Sean O'Connor

  • 5381 Citations
  • 44 h-Index
1983 …2019
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Publications 1983 2019

  • 5381 Citations
  • 44 h-Index
  • 117 Article
  • 6 Conference contribution
  • 1 Review article
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53 Citations (Scopus)

A cholinergic receptor gene (CHRM2) affects event-related oscillations

Jones, K. A., Porjesz, B., Almasy, L., Bierut, L., Dick, D., Goate, A., Hinrichs, A., Rice, J. P., Wang, J. C., Bauer, L. O., Crowe, R., Foroud, T., Hesselbrock, V., Kuperman, S., Nurnberger, J., O'Connor, S., Rohrbaugh, J., Schuckit, M. A., Tischfield, J., Edenberg, H. & 1 others, Begleiter, H., Sep 2006, In : Behavior Genetics. 36, 5, p. 627-639 13 p.

Research output: Contribution to journalArticle

cholinergic receptors
cholinergic agents
Cholinergic Receptors
cognition
Cholinergic Agents
5 Citations (Scopus)

A comparison of pressure-volume models in hydrocephalus

Simon, R. H., Lehman, R. A. W. & O'Connor, S., 1984, In : Neurosurgery. 15, 5, p. 694-699 6 p.

Research output: Contribution to journalArticle

Hydrocephalus
Pressure
11 Citations (Scopus)
Drinking
Genotype
Alcohols
Alcoholism
Single Nucleotide Polymorphism
8 Citations (Scopus)

Adolescent Women Induce Lower Blood Alcohol Levels Than Men in a Laboratory Alcohol Self-Administration Experiment

Jünger, E., Gan, G., Mick, I., Seipt, C., Markovic, A., Sommer, C., Plawecki, M. H., O'Connor, S., Smolka, M. N. & Zimmermann, U. S., Aug 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 8, p. 1769-1778 10 p.

Research output: Contribution to journalArticle

Self Administration
Blood
Alcohols
Drinking
Experiments
168 Citations (Scopus)

A family study of alcohol dependence: Coaggregation of multiple disorders in relatives of alcohol-dependent probands

Nurnberger, J., Wiegand, R., Bucholz, K., O'Connor, S., Meyer, E. T., Reich, T., Rice, J., Schuckit, M., King, L., Petti, T., Bierut, L., Hinrichs, A. L., Kuperman, S., Hesselbrock, V. & Porjesz, B., Dec 2004, In : Archives of General Psychiatry. 61, 12, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Diagnostic and Statistical Manual of Mental Disorders
Substance-Related Disorders
Antisocial Personality Disorder
4 Citations (Scopus)

A Graphical Technique for Displaying Correlation Matrices

Koziol, J. A., Alexander, J. E., Bauer, L. O., Kuperman, S., Morzorati, S., O'Connor, S., Rohrbaugh, J., Porjesz, B., Begleiter, H. & Polich, J., Nov 1997, In : American Statistician. 51, 4, p. 301-304 4 p.

Research output: Contribution to journalArticle

Correlation Matrix
Graphical Methods
Immediately
Equality
Experimental Data

Alcohol affects the P3 component of an adaptive stop signal task ERP

Plawecki, M. H., Windisch, K. A., Wetherill, L., Kosobud, A., Dzemidzic, M., Kareken, D. & O'Connor, S., Aug 1 2018, In : Alcohol. 70, p. 1-10 10 p.

Research output: Contribution to journalArticle

Silver Sulfadiazine
Evoked Potentials
alcohol
Alcohols
event
121 Citations (Scopus)

Alcohol Dehydrogenase Polymorphisms Influence Alcohol-Elimination Rates in a Male Jewish Population

Neumark, Y. D., Friedlander, Y., Durst, R., Leitersdorf, E., Jaffe, D., Ramchandani, V. A., O'Connor, S., Carr, L. G. & Li, T. K., Jan 2004, In : Alcoholism: Clinical and Experimental Research. 28, 1, p. 10-14 5 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Polymorphism
Alcohols
Population
Jews
25 Citations (Scopus)

Alcohol effects on the heritability of EEG spectral power

Sorbel, J., Morzorati, S., O'Connor, S., Li, T. K. & Christian, J. C., 1996, In : Alcoholism: Clinical and Experimental Research. 20, 9, p. 1523-1527 5 p.

Research output: Contribution to journalArticle

Electroencephalography
Alcohols
Viverridae
Dizygotic Twins
Power spectral density
10 Citations (Scopus)

Alcohol Exposure Rate Control Through Physiologically Based Pharmacokinetic Modeling

Plawecki, M. H., Zimmermann, U. S., Vitvitskiy, V., Doerschuk, P. C., Crabb, D. & O'Connor, S., Jun 2012, In : Alcoholism: Clinical and Experimental Research. 36, 6, p. 530-542 13 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Alcohols
Trajectories
Intravenous Infusions
Design of experiments
1 Citation (Scopus)

Alcohol intoxication progressively impairs drivers' capacity to detect important environmental stimuli

Plawecki, M. H., Koskie, S., Kosobud, A., Justiss, M. D. & O'Connor, S., Dec 1 2018, In : Pharmacology Biochemistry and Behavior. 175, p. 62-68 7 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Alcohols
Motor Vehicles
Accidents
Young Adult
85 Citations (Scopus)

Alcohol-Related Olfactory Cues Activate the Nucleus Accumbens and Ventral Tegmental Area in High-Risk Drinkers: Preliminary Findings

Kareken, D., Claus, E. D., Sabri, M., Dzemidzic, M., Kosobud, A., Radnovich, A., Hector, D., Ramchandani, V. A., O'Connor, S., Lowe, M. & Li, T. K., Apr 2004, In : Alcoholism: Clinical and Experimental Research. 28, 4, p. 550-557 8 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Nucleus Accumbens
Cues
Odors
Alcohols
47 Citations (Scopus)

Alcohol sensitizes cerebral responses to the odors of alcoholic drinks: An fMRI study

Bragulat, V., Dzemidzic, M., Talavage, T., Davidson, D., O'Connor, S. & Kareken, D., Jul 2008, In : Alcoholism: Clinical and Experimental Research. 32, 7, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

Odors
Gyrus Cinguli
Odor control
Alcohols
Magnetic Resonance Imaging
9 Citations (Scopus)

A model referenced method for the identification of evoked potential component wave forms

O'Connor, S., Tasman, A., Simon, R. H. & Hale, M. S., 1983, In : Electroencephalography and Clinical Neurophysiology. 55, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Neurophysiology
Visual Evoked Potentials
Visual Cortex
Evoked Potentials
Anesthetics
104 Citations (Scopus)

Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project

Porjesz, B., Begleiter, H., Reich, T., Van Eerdewegh, P., Edenberg, H., Foroud, T., Goate, A., Litke, A., Chorlian, D. B., Stimus, A., Rice, J., Blangero, J., Almasy, L., Sorbell, J., Bauer, L. O., Kuperman, S., O'Connor, S. & Rohrbaugh, J., Sep 1998, In : Alcoholism: Clinical and Experimental Research. 22, 6, p. 1317-1323 7 p.

Research output: Contribution to journalArticle

P300 Event-Related Potentials
Alcoholism
Psychiatry
Alcohols
Sex Distribution
121 Citations (Scopus)

A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping

Ramchandani, V. A., Bolane, J., Li, T. K. & O'Connor, S., Apr 1999, In : Alcoholism: Clinical and Experimental Research. 23, 4, p. 617-623 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Constriction
Alcohols
Ethanol
Clamping devices
48 Citations (Scopus)

A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study

Kareken, D., Liang, T., Wetherill, L., Dzemidzic, M., Bragulat, V., Cox, C., Talavage, T., O'Connor, S. & Foroud, T., Dec 2010, In : Alcoholism: Clinical and Experimental Research. 34, 12, p. 2169-2178 10 p.

Research output: Contribution to journalArticle

Polymorphism
Cues
Odor control
Alcohols
Magnetic Resonance Imaging
51 Citations (Scopus)

A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism

Ramchandani, V. A., O'Connor, S., Blekher, T., Kareken, D., Morzorati, S., Nurnberger, J. & Li, T. K., 1999, In : Alcoholism: Clinical and Experimental Research. 23, 8, p. 1320-1330 11 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Constriction
Brain
Eye movements
54 Citations (Scopus)

A prospective 5-year re-examination of alcohol response in heavy drinkers progressing in alcohol use disorder

King, A. C., Hasin, D., O'Connor, S., McNamara, P. J. & Cao, D., Mar 15 2016, In : Biological Psychiatry. 79, 6, p. 489-498 10 p.

Research output: Contribution to journalArticle

Alcohols
Allostasis
Reward
Drinking Behavior
Hypnotics and Sedatives
49 Citations (Scopus)

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence

Chen, A. C. H., Tang, Y., Rangaswamy, M., Wang, J. C., Almasy, L., Foroud, T., Edenberg, H., Hesselbrock, V., Nurnberger, J., Kuperman, S., O'Connor, S., Schuckit, M. A., Bauer, L. O., Tischfield, J., Rice, J. P., Bierut, L., Goate, A. & Porjesz, B., Apr 5 2009, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 150, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Alcoholism
Single Nucleotide Polymorphism
Genes
Delta Rhythm
14 Citations (Scopus)

A twin study of genetic influences on the acute adaptation of the EEG to alcohol

O'Connor, S., Sorbel, J., Morzorati, S., Li, T. K. & Christian, J. C., Mar 1999, In : Alcoholism: Clinical and Experimental Research. 23, 3, p. 494-501 8 p.

Research output: Contribution to journalArticle

Twin Studies
Electroencephalography
Alcohols
Extremities
Dizygotic Twins
18 Citations (Scopus)

Beer self-administration provokes lateralized nucleus accumbens dopamine release in male heavy drinkers

Oberlin, B. G., Dzemidzic, M., Tran, S. M., Soeurt, C. M., O'Connor, S., Yoder, K. & Kareken, D., 2015, In : Psychopharmacology. 232, 5, p. 861-870 10 p.

Research output: Contribution to journalArticle

Self Administration
Nucleus Accumbens
Dopamine
Ethanol
Raclopride
53 Citations (Scopus)

Behavioral and EEG responses to alcohol in nonalcoholic men with a family history of alcoholism

Kaplan, R. F., Hesselbrock, V. M., O'Connor, S. & Depalma, N., 1988, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 12, 6, p. 873-885 13 p.

Research output: Contribution to journalArticle

Alcoholism
Electroencephalography
Placebos
Alcohols
Alcohol Drinking
193 Citations (Scopus)

Beta power in the EEG of alcoholics

Rangaswamy, M., Porjesz, B., Chorlian, D. B., Wang, K., Jones, K. A., Bauer, L. O., Rohrbaugh, J., O'Connor, S., Kuperman, S., Reich, T. & Begleiter, H., Oct 15 2002, In : Biological Psychiatry. 52, 8, p. 831-842 12 p.

Research output: Contribution to journalArticle

Alcoholics
Electroencephalography
Alcohols
Scalp
Drinking
35 Citations (Scopus)

Bidirectional interactions between acute psychosocial stress and acute intravenous alcohol in healthy men

Childs, E., O'Connor, S. & de Wit, H., Oct 2011, In : Alcoholism: Clinical and Experimental Research. 35, 10, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

Alcohols
Placebos
Hypnotics and Sedatives
Exercise Test
Hydrocortisone
123 Citations (Scopus)
Constriction
Alcohols
Clamping devices
Intravenous Infusions
Oral Administration

Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures

Plawecki, M. H., Durrani, A. M., Boes, J., Wetherill, L., Kosobud, A., O'Connor, S. & Ramchandani, V. A., Jan 1 2019, In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Intravenous Administration
Alcohols
Trajectories
Body Water
Research
65 Citations (Scopus)

Correlates of increased risk for alcoholism in young men

O'Connor, S., Hesselbrock, V. & Allan, T., 1986, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 10, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Fathers
Alcoholism
Drinking
Alcoholics
Evoked Potentials
72 Citations (Scopus)

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy, M., Jones, K. A., Porjesz, B., Chorlian, D. B., Padmanabhapillai, A., Kamarajan, C., Kuperman, S., Rohrbaugh, J., O'Connor, S., Bauer, L. O., Schuckit, M. A. & Begleiter, H., Jan 2007, In : International Journal of Psychophysiology. 63, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

Alcoholics
Electroencephalography
Cholinergic Agents
Alcoholism
Power (Psychology)
40 Citations (Scopus)

Development and Pilot Validation of Computer-Assisted Self-Infusion of Ethanol (CASE): A New Method to Study Alcohol Self-Administration in Humans

Zimmermann, U. S., Mick, I., Vitvitskyi, V., Plawecki, M. H., Mann, K. F. & O'Connor, S., Jul 2008, In : Alcoholism: Clinical and Experimental Research. 32, 7, p. 1321-1328 8 p.

Research output: Contribution to journalArticle

Self Administration
Ethanol
Alcohols
Blood
Outcome Assessment (Health Care)
16 Citations (Scopus)

Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics

Yoder, K., Albrecht, D. S., Dzemidzic, M., Normandin, M. D., Federici, L. M., Graves, T., Herring, C. M., Hile, K. L., Walters, J. W., Liang, T., Plawecki, M. H., O'Connor, S. & Kareken, D., Mar 1 2016, In : Drug and Alcohol Dependence. 160, p. 163-169 7 p.

Research output: Contribution to journalArticle

Alcoholics
Dopamine
Alcohols
Alcoholic Intoxication
Corpus Striatum
64 Citations (Scopus)

Dopamine D2 receptor availability is associated with subjective responses to alcohol

Yoder, K., Kareken, D., Seyoum, R. A., O'Connor, S., Wang, C., Zheng, Q-H., Mock, B. & Morris, E. D., Jun 2005, In : Alcoholism: Clinical and Experimental Research. 29, 6, p. 965-970 6 p.

Research output: Contribution to journalArticle

Dopamine D2 Receptors
Alcohols
Alcoholism
Availability
Raclopride
7 Citations (Scopus)

Estimation from PET data of transient changes in dopamine concentration induced by alcohol: Support for a non-parametric signal estimation method

Constantinescu, C. C., Yoder, K., Kareken, D., Bouman, C. A., O'Connor, S., Normandin, M. D. & Morris, E. D., Mar 7 2008, In : Physics in Medicine and Biology. 53, 5, p. 1353-1367 15 p.

Research output: Contribution to journalArticle

Raclopride
dopamine
Dopamine
alcohols
Alcohols
29 Citations (Scopus)

Evoked gamma band response in male adolescent subjects at high risk for alcoholism during a visual oddball task

Padmanabhapillai, A., Tang, Y., Ranganathan, M., Rangaswamy, M., Jones, K. A., Chorlian, D. B., Kamarajan, C., Stimus, A., Kuperman, S., Rohrbaugh, J., O'Connor, S., Bauer, L. O., Schuckit, M. A., Begleiter, H. & Porjesz, B., Nov 2006, In : International Journal of Psychophysiology. 62, 2, p. 262-271 10 p.

Research output: Contribution to journalArticle

Alcoholism
Parietal Lobe
Electroencephalography
13 Citations (Scopus)

Exposure-response relationships during free-access intravenous alcohol self-administration in nondependent drinkers: Influence of alcohol expectancies and impulsivity

Stangl, B. L., Vatsalya, V., Zametkin, M. R., Cooke, M. E., Plawecki, M. H., O'Connor, S. & Ramchandani, V. A., 2017, In : International Journal of Neuropsychopharmacology. 20, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Self Administration
Impulsive Behavior
Alcohols
Alcohol Drinking
Pleasure
28 Citations (Scopus)

Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition

Kareken, D., Dzemidzic, M., Wetherill, L., Eiler, W., Oberlin, B. G., Harezlak, J., Wang, Y. & O'Connor, S., Jul 2013, In : Psychopharmacology. 228, 2, p. 335-345 11 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Brain
Impulsive Behavior
Magnetic Resonance Imaging
51 Citations (Scopus)

Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers

Kareken, D., Bragulat, V., Dzemidzic, M., Cox, C., Talavage, T., Davidson, D. & O'Connor, S., Mar 2010, In : NeuroImage. 50, 1, p. 267-276 10 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Alcoholic Intoxication
Brain
Placebos
14 Citations (Scopus)

fMRI of the brain's response to stimuli experimentally paired with alcohol intoxication

Kareken, D., Grahame, N., Dzemidzic, M., Walker, M. J., Lehigh, C. A. & O'Connor, S., 2012, In : Psychopharmacology. 220, 4, p. 787-797 11 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Alcohols
Magnetic Resonance Imaging
Brain
Frontal Lobe
120 Citations (Scopus)

Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

Costa, L., Bauer, L., Kuperman, S., Porjesz, B., O'Connor, S., Hesselbrock, V., Rohrbaugh, J. & Begleiter, H., Jun 2000, In : Biological Psychiatry. 47, 12, p. 1064-1071 8 p.

Research output: Contribution to journalArticle

Antisocial Personality Disorder
Alcoholism
Electrodes
Brain
P300 Event-Related Potentials
119 Citations (Scopus)

Frontal P300 decrements in antisocial personality disorder

Bauer, L. O., O'Connor, S. & Hesselbrock, V. M., 1994, In : Alcoholism: Clinical and Experimental Research. 18, 6, p. 1300-1305 6 p.

Research output: Contribution to journalArticle

Antisocial Personality Disorder
Brain
Electrodes
Evoked Potentials
Alcoholics
125 Citations (Scopus)

Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for body mass

Kwo, P. Y., Ramchandani, V. A., O'Connor, S., Amann, D., Carr, L. G., Sandrasegaran, K., Kopecky, K. K. & Li, T. K., 1998, In : Gastroenterology. 115, 6, p. 1552-1557 6 p.

Research output: Contribution to journalArticle

Alcohols
Liver
Ethanol
Alcoholic Liver Diseases
Intravenous Infusions
6 Citations (Scopus)

Gender-Specific Effects of Mood on Alcohol-Seeking Behaviors: Preliminary Findings Using Intravenous Alcohol Self-Administration

Cyders, M. A., Vanderveen, J. D., Plawecki, M., Millward, J. B., Hays, J., Kareken, D. & O'Connor, S., Feb 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Self Administration
Alcohols
Independent Living
Experiments
Drinking
44 Citations (Scopus)

Genetic analysis of the resting electroencephalographic power spectrum in human twins

Christian, J. C., Morzorati, S., Norton, J. A., Williams, C. J., O'Connor, S. & Li, T. K., Sep 1996, In : Psychophysiology. 33, 5, p. 584-591 8 p.

Research output: Contribution to journalArticle

Electroencephalography
Twin Studies
Genes
Genetic Models
Dizygotic Twins
103 Citations (Scopus)

Genetic and environmental influences on alcohol metabolism in humans

Li, T. K., Yin, S. J., Crabb, D., O'Connor, S. & Ramchandani, V. A., 2001, In : Alcoholism: Clinical and Experimental Research. 25, 1, p. 136-144 9 p.

Research output: Contribution to journalArticle

Metabolism
Tolnaftate
Alcohols
Polymorphism
Constriction
25 Citations (Scopus)

Genetic influences on bipolar EEG power spectra

Tang, Y., Chorlian, D. B., Rangaswamy, M., Porjesz, B., Bauer, L., Kuperman, S., O'Connor, S., Rohrbaugh, J., Schuckit, M., Stimus, A. & Begleiter, H., Jul 2007, In : International Journal of Psychophysiology. 65, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Electroencephalography
Electrodes
Endophenotypes
Alcoholism
Psychiatry
50 Citations (Scopus)

Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism

Almasy, L., Porjesz, B., Blangero, J., Goate, A., Edenberg, H., O'Connor, S., Kuperman, S., O'Connor, S. J., Rohrbaugh, J., Bauer, L. O., Foroud, T., Rice, J. P., Reich, T. & Begleiter, H., 2001, In : American Journal of Human Genetics. 68, 1, p. 128-135 8 p.

Research output: Contribution to journalArticle

Evoked Potentials
Semantics
Alcoholism
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 4
16 Citations (Scopus)

Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms

Collaborative Study of the Genetics of Alcoholism Consortium & the German Study of the Genetics of Addiction Consortium, May 1 2017, In : Alcoholism: Clinical and Experimental Research. 41, 5, p. 911-928 18 p.

Research output: Contribution to journalArticle

Alcoholism
Ethanol
Genes
Alcohols
Long Noncoding RNA
58 Citations (Scopus)

Hemispheric differences for P300 amplitude from an auditory oddball task

Alexander, J. E., Bauer, L. O., Kuperman, S., Morzorati, S., O'Connor, S., Rohrbaugh, J., Porjesz, B., Begleiter, H. & Polich, J., Feb 3 1996, In : International Journal of Psychophysiology. 21, 2-3, p. 189-196 8 p.

Research output: Contribution to journalArticle

Electrodes
P300 Event-Related Potentials
8 Citations (Scopus)

Heritability of bipolar EEG spectra in a large sib-pair population

Tang, Y., Chorlian, D. B., Rangaswamy, M., O'Connor, S., Taylor, R., Rohrbaugh, J., Porjesz, B. & Begleiter, H., Mar 2007, In : Behavior Genetics. 37, 2, p. 302-313 12 p.

Research output: Contribution to journalArticle

heritability
Electroencephalography
electrodes
Electrodes
Population
17 Citations (Scopus)

Heritability of EEG coherence in a large sib-pair population

Chorlian, D. B., Tang, Y., Rangaswamy, M., O'Connor, S., Rohrbaugh, J., Taylor, R. & Porjesz, B., Jul 2007, In : Biological Psychology. 75, 3, p. 260-266 7 p.

Research output: Contribution to journalArticle

Electroencephalography
Population
Phenotype