Sean O'Connor

  • 5360 Citations
  • 44 h-Index
1983 …2019
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Publications 1983 2019

  • 5360 Citations
  • 44 h-Index
  • 117 Article
  • 6 Conference contribution
  • 1 Review article
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Article
2019

Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures

Plawecki, M. H., Durrani, A. M., Boes, J., Wetherill, L., Kosobud, A., O'Connor, S. & Ramchandani, V. A., Jan 1 2019, In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Intravenous Administration
Alcohols
Trajectories
Body Water
Research
2018

Alcohol affects the P3 component of an adaptive stop signal task ERP

Plawecki, M. H., Windisch, K. A., Wetherill, L., Kosobud, A., Dzemidzic, M., Kareken, D. & O'Connor, S., Aug 1 2018, In : Alcohol. 70, p. 1-10 10 p.

Research output: Contribution to journalArticle

Silver Sulfadiazine
Evoked Potentials
alcohol
Alcohols
event
1 Citation (Scopus)

Alcohol intoxication progressively impairs drivers' capacity to detect important environmental stimuli

Plawecki, M. H., Koskie, S., Kosobud, A., Justiss, M. D. & O'Connor, S., Dec 1 2018, In : Pharmacology Biochemistry and Behavior. 175, p. 62-68 7 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Alcohols
Motor Vehicles
Accidents
Young Adult
1 Citation (Scopus)

Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks

Oberlin, B. G., Dzemidzic, M., Eiler, W. J. A., Carron, C. R., Soeurt, C. M., Plawecki, M. H., Grahame, N. J., O'Connor, S. & Kareken, D., Jan 1 2018, (Accepted/In press) In : Psychopharmacology.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Cues
Alcohols
Parietal Lobe
Reward
1 Citation (Scopus)

Sex Differences in Motivation to Self-Administer Alcohol After 2 Weeks of Abstinence in Young-Adult Heavy Drinkers

Plawecki, M. H., White, K., Kosobud, A., Grahame, N., Zimmermann, U. S., Crabb, D. & O'Connor, S., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Sex Characteristics
Motivation
Young Adult
Alcohols
Drinking
1 Citation (Scopus)

Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes

Ramchandani, V. A., Stangl, B. L., Blaine, S. K., Plawecki, M. H., Schwandt, M. L., Kwako, L. E., Sinha, R., Cyders, M. A., O'Connor, S. & Zakhari, S., Nov 1 2018, In : Alcohol. 72, p. 75-88 14 p.

Research output: Contribution to journalArticle

vulnerability
alcohol
Alcohols
Self Administration
self-administration
5 Citations (Scopus)

Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers

Weafer, J., Ross, T. J., O'Connor, S., Stein, E. A., de Wit, H. & Childs, E., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Corpus Striatum
Healthy Volunteers
Alcohols
Placebos
Magnetic Resonance Imaging
2017
13 Citations (Scopus)

Exposure-response relationships during free-access intravenous alcohol self-administration in nondependent drinkers: Influence of alcohol expectancies and impulsivity

Stangl, B. L., Vatsalya, V., Zametkin, M. R., Cooke, M. E., Plawecki, M. H., O'Connor, S. & Ramchandani, V. A., 2017, In : International Journal of Neuropsychopharmacology. 20, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Self Administration
Impulsive Behavior
Alcohols
Alcohol Drinking
Pleasure
16 Citations (Scopus)

Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms

Collaborative Study of the Genetics of Alcoholism Consortium & the German Study of the Genetics of Addiction Consortium, May 1 2017, In : Alcoholism: Clinical and Experimental Research. 41, 5, p. 911-928 18 p.

Research output: Contribution to journalArticle

Alcoholism
Ethanol
Genes
Alcohols
Long Noncoding RNA
11 Citations (Scopus)
Drinking
Trajectories
Alcohols
Genes
Alcoholism
3 Citations (Scopus)
Chromatin Assembly and Disassembly
Alcoholism
Chromatin
Sucrose
Alcohols
2016
8 Citations (Scopus)

Adolescent Women Induce Lower Blood Alcohol Levels Than Men in a Laboratory Alcohol Self-Administration Experiment

Jünger, E., Gan, G., Mick, I., Seipt, C., Markovic, A., Sommer, C., Plawecki, M. H., O'Connor, S., Smolka, M. N. & Zimmermann, U. S., Aug 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 8, p. 1769-1778 10 p.

Research output: Contribution to journalArticle

Self Administration
Blood
Alcohols
Drinking
Experiments
53 Citations (Scopus)

A prospective 5-year re-examination of alcohol response in heavy drinkers progressing in alcohol use disorder

King, A. C., Hasin, D., O'Connor, S., McNamara, P. J. & Cao, D., Mar 15 2016, In : Biological Psychiatry. 79, 6, p. 489-498 10 p.

Research output: Contribution to journalArticle

Alcohols
Allostasis
Reward
Drinking Behavior
Hypnotics and Sedatives
16 Citations (Scopus)

Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics

Yoder, K., Albrecht, D. S., Dzemidzic, M., Normandin, M. D., Federici, L. M., Graves, T., Herring, C. M., Hile, K. L., Walters, J. W., Liang, T., Plawecki, M. H., O'Connor, S. & Kareken, D., Mar 1 2016, In : Drug and Alcohol Dependence. 160, p. 163-169 7 p.

Research output: Contribution to journalArticle

Alcoholics
Dopamine
Alcohols
Alcoholic Intoxication
Corpus Striatum
6 Citations (Scopus)

Gender-Specific Effects of Mood on Alcohol-Seeking Behaviors: Preliminary Findings Using Intravenous Alcohol Self-Administration

Cyders, M. A., Vanderveen, J. D., Plawecki, M., Millward, J. B., Hays, J., Kareken, D. & O'Connor, S., Feb 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Self Administration
Alcohols
Independent Living
Experiments
Drinking
9 Citations (Scopus)

Negative urgency, mood induction, and alcohol seeking behaviors

VanderVeen, J. D., Plawecki, M. H., Millward, J. B., Hays, J., Kareken, D., O'Connor, S. & Cyders, M. A., Aug 1 2016, In : Drug and Alcohol Dependence. 165, p. 151-158 8 p.

Research output: Contribution to journalArticle

Alcohols
Self Administration
Hydrocortisone
Independent Living
Impulsive Behavior
2015
11 Citations (Scopus)
Drinking
Genotype
Alcohols
Alcoholism
Single Nucleotide Polymorphism
17 Citations (Scopus)

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

Oberlin, B. G., Dzemidzic, M., Tran, S. M., Soeurt, C. M., O'Connor, S., Yoder, K. & Kareken, D., 2015, In : Psychopharmacology. 232, 5, p. 861-870 10 p.

Research output: Contribution to journalArticle

Self Administration
Nucleus Accumbens
Dopamine
Ethanol
Raclopride
34 Citations (Scopus)

Integrating mRNA and miRNA weighted gene co-expression networks with eQTLs in the nucleus accumbens of subjects with alcohol dependence

Mamdani, M., Williamson, V., McMichael, G. O., Blevins, T., Aliev, F., Adkins, A., Hack, L., Bigdeli, T., Van Der Vaart, A. D., Web, B. T., Bacanu, S. A., Kalsi, G., Kendler, K. S., Miles, M. F., Dick, D., Riley, B. P., Dumur, C., Vladimirov, V. I., Hesselbrock, V., Edenberg, H. & 29 others, Nurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Porjesz, B., Bierut, L., Goate, A., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Almasy, L., Taylor, R., Dick, D., Bauer, L., Koller, D., O'Connor, S., Wetherill, L., Xuei, X., Chan, G., Kang, S., Manz, N., Rangaswamy, M., Rohrbaugh, J., Wang, J. C., Brooks, A., Aliev, F., Parsian, A. & Reilly, M., Sep 18 2015, In : PLoS One. 10, 9, e0137671.

Research output: Contribution to journalArticle

Nucleus Accumbens
alcohol abuse
MicroRNAs
microRNA
Alcoholism
11 Citations (Scopus)

Novel serum biomarkers for detection of excessive alcohol use

Liangpunsakul, S., Lai, X., Ross, R. A., Yu, Z., Modlik, E., Westerhold, C., Heathers, L., Paul, R., O'Connor, S., Crabb, D. & Witzmann, F., Mar 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 3, p. 556-565 10 p.

Research output: Contribution to journalArticle

Biomarkers
Alcohols
Serum
Erythrocyte Indices
Alanine Transaminase
8 Citations (Scopus)

The apéritif effect: Alcohol's effects on the brain's response to food aromas in women

Eiler, W. J. A., Dzemidzic, M., Case, K. R., Soeurt, C. M., Armstrong, C. L. H., Mattes, R. D., O'Connor, S., Harezlak, J., Acton, A. J., Considine, R. & Kareken, D., Jul 1 2015, In : Obesity. 23, 7, p. 1386-1393 8 p.

Research output: Contribution to journalArticle

Alcohols
Food
Brain
Intravenous Infusions
Meat
2013
25 Citations (Scopus)

Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition

Kareken, D., Dzemidzic, M., Wetherill, L., Eiler, W., Oberlin, B. G., Harezlak, J., Wang, Y. & O'Connor, S., Jul 2013, In : Psychopharmacology. 228, 2, p. 335-345 11 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Brain
Impulsive Behavior
Magnetic Resonance Imaging
34 Citations (Scopus)

Modeling alcohol self-administration in the human laboratory.

Zimmermann, U. S., O'Connor, S. & Ramchandani, V. A., 2013, In : Current Topics in Behavioral Neurosciences. 13, p. 315-353 39 p.

Research output: Contribution to journalArticle

Self Administration
Alcohols
rimonabant
Alcoholics
Ethanol
17 Citations (Scopus)
Self Administration
Lorazepam
Polymorphism
Intravenous Administration
Genotype
2012
10 Citations (Scopus)

Alcohol Exposure Rate Control Through Physiologically Based Pharmacokinetic Modeling

Plawecki, M. H., Zimmermann, U. S., Vitvitskiy, V., Doerschuk, P. C., Crabb, D. & O'Connor, S., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 530-542 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Alcohols
Trajectories
Intravenous Infusions
Design of experiments
14 Citations (Scopus)

fMRI of the brain's response to stimuli experimentally paired with alcohol intoxication

Kareken, D., Grahame, N., Dzemidzic, M., Walker, M. J., Lehigh, C. A. & O'Connor, S., 2012, In : Psychopharmacology. 220, 4, p. 787-797 11 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Alcohols
Magnetic Resonance Imaging
Brain
Frontal Lobe
19 Citations (Scopus)

Limbic responses to reward cues correlate with antisocial trait density in heavy drinkers

Oberlin, B. G., Dzemidzic, M., Bragulat, V., Lehigh, C. A., Talavage, T., O'Connor, S. & Kareken, D., Mar 2012, In : NeuroImage. 60, 1, p. 644-652 9 p.

Research output: Contribution to journalArticle

Reward
Cues
Alcohols
Amygdala
Prefrontal Cortex
6 Citations (Scopus)

Reliability of striatal [ 11C]raclopride binding in smokers wearing transdermal nicotine patches

Yoder, K., Albrecht, D. S., Kareken, D., Federici, L. M., Perry, K. M., Patton, E. A., Zheng, Q-H., Mock, B. H., O'Connor, S. & Herring, C. M., Feb 2012, In : European Journal of Nuclear Medicine and Molecular Imaging. 39, 2, p. 220-225 6 p.

Research output: Contribution to journalArticle

Tobacco Use Cessation Products
Raclopride
Corpus Striatum
Dopamine
Tobacco Products
17 Citations (Scopus)

Subjective Perceptions Associated with the Ascending and Descending Slopes of Breath Alcohol Exposure Vary with Recent Drinking History

Wetherill, L., Morzorati, S., Foroud, T., Windisch, K., Darlington, T., Zimmerman, U. S., Plawecki, M. H. & O'Connor, S., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 1050-1057 8 p.

Research output: Contribution to journalArticle

Drinking
Alcohols
Alcoholism
Young Adult
Emotions
2011
35 Citations (Scopus)

Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men

Childs, E., O'Connor, S. & de Wit, H., Oct 2011, In : Alcoholism: Clinical and Experimental Research. 35, 10, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

Alcohols
Placebos
Hypnotics and Sedatives
Exercise Test
Hydrocortisone
19 Citations (Scopus)

Test-retest variability of [11C]raclopride-binding potential in nontreatment-seeking alcoholics

Yoder, K., Albrecht, D. S., Kareken, D., Federici, L. M., Perry, K. M., Patton, E. A., Zheng, Q-H., Mock, B. H., O'Connor, S. & Herring, C. M., Jul 2011, In : Synapse. 65, 7, p. 553-561 9 p.

Research output: Contribution to journalArticle

Raclopride
Corpus Striatum
Alcoholics
Putamen
Dopamine
2010
48 Citations (Scopus)

A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study

Kareken, D., Liang, T., Wetherill, L., Dzemidzic, M., Bragulat, V., Cox, C., Talavage, T., O'Connor, S. & Foroud, T., Dec 2010, In : Alcoholism: Clinical and Experimental Research. 34, 12, p. 2169-2178 10 p.

Research output: Contribution to journalArticle

Polymorphism
Cues
Odor control
Alcohols
Magnetic Resonance Imaging
51 Citations (Scopus)

Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers

Kareken, D., Bragulat, V., Dzemidzic, M., Cox, C., Talavage, T., Davidson, D. & O'Connor, S., Mar 2010, In : NeuroImage. 50, 1, p. 267-276 10 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Alcoholic Intoxication
Brain
Placebos
12 Citations (Scopus)

Obesity, smoking, and frontal brain dysfunction

Bauer, L., Dick, D., Bierut, L., Bucholz, K., Edenberg, H., Kuperman, S., Kramer, J., Nurnberger, J., O'Connor, S., Rice, J., Rohrbaugh, J., Schuckit, M., Tischfield, J., Porjesz, B. & Hesselbrock, V., Sep 2010, In : American Journal on Addictions. 19, 5, p. 391-400 10 p.

Research output: Contribution to journalArticle

Scalp
Obesity
Smoking
Brain
Genotype
51 Citations (Scopus)

Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence

Chen, A. C. H., Manz, N., Tang, Y., Rangaswamy, M., Almasy, L., Kuperman, S., Nurnberger, J., O'Connor, S., Edenberg, H., Schuckit, M. A., Tischfield, J., Foroud, T., Bierut, L. J., Rohrbaugh, J., Rice, J. P., Goate, A., Hesselbrock, V. & Porjesz, B., 2010, In : Alcoholism: Clinical and Experimental Research. 34, 6, p. 988-996 9 p.

Research output: Contribution to journalArticle

Corticotropin-Releasing Hormone Receptors
Polymorphism
Evoked Potentials
Alcoholism
Single Nucleotide Polymorphism
2009
49 Citations (Scopus)

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence

Chen, A. C. H., Tang, Y., Rangaswamy, M., Wang, J. C., Almasy, L., Foroud, T., Edenberg, H., Hesselbrock, V., Nurnberger, J., Kuperman, S., O'Connor, S., Schuckit, M. A., Bauer, L. O., Tischfield, J., Rice, J. P., Bierut, L., Goate, A. & Porjesz, B., Apr 5 2009, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 150, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Alcoholism
Single Nucleotide Polymorphism
Genes
Delta Rhythm
36 Citations (Scopus)

Intravenous ethanol infusions can mimic the time course of breath alcohol concentrations following oral alcohol administration in healthy volunteers

Ramchandani, V. A., Plawecki, M., Li, T. K. & O'Connor, S., May 2009, In : Alcoholism: Clinical and Experimental Research. 33, 5, p. 938-944 7 p.

Research output: Contribution to journalArticle

Intravenous Infusions
Oral Administration
Healthy Volunteers
Ethanol
Alcohols
11 Citations (Scopus)

In vivo wireless ethanol vapor detection in the Wistar rat

Cheney, C. P., Srijanto, B., Hedden, D. L., Gehl, A., Ferrell, T. L., Schultz, J., Engleman, E., McBride, W. J. & O'Connor, S., Apr 24 2009, In : Sensors and Actuators, B: Chemical. 138, 1, p. 264-269 6 p.

Research output: Contribution to journalArticle

rats
Rats
alcohols
Alcohols
Ethanol
31 Citations (Scopus)

Offspring of parents with an alcohol use disorder prefer higher levels of brain alcohol exposure in experiments involving computer-assisted self-infusion of ethanol (CASE)

Zimmermann, U. S., Mick, I., Laucht, M., Vitvitskiy, V., Plawecki, M. H., Mann, K. F. & O'Connor, S., Mar 2009, In : Psychopharmacology. 202, 4, p. 689-697 9 p.

Research output: Contribution to journalArticle

Ethanol
Parents
Alcohols
Self Administration
Brain

Pharmacologic treatment for substance use disorders in children and adolescents

Plawecki, M. H., Erickson, C. A. & O'Connor, S., Sep 2009, In : Psychopharm Review. 44, 9, p. 65-72 8 p.

Research output: Contribution to journalArticle

Substance-Related Disorders
Therapeutics
14 Citations (Scopus)

Priming deficiency in male subjects at risk for alcoholism: The N4 during a lexical decision task

Roopesh, B. N., Rangaswamy, M., Kamarajan, C., Chorlian, D. B., Stimus, A., Bauer, L. O., Rohrbaugh, J., O'Connor, S., Kuperman, S., Schuckit, M. & Porjesz, B., Dec 2009, In : Alcoholism: Clinical and Experimental Research. 33, 12, p. 2027-2036 10 p.

Research output: Contribution to journalArticle

Semantics
Alcoholism
Alcoholics
Fathers
P300 Event-Related Potentials
48 Citations (Scopus)

When what you see isn't what you get: Alcohol cues, alcohol administration, prediction error, and human striatal dopamine

Yoder, K., Morris, E. D., Constantinescu, C. C., Cheng, T. E., Normandin, M. D., O'Connor, S. & Kareken, D., Jan 2009, In : Alcoholism: Clinical and Experimental Research. 33, 1, p. 139-149 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Cues
Dopamine
Alcohols
Reward
2008
46 Citations (Scopus)

Alcohol sensitizes cerebral responses to the odors of alcoholic drinks: An fMRI study

Bragulat, V., Dzemidzic, M., Talavage, T., Davidson, D., O'Connor, S. & Kareken, D., Jul 2008, In : Alcoholism: Clinical and Experimental Research. 32, 7, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

Odors
Gyrus Cinguli
Odor control
Alcohols
Magnetic Resonance Imaging
39 Citations (Scopus)

Development and Pilot Validation of Computer-Assisted Self-Infusion of Ethanol (CASE): A New Method to Study Alcohol Self-Administration in Humans

Zimmermann, U. S., Mick, I., Vitvitskyi, V., Plawecki, M. H., Mann, K. F. & O'Connor, S., Jul 2008, In : Alcoholism: Clinical and Experimental Research. 32, 7, p. 1321-1328 8 p.

Research output: Contribution to journalArticle

Self Administration
Ethanol
Alcohols
Blood
Outcome Assessment (Health Care)
7 Citations (Scopus)

Estimation from PET data of transient changes in dopamine concentration induced by alcohol: Support for a non-parametric signal estimation method

Constantinescu, C. C., Yoder, K., Kareken, D., Bouman, C. A., O'Connor, S., Normandin, M. D. & Morris, E. D., Mar 7 2008, In : Physics in Medicine and Biology. 53, 5, p. 1353-1367 15 p.

Research output: Contribution to journalArticle

Raclopride
dopamine
Dopamine
alcohols
Alcohols
5 Citations (Scopus)

In vivo time-course changes in ethanol levels sampled with subcutaneous microdialysis

Engleman, E. A., Ingraham, C. M., Franklin, K. M., Keith, C. M., McClaren, J. A., Schultz, J. A., Morzorati, S. L., O'Connor, S., Thielen, R. J., Murphy, J. M. & McBride, W. J., Mar 2008, In : Alcoholism: Clinical and Experimental Research. 32, 3, p. 435-442 8 p.

Research output: Contribution to journalArticle

Microdialysis
Ethanol
Rats
Blood
Alcohols
2 Citations (Scopus)

Models and signal processing for an implanted ethanol bio-sensor

Han, J. J., Doerschuk, P. C., Gelfand, S. B. & O'Connor, S., Feb 2008, In : IEEE Transactions on Biomedical Engineering. 55, 2, p. 603-613 11 p.

Research output: Contribution to journalArticle

Signal processing
Ethanol
Sensors
Tissue
Physiology
29 Citations (Scopus)

Physiologically based pharmacokinetic (PBPK) models for ethanol

Plawecki, M. H., Han, J. J., Doerschuk, P. C., Ramchandani, V. A. & O'Connor, S., Dec 2008, In : IEEE Transactions on Biomedical Engineering. 55, 12, p. 2691-2700 10 p., 5.

Research output: Contribution to journalArticle

Pharmacokinetics
Ethanol
Pharmacodynamics
Ordinary differential equations
Identification (control systems)
2007
72 Citations (Scopus)

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy, M., Jones, K. A., Porjesz, B., Chorlian, D. B., Padmanabhapillai, A., Kamarajan, C., Kuperman, S., Rohrbaugh, J., O'Connor, S., Bauer, L. O., Schuckit, M. A. & Begleiter, H., Jan 2007, In : International Journal of Psychophysiology. 63, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

Alcoholics
Electroencephalography
Cholinergic Agents
Alcoholism
Power (Psychology)