2018
1 Citation (Scopus)

Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function

Sims, E. K., Park, G., Mather, K., Mirmira, R., Liu, Z. & Gupta, S., May 1 2018, In : PLoS One. 13, 5, e0197080.

Research output: Contribution to journalArticle

HIV infections
HIV Infections
HIV
Glucose
therapeutics
2 Citations (Scopus)

Long-Term kidney function, proteinuria, and associated risks among HIV-infected and uninfected men

Palella, F. J., Li, X., Gupta, S., Estrella, M. M., Phair, J. P., Margolick, J. B., Detels, R., Kingsley, L. & Jacobson, L. P., Jun 19 2018, In : AIDS. 32, 10, p. 1247-1256 10 p.

Research output: Contribution to journalArticle

Proteinuria
HIV
Kidney
Highly Active Antiretroviral Therapy
Tenofovir
1 Citation (Scopus)

Women have enhanced bone loss associated with phosphaturia and CD4+ cell restoration during initial antiretroviral therapy

ACTG A5224s, A5303 Teams, Nov 13 2018, In : AIDS (London, England). 32, 17, p. 2517-2524 8 p.

Research output: Contribution to journalArticle

Familial Hypophosphatemia
Tenofovir
Bone Density
Bone and Bones
Pelvic Bones
2017
7 Citations (Scopus)

BCL6 represses antiviral resistance in follicular T helper cells

Amet, T., Son, Y. M., Jiang, L., Cheon, I. S., Huang, S., Gupta, S., Dent, A., Montaner, L. J., Yu, A. & Sun, J., Aug 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 527-536 10 p.

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Antiviral Agents
HIV Infections
R Factors
Genes
4 Citations (Scopus)

Bone mineral density reductions after tenofovir disoproxil fumarate initiation and changes in phosphaturia: A secondary analysis of ACTG A5224s

Gupta, S., Yeh, E., Kitch, D. W., Brown, T. T., Venuto, C. S., Morse, G. D., Ha, B., Melbourne, K. & McComsey, G. A., Jul 1 2017, In : Journal of Antimicrobial Chemotherapy. 72, 7, p. 2042-2048 7 p., dkx076.

Research output: Contribution to journalArticle

Tenofovir
Familial Hypophosphatemia
Bone Density
efavirenz
Pelvic Bones
4 Citations (Scopus)

HIV infection, antiretroviral therapy, and measures of endothelial function, inflammation, metabolism, and oxidative stress

Dysangco, A., Liu, Z., Stein, J. H., Dubé, M. P. & Gupta, S., Aug 1 2017, In : PLoS One. 12, 8, e0183511.

Research output: Contribution to journalArticle

Oxidative stress
HIV infections
Metabolism
HIV Infections
Oxidative Stress
17 Citations (Scopus)

MMPs/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders

Xing, Y., Shepherd, N., Lan, J., Li, W., Rane, S., Gupta, S., Zhang, S., Dong, J. & Yu, A., Jan 10 2017, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Cerebrospinal Fluid
HIV-1
Matrix Metalloproteinase 2
2016
10 Citations (Scopus)

Association Between Depressive Disorders and Incident Acute Myocardial Infarction in Human Immunodeficiency Virus-Infected Adults: Veterans Aging Cohort Study

Khambaty, T., Stewart, J. C., Gupta, S., Chang, C. C. H., Bedimo, R. J., Budoff, M. J., Butt, A. A., Crane, H., Gibert, C. L., Leaf, D. A., Rimland, D., Tindle, H. A., So-Armah, K. A., Justice, A. C. & Freiberg, M. S., Nov 1 2016, In : JAMA Cardiology. 1, 8, p. 929-937 9 p.

Research output: Contribution to journalArticle

Veterans
Depressive Disorder
International Classification of Diseases
Cohort Studies
Myocardial Infarction
6 Citations (Scopus)

Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): A phase 2b randomised, controlled, partly blinded trial

Gupta, S., McComsey, G. A., Lombaard, J., Echevarría, J., Orrell, C., Avihingsanon, A., Osiyemi, O., Santoscoy, M., Ray, N., Stock, D. A., Joshi, S. R., Hanna, G. J. & Lataillade, M., Jan 1 2016, In : The Lancet HIV. 3, 1, p. e13-e22

Research output: Contribution to journalArticle

Tenofovir
HIV Reverse Transcriptase
Reverse Transcriptase Inhibitors
Nucleosides
Safety
2 Citations (Scopus)

Plasma and Intracellular Concentrations in HIV-infected Patients Requiring Hemodialysis Dosed with Tenofovir Disoproxil Fumarate and Emtricitabine: TDF and FTC in HD

Slaven, J. E., Decker, B., Kashuba, A. D. M., Atta, M. G., Wyatt, C. M. & Gupta, S., Jun 9 2016, (Accepted/In press) In : Journal of Acquired Immune Deficiency Syndromes.

Research output: Contribution to journalArticle

2015
20 Citations (Scopus)

A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome

Dahlin, A., Wittwer, M., De La Cruz, M., Woo, J. M., Bam, R., Scharen-Guivel, V., Flaherty, J., Ray, A. S., Cihlar, T., Gupta, S. & Giacomini, K. M., Feb 13 2015, In : Pharmacogenetics and Genomics. 25, 2, p. 82-92 11 p.

Research output: Contribution to journalArticle

Tenofovir
Fanconi Syndrome
Pharmacogenetics
Single Nucleotide Polymorphism
Genes
5 Citations (Scopus)

A randomized, controlled trial of the effect of rilpivirine versus efavirenz on cardiovascular risk in healthy volunteers

Gupta, S., Slaven, J. E., Kamendulis, L. M. & Liu, Z., Oct 1 2015, In : Journal of Antimicrobial Chemotherapy. 70, 10, p. 2889-2893 5 p., dkv195.

Research output: Contribution to journalArticle

Rilpivirine
efavirenz
Healthy Volunteers
Randomized Controlled Trials
HIV
1 Citation (Scopus)

A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice

Eadon, M., Zhang, H., Skaar, T., Hato, T., Dagher, P., Gupta, S. & Desta, Z., Jan 1 2015, In : Antiviral Chemistry and Chemotherapy. 24, 2, p. 72-76 5 p.

Research output: Contribution to journalArticle

Integrase Inhibitors
Creatinine
Kidney
Water
Serum
5 Citations (Scopus)

Blockage of CD59 function restores activities of neutralizing and nonneutralizing antibodies in triggering antibody-dependent complement-mediated lysis of HIV-1 virions and provirus-activated latently infected cells

Yang, K., Lan, J., Shepherd, N., Hu, N., Xing, Y., Byrd, D., Amet, T., Jewell, C., Gupta, S., Kounga, C., Gao, J. & Yu, A., 2015, In : Journal of Virology. 89, 18, p. 9393-9406 14 p.

Research output: Contribution to journalArticle

proviruses
Proviruses
Human immunodeficiency virus 1
Neutralizing Antibodies
virion
2 Citations (Scopus)

Brief report: Endothelial colony-forming cells and inflammatory monocytes in HIV

Hays, T. R., Mund, J. A., Liu, Z., Case, J., Ingram, D. & Gupta, S., Apr 15 2015, In : Journal of Acquired Immune Deficiency Syndromes. 68, 5, p. 550-553 4 p.

Research output: Contribution to journalArticle

Monocytes
HIV
HIV Infections
Atherosclerosis
21 Citations (Scopus)

Depression and human immunodeficiency virus infection are risk factors for incident heart failure among veterans veterans aging cohort study

White, J. R., Chang, C. C. H., So-Armah, K. A., Stewart, J. C., Gupta, S., Butt, A. A., Gibert, C. L., Rimland, D., Rodriguez-Barradas, M. C., Leaf, D. A., Bedimo, R. J., Gottdiener, J. S., Kop, W. J., Gottlieb, S. S., Budoff, M. J., Khambaty, T., Tindle, H. A., Justice, A. C. & Freiberg, M. S., Oct 27 2015, In : Circulation. 132, 17, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Veterans
Virus Diseases
Major Depressive Disorder
Cohort Studies
Heart Failure
8 Citations (Scopus)

Intracellular Nef detected in peripheral blood mononuclear cells from HIV patients

Wang, T., Green, L. A., Gupta, S., Amet, T., Byrd, D. J., Yu, A., Twigg, H. & Clauss, M., Feb 1 2015, In : AIDS Research and Human Retroviruses. 31, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

Blood Cells
HIV
Therapeutics
Pathology
Proteins
18 Citations (Scopus)

Markers of renal disease and function are associated with systemic inflammation in HIV infection

AIDS Clinical Trials Group Study A5224s Team, Nov 1 2015, In : HIV Medicine. 16, 10, p. 591-598 8 p.

Research output: Contribution to journalArticle

HIV Infections
Creatinine
Inflammation
Kidney
Urine
5 Citations (Scopus)

Reductions in plasma cystatin c after initiation of antiretroviral therapy are associated with reductions in inflammation: ACTG A5224s

Longenecker, C. T., Kitch, D., Sax, P. E., Daar, E. S., Tierney, C., Gupta, S. & McComsey, G. A., Jun 1 2015, In : Journal of Acquired Immune Deficiency Syndromes. 69, 2, p. 168-177 10 p.

Research output: Contribution to journalArticle

Cystatins
Cystatin C
efavirenz
Inflammation
Therapeutics
3 Citations (Scopus)

Relationships between renal parameters and serum and urine markers of inflammation in those with and without HIV infection

Shinha, T., Mi, D., Liu, Z., Orschell, C., Lederman, M. M. & Gupta, S., Apr 1 2015, In : AIDS Research and Human Retroviruses. 31, 4, p. 375-383 9 p.

Research output: Contribution to journalArticle

HIV Infections
Biomarkers
Urine
Inflammation
Kidney
115 Citations (Scopus)
HIV
Kidney
Creatinine
Tenofovir
Proteinuria
2014

Antiretroviral treatment initiation

Gupta, S., 2014, In : The Lancet Infectious Diseases. 14, 12, p. 1175-1176 2 p.

Research output: Contribution to journalArticle

AIDS-Related Opportunistic Infections
Anti-Retroviral Agents
Pulmonary Tuberculosis
HIV-1
Acquired Immunodeficiency Syndrome
14 Citations (Scopus)

Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: Data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine

Wyatt, C. M., Kitch, D., Gupta, S., Tierney, C., Daar, E. S., Sax, P. E., Ha, B., Melbourne, K. & McComsey, G. A., Sep 1 2014, In : Journal of Acquired Immune Deficiency Syndromes. 67, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Tenofovir
Albuminuria
Reverse Transcriptase Inhibitors
Proteinuria
Creatinine
129 Citations (Scopus)

Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV medicine association of the infectious diseases society of America

Lucas, G. M., Ross, M. J., Stock, P. G., Shlipak, M. G., Wyatt, C. M., Gupta, S., Atta, M. G., Wools-Kaloustian, K., Pham, P. A., Bruggeman, L. A., Lennox, J. L., Ray, P. E. & Kalayjian, R. C., Nov 1 2014, In : Clinical Infectious Diseases. 59, 9, p. e96-e138

Research output: Contribution to journalArticle

Infectious Disease Medicine
Practice Management
Chronic Renal Insufficiency
Practice Guidelines
HIV
19 Citations (Scopus)

Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV medicine association of the infectious diseases society of America

Lucas, G. M., Ross, M. J., Stock, P. G., Shlipak, M. G., Wyatt, C. M., Gupta, S., Atta, M. G., Wools-Kaloustian, K., Pham, P. A., Bruggeman, L. A., Lennox, J. L., Ray, P. E. & Kalayjian, R. C., Nov 1 2014, In : Clinical Infectious Diseases. 59, 9, p. 1203-1207 5 p.

Research output: Contribution to journalArticle

Infectious Disease Medicine
Practice Management
Chronic Renal Insufficiency
Practice Guidelines
HIV
7 Citations (Scopus)

Cystatin C-based renal function changes after antiretroviral initiation: A substudy of a randomized trial

Gupta, S., Kitch, D., Tierney, C., Daar, E. S., Sax, P. E., Melbourne, K., Ha, B. & McComsey, G. A., 2014, In : Open Forum Infectious Diseases. 1, 1

Research output: Contribution to journalArticle

Cystatin C
Tenofovir
Kidney
efavirenz
Ritonavir
28 Citations (Scopus)

Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: A prospective, case-control study of predictors and resolution in HIV-infected patients

Gupta, S., Anderson, A. M., Ebrahimi, R., Fralich, T., Graham, H., Scharen-Guivel, V., Flaherty, J. F., Fortin, C., Kalayjian, R. C., Rachlis, A. & Wyatt, C. M., Mar 20 2014, In : PLoS One. 9, 3, e92717.

Research output: Contribution to journalArticle

Tenofovir
Fanconi syndrome
Fanconi Syndrome
renal function
case-control studies
4 Citations (Scopus)

HIV-1 coinfection profoundly alters intrahepatic chemokine but not inflammatory cytokine profiles in HCV-infected subjects

Hu, S., Ghabril, M., Amet, T., Hu, N., Byrd, D., Yang, K., Vuppalanchi, R., Saxena, R., Desai, M., Lan, J., Johnson, R., Gupta, S., Chalasani, N. & Yu, A., Feb 6 2014, In : PLoS One. 9, 2, e86964.

Research output: Contribution to journalArticle

Hepatitis C virus
chemokines
Human immunodeficiency virus 1
Coinfection
mixed infection
20 Citations (Scopus)
Human Immunodeficiency Virus env Gene Products
CXCR3 Receptors
Emphysema
Up-Regulation
Endothelial Cells
14 Citations (Scopus)

Microbial translocation and metabolic and body composition measures in treated and untreated HIV infection

Timmons, T., Shen, C., Aldrovandi, G., Rollie, A., Gupta, S., Stein, J. H. & Dubé, M. P., Mar 1 2014, In : AIDS Research and Human Retroviruses. 30, 3, p. 272-277 6 p.

Research output: Contribution to journalArticle

Body Weights and Measures
Body Composition
HIV Infections
Lipopolysaccharides
HDL Lipoproteins
52 Citations (Scopus)

Plasma apolipoprotein L1 levels do not correlate with CKD

Bruggeman, L. A., O'Toole, J. F., Ross, M. D., Madhavan, S. M., Smurzynski, M., Wu, K., Bosch, R. J., Gupta, S., Pollak, M. R., Sedor, J. R. & Kalayjian, R. C., Mar 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 634-644 11 p.

Research output: Contribution to journalArticle

Apolipoproteins
Proteinuria
Genotype
HIV
Cytokines
12 Citations (Scopus)

Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells

Lan, J., Yang, K., Byrd, D., Hu, N., Amet, T., Shepherd, N., Desai, M., Gao, J., Gupta, S., Sun, Y. & Yu, A., Oct 1 2014, In : Journal of Immunology. 193, 7, p. 3577-3589 13 p.

Research output: Contribution to journalArticle

Proviruses
HIV-1
Antibodies
Complement Activation
Protease Inhibitors
4 Citations (Scopus)

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. & Desta, Z., Dec 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 64-69 6 p.

Research output: Contribution to journalArticle

efavirenz
Bilirubin
Healthy Volunteers
Drug Interactions
Hemoglobins
29 Citations (Scopus)

Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction

Wang, T., Green, L. A., Gupta, S., Kim, C., Wang, L., Almodovar, S., Flores, S. C., Prudovsky, I. A., Jolicoeur, P., Liu, Z. & Clauss, M., Mar 7 2014, In : PLoS One. 9, 3, e91063.

Research output: Contribution to journalArticle

nef Gene Products
Endothelial cells
endothelium
Endothelium
Endothelial Cells
2013
33 Citations (Scopus)
Tenofovir
efavirenz
Minerals
Randomized Controlled Trials
Inflammation
14 Citations (Scopus)

Pentoxifylline, Inflammation, and Endothelial Function in HIV-Infected Persons: A Randomized, Placebo-Controlled Trial

Gupta, S., Mi, D., Dubé, M. P., Saha, C., Johnson, R. M., Stein, J. H., Clauss, M., Mather, K., Desta, Z. & Liu, Z., Apr 9 2013, In : PLoS One. 8, 4, e60852.

Research output: Contribution to journalArticle

pentoxifylline
Pentoxifylline
placebos
Randomized Controlled Trials
inflammation
2012
66 Citations (Scopus)

Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV Type 1-infected subjects over 48 weeks

Aberg, J. A., Tebas, P., Overton, E. T., Gupta, S., Sax, P. E., Landay, A., Falcon, R., Ryan, R. & De La Rosa, G., Oct 1 2012, In : AIDS Research and Human Retroviruses. 28, 10, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

Ritonavir
HIV-1
Tenofovir
Lipids
Insulin Resistance
14 Citations (Scopus)

Pentoxifylline reduces tumor necrosis factor-α and HIV-induced vascular endothelial activation

Green, L. A., Kim, C., Gupta, S., Rajashekhar, G., Rehman, J. & Clauss, M., Oct 1 2012, In : AIDS Research and Human Retroviruses. 28, 10, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

Pentoxifylline
Vascular Cell Adhesion Molecule-1
Blood Vessels
Tumor Necrosis Factor-alpha
HIV
26 Citations (Scopus)

Relationship between Microbial Translocation and Endothelial Function in HIV Infected Patients

Blodget, E., Shen, C., Aldrovandi, G., Rollie, A., Gupta, S., Stein, J. H. & Dubé, M. P., Aug 30 2012, In : PLoS One. 7, 8, e42624.

Research output: Contribution to journalArticle

Lipopolysaccharides
HIV
therapeutics
lipopolysaccharides
Dilatation
37 Citations (Scopus)

Worsening Endothelial Function with Efavirenz Compared to Protease Inhibitors: A 12-Month Prospective Study

Gupta, S., Shen, C., Moe, S., Kamendulis, L. M., Goldman, M. & Dubé, M. P., Sep 20 2012, In : PLoS One. 7, 9, e45716.

Research output: Contribution to journalArticle

efavirenz
compound A 12
Tenofovir
proteinase inhibitors
Protease Inhibitors
2011
9 Citations (Scopus)

Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells

Kim, C., Gupta, S., Green, L., Taylor, B. M., Deuter-Reinhard, M., Desta, Z. & Clauss, M., 2011, In : Antiviral Therapy. 16, 8, p. 1335-1339 5 p.

Research output: Contribution to journalArticle

Tenofovir
Didanosine
Oxidative Stress
Endothelial Cells
Genes
3 Citations (Scopus)
etravirine
Volunteers
HIV
Safety
Dilatation
5 Citations (Scopus)
Albuminuria
Proteinuria
Creatinine
HIV
Hypertension
9 Citations (Scopus)
Acquired Immunodeficiency Syndrome
HIV
Kidney
CD4 Lymphocyte Count
Mortality