Sean O'Connor

  • 5582 Citations
  • 45 h-Index
1983 …2020

Research output per year

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Publications

  • 5582 Citations
  • 45 h-Index
  • 115 Article
  • 7 Conference contribution
  • 4 Review article
2008

In vivo time-course changes in ethanol levels sampled with subcutaneous microdialysis

Engleman, E. A., Ingraham, C. M., Franklin, K. M., Keith, C. M., McClaren, J. A., Schultz, J. A., Morzorati, S. L., O'Connor, S., Thielen, R. J., Murphy, J. M. & McBride, W. J., Mar 1 2008, In : Alcoholism: Clinical and Experimental Research. 32, 3, p. 435-442 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Models and signal processing for an implanted ethanol bio-sensor

Han, J. J., Doerschuk, P. C., Gelfand, S. B. & O'Connor, S. J., Feb 1 2008, In : IEEE Transactions on Biomedical Engineering. 55, 2, p. 603-613 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Physiologically based pharmacokinetic (PBPK) models for ethanol

Plawecki, M. H., Han, J. J., Doerschuk, P. C., Ramchandani, V. A. & O'Connor, S. J., Dec 1 2008, In : IEEE Transactions on Biomedical Engineering. 55, 12, p. 2691-2700 10 p., 5.

Research output: Contribution to journalArticle

32 Scopus citations
2007

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy, M., Jones, K. A., Porjesz, B., Chorlian, D. B., Padmanabhapillai, A., Kamarajan, C., Kuperman, S., Rohrbaugh, J., O'Connor, S. J., Bauer, L. O., Schuckit, M. A. & Begleiter, H., Jan 1 2007, In : International Journal of Psychophysiology. 63, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Genetic influences on bipolar EEG power spectra

Tang, Y., Chorlian, D. B., Rangaswamy, M., Porjesz, B., Bauer, L., Kuperman, S., O'Connor, S., Rohrbaugh, J., Schuckit, M., Stimus, A. & Begleiter, H., Jul 1 2007, In : International Journal of Psychophysiology. 65, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Heritability of bipolar EEG spectra in a large sib-pair population

Tang, Y., Chorlian, D. B., Rangaswamy, M., O'Connor, S., Taylor, R., Rohrbaugh, J., Porjesz, B. & Begleiter, H., Mar 1 2007, In : Behavior Genetics. 37, 2, p. 302-313 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Heritability of EEG coherence in a large sib-pair population

Chorlian, D. B., Tang, Y., Rangaswamy, M., O'Connor, S., Rohrbaugh, J., Taylor, R. & Porjesz, B., Jul 1 2007, In : Biological Psychology. 75, 3, p. 260-266 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Heterogeneous effects of alcohol on dopamine release in the striatum: A PET study

Yoder, K. K., Constantinescu, C. C., Kareken, D. A., Normandin, M. D., Cheng, T. E., O'Connor, S. J. & Morris, E. D., Jun 1 2007, In : Alcoholism: Clinical and Experimental Research. 31, 6, p. 965-973 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Improved transformation of morphometric measurements for a priori parameter estimation in a physiologically-based pharmacokinetic model of ethanol

Plawecki, M. H., DeCarlo, R. A., Ramchandani, V. A. & O'Connor, S., Apr 1 2007, In : Biomedical Signal Processing and Control. 2, 2, p. 97-110 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

In vivo real-time ethanol vapor detection in the interstitial fluid of a Wistar rat using piezoresistive microcantilevers

Cheney, C. P., Wig, A., Farahi, R. H., Gehl, A., Hedden, D. L., Ferrell, T. L., Ji, D., Bell, R., McBride, W. J. & O'Connor, S., Jan 15 2007, In : Applied Physics Letters. 90, 1, 013901.

Research output: Contribution to journalArticle

6 Scopus citations
2006

A cholinergic receptor gene (CHRM2) affects event-related oscillations

Jones, K. A., Porjesz, B., Almasy, L., Bierut, L., Dick, D., Goate, A., Hinrichs, A., Rice, J. P., Wang, J. C., Bauer, L. O., Crowe, R., Foroud, T., Hesselbrock, V., Kuperman, S., Nurnberger, J., O'Connor, S. J., Rohrbaugh, J., Schuckit, M. A., Tischfield, J., Edenberg, H. J. & 1 others, Begleiter, H., Sep 1 2006, In : Behavior Genetics. 36, 5, p. 627-639 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

Padmanabhapillai, A., Tang, Y., Ranganathan, M., Rangaswamy, M., Jones, K. A., Chorlian, D. B., Kamarajan, C., Stimus, A., Kuperman, S., Rohrbaugh, J., O'Connor, S. J., Bauer, L. O., Schuckit, M. A., Begleiter, H. & Porjesz, B., Nov 1 2006, In : International Journal of Psychophysiology. 62, 2, p. 262-271 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology

Han, J. J., Plawecki, M. H., Doerschuk, P. C., Ramchandani, V. A. & O'Connor, S., Dec 1 2006, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. p. 5033-5036 4 p. 4029183. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Patterns of regional brain activity in alcohol-dependent subjects

Hayden, E. P., Wiegand, R. E., Meyer, E. T., Bauer, L. O., O'Connor, S. J., Nurnberger, J. I., Chorlian, D. B., Porjesz, B. & Begleiter, H., Dec 1 2006, In : Alcoholism: Clinical and Experimental Research. 30, 12, p. 1986-1991 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Statistical Signal processing for an implantable ethanol biosensor

Han, J. J., Doerschuk, P. C., Gelfand, S. B. & O'Connor, S. J., Dec 1 2006, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. p. 3704-3707 4 p. 4029185. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Studying alcohol elimination using the alcohol clamp method

Ramchandani, V. A. & O'Connor, S., Dec 1 2006, In : Alcohol Research and Health. 29, 4, p. 286-290 5 p.

Research output: Contribution to journalReview article

23 Scopus citations

The alcohol clamp: Applications, challenges, and new directions - An RSA 2004 symposium summary

Ramchandani, V. A., O'Connor, S., Neumark, Y., Zimmermann, U. S., Morzorati, S. L. & De Wit, H., Jan 1 2006, In : Alcoholism: Clinical and Experimental Research. 30, 1, p. 155-164 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Dopamine D2 receptor availability is associated with subjective responses to alcohol

Yoder, K. K., Kareken, D. A., Seyoum, R. A., O'Connor, S. J., Wang, C., Zheng, Q. H., Mock, B. & Morris, E. D., Jun 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 6, p. 965-970 6 p.

Research output: Contribution to journalArticle

65 Scopus citations
2004

A family study of alcohol dependence: Coaggregation of multiple disorders in relatives of alcohol-dependent probands

Nurnberger, J. I., Wiegand, R., Bucholz, K., O'Connor, S., Meyer, E. T., Reich, T., Rice, J., Schuckit, M., King, L., Petti, T., Bierut, L., Hinrichs, A. L., Kuperman, S., Hesselbrock, V. & Porjesz, B., Dec 1 2004, In : Archives of general psychiatry. 61, 12, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

173 Scopus citations

Alcohol Dehydrogenase Polymorphisms Influence Alcohol-Elimination Rates in a Male Jewish Population

Neumark, Y. D., Friedlander, Y., Durst, R., Leitersdorf, E., Jaffe, D., Ramchandani, V. A., O'Connor, S., Carr, L. G. & Li, T. K., Jan 1 2004, In : Alcoholism: Clinical and Experimental Research. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

124 Scopus citations

Alcohol-Related Olfactory Cues Activate the Nucleus Accumbens and Ventral Tegmental Area in High-Risk Drinkers: Preliminary Findings

Kareken, D. A., Claus, E. D., Sabri, M., Dzemidzic, M., Kosobud, A. E. K., Radnovich, A. J., Hector, D., Ramchandani, V. A., O'Connor, S. J., Lowe, M. & Li, T. K., Apr 1 2004, In : Alcoholism: Clinical and Experimental Research. 28, 4, p. 550-557 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models

Plawecki, M. H., DeCarlo, R. A., Ramchandani, V. A. & O'Connor, S., 2004, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 I. p. 778-781 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: Implications for human brain dynamics and cognition

Jones, K. A., Porjesz, B., Almasy, L., Bierut, L., Goate, A., Wang, J. C., Dick, D. M., Hinrichs, A., Kwon, J., Rice, J. P., Rohrbaugh, J., Stock, H., Wu, W., Bauer, L. O., Chorlian, D. B., Crowe, R. R., Edenberg, H. J., Foroud, T., Hesselbrock, V., Kuperman, S. & 7 others, Nurnberger, J., O'Connor, S. J., Schuckit, M. A., Stimus, A. T., Tischfield, J. A., Reich, T. & Begleiter, H., Jul 1 2004, In : International Journal of Psychophysiology. 53, 2, p. 75-90 16 p.

Research output: Contribution to journalArticle

110 Scopus citations

Naltrexone and brief counseling to reduce heavy drinking in hazardous drinkers

Davidson, D., Saha, C., Scifres, S., Fyffe, J., O'Connor, S. & Selzer, C., Aug 1 2004, In : Addictive Behaviors. 29, 6, p. 1253-1258 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Resting EEG in offspring of male alcoholics: Beta frequencies

Rangaswamy, M., Porjesz, B., Chorlian, D. B., Wang, K., Jones, K. A., Kuperman, S., Rohrbaugh, J., O'Connor, S. J., Bauer, L. O., Reich, T. & Begleiter, H., Feb 2004, In : International Journal of Psychophysiology. 51, 3, p. 239-251 13 p.

Research output: Contribution to journalArticle

111 Scopus citations

Variations in GABRA2, Encoding the α2 Subunit of the GABA A Receptor, Are Associated with Alcohol Dependence and with Brain Oscillations

Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R. R., Goate, A., Hesselbrock, V., Jones, K., Kwon, J., Li, T. K., Nurnberger, J. I., O'Connor, S. J., Reich, T., Rice, J., Schuckit, M. A., Porjesz, B., Foroud, T. & Begleiter, H., Apr 2004, In : American Journal of Human Genetics. 74, 4, p. 705-714 10 p.

Research output: Contribution to journalArticle

487 Scopus citations
2003

Theta power in the EEG of alcoholics

Rangaswamy, M., Porjesz, B., Chorlian, D. B., Choi, K., Jones, K. A., Wang, K., Rohrbaugh, J., O'Connor, S., Kuperman, S., Reich, T. & Begleiter, H., Apr 1 2003, In : Alcoholism: Clinical and Experimental Research. 27, 4, p. 607-615 9 p.

Research output: Contribution to journalArticle

71 Scopus citations
2002

Beta power in the EEG of alcoholics

Rangaswamy, M., Porjesz, B., Chorlian, D. B., Wang, K., Jones, K. A., Bauer, L. O., Rohrbaugh, J., O'Connor, S. J., Kuperman, S., Reich, T. & Begleiter, H., Oct 15 2002, In : Biological psychiatry. 52, 8, p. 831-842 12 p.

Research output: Contribution to journalArticle

200 Scopus citations

Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes

Porjesz, B., Begleiter, H., Wang, K., Almasy, L., Chorlian, D. B., Stimus, A. T., Kuperman, S., O'Connor, S. J., Rohrbaugh, J., Bauer, L. O., Edenberg, H. J., Goate, A., Rice, J. P. & Reich, T., Oct 2002, In : Biological Psychology. 61, 1-2, p. 229-248 20 p.

Research output: Contribution to journalArticle

89 Scopus citations

Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Porjesz, B., Almasy, L., Edenberg, H. J., Wang, K., Chorlian, D. B., Foroud, T., Goate, A., Rice, J. P., O'Connor, S. J., Rohrbaugh, J., Kuperman, S., Bauer, L. O., Crowe, R. R., Schuckit, M. A., Hesselbrock, V., Conneally, P. M., Tischfield, J. A., Li, T. K., Reich, T. & Begleiter, H., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3729-3733 5 p.

Research output: Contribution to journalArticle

235 Scopus citations

Maintaining steady state arterial alcohol levels in rats by using a physiologically based pharmacokinetic model

Morzorati, S. L., Ramchandani, V. A., Li, T. K. & O'Connor, S., Nov 1 2002, In : Alcohol. 28, 3, p. 189-195 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Recent drinking history: Association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp

Ramchandani, V. A., Flury, L., Morzorati, S. L., Kareken, D., Blekher, T., Foroud, T., Li, T. K. & O'Connor, S., Nov 2002, In : Journal of Studies on Alcohol. 63, 6, p. 734-744 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Response of saccadic eye movements to alcohol in African American and non-Hispanic white college students

Blekher, T., Beard, J. D., O'Connor, S., Orr, W. E., Ramchandani, V. A., Miller, K., Yee, R. D. & Li, T. K., Jan 1 2002, In : Alcoholism: Clinical and Experimental Research. 26, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol

Blekher, T., Ramchandani, V. A., Flury, L., Foroud, T., Kareken, D., Yee, R. D., Li, T. K. & O'Connor, S., Oct 2002, In : Alcoholism: Clinical and Experimental Research. 26, 10, p. 1568-1573 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant

Morzorati, S. L., Ramchandani, V. A., Flury, L., Li, T. K. & O'Connor, S., Aug 2002, In : Alcoholism: Clinical and Experimental Research. 26, 8, p. 1299-1306 8 p.

Research output: Contribution to journalArticle

89 Scopus citations
2001

Genetic and environmental influences on alcohol metabolism in humans

Li, T. K., Yin, S. J., Crabb, D. W., O'Connor, S. & Ramchandani, V. A., Jan 1 2001, In : Alcoholism: Clinical and Experimental Research. 25, 1, p. 136-144 9 p.

Research output: Contribution to journalArticle

104 Scopus citations

Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism

Almasy, L., Porjesz, B., Blangero, J., Goate, A., Edenberg, H. J. & O'Connor, S. J., 2001, In : American Journal of Human Genetics. 68, 1, p. 128-135 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

P300 event-related potential amplitude as an endophenotype of alcoholism - Evidence from the Collaborative Study on the Genetics of Alcoholism

Hesselbrock, V., Begleiter, H., Porjesz, B., O'Connor, S. & Bauer, L., Feb 6 2001, In : Journal of Biomedical Science. 8, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

93 Scopus citations
2000

Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

Costa, L., Bauer, L., Kuperman, S., Porjesz, B., O'Connor, S., Hesselbrock, V., Rohrbaugh, J. & Begleiter, H., Jun 1 2000, In : Biological psychiatry. 47, 12, p. 1064-1071 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

PBPK modeling as a basis for achieving a steady of 60 ± 5 mg% within ten minutes

O'Connor, S., Ramchandani, V. A. & Li, T. K., Apr 1 2000, In : Alcoholism: Clinical and Experimental Research. 24, 4, p. 426-427 2 p.

Research output: Contribution to journalArticle

37 Scopus citations

The p300 brain potential is reduced in smokers

Anokhin, A. P., Vedeniapin, A. B., Sirevaag, E. J., Bauer, L. O., O'Connor, S. J., Kuperman, S., Porjesz, B., Reich, T., Begleiter, H., Polich, J. & Rohrbaugh, J. W., Jan 1 2000, In : Psychopharmacology. 149, 4, p. 409-413 5 p.

Research output: Contribution to journalArticle

78 Scopus citations
1999

A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping

Ramchandani, V. A., Bolane, J., Li, T. K. & O'Connor, S., Apr 1 1999, In : Alcoholism: Clinical and Experimental Research. 23, 4, p. 617-623 7 p.

Research output: Contribution to journalArticle

123 Scopus citations

A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism

Ramchandani, V. A., O'Connor, S., Blekher, T., Kareken, D., Morzorati, S., Nurnberger, J. & Li, T. K., Jan 1 1999, In : Alcoholism: Clinical and Experimental Research. 23, 8, 1 p.

Research output: Contribution to journalArticle

52 Scopus citations

A twin study of genetic influences on the acute adaptation of the EEG to alcohol

O'Connor, S., Sorbel, J., Morzorati, S., Li, T. K. & Christian, J. C., Mar 1999, In : Alcoholism: Clinical and Experimental Research. 23, 3, p. 494-501 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Heritability of event-related brain potentials in families with a history of alcoholism

Almasy, L., Porjesz, B., Blangero, J., Chorlian, D. B., O'Connor, S. J., Kuperman, S., Rohrbaugh, J., Bauer, L. O., Reich, T., Polich, J. & Begleiter, H., Aug 20 1999, In : American Journal of Medical Genetics - Neuropsychiatric Genetics. 88, 4, p. 383-390 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
1998

Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project

Porjesz, B., Begleiter, H., Reich, T., Van Eerdewegh, P., Edenberg, H. J., Foroud, T., Goate, A., Litke, A., Chorlian, D. B., Stimus, A., Rice, J., Blangero, J., Almasy, L., Sorbell, J., Bauer, L. O., Kuperman, S., O'Connor, S. J. & Rohrbaugh, J., Sep 1 1998, In : Alcoholism: Clinical and Experimental Research. 22, 6, p. 1317-1323 7 p.

Research output: Contribution to journalArticle

105 Scopus citations
126 Scopus citations

Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for body mass

Kwo, P. Y., Ramchandani, V. A., O'Connor, S., Amann, D., Carr, L. G., Sandrasegaran, K., Kopecky, K. K. & Li, T. K., Jan 1 1998, In : Gastroenterology. 115, 6, p. 1552-1557 6 p.

Research output: Contribution to journalArticle

125 Scopus citations